{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:37:50Z","timestamp":1792604270768,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Deltaplan Alvleesklierkanker"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current guidelines do not recommend routine sampling of lymph node stations (LNS) 16b1, 9, and 8a during pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC) and other periampullary cancers because prospective multicentre studies are lacking. This study evaluated the association between the involvement of these LNS and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicentre study included patients undergoing pancreatoduodenectomy for PDAC, distal cholangiocarcinoma, ampullary cancer, or duodenal cancer between October 2015 and April 2020. Associations between involvement of LNS 16b1, 9, and 8a and OS were analysed using multivariable Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1218 included patients, 673 had PDAC, 228 had distal cholangiocarcinoma, 212 had ampullary cancer, and 105 had duodenal cancer. LNS 16b1 involvement was associated with worse OS in PDAC (10 versus 24\u2005months; adjusted hazard ratio (aHR) 2.33; 95% confidence interval (c.i.) 1.62 to 3.35), distal cholangiocarcinoma (7 versus 28\u2005months; aHR 6.95; 95% c.i. 2.88 to 16.77), ampullary cancer (9 versus 62\u2005months; aHR 4.35; 95% c.i. 1.73 to 10.94), and duodenal cancer (13\u2005months versus endpoint not reached; aHR 3.95; 95% c.i. 1.15 to 13.47). LNS 8a involvement was associated with worse OS in PDAC (13 versus 22\u2005months; aHR 1.38; 95% c.i. 1.03 to 1.86), distal cholangiocarcinoma (16 versus 26\u2005months; aHR 1.68; 95% c.i. 1.00 to 2.81), and ampullary cancer (16 versus 62\u2005months; aHR 2.89; 95% c.i. 1.51 to 5.53). LNS 9 involvement was associated with worse OS only in ampullary cancer (4 versus 35\u2005months; aHR 8.19; 95% c.i. 2.34 to 28.57).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LNS 16b1 involvement was associated with poor OS in PDAC and periampullary cancer. Future studies should assess routine preoperative and intraoperative sampling of LNS 16b1 and the impact of neoadjuvant treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjsopen\/zrag157","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:14:13Z","timestamp":1786101253000},"source":"Crossref","is-referenced-by-count":0,"title":["Survival impact of involvement of lymph node stations 16b1, 9, and 8a during pancreatoduodenectomy for pancreatic and periampullary cancers (PANODE): prospective multicentre study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5622","authenticated-orcid":false,"given":"J Annelie","family":"Suurmeijer","sequence":"first","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6304-7987","authenticated-orcid":false,"given":"Bobby K","family":"Pranger","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard W F","family":"Seelen","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Centre and St Antonius Hospital Nieuwegein: Regional Academic Cancer Centre Utrecht , Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-6323","authenticated-orcid":false,"given":"Mahsoem","family":"Ali","sequence":"additional","affiliation":[{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Bengt","family":"van Rijssen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-580X","authenticated-orcid":false,"given":"Dorine S","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Centre and St Antonius Hospital Nieuwegein: Regional Academic Cancer Centre Utrecht , Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M","family":"Mackay","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-9035","authenticated-orcid":false,"given":"Jacob L","family":"van Dam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC, University Medical Centre Rotterdam , Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hjalmar C","family":"van Santvoort","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Centre and St Antonius Hospital Nieuwegein: Regional Academic Cancer Centre Utrecht , Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-6973","authenticated-orcid":false,"given":"Bas","family":"Groot Koerkamp","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC, University Medical Centre Rotterdam , Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantza Farina","family":"Sarasqueta","sequence":"additional","affiliation":[{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Pathology, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper H","family":"van Eijck","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC, University Medical Centre Rotterdam , Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike S L","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medisch Spectrum Twente , Enschede ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Kazemier","sequence":"additional","affiliation":[{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent B","family":"Nieuwenhuijs","sequence":"additional","affiliation":[{"name":"Department of Surgery, Isala Zwolle , Zwolle ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-4390","authenticated-orcid":false,"given":"Ignace H","family":"de Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost M","family":"Klaase","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-1505","authenticated-orcid":false,"given":"Joris I","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-6831","authenticated-orcid":false,"given":"Olivier R","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Cancer Centre Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Quintus","family":"Molenaar","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMC Utrecht Cancer Centre and St Antonius Hospital Nieuwegein: Regional Academic Cancer Centre Utrecht , Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-5917","authenticated-orcid":false,"given":"Vincent E","family":"de Meijer","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-9350","authenticated-orcid":false,"given":"Marc G","family":"Besselink","sequence":"additional","affiliation":[{"name":"Department of 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