{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:35Z","timestamp":1787008535791,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Source of data<\/jats:title>\n                    <jats:p>Current scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Areas of agreement<\/jats:title>\n                    <jats:p>Recently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Areas of controversy<\/jats:title>\n                    <jats:p>Evaluation of the role of miRNAs in patients with meniscal tears is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Growing points<\/jats:title>\n                    <jats:p>A systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Areas timely for developing research<\/jats:title>\n                    <jats:p>Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bmb\/ldac039","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T09:49:13Z","timestamp":1671616153000},"page":"141-150","source":"Crossref","is-referenced-by-count":5,"title":["Micro RNA in meniscal ailments: current concepts"],"prefix":"10.1093","volume":"145","author":[{"given":"Filippo","family":"Migliorini","sequence":"first","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstra\u00dfe 30, 52074 Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Medicine , Surgery and Dentistry, , Baronissi 84081 , Italy"},{"name":"University of Salerno , Surgery and Dentistry, , Baronissi 84081 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Giorgino","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, IRCCS Orthopaedic Institute Galeazzi , Milano 20161 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Eschweiler","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstra\u00dfe 30, 52074 Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, RWTH University Hospital Aachen , Pauwelsstra\u00dfe 30, 52074 Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, IRCCS Orthopaedic Institute Galeazzi , Milano 20161 , Italy"},{"name":"Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, Queen Mary University of London , 275 Bancroft Road, London E1 4DG , UK"},{"name":"School of Pharmacy and Bioengineering, Keele University Faculty of Medicine , Thornburrow Drive, Stoke on Trent ST4 7QB , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1042\/BST0361224","article-title":"How do microRNAs regulate gene expression?","volume":"36","author":"Cannell","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","article-title":"MicroRNA maturation: stepwise processing and subcellular localization","volume":"21","author":"Lee","year":"2002","journal-title":"EMBO J"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","article-title":"Role for a bidentate ribonuclease in the initiation step of RNA interference","volume":"409","author":"Bernstein","year":"2001","journal-title":"Nature"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","article-title":"A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA","volume":"293","author":"Hutvagner","year":"2001","journal-title":"Science"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1101\/gad.927801","article-title":"Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans","volume":"15","author":"Ketting","year":"2001","journal-title":"Genes Dev"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1126\/science.1062039","article-title":"A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans","volume":"293","author":"Knight","year":"2001","journal-title":"Science"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature03868","article-title":"TRBP recruits the dicer complex to Ago2 for microRNA processing and gene silencing","volume":"436","author":"Chendrimada","year":"2005","journal-title":"Nature"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat Cell Biol"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12033-007-9013-8","article-title":"The microRNA (miRNA): overview of the RNA genes that modulate gene function","volume":"38","author":"Ying","year":"2008","journal-title":"Mol Biotechnol"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1615\/CritRevEukaryotGeneExpr.2017019494","article-title":"miRNA: a diagnostic and therapeutic tool for pancreatic cancer","volume":"27","author":"Qadir","year":"2017","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.2174\/1381612823666170714151715","article-title":"MiRNA-based therapeutics for lung cancer","volume":"23","author":"Wu","year":"2018","journal-title":"Curr Pharm Des"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1002\/bjs.10790","article-title":"Role of micro-RNAs in breast cancer surgery","volume":"105","author":"McAnena","year":"2018","journal-title":"Br J Surg"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/jmedgenet-2018-105387","article-title":"Significance of non-coding circular RNAs and micro RNAs in the pathogenesis of cardiovascular diseases","volume":"55","author":"Zhao","year":"2018","journal-title":"J Med Genet"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"101664","DOI":"10.1016\/j.pneurobio.2019.101664","article-title":"microRNA dysregulation in neurodegenerative diseases: a systematic review","volume":"182","author":"Juzwik","year":"2019","journal-title":"Prog Neurobiol"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.joca.2020.09.004","article-title":"Regulation of inflammatory and catabolic responses to IL-1beta in rat articular chondrocytes by microRNAs miR-122 and miR-451","volume":"29","author":"Scott","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.omtn.2020.10.004","article-title":"The synovium attenuates cartilage degeneration in KOA through activation of the Smad2\/3-Runx1 Cascade and Chondrogenesis-related miRNAs","volume":"22","author":"Zhao","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"600867","DOI":"10.3389\/fcell.2020.600867","article-title":"Roles of MicroRNAs in bone destruction of rheumatoid arthritis","volume":"8","author":"Zhao","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2023040514215694200_","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cell"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2741\/4301","article-title":"The expression and function of microRNAs in bone homeostasis","volume":"20","author":"Pi","year":"2015","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/bmb\/ldz015","article-title":"MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge","volume":"130","author":"Oliviero","year":"2019","journal-title":"Br Med Bull"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.1915510","article-title":"MicroRNA-140 plays dual roles in both cartilage development and homeostasis","volume":"24","author":"Miyaki","year":"2010","journal-title":"Genes Dev"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.joca.2017.06.002","article-title":"Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats","volume":"25","author":"Si","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.gene.2017.06.027","article-title":"miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis","volume":"627","author":"Soyocak","year":"2017","journal-title":"Gene"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"a006643","DOI":"10.1101\/cshperspect.a006643","article-title":"miRNAs as modulators of angiogenesis","volume":"3","author":"Landskroner-Eiger","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00776-015-0709-5","article-title":"The effect of administration of double stranded MicroRNA-210 on acceleration of Achilles tendon healing in a rat model","volume":"20","author":"Usman","year":"2015","journal-title":"J Orthop Sci"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2023040514215694200_","volume-title":"The 2011 Oxford CEBM Levels of Evidence","author":"Howick","year":"2011"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jor.23086","article-title":"Inflammatory cytokines induce specific time- and concentration-dependent MicroRNA release by chondrocytes, synoviocytes, and meniscus cells","volume":"34","author":"Genemaras","year":"2016","journal-title":"J Orthop Res"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1947603516684589","article-title":"Effects of anti-inflammatory agents on expression of early responsive inflammatory and catabolic genes in ex vivo porcine model of acute knee cartilage injury","volume":"9","author":"Genemaras","year":"2018","journal-title":"Cartilage"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s13075-014-0488-y","article-title":"Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model","volume":"16","author":"Kawanishi","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/s12891-019-2943-z","article-title":"Substantive molecular and histological changes within the meniscus with tears","volume":"20","author":"Long","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1177\/0363546520934766","article-title":"Traumatic meniscal tears are associated with meniscal degeneration","volume":"48","author":"Wesdorp","year":"2020","journal-title":"Am J Sports Med"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ca.22456","article-title":"The human meniscus: a review of anatomy, function, injury, and advances in treatment","volume":"28","author":"Fox","year":"2015","journal-title":"Clin Anat"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am J Sports Med"},{"key":"2023040514215694200_","first-page":"776","article-title":"Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study","volume":"34","author":"Ding","year":"2007","journal-title":"J Rheumatol"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/art.24383","article-title":"Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: the Multicenter osteoarthritis study","volume":"60","author":"Englund","year":"2009","journal-title":"Arthritis Rheum"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1055\/s-0038-1668123","article-title":"A meta-analysis of arthroscopic meniscal repair: inside-out versus outside-in versus all-inside techniques","volume":"32","author":"Elmallah","year":"2019","journal-title":"J Knee Surg"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5312\/wjo.v5.i3.233","article-title":"Treatment of meniscal tears: an evidence based approach","volume":"5","author":"Mordecai","year":"2014","journal-title":"World J Orthop"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1302\/0301-620X.86B7.14349","article-title":"Expression of vascular endothelial growth factor during healing of the meniscus in a rabbit model","volume":"86-B","author":"Becker","year":"2004","journal-title":"J Bone Joint Surg Br"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1074\/jbc.M800731200","article-title":"MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3","volume":"283","author":"Fasanaro","year":"2008","journal-title":"J Biol Chem"},{"key":"2023040514215694200_","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/iub.427","article-title":"miR-210: more than a silent player in hypoxia","volume":"63","author":"Devlin","year":"2011","journal-title":"IUBMB Life"}],"container-title":["British Medical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bmb\/article-pdf\/145\/1\/141\/49765371\/ldac039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bmb\/article-pdf\/145\/1\/141\/49765371\/ldac039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T05:52:15Z","timestamp":1701582735000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bmb\/article\/145\/1\/141\/7005167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,29]]},"published-print":{"date-parts":[[2023,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/bmb\/ldac039","relation":{},"ISSN":["0007-1420","1471-8391"],"issn-type":[{"value":"0007-1420","type":"print"},{"value":"1471-8391","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3]]},"published":{"date-parts":[[2023,1,29]]}}}