{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:48:37Z","timestamp":1789984117877,"version":"4.0.1"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic low back pain, common from the sixth decade, negatively impacts the quality of life of patients and health care systems. Recently, mesenchymal stem cells (MSCs) have been introduced in the management of degenerative discogenic pain. The present study summarizes the current knowledge on the effectiveness of MSCs in patients with discogenic back pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sources of data<\/jats:title><jats:p>We performed a systematic review of the literature following the PRISMA guidelines. We searched PubMed and Google Scholar database, and identified 14 articles about management of chronic low back pain with MSCs injection therapy. We recorded information on type of stem cells employed, culture medium, clinical scores and MRI outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Areas of agreement<\/jats:title><jats:p>We identified a total of 303 patients. Ten studies used bone marrow stem cells. In the other four studies, different stem cells were used (of adipose, umbilical, or chondrocytic origin and a pre-packaged product). The most commonly used scores were Visual Analogue Scale and Oswestry Disability Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Areas of controversy<\/jats:title><jats:p>There are few studies with many missing data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Growing points<\/jats:title><jats:p>The studies analysed demonstrate that intradiscal injections of MSCs are effective on discogenic low-back pain. This effect may result from inhibition of nociceptors, reduction of catabolism and repair of injured or degenerated tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Areas timely for developing research<\/jats:title><jats:p>Further research should define the most effective procedure, trying to standardize a single method.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bmb\/ldad008","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T08:52:41Z","timestamp":1683795161000},"page":"73-87","source":"Crossref","is-referenced-by-count":27,"title":["Stem cells and discogenic back pain"],"prefix":"10.1093","volume":"146","author":[{"given":"Luca","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Disorders , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"University of Salerno , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi D\u2019Aragona , Via San Leonardo, Salerno 84131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Disorders , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"University of Salerno , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi D\u2019Aragona , Via San Leonardo, Salerno 84131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Disorders , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"University of Salerno , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi D\u2019Aragona , Via San Leonardo, Salerno 84131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Disorders , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"University of Salerno , Faculty of Medicine and Surgery, , Via Salvador Allende, 43, Baronissi SA 84081 , Italy"},{"name":"Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi D\u2019Aragona , Via San Leonardo, Salerno 84131 , Italy"},{"name":"Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End Hospital , 275 Bancroft Road, London E1 4DG, England"},{"name":"Guy Hilton Research Centre, Faculty of Medicine, School of Pharmacy and Bioengineering, Keele 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