{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:20:23Z","timestamp":1790058023143,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1093\/bmb\/ldh044","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T11:48:23Z","timestamp":1114084103000},"page":"49-64","source":"Crossref","is-referenced-by-count":117,"title":["Obstructive sleep apnoea syndrome: underestimated and undertreated"],"prefix":"10.1093","volume":"72","author":[{"given":"G. J.","family":"Gibson","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Freeman Hospital Newcastle upon Tyne, NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,3,29]]},"reference":[{"key":"key\n\t\t\t\t20180712075117_BIB1","doi-asserted-by":"crossref","unstructured":"Gastaut H , Tassinari CA, Duron B. (1966) Polygraphic study of the episodic diurnal and nocturnal (hypnic and respiratory) manifestations of the Pickwick syndrome. Brain Res, 1, 167\u2013186.","DOI":"10.1016\/0006-8993(66)90117-X"},{"key":"key\n\t\t\t\t20180712075117_BIB2","doi-asserted-by":"crossref","unstructured":"Gould GA , Whyte KF, Rhind GB (1988) The sleep hypopnoea syndrome. Am Rev Respir Dis, 137, 895\u2013898.","DOI":"10.1164\/ajrccm\/137.4.895"},{"key":"key\n\t\t\t\t20180712075117_BIB3","doi-asserted-by":"crossref","unstructured":"Young T , Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnoea: a population health perspective. Am J Respir Crit Care Med, 165, 1217\u20131239.","DOI":"10.1164\/rccm.2109080"},{"key":"key\n\t\t\t\t20180712075117_BIB4","doi-asserted-by":"crossref","unstructured":"Engleman HM , Douglas NJ (2004) Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea\/hypopnoea syndrome. Thorax, 59, 618\u2013622.","DOI":"10.1136\/thx.2003.015867"},{"key":"key\n\t\t\t\t20180712075117_BIB5","doi-asserted-by":"crossref","unstructured":"Stradling JR , Davies RJO (2004) Obstructive sleep apnoea\/hypopnoea syndrome: definitions, epidemiology, and natural history. Thorax, 59, 73\u201378.","DOI":"10.1136\/thx.2003.007161"},{"key":"key\n\t\t\t\t20180712075117_BIB6","doi-asserted-by":"crossref","unstructured":"Young T , Evans L, Finn L, Palta M (1997) Estimation of the clinically diagnosed proportion of sleep apneoa syndrome in middle-aged men and women. Sleep, 20, 705\u2013706.","DOI":"10.1093\/sleep\/20.9.705"},{"key":"key\n\t\t\t\t20180712075117_BIB7","doi-asserted-by":"crossref","unstructured":"Bixler EO , Vgontzas AN, Lin HM et al. (2001) Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med, 163, 608\u2013613.","DOI":"10.1164\/ajrccm.163.3.9911064"},{"key":"key\n\t\t\t\t20180712075117_BIB8","doi-asserted-by":"crossref","unstructured":"Mortimore IL , Marshall I, Wraith PK et al. (1998) Neck and total body fat deposition in non-obese and obese patients with sleep apnoea compared with that in control subjects. Am J Respir Crit Care Med, 157, 280\u2013283.","DOI":"10.1164\/ajrccm.157.1.9703018"},{"key":"key\n\t\t\t\t20180712075117_BIB9","doi-asserted-by":"crossref","unstructured":"Peppard PE , Young T, Palta M, Dempsey J, Skatrud J (2000) Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA, 284, 3015\u20133021.","DOI":"10.1001\/jama.284.23.3015"},{"key":"key\n\t\t\t\t20180712075117_BIB10","doi-asserted-by":"crossref","unstructured":"Ohayon MM , Guilleminault C, Priest RG, Caulet M (1997) Snoring and breathing pauses during sleep: telephone interview survey of a United Kingdom population sample. BMJ, 314, 860\u2013863.","DOI":"10.1136\/bmj.314.7084.860"},{"key":"key\n\t\t\t\t20180712075117_BIB11","doi-asserted-by":"crossref","unstructured":"Coltman R , Taylor DR, Whyte K, Harkness M (2000) Craniofacial form and obstructive sleep apnea in Polynesian and Caucasian men. Sleep, 23, 943\u2013950.","DOI":"10.1093\/sleep\/23.7.1h"},{"key":"key\n\t\t\t\t20180712075117_BIB12","doi-asserted-by":"crossref","unstructured":"Li KK , Kushida C, Powell NB, Riley RW, Guilleminault C (2000) Obstructive sleep apnea syndrome: a comparison between Far-East Asian and white men. Laryngoscope, 110, 1689\u20131693.","DOI":"10.1097\/00005537-200010000-00022"},{"key":"key\n\t\t\t\t20180712075117_BIB13","doi-asserted-by":"crossref","unstructured":"Ip MS , Lam B, Lauder IJ et al. (2001) A community study of sleep-disordered breathing in middle-aged Chinese men in Hong Kong. Chest, 119, 62\u201369.","DOI":"10.1378\/chest.119.1.62"},{"key":"key\n\t\t\t\t20180712075117_BIB14","doi-asserted-by":"crossref","unstructured":"Kim JK , In KH, Kim JH et al. (2004) Prevalence of sleep disordered breathing in middle-aged Korean men and women. Am J Respir Crit Care Med, 170, 1108\u20131113.","DOI":"10.1164\/rccm.200404-519OC"},{"key":"key\n\t\t\t\t20180712075117_BIB15","doi-asserted-by":"crossref","unstructured":"Fogel RB , Malhotra A, White DP (2003) Pathophysiology of obstructive sleep apnoea\/hypopnoea syndrome. Thorax, 59, 159\u2013163.","DOI":"10.1136\/thorax.2003.015859"},{"key":"key\n\t\t\t\t20180712075117_BIB16","doi-asserted-by":"crossref","unstructured":"Mathur R , Douglas NJ (1995) Family studies in patients with the sleep apnoea\u2013hypopnoea syndrome. Ann Intern Med, 122, 174\u2013178.","DOI":"10.7326\/0003-4819-122-3-199502010-00003"},{"key":"key\n\t\t\t\t20180712075117_BIB17","doi-asserted-by":"crossref","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 14, 540\u2013545.","DOI":"10.1093\/sleep\/14.6.540"},{"key":"key\n\t\t\t\t20180712075117_BIB18","doi-asserted-by":"crossref","unstructured":"Netzer N , Eliasson AH, Netzer C, Kristo DA (2001) Overnight pulse oximetry for sleep-disordered breathing in adults: a review. Chest, 120, 625\u2013633.","DOI":"10.1378\/chest.120.2.625"},{"key":"key\n\t\t\t\t20180712075117_BIB19","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN) (2003) Management of obstructive sleep apnoea\/hypopnoea syndrome in adults. Available online at www.sign.ac.uk."},{"key":"key\n\t\t\t\t20180712075117_BIB20","doi-asserted-by":"crossref","unstructured":"Schlosshan D , Elliott MW (2004) Clinical presentation and diagnosis of the obstructive sleep apnoea hypopnoea syndrome. Thorax, 59, 347\u2013352.","DOI":"10.1136\/thx.2003.007179"},{"key":"key\n\t\t\t\t20180712075117_BIB21","doi-asserted-by":"crossref","unstructured":"American Academy of Sleep Medicine (1999) Sleep related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep, 22, 667\u2013689.","DOI":"10.1093\/sleep\/22.5.667"},{"key":"key\n\t\t\t\t20180712075117_BIB22","doi-asserted-by":"crossref","unstructured":"Gibson GJ (2004) Sleep disordered breathing and the outcome of stroke. Thorax, 59, 361\u2013363.","DOI":"10.1136\/thx.2003.020040"},{"key":"key\n\t\t\t\t20180712075117_BIB23","doi-asserted-by":"crossref","unstructured":"Vgontzas AN , Bixler ER, Chrousos GP (2003) Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance. J Intern Med, 254, 32\u201344.","DOI":"10.1046\/j.1365-2796.2003.01177.x"},{"key":"key\n\t\t\t\t20180712075117_BIB24","doi-asserted-by":"crossref","unstructured":"Sanders MH , Newman AB, Haggerty CL et al. (2003) Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med, 167, 7\u201314.","DOI":"10.1164\/rccm.2203046"},{"key":"key\n\t\t\t\t20180712075117_BIB25","doi-asserted-by":"crossref","unstructured":"Meston N , Davies RJO, Mullins R, Jenkinson C, Wass JAH, Stradling JR (2003) Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. J Intern Med, 254, 447\u2013454.","DOI":"10.1046\/j.1365-2796.2003.01212.x"},{"key":"key\n\t\t\t\t20180712075117_BIB26","doi-asserted-by":"crossref","unstructured":"Umlauf MG , Chasens ER (2003) Sleep disordered breathing and nocturnal polyuria: nocturia and enuresis. Sleep Med Rev, 7, 403\u2013411.","DOI":"10.1053\/smrv.2002.0273"},{"key":"key\n\t\t\t\t20180712075117_BIB27","doi-asserted-by":"crossref","unstructured":"Kapur V , Blough DK, Sandblom RE et al. (1999) The medical cost of undiagnosed sleep apnea. Sleep, 22, 749\u2013755.","DOI":"10.1093\/sleep\/22.6.749"},{"key":"key\n\t\t\t\t20180712075117_BIB28","doi-asserted-by":"crossref","unstructured":"Ulfberg J , Carter N, Talback M, Edling C (1996) Excessive daytime sleepiness at work and subjective work performance in the general population and among heavy snorers and patients with obstructive sleep apnea. Chest, 110, 659\u2013663.","DOI":"10.1378\/chest.110.3.659"},{"key":"key\n\t\t\t\t20180712075117_BIB29","doi-asserted-by":"crossref","unstructured":"European Respiratory Society Task Force (2002) Public health and medicolegal implications of sleep apnoea. Eur Respir J, 20, 1594\u20131609.","DOI":"10.1183\/09031936.02.00404502"},{"key":"key\n\t\t\t\t20180712075117_BIB30","doi-asserted-by":"crossref","unstructured":"Flemons WW , Reimer MA (1998) Development of a disease-specific health-related quality of life questionnaire for sleep apnea. Am J Respir Crit Care Med, 158, 494\u2013503.","DOI":"10.1164\/ajrccm.158.2.9712036"},{"key":"key\n\t\t\t\t20180712075117_BIB31","unstructured":"Weaver TE , Laizner AM, Evans LK et al. (1997) An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep, 20, 835\u2013843."},{"key":"key\n\t\t\t\t20180712075117_BIB32","doi-asserted-by":"crossref","unstructured":"Sullivan CE, Issa FG, Berthon-Jones M, Eves L (1981) Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet, i, 862\u2013865.","DOI":"10.1016\/S0140-6736(81)92140-1"},{"key":"key\n\t\t\t\t20180712075117_BIB33","doi-asserted-by":"crossref","unstructured":"Massie CA , McArdle N, Hart RW et al. (2003) Comparison between automatic and fixed positive airway pressure therapy in the home. Am J Respir Crit Care Med, 167, 20\u201323.","DOI":"10.1164\/rccm.200201-022OC"},{"key":"key\n\t\t\t\t20180712075117_BIB34","doi-asserted-by":"crossref","unstructured":"Wright J , Johns R, Watt I, Melville A, Sheldon T (1997) Health effects of obstructive sleep apnoea and the effectiveness of continuous positive airways pressure: a systematic review of the research evidence. BMJ, 314, 851\u2013860.","DOI":"10.1136\/bmj.314.7084.851"},{"key":"key\n\t\t\t\t20180712075117_BIB35","unstructured":"Lim J , Lasserson TJ, Fleetham J, Wright J (2003) Oral appliances for obstructive sleep apnoea. Cochrane Database Syst Rev, 4, CD004435."},{"key":"key\n\t\t\t\t20180712075117_BIB36","doi-asserted-by":"crossref","unstructured":"Rasheid S , Banasiak M, Gallagher SF et al. (2003) Gastric bypass is an effective treatment for obstructive sleep apnea in patients with clinically significant obesity. Obes Surg, 13, 58\u201361.","DOI":"10.1381\/096089203321136593"}],"container-title":["British Medical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bmb\/article-pdf\/72\/1\/49\/25152152\/ldh044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:57:46Z","timestamp":1550192266000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bmb\/article\/72\/1\/49\/272854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,3,29]]},"published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bmb\/ldh044","relation":{},"ISSN":["1471-8391","0007-1420"],"issn-type":[{"value":"1471-8391","type":"electronic"},{"value":"0007-1420","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004]]},"published":{"date-parts":[[2004,1,1]]}}}