{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:29:33Z","timestamp":1788838173044,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Medical Bulletin"],"published-print":{"date-parts":[[2010,3,1]]},"DOI":"10.1093\/bmb\/ldp049","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T15:58:11Z","timestamp":1268063891000},"page":"145-159","source":"Crossref","is-referenced-by-count":50,"title":["Motor neuron disease: systematic reviews of treatment for ALS and SMA"],"prefix":"10.1093","volume":"93","author":[{"given":"R. W.","family":"Orrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,15]]},"reference":[{"key":"1_35104529","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ana.21543","volume":"65","year":"2009","journal-title":"Annals of neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"issue":"9","key":"3_14673304","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1056\/NEJM199403033300901","volume":"330","author":"Bensimon","year":"1994","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"9013","key":"4_16231389","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","volume":"347","author":"Lacomblez","year":"1996","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"5","key":"5_17061837","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s004150200071","volume":"249","author":"Bensimon","year":"2002","journal-title":"Journal of neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0340-5354","issn-type":"print"},{"key":"6_35703725","first-page":"851","volume":"182","year":"1997","journal-title":"IGAKUNO AYUMI"},{"issue":"1","key":"8_11246281","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/146608201300079364","volume":"2","author":"Desnuelle","year":"2001","journal-title":"Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/1466-0822","issn-type":"print"},{"issue":"5","key":"9_19159350","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00702-004-0220-1","volume":"112","author":"Graf","year":"2005","journal-title":"Journal of neural transmission","ISSN":"https:\/\/id.crossref.org\/issn\/0300-9564","issn-type":"print"},{"issue":"3-4","key":"10_6138554","first-page":"325","volume":"17","author":"Apostolski","year":"1998","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0731-8898","issn-type":"print"},{"issue":"6","key":"11_15889023","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1001\/archneur.1995.00540300031009","volume":"52","author":"Louwerse","year":"1995","journal-title":"Archives of Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9942","issn-type":"print"},{"issue":"5","key":"13_16218987","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1212\/WNL.46.5.1244","volume":"46","author":"ALS CNTF Treatment Study Group","year":"1996","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"2","key":"14_16205074","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/ana.410390215","volume":"39","author":"Miller","year":"1996","journal-title":"Annals of neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"issue":"2","key":"16_6121145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1212\/WNL.51.2.583","volume":"51","author":"Borasio","year":"1998","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"6","key":"17_5837412","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.49.6.1621","volume":"49","author":"Lai","year":"1997","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"22","key":"18_32673005","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1212\/01.wnl.0000335970.78664.36","volume":"71","author":"Sorenson","year":"2008","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"1-2","key":"21_11373231","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0022-510X(01)00610-4","volume":"191","author":"Drory","year":"2001","journal-title":"Journal of the neurological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"issue":"23","key":"22_28782885","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1212\/01.wnl.0000264418.92308.a4","volume":"68","author":"Bello-Haas","year":"2007","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"11","key":"26_35748836","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/nrg2680","volume":"10","author":"Dion","year":"2009","journal-title":"Nature reviews. Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"11","key":"29_17910394","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1001\/archneur.60.11.1601","volume":"60","author":"Russman","year":"2003","journal-title":"Archives of Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9942","issn-type":"print"},{"key":"31_36186994","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/CND.0b013e3180315c99","volume":"8","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1522-0443","issn-type":"print"},{"issue":"1","key":"32_22911068","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1212\/01.wnl.0000249142.82285.d6","volume":"68","year":"2007","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"1-2","key":"33_11373230","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0022-510X(01)00632-3","volume":"191","author":"Miller","year":"2001","journal-title":"Journal of the neurological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"issue":"5","key":"34_10477492","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/00002060-200009000-00005","volume":"79","author":"Tzeng","year":"2000","journal-title":"American journal of physical medicine & rehabilitation \/ Association of Academic Physiatrists","ISSN":"https:\/\/id.crossref.org\/issn\/0894-9115","issn-type":"print"},{"issue":"1","key":"35_22355345","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1212\/01.wnl.0000223353.34006.54","volume":"67","author":"Traynor","year":"2006","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"2","key":"36_31653805","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jpainsymman.2008.02.006","volume":"37","author":"Stone","year":"2009","journal-title":"Journal of pain and symptom management","ISSN":"https:\/\/id.crossref.org\/issn\/0885-3924","issn-type":"print"},{"issue":"2","key":"37_21572755","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1474-4422(05)70326-4","volume":"5","author":"Bourke","year":"2006","journal-title":"Lancet. Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/1474-4422","issn-type":"print"},{"key":"38_36186995","first-page":"20","volume":"2","year":"2001","journal-title":"Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/1466-0822","issn-type":"print"},{"issue":"4","key":"39_17560868","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/ana.10554","volume":"53","author":"Groeneveld","year":"2003","journal-title":"Annals of neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"issue":"9","key":"40_18514178","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1212\/01.WNL.0000142992.81995.F0","volume":"63","author":"Shefner","year":"2004","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"7","key":"41_11105699","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1212\/WNL.56.7.843","volume":"56","author":"Miller","year":"2001","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"6","key":"42_30376440","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1073\/pnas.0708022105","volume":"105","year":"2008","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"43_35416974","first-page":"567","volume":"155","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1873-7544","issn-type":"print"},{"issue":"12","key":"44_29919736","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(07)70270-3","volume":"6","author":"Gordon","year":"2007","journal-title":"Lancet. Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/1474-4422","issn-type":"print"},{"issue":"1","key":"45_30462178","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1080\/17482960701856300","volume":"9","author":"Scott","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1471-180X","issn-type":"print"},{"issue":"4","key":"46_29149068","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/17482960701292837","volume":"8","author":"Ludolph","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1471-180X","issn-type":"print"},{"issue":"12","key":"47_19735323","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1468-1331.2005.01351.x","volume":"12","author":"Andersen","year":"2005","journal-title":"European journal of neurology : the official journal of the European Federation of Neurological Societies","ISSN":"https:\/\/id.crossref.org\/issn\/1351-5101","issn-type":"print"},{"issue":"4","key":"48_29149066","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/17482960701262376","volume":"8","author":"Andersen","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1471-180X","issn-type":"print"},{"issue":"15","key":"49_35703710","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"15","key":"50_35703711","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1212\/WNL.0b013e3181bc01a4","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"}],"container-title":["British Medical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bmb\/article-pdf\/93\/1\/145\/877081\/ldp049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T02:44:19Z","timestamp":1551235459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bmb\/article-lookup\/doi\/10.1093\/bmb\/ldp049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,15]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,3,8]]},"published-print":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bmb\/ldp049","relation":{},"ISSN":["0007-1420","1471-8391"],"issn-type":[{"value":"0007-1420","type":"print"},{"value":"1471-8391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,15]]}}}