{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T04:28:26Z","timestamp":1648787306842},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"DOI":"10.1093\/bmb\/ldr021","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T15:50:07Z","timestamp":1323359407000},"page":"123-135","source":"Crossref","is-referenced-by-count":4,"title":["Stem cells and the endocrine pancreas"],"prefix":"10.1093","volume":"100","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[{"name":"Diabetes Research Group, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanta J.","family":"Persaud","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,3]]},"reference":[{"key":"key\n\t\t\t\t20180712065049_LDR021C1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"key\n\t\t\t\t20180712065049_LDR021C2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2337\/dc09-0459","article-title":"Projecting the future diabetes population size and related costs for the U.S","volume":"32","author":"Huang","year":"2009","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180712065049_LDR021C3","doi-asserted-by":"crossref","first-page":"d217","DOI":"10.1136\/bmj.d217","article-title":"Islet transplantation in type 1 diabetes","volume":"342","author":"de Kort","year":"2011","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20180712065049_LDR021C4","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1600-6143.2008.02353.x","article-title":"The clinical impact of islet transplantation","volume":"8","author":"Fiorina","year":"2008","journal-title":"Am J Transplant"},{"key":"key\n\t\t\t\t20180712065049_LDR021C5","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2337\/diabetes.50.10.2181","article-title":"Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?","volume":"50","author":"Halban","year":"2001","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180712065049_LDR021C6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/9781444324808.ch6","article-title":"Islet function and insulin secretion","volume-title":"Textbook of Diabetes","author":"Jones","year":"2010","edition":"4th edn"},{"key":"key\n\t\t\t\t20180712065049_LDR021C7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00125-007-0855-1","article-title":"Proliferation of sorted human and rat beta cells","volume":"51","author":"Parnaud","year":"2008","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180712065049_LDR021C8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1677\/joe.0.1720653","article-title":"Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo","volume":"172","author":"Shaw","year":"2002","journal-title":"J Endocrinol"},{"issue":"Suppl. 2","key":"key\n\t\t\t\t20180712065049_LDR021C9","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1007\/s001250051398","article-title":"Engineered cell lines for insulin replacement in diabetes: current status and future prospects","volume":"40","author":"Newgard","year":"1997","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180712065049_LDR021C10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.addr.2007.08.033","article-title":"Beta-cell replacement for insulin-dependent diabetes mellitus","volume":"60","author":"Efrat","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"key\n\t\t\t\t20180712065049_LDR021C11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.trsl.2010.06.005","article-title":"Stem cell approaches for the treatment of type 1 diabetes mellitus","volume":"156","author":"Wagner","year":"2010","journal-title":"Transl Res"},{"key":"key\n\t\t\t\t20180712065049_LDR021C12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180712065049_LDR021C13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180712065049_LDR021C14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1677\/JOE-07-0436","article-title":"Evidence for the presence of stem cell-like progenitor cells in human adult pancreas","volume":"195","author":"Zhao","year":"2007","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20180712065049_LDR021C15","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180712065049_LDR021C16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2337\/diabetes.50.3.521","article-title":"Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes","volume":"50","author":"Zulewski","year":"2001","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180712065049_LDR021C17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI200316502","article-title":"In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion","volume":"111","author":"Ianus","year":"2003","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180712065049_LDR021C18","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2337\/diabetes.53.7.1721","article-title":"In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow","volume":"53","author":"Tang","year":"2004","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180712065049_LDR021C19","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1634\/stemcells.2007-0164","article-title":"Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation","volume":"25","author":"Karnieli","year":"2007","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180712065049_LDR021C20","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1210\/en.2006-1351","article-title":"Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization","volume":"148","author":"Hasegawa","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180712065049_LDR021C21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"Ferber","year":"2000","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180712065049_LDR021C22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00125-006-0549-0","article-title":"How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver","volume":"50","author":"Perl","year":"2007","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180712065049_LDR021C23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.devcel.2009.01.012","article-title":"Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes","volume":"16","author":"Yechoor","year":"2009","journal-title":"Dev Cell"},{"key":"key\n\t\t\t\t20180712065049_LDR021C24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180712065049_LDR021C25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180712065049_LDR021C26","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180712065049_LDR021C27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20180712065049_LDR021C28","first-page":"417","article-title":"Pluripotent stem cells, a potential source of beta-cells for diabetes therapy","volume":"11","author":"Hansson","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"key\n\t\t\t\t20180712065049_LDR021C29","first-page":"213","article-title":"Beta cell replacement technologies: the potential of stem cells for transplantation therapy for Type 1 diabetes","volume":"1","author":"Jones","year":"2004","journal-title":"Drug Discov Today"},{"key":"key\n\t\t\t\t20180712065049_LDR021C30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/er.2007-0016","article-title":"An illustrated review of early pancreas development in the mouse","volume":"28","author":"Jorgensen","year":"2007","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20180712065049_LDR021C31","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nbt1163","article-title":"Efficient differentiation of human embryonic stem cells to definitive endoderm","volume":"23","author":"D'Amour","year":"2005","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180712065049_LDR021C32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1089\/clo.2006.8.96","article-title":"Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells","volume":"8","author":"Xu","year":"2006","journal-title":"Cloning Stem Cells"},{"key":"key\n\t\t\t\t20180712065049_LDR021C33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/cr.2007.28","article-title":"In vitro derivation of functional insulin-producing cells from human embryonic stem cells","volume":"17","author":"Jiang","year":"2007","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20180712065049_LDR021C34","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D'Amour","year":"2006","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180712065049_LDR021C35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20180712065049_LDR021C36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/cr.2009.28","article-title":"Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20180712065049_LDR021C37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2007.11.112","article-title":"Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells","volume":"366","author":"Cho","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20180712065049_LDR021C38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MPA.0b013e3181b79d3c","article-title":"Importance of quantitative analysis in the generation of insulin-expressing cells from human embryonic stem cells","volume":"39","author":"Courtney","year":"2010","journal-title":"Pancreas"},{"key":"key\n\t\t\t\t20180712065049_LDR021C39","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1007\/s00125-007-0634-z","article-title":"Directed differentiation of human embryonic stem cells towards a pancreatic cell fate","volume":"50","author":"Shim","year":"2007","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180712065049_LDR021C40","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1634\/stemcells.2006-0761","article-title":"Generation of insulin-producing islet-like clusters from human embryonic stem cells","volume":"25","author":"Jiang","year":"2007","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180712065049_LDR021C41","doi-asserted-by":"crossref","DOI":"10.1007\/s12015-011-9232-z","article-title":"Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling","author":"Talavera-Adame","year":"2011","journal-title":"Stem Cell Rev"},{"key":"key\n\t\t\t\t20180712065049_LDR021C42","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1369\/jhc.2009.953307","article-title":"Endocrine cell clustering during human pancreas development","volume":"57","author":"Jeon","year":"2009","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20180712065049_LDR021C43","doi-asserted-by":"crossref","first-page":"E713","DOI":"10.1152\/ajpendo.00279.2010","article-title":"Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats","volume":"299","author":"Matveyenko","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20180712065049_LDR021C44","doi-asserted-by":"crossref","first-page":"31601","DOI":"10.1074\/jbc.M806597200","article-title":"Generation of insulin-secreting islet-like clusters from human skin fibroblasts","volume":"283","author":"Tateishi","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180712065049_LDR021C45","doi-asserted-by":"crossref","first-page":"15768","DOI":"10.1073\/pnas.0906894106","article-title":"Generation of pluripotent stem cells from patients with type 1 diabetes","volume":"106","author":"Maehr","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180712065049_LDR021C46","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cell.2010.10.008","article-title":"Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues","volume":"143","author":"Hanna","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180712065049_LDR021C47","doi-asserted-by":"crossref","DOI":"10.1038\/nature09798","article-title":"Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells","author":"Lister","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180712065049_LDR021C48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature09871","article-title":"Copy number variation and selection during reprogramming to pluripotency","volume":"471","author":"Hussein","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180712065049_LDR021C49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature09805","article-title":"Somatic coding mutations in human induced pluripotent stem cells","volume":"471","author":"Gore","year":"2011","journal-title":"Nature"}],"container-title":["British Medical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bmb\/article-pdf\/100\/1\/123\/25151127\/ldr021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T15:59:38Z","timestamp":1561046378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bmb\/article\/100\/1\/123\/271598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,3]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,6,3]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bmb\/ldr021","relation":{},"ISSN":["1471-8391","0007-1420"],"issn-type":[{"value":"1471-8391","type":"electronic"},{"value":"0007-1420","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,12]]},"published":{"date-parts":[[2011,6,3]]}}}