{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:04:31Z","timestamp":1790805871250,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med Bull"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1093\/bmb\/ldw026","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T12:13:29Z","timestamp":1473682409000},"page":"87-98","source":"Crossref","is-referenced-by-count":164,"title":["Pathogenesis of amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"119","author":[{"given":"Sarah","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Orrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"2016091205132402000_119.1.87.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70219-4"},{"key":"2016091205132402000_119.1.87.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.203"},{"key":"2016091205132402000_119.1.87.3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.207464"},{"key":"2016091205132402000_119.1.87.4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1184"},{"key":"2016091205132402000_119.1.87.5","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24198"},{"key":"2016091205132402000_119.1.87.6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3584"},{"key":"2016091205132402000_119.1.87.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70043-1"},{"key":"2016091205132402000_119.1.87.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.05.011"},{"key":"2016091205132402000_119.1.87.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.11.016"},{"key":"2016091205132402000_119.1.87.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70233-9"},{"key":"2016091205132402000_119.1.87.11","doi-asserted-by":"crossref","unstructured":"Gijselinck I , Van Mossevelde S , van der Zee J , et al . The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter. Mol Psychiatry 2015 epub.","DOI":"10.1038\/mp.2015.159"},{"key":"2016091205132402000_119.1.87.12","doi-asserted-by":"crossref","unstructured":"Bennion Callister J and Pickering-Brown SM . Pathogenesis\/genetics of frontotemporal dementia and how it relates to ALS. Exp Neurol 2104;262:84\u201390.","DOI":"10.1016\/j.expneurol.2014.06.001"},{"key":"2016091205132402000_119.1.87.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1237-z"},{"key":"2016091205132402000_119.1.87.14","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"2016091205132402000_119.1.87.15","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000299187.90432.3f"},{"key":"2016091205132402000_119.1.87.16","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22319"},{"key":"2016091205132402000_119.1.87.17","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.78"},{"key":"2016091205132402000_119.1.87.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.013"},{"key":"2016091205132402000_119.1.87.19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ana.24306","article-title":"Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes","volume":"77","author":"Cady","year":"2015","journal-title":"Ann Neurol"},{"key":"2016091205132402000_119.1.87.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.12.017"},{"key":"2016091205132402000_119.1.87.21","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.57"},{"key":"2016091205132402000_119.1.87.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.07.021"},{"key":"2016091205132402000_119.1.87.23","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.221"},{"key":"2016091205132402000_119.1.87.24","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305617"},{"key":"2016091205132402000_119.1.87.25","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu162"},{"key":"2016091205132402000_119.1.87.26","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24150"},{"key":"2016091205132402000_119.1.87.27","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181ee7d85"},{"key":"2016091205132402000_119.1.87.28","first-page":"181","article-title":"Risk factors for amyotrophic lateral sclerosis","volume":"7","author":"Ingre","year":"2015","journal-title":"Clin Epidemiol"},{"key":"2016091205132402000_119.1.87.29","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8673-1"},{"key":"2016091205132402000_119.1.87.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.01.011"},{"key":"2016091205132402000_119.1.87.31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71601"},{"key":"2016091205132402000_119.1.87.32","doi-asserted-by":"publisher","DOI":"10.3109\/01677063.2013.876021"},{"key":"2016091205132402000_119.1.87.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118649"},{"key":"2016091205132402000_119.1.87.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.065"},{"key":"2016091205132402000_119.1.87.35","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00147"},{"key":"2016091205132402000_119.1.87.36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fncel.2015.00336","article-title":"SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis","volume":"9","author":"Tafuri","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"2016091205132402000_119.1.87.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.001"},{"key":"2016091205132402000_119.1.87.38","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu138"},{"key":"2016091205132402000_119.1.87.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1536-12.2013"},{"key":"2016091205132402000_119.1.87.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097803"},{"key":"2016091205132402000_119.1.87.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.02.009"},{"key":"2016091205132402000_119.1.87.42","doi-asserted-by":"publisher","DOI":"10.4161\/pri.27602"},{"key":"2016091205132402000_119.1.87.43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00117"},{"key":"2016091205132402000_119.1.87.44","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1429-7"},{"key":"2016091205132402000_119.1.87.45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fphys.2013.00356","article-title":"More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases","volume":"4","author":"Boyer","year":"2013","journal-title":"Front Physiol"},{"key":"2016091205132402000_119.1.87.46","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8578-4"},{"key":"2016091205132402000_119.1.87.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.036"},{"key":"2016091205132402000_119.1.87.48","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24255"},{"key":"2016091205132402000_119.1.87.49","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.184"},{"key":"2016091205132402000_119.1.87.50","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.077180"},{"key":"2016091205132402000_119.1.87.51","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.933807"},{"key":"2016091205132402000_119.1.87.52","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.bbadis.2013.03.012","article-title":"Rodent models of amyotrophic lateral sclerosis","volume":"1832","author":"McGoldrick","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2016091205132402000_119.1.87.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.07.001"},{"key":"2016091205132402000_119.1.87.54","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70061-9"},{"key":"2016091205132402000_119.1.87.55","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1044894"},{"key":"2016091205132402000_119.1.87.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.09.001"},{"key":"2016091205132402000_119.1.87.57","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305546"},{"key":"2016091205132402000_119.1.87.58","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305726"}],"container-title":["British Medical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bmb\/article-pdf\/119\/1\/87\/6700830\/ldw026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T11:27:48Z","timestamp":1568374068000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bmb\/article-lookup\/doi\/10.1093\/bmb\/ldw026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,9,12]]},"published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1093\/bmb\/ldw026"],"URL":"https:\/\/doi.org\/10.1093\/bmb\/ldw026","relation":{},"ISSN":["0007-1420","1471-8391"],"issn-type":[{"value":"0007-1420","type":"print"},{"value":"1471-8391","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]}}}