{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T15:03:39Z","timestamp":1779030219341,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS090900"],"award-info":[{"award-number":["K23 NS090900"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS092923"],"award-info":[{"award-number":["K23 NS092923"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS105950"],"award-info":[{"award-number":["K23 NS105950"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K24 NS088568"],"award-info":[{"award-number":["K24 NS088568"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS062092"],"award-info":[{"award-number":["R01 NS062092"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS102190"],"award-info":[{"award-number":["R01 NS102190"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS102574"],"award-info":[{"award-number":["R01 NS102574"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS107291"],"award-info":[{"award-number":["R01 NS107291"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R25 NS065743"],"award-info":[{"award-number":["R25 NS065743"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravenous third-line anaesthetic agents are typically titrated in refractory status epilepticus to achieve either seizure suppression or burst suppression on continuous EEG. However, the optimum treatment paradigm is unknown and little data exist to guide the withdrawal of anaesthetics in refractory status epilepticus. Premature withdrawal of anaesthetics risks the recurrence of seizures, whereas the prolonged use of anaesthetics increases the risk of treatment-associated adverse effects. This study sought to measure the accuracy of features of EEG activity during anaesthetic weaning in refractory status epilepticus as predictors of successful weaning from intravenous anaesthetics. We prespecified a successful anaesthetic wean as the discontinuation of intravenous anaesthesia without developing recurrent status epilepticus, and a wean failure as either recurrent status epilepticus or the resumption of anaesthesia for the purpose of treating an EEG pattern concerning for incipient status epilepticus. We evaluated two types of features as predictors of successful weaning: spectral components of the EEG signal, and spatial-correlation-based measures of functional connectivity. The results of these analyses were used to train a classifier to predict wean outcome. Forty-seven consecutive anaesthetic weans (23 successes, 24 failures) were identified from a single-centre cohort of patients admitted with refractory status epilepticus from 2016 to 2019. Spectral components of the EEG revealed no significant differences between successful and unsuccessful weans. Analysis of functional connectivity measures revealed that successful anaesthetic weans were characterized by the emergence of larger, more densely connected, and more highly clustered spatial functional networks, yielding 75.5% (95% confidence interval: 73.1\u201377.8%) testing accuracy in a bootstrap analysis using a hold-out sample of 20% of data for testing and 74.6% (95% confidence interval 73.2\u201375.9%) testing accuracy in a secondary external validation cohort, with an area under the curve of 83.3%. Distinct signatures in the spatial networks of functional connectivity emerge during successful anaesthetic liberation in status epilepticus; these findings are absent in patients with anaesthetic wean failure. Identifying features that emerge during successful anaesthetic weaning may allow faster and more successful anaesthetic liberation after refractory status epilepticus.<\/jats:p>","DOI":"10.1093\/brain\/awaa069","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T20:15:27Z","timestamp":1582661727000},"source":"Crossref","is-referenced-by-count":12,"title":["Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus"],"prefix":"10.1093","author":[{"given":"Daniel B","family":"Rubin","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-7069","authenticated-orcid":false,"given":"Brigid","family":"Angelini","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryum","family":"Shoukat","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar F","family":"Zafar","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Brandon","family":"Westover","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney S","family":"Cash","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"2020040816352273900_awaa069-B1","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1111\/epi.12947","article-title":"Drug-induced EEG pattern predicts effectiveness of ketamine in treating refractory status epilepticus","volume":"56","author":"Basha","year":"2015","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B2","doi-asserted-by":"crossref","first-page":"h5527","DOI":"10.1136\/bmj.h5527","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt","year":"2015","journal-title":"BMJ"},{"key":"2020040816352273900_awaa069-B3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"2020040816352273900_awaa069-B5","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1523\/JNEUROSCI.5669-11.2012","article-title":"Emergence of stable functional networks in long-term human electroencephalography","volume":"32","author":"Chu","year":"2012","journal-title":"J Neurosci"},{"key":"2020040816352273900_awaa069-B6","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.clinph.2004.06.017","article-title":"Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage","volume":"115","author":"Claassen","year":"2004","journal-title":"Clin Neurophysiol"},{"key":"2020040816352273900_awaa069-B7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ana.23859","article-title":"Nonconvulsive seizures after subarachnoid hemorrhage: multimodal detection and outcomes","volume":"74","author":"Claassen","year":"2013","journal-title":"Ann Neurol"},{"key":"2020040816352273900_awaa069-B8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00994018","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach Learn"},{"key":"2020040816352273900_awaa069-B9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.seizure.2018.11.019","article-title":"Ultra-short burst suppression as a \u2018reset switch\u2019 for refractory status epilepticus","volume":"64","author":"Das","year":"2019","journal-title":"Seizure"},{"key":"2020040816352273900_awaa069-B10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s12028-018-0552-6","article-title":"Successful wean despite emergence of ictal-interictal EEG patterns during the weaning of prolonged burst-suppression therapy for super-refractory status epilepticus","volume":"29","author":"Das","year":"2018","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1467-9531.2007.00179.x","article-title":"Very local structure in social networks","volume":"37","author":"Faust","year":"2016","journal-title":"Sociol Methodol"},{"key":"2020040816352273900_awaa069-B12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr"},{"key":"2020040816352273900_awaa069-B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNP.0b013e3182784729","article-title":"American clinical neurophysiology society\u2019s standardized critical care EEG terminology: 2012 version","volume":"30","author":"Hirsch","year":"2013","journal-title":"J Clin Neurophysiol"},{"key":"2020040816352273900_awaa069-B14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jamaneurol.2013.578","article-title":"Predictors of outcome in refractory status epilepticus","volume":"70","author":"Hocker","year":"2013","journal-title":"JAMA Neurol"},{"key":"2020040816352273900_awaa069-B15","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/jnnp.74.8.1095","article-title":"The management of refractory generalised convulsive and complex partial status epilepticus in three European countries: a survey among epileptologists and critical care neurologists","volume":"74","author":"Holtkamp","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2020040816352273900_awaa069-B16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/jnnp.2004.041947","article-title":"Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit","volume":"76","author":"Holtkamp","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2020040816352273900_awaa069-B17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12028-016-0294-2","article-title":"EEG characteristics of successful burst suppression for refractory status epilepticus","volume":"25","author":"Johnson","year":"2016","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B18","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1002\/hbm.24724","article-title":"EEG-based outcome prediction after cardiac arrest with convolutional neural networks: performance and visualization of discriminative features","volume":"40","author":"Jonas","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"2020040816352273900_awaa069-B19","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/npp.2015.352","article-title":"Dynamic resting-state functional connectivity in major depression","volume":"41","author":"Kaiser","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"2020040816352273900_awaa069-B20","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jocn.2014.03.018","article-title":"Etiology and prognosis of non-convulsive status epilepticus","volume":"21","author":"Kang","year":"2014","journal-title":"J Clin Neurosci"},{"key":"2020040816352273900_awaa069-B21","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1097\/CCM.0b013e3182591ff1","article-title":"Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation","volume":"40","author":"Kowalski","year":"2012","journal-title":"Crit Care Med"},{"key":"2020040816352273900_awaa069-B22","doi-asserted-by":"crossref","first-page":"061916","DOI":"10.1103\/PhysRevE.79.061916","article-title":"Network inference with confidence from multivariate time series","volume":"79","author":"Kramer","year":"2009","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"2020040816352273900_awaa069-B23","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1523\/JNEUROSCI.6309-09.2010","article-title":"Coalescence and fragmentation of cortical networks during focal seizures","volume":"30","author":"Kramer","year":"2010","journal-title":"J Neurosci"},{"key":"2020040816352273900_awaa069-B24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.resuscitation.2019.05.021","article-title":"Electroencephalography-based power spectra allow coma outcome prediction within 24 h of cardiac arrest","volume":"142","author":"Kustermann","year":"2019","journal-title":"Resuscitation"},{"key":"2020040816352273900_awaa069-B25","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1097\/CCM.0b013e3181f859a6","article-title":"Functional outcome after convulsive status epilepticus","volume":"38","author":"Legriel","year":"2010","journal-title":"Crit Care Med"},{"key":"2020040816352273900_awaa069-B26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.seizure.2017.09.003","article-title":"Factors associated with occurrence and outcome of super-refractory status epilepticus","volume":"52","author":"Madzar","year":"2017","journal-title":"Seizure"},{"key":"2020040816352273900_awaa069-B27","first-page":"9768949","article-title":"Updates in refractory status epilepticus","volume":"2018","author":"Marawar","year":"2018","journal-title":"Crit Care Res Pract"},{"key":"2020040816352273900_awaa069-B28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/CCM.0000000000000881","article-title":"Status epilepticus: impact of therapeutic coma on outcome","volume":"43","author":"Marchi","year":"2015","journal-title":"Crit Care Med"},{"key":"2020040816352273900_awaa069-B29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12883-015-0355-8","article-title":"Robust disruptions in electroencephalogram cortical oscillations and large-scale functional networks in autism","volume":"15","author":"Matlis","year":"2015","journal-title":"BMC Neurol"},{"key":"2020040816352273900_awaa069-B30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archneur.59.2.205","article-title":"Refractory status epilepticus: frequency, risk factors, and impact on outcome","volume":"59","author":"Mayer","year":"2002","journal-title":"Arch Neurol"},{"key":"2020040816352273900_awaa069-B31","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/epi.14706","article-title":"Duration of therapeutic coma and outcome of refractory status epilepticus","volume":"60","author":"Muhlhofer","year":"2019","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1528-1167.2009.02323.x","article-title":"Refractory status epilepticus: a prospective observational study","volume":"51","author":"Novy","year":"2010","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B33","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1212\/WNL.37.7.1153","article-title":"Evaluation of stroke using EEG frequency analysis and topographic mapping","volume":"37","author":"Nuwer","year":"1987","journal-title":"Neurology"},{"key":"2020040816352273900_awaa069-B34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.seizure.2019.09.011","article-title":"A pragmatic approach to intravenous anaesthetics and electroencephalographic endpoints for the treatment of refractory and super-refractory status epilepticus in critical care","volume":"75","author":"Prisco","year":"2020","journal-title":"Seizure"},{"key":"2020040816352273900_awaa069-B35","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ana.25232","article-title":"Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective study of diagnostic accuracy","volume":"83","author":"Rosenthal","year":"2018","journal-title":"Ann Neurol"},{"key":"2020040816352273900_awaa069-B36","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S1474-4422(11)70187-9","article-title":"Management of refractory status epilepticus in adults: still more questions than answers","volume":"10","author":"Rossetti","year":"2011","journal-title":"Lancet Neurol"},{"key":"2020040816352273900_awaa069-B37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12028-010-9445-z","article-title":"A randomized trial for the treatment of refractory status epilepticus","volume":"14","author":"Rossetti","year":"2011","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B38","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.0013-9580.2004.01904.x","article-title":"Propofol treatment of refractory status epilepticus: a study of 31 episodes","volume":"45","author":"Rossetti","year":"2004","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B39","doi-asserted-by":"crossref","first-page":"033119","DOI":"10.1063\/1.2966112","article-title":"Evolving functional network properties and synchronizability during human epileptic seizures","volume":"18","author":"Schindler","year":"2008","journal-title":"Chaos"},{"key":"2020040816352273900_awaa069-B40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12028-016-0245-y","article-title":"Metabolic correlates of the ictal-interictal continuum: FDG-PET during continuous EEG","volume":"24","author":"Struck","year":"2016","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40263-016-0389-5","article-title":"Anesthetics and outcome in status epilepticus: a matched two-center cohort study","volume":"31","author":"Sutter","year":"2017","journal-title":"CNS Drugs"},{"key":"2020040816352273900_awaa069-B42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/CCM.0000000000002843","article-title":"Acute systemic complications of convulsive status epilepticus-A systematic review","volume":"46","author":"Sutter","year":"2018","journal-title":"Crit Care Med"},{"key":"2020040816352273900_awaa069-B43","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1212\/WNL.0000000000000009","article-title":"Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study","volume":"82","author":"Sutter","year":"2014","journal-title":"Neurology"},{"key":"2020040816352273900_awaa069-B44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/WNP.0000000000000232","article-title":"Highly epileptiform bursts are associated with seizure recurrence","volume":"33","author":"Thompson","year":"2016","journal-title":"J Clin Neurophysiol"},{"key":"2020040816352273900_awaa069-B45","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus\u2013Report of the ILAE Task Force on Classification of Status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pneurobio.2014.06.004","article-title":"Functional brain connectivity from EEG in epilepsy: seizure prediction and epileptogenic focus localization","volume":"121","author":"van Mierlo","year":"2014","journal-title":"Prog Neurobiol"},{"key":"2020040816352273900_awaa069-B47","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.24606","article-title":"Metabolic crisis occurs with seizures and periodic discharges after brain trauma","volume":"79","author":"Vespa","year":"2016","journal-title":"Ann Neurol"},{"key":"2020040816352273900_awaa069-B48","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1212\/WNL.0b013e3181f07334","article-title":"Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy","volume":"75","author":"Vespa","year":"2010","journal-title":"Neurology"},{"key":"2020040816352273900_awaa069-B49","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"2020040816352273900_awaa069-B50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/epi.12280","article-title":"The multifaceted care of status epilepticus","volume":"54 Suppl 6","author":"Wijdicks","year":"2013","journal-title":"Epilepsia"},{"key":"2020040816352273900_awaa069-B51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12028-017-0419-2","article-title":"Quantitative EEG metrics differ between outcome groups and change over the first 72 h in comatose cardiac arrest patients","volume":"28","author":"Wiley","year":"2017","journal-title":"Neurocrit Care"},{"key":"2020040816352273900_awaa069-B52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.clinph.2017.01.020","article-title":"EEG synchronization measures are early outcome predictors in comatose patients after cardiac arrest","volume":"128","author":"Zubler","year":"2017","journal-title":"Clin Neurophysiol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaa069\/33026916\/awaa069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awaa069\/33026916\/awaa069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T23:52:10Z","timestamp":1614556330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awaa069\/5817928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":52,"URL":"https:\/\/doi.org\/10.1093\/brain\/awaa069","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]},"article-number":"awaa069"}}