{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:00Z","timestamp":1790790300309,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The University of Bordeaux"},{"DOI":"10.13039\/501100004794","name":"the Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Michael J Fox Foundation","award":["2013-8499"],"award-info":[{"award-number":["2013-8499"]}]},{"name":"Fundacion de Investigacion HM Hospitales"},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["FS19540\/PI\/14"],"award-info":[{"award-number":["FS19540\/PI\/14"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Simone and Cino Del Duca Prize"},{"DOI":"10.13039\/100015118","name":"French Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015118","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministe\u0300re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche"},{"name":"France Parkinson Foundation"},{"name":"CECAP"},{"name":"MINECO\/AEI\/FEDER-UE","award":["SAF2015-67239-P"],"award-info":[{"award-number":["SAF2015-67239-P"]}]},{"name":"Bordeaux Imaging Center"},{"name":"national infrastructure France BioImaging","award":["ANR-10INBS-04-0"],"award-info":[{"award-number":["ANR-10INBS-04-0"]}]},{"name":"Biochemistry and Biophysics Platform of the Bordeaux Neurocampus at the Bordeaux University"},{"name":"LABEX BRAIN","award":["ANR-10-LABX-43"],"award-info":[{"award-number":["ANR-10-LABX-43"]}]},{"name":"Brain Bank GIE NeuroCEB","award":["0033-00011"],"award-info":[{"award-number":["0033-00011"]}]},{"name":"France Alzheimer"},{"name":"Conna\u00eetre les Syndromes C\u00e9r\u00e9belleux"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In Parkinson\u2019s disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the pathological consequences of either intrastriatal or enteric injection of \u03b1-synuclein-containing Lewy body extracts from patients with Parkinson\u2019s disease. This study shows that patient-derived \u03b1-synuclein aggregates are able to induce nigrostriatal lesions and enteric nervous system pathology after either enteric or striatal injection in a non-human primate model. This finding suggests that the progression of \u03b1-synuclein pathology might be either caudo-rostral or rostro-caudal, varying between patients and disease subtypes. In addition, we report that \u03b1-synuclein pathological lesions were not found in the vagal nerve in our experimental setting. This study does not support the hypothesis of a transmission of \u03b1-synuclein pathology through the vagus nerve and the dorsal motor nucleus of the vagus. Instead, our results suggest a possible systemic mechanism in which the general circulation would act as a route for long-distance bidirectional transmission of endogenous \u03b1-synuclein between the enteric and the central nervous systems. Taken together, our study provides invaluable primate data exploring the role of the gut-brain axis in the initiation and propagation of Parkinson\u2019s disease pathology and should open the door to the development and testing of new therapeutic approaches aimed at interfering with the development of sporadic Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1093\/brain\/awaa096","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T16:10:55Z","timestamp":1584461455000},"page":"1462-1475","source":"Crossref","is-referenced-by-count":209,"title":["Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates"],"prefix":"10.1093","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-3700","authenticated-orcid":false,"given":"Marie-Laure","family":"Arotcarena","sequence":"first","affiliation":[{"name":"University of Bordeaux, Neurodegenerative Diseases Institute, UMR 5293, F-33000 Bordeaux, 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