{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:38Z","timestamp":1787008538516,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Magnetic resonance guided high intensity focused ultrasound is a novel, non-invasive, image-guided procedure that is able to ablate intracranial tissue with submillimetre precision. It is currently FDA approved for essential tremor and tremor dominant Parkinson\u2019s disease. The aim of this update is to review the limitations of current landmark-based targeting techniques of the ventral intermediate nucleus and demonstrate the role of emerging imaging techniques that are relevant for both magnetic resonance guided high intensity focused ultrasound and deep brain stimulation. A significant limitation of standard MRI sequences is that the ventral intermediate nucleus, dentatorubrothalamic tract, and other deep brain nuclei cannot be clearly identified. This paper provides original, annotated images demarcating the ventral intermediate nucleus, dentatorubrothalamic tract, and other deep brain nuclei on advanced MRI sequences such as fast grey matter acquisition T1 inversion recovery, quantitative susceptibility mapping, susceptibility weighted imaging, and diffusion tensor imaging tractography. Additionally, the paper reviews clinical efficacy of targeting with these novel MRI techniques when compared to current established landmark-based targeting techniques. The paper has widespread applicability to both deep brain stimulation and magnetic resonance guided high intensity focused ultrasound.<\/jats:p>","DOI":"10.1093\/brain\/awaa107","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T16:10:48Z","timestamp":1584547848000},"page":"2664-2672","source":"Crossref","is-referenced-by-count":44,"title":["Advanced MRI techniques for transcranial high intensity focused ultrasound targeting"],"prefix":"10.1093","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-6174","authenticated-orcid":false,"given":"Bhavya R","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Radiology, University\u00a0of Texas Southwestern, Dallas, TX 75390, USA"},{"name":"Department of Neurosurgery, University of Texas Southwestern, Dallas, TX 75390, USA"},{"name":"O\u2019Donnell Brain Institute, University of Texas Southwestern, Dallas, TX 75390, USA"},{"name":"Advanced Imaging Research Center, University of Texas Southwestern, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance T","family":"Lehman","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Blezek","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Waugh","sequence":"additional","affiliation":[{"name":"O\u2019Donnell Brain Institute, University of Texas Southwestern, Dallas, TX 75390, USA"},{"name":"Department of Pediatrics, University of Texas Southwestern, Dallas, TX 75390, 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