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ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n\u2009=\u2009599), temporal lobe epilepsy with normal MRI (n\u2009=\u2009275), genetic generalized epilepsy (n\u2009=\u2009182) and non-lesional extratemporal epilepsy (n\u2009=\u2009193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fibre tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at P\u2009&amp;lt;\u20090.001). Across \u2018all epilepsies\u2019 lower fractional anisotropy was observed in most fibre tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. There were also less robust increases in mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Individuals with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced reductions in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and increased mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of diffusion abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibres in a large multicentre study of epilepsy. Overall, patients with epilepsy showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding more detailed insights into pathological substrates that may explain cognitive and psychiatric co-morbidities and be used to guide biomarker studies of treatment outcomes and\/or genetic research.<\/jats:p>","DOI":"10.1093\/brain\/awaa200","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T15:22:29Z","timestamp":1591370549000},"page":"2454-2473","source":"Crossref","is-referenced-by-count":229,"title":["White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study"],"prefix":"10.1093","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-8726","authenticated-orcid":false,"given":"Sean N","family":"Hatton","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego , La Jolla 92093 CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-0733","authenticated-orcid":false,"given":"Khoa H","family":"Huynh","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics, University of California San Diego , La Jolla 92093 CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Bonilha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of South Carolina , Charleston 29425 SC,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Abela","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience , Kings College London, London SE5 9NU","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud","family":"Alhusaini","sequence":"additional","affiliation":[{"name":"Neurology Department, Yale School of Medicine , New Haven 6510 CT,","place":["USA"]},{"name":"Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-2393","authenticated-orcid":false,"given":"Andre","family":"Altmann","sequence":"additional","affiliation":[{"name":"Centre of Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London , London WC1V 6LJ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina K M","family":"Alvim","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Campinas - UNICAMP, Campinas 13083-888 S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-361X","authenticated-orcid":false,"given":"Akshara R","family":"Balachandra","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics, UCSD School of Medicine , La Jolla 92037 CA,","place":["USA"]},{"name":"Boston University School of Medicine , Boston 2118 MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-1941","authenticated-orcid":false,"given":"Emanuele","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children\u2019s Hospital A. 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