{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:32:55Z","timestamp":1780331575810,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alzheimer's Research UK"},{"DOI":"10.13039\/501100000368","name":"Brain Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"The Wolfson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017506","name":"Alzheimer\u2019s Society","doi-asserted-by":"crossref","award":["AS-PG-16-007"],"award-info":[{"award-number":["AS-PG-16-007"]}],"id":[{"id":"10.13039\/501100017506","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","award":["ES\/L001810\/1"],"award-info":[{"award-number":["ES\/L001810\/1"]}],"id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"},{"name":"UCL Leonard Wolfson Experimental Neurology Centre","award":["PR\/ylr\/18575"],"award-info":[{"award-number":["PR\/ylr\/18575"]}]},{"name":"Action on Hearing Loss-Dunhill Medical Trust Pauline Ashley Fellowship","award":["PA23_Hardy"],"award-info":[{"award-number":["PA23_Hardy"]}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","award":["453 (AS-JF-18-003"],"award-info":[{"award-number":["453 (AS-JF-18-003"]}],"id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000269","name":"ESRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","award":["ES\/L001810\/1"],"award-info":[{"award-number":["ES\/L001810\/1"]}],"id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer\u2019s Research UK Senior Research"},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["091673\/Z\/10\/Z"],"award-info":[{"award-number":["091673\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although posterior cortical atrophy is often regarded as the canonical \u2018visual dementia\u2019, auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process\u2014parsing of the auditory environment (\u2018auditory scene analysis\u2019)\u2014has been poorly characterized. In this cross-sectional study, we used customized perceptual tasks to assess two generic cognitive operations underpinning auditory scene analysis\u2014sound source segregation and sound event grouping\u2014in a cohort of 21 patients with posterior cortical atrophy, referenced to 15 healthy age-matched individuals and 21 patients with typical Alzheimer\u2019s disease. After adjusting for peripheral hearing function and performance on control tasks assessing perceptual and executive response demands, patients with posterior cortical atrophy performed significantly worse on both auditory scene analysis tasks relative to healthy controls and patients with typical Alzheimer\u2019s disease (all P\u2009&amp;lt;\u20090.05). Our findings provide further evidence of central auditory dysfunction in posterior cortical atrophy, with implications for our pathophysiological understanding of Alzheimer syndromes as well as clinical diagnosis and management.<\/jats:p>","DOI":"10.1093\/brain\/awaa221","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T11:15:44Z","timestamp":1592478944000},"page":"2689-2695","source":"Crossref","is-referenced-by-count":27,"title":["Impairments of auditory scene analysis in posterior cortical atrophy"],"prefix":"10.1093","volume":"143","author":[{"given":"Chris J D","family":"Hardy","sequence":"first","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir X X","family":"Yong","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C","family":"Goll","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J","family":"Crutch","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"2020111212331871000_awaa221-B1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.nicl.2018.03.008","article-title":"Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: beyond the visual syndrome","volume":"18","author":"Ahmed","year":"2018","journal-title":"NeuroImage Clin"},{"key":"2020111212331871000_awaa221-B2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archneur.1988.00520310107024","article-title":"Posterior cortical atrophy","volume":"45","author":"Benson","year":"1988","journal-title":"Arch Neurol"},{"key":"2020111212331871000_awaa221-B3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/02643294.2012.707122","article-title":"The origins and structure of quantitative concepts","volume":"29","author":"Bonn","year":"2012","journal-title":"Cogn Neuropsychol"},{"key":"2020111212331871000_awaa221-B4","year":"1994"},{"key":"2020111212331871000_awaa221-B5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(11)70289-7","article-title":"Posterior cortical atrophy","volume":"11","author":"Crutch","year":"2012","journal-title":"Lancet Neurol"},{"key":"2020111212331871000_awaa221-B6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/jnnp-2012-303309","article-title":"The language profile of Posterior cortical atrophy","volume":"84","author":"Crutch","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2020111212331871000_awaa221-B7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jalz.2017.01.014","article-title":"Consensus classification of posterior cortical atrophy. Alzheimers","volume":"13","author":"Crutch","year":"2017","journal-title":"Dement"},{"key":"2020111212331871000_awaa221-B8","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1177\/1471301218789296","article-title":"Contributions of patient and citizen researchers to \u2018Am I the right way up?\u2019 Study of balance in posterior cortical atrophy and typical Alzheimer\u2019s disease","volume":"17","author":"Crutch","year":"2018","journal-title":"Dementia"},{"key":"2020111212331871000_awaa221-B9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuropsychologia.2005.04.013","article-title":"Number processing in posterior cortical atrophy - A neuropsycholgical case study","volume":"44","author":"Delazer","year":"2006","journal-title":"Neuropsychologia"},{"key":"2020111212331871000_awaa221-B10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS-ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol"},{"key":"2020111212331871000_awaa221-B11","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1093\/brain\/awz136","article-title":"Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy","volume":"142","author":"Firth","year":"2019","journal-title":"Brain"},{"key":"2020111212331871000_awaa221-B12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neurobiolaging.2015.12.006","article-title":"Functional neuroanatomy of spatial sound processing in Alzheimer\u2019s disease","volume":"39","author":"Golden","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2020111212331871000_awaa221-B13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/brain\/awu337","article-title":"Auditory spatial processing in Alzheimer\u2019s disease","volume":"138","author":"Golden","year":"2015","journal-title":"Brain"},{"key":"2020111212331871000_awaa221-B14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/brain\/awr260","article-title":"Impairments of auditory scene analysis in Alzheimer\u2019s disease","volume":"135","author":"Goll","year":"2012","journal-title":"Brain"},{"key":"2020111212331871000_awaa221-B15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuropsychologia.2019.05.004","article-title":"Where words meet numbers: comprehension of measurement unit terms in posterior cortical atrophy","volume":"131","author":"Gonz\u00e1lez","year":"2019","journal-title":"Neuropsychologia"},{"key":"2020111212331871000_awaa221-B16","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer\u2019s disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020111212331871000_awaa221-B17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrn1538","article-title":"What is an auditory object?","volume":"5","author":"Griffiths","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"2020111212331871000_awaa221-B18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/jamaneurol.2018.4799","article-title":"Findings of impaired hearing in patients with nonfluent\/agrammatic variant primary progressive aphasia","volume":"76","author":"Hardy","year":"2019","journal-title":"JAMA Neurol"},{"key":"2020111212331871000_awaa221-B19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/acn3.471","article-title":"Donepezil enhances understanding of degraded speech in Alzheimer\u2019s disease","volume":"4","author":"Hardy","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"key":"2020111212331871000_awaa221-B20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13195-018-0399-2","article-title":"Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer\u2019s disease","volume":"10","author":"Hardy","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"2020111212331871000_awaa221-B21","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00415-016-8208-y","article-title":"Hearing and dementia","volume":"263","author":"Hardy","year":"2016","journal-title":"J Neurol"},{"key":"2020111212331871000_awaa221-B8906446","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51101"},{"key":"2020111212331871000_awaa221-B22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cortex.2007.08.002","article-title":"Mental representation: what can pitch tell us about the distance effect?","volume":"44","author":"Kadosh","year":"2008","journal-title":"Cortex"},{"key":"2020111212331871000_awaa221-B23","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/brain\/awz091","article-title":"Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer\u2019s disease","volume":"142","author":"Phillips","year":"2019","journal-title":"Brain"},{"key":"2020111212331871000_awaa221-B24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.heares.2013.07.020","article-title":"Pitch coding and pitch processing in the human brain","volume":"307","author":"Plack","year":"2014","journal-title":"Hear Res"},{"key":"2020111212331871000_awaa221-B25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cortex.2018.04.010","article-title":"Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy","volume":"106","author":"Putcha","year":"2018","journal-title":"Cortex"},{"key":"2020111212331871000_awaa221-B26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3389\/fnhum.2013.00621","article-title":"Scene perception in posterior cortical atrophy: categorization, description and fixation patterns","volume":"7","author":"Shakespeare","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"2020111212331871000_awaa221-B27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cortex.2019.02.003","article-title":"The functional neuroanatomy of musical memory in Alzheimer\u2019s disease","volume":"115","author":"Slattery","year":"2019","journal-title":"Cortex"},{"key":"2020111212331871000_awaa221-B28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/ana.24885","article-title":"Typical and atypical pathology in primary progressive aphasia variants","volume":"81","author":"Spinelli","year":"2017","journal-title":"Ann Neurol"},{"key":"2020111212331871000_awaa221-B29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuropsychologia.2014.09.030","article-title":"Counting or chunking? Mathematical and heuristic abilities in patients with corticobasal syndrome and posterior cortical atrophy","volume":"64","author":"Spotorno","year":"2014","journal-title":"Neuropsychologia"},{"key":"2020111212331871000_awaa221-B30","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s10072-019-03869-5","article-title":"Working memory in posterior cortical atrophy","volume":"40","author":"Trotta","year":"2019","journal-title":"Neurol Sci"},{"key":"2020111212331871000_awaa221-B31","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/acn3.566","article-title":"Navigational cue effects in Alzheimer\u2019s disease and posterior cortical atrophy","volume":"5","author":"Yong","year":"2018","journal-title":"Ann Clin Transl Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/143\/9\/2689\/34279933\/awaa221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/143\/9\/2689\/34279933\/awaa221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T18:34:14Z","timestamp":1605206054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/143\/9\/2689\/5900355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,1]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaa221","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,9,1]]}}}