{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:21:26Z","timestamp":1789010486495,"version":"build-2803163510"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alzheimer\u2019s Research UK Clinical Research Fellowship","award":["2018B-001"],"award-info":[{"award-number":["2018B-001"]}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Clinical Research Career Development Fellowship","award":["201567\/Z\/16\/Z"],"award-info":[{"award-number":["201567\/Z\/16\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Visual hallucinations are common in Parkinson\u2019s disease and are associated with poorer prognosis. Imaging studies show white matter loss and functional connectivity changes with Parkinson\u2019s visual hallucinations, but the biological factors underlying selective vulnerability of affected parts of the brain network are unknown. Recent models for Parkinson\u2019s disease hallucinations suggest they arise due to a shift in the relative effects of different networks. Understanding how structural connectivity affects the interplay between networks will provide important mechanistic insights. To address this, we investigated the structural connectivity changes that accompany visual hallucinations in Parkinson\u2019s disease and the organizational and gene expression characteristics of the preferentially affected areas of the network. We performed diffusion-weighted imaging in 100 patients with Parkinson\u2019s disease (81 without hallucinations, 19 with visual hallucinations) and 34 healthy age-matched controls. We used network-based statistics to identify changes in structural connectivity in Parkinson\u2019s disease patients with hallucinations and performed an analysis of controllability, an emerging technique that allows quantification of the influence a brain region has across the rest of the network. Using these techniques, we identified a subnetwork of reduced connectivity in Parkinson\u2019s disease hallucinations. We then used the Allen Institute for Brain Sciences human transcriptome atlas to identify regional gene expression patterns associated with affected areas of the network. Within this network, Parkinson\u2019s disease patients with hallucinations showed reduced controllability (less influence over other brain regions), than Parkinson\u2019s disease patients without hallucinations and controls. This subnetwork appears to be critical for overall brain integration, as even in controls, nodes with high controllability were more likely to be within the subnetwork. Gene expression analysis of gene modules related to the affected subnetwork revealed that down-weighted genes were most significantly enriched in genes related to mRNA and chromosome metabolic processes (with enrichment in oligodendrocytes) and upweighted genes to protein localization (with enrichment in neuronal cells). Our findings provide insights into how hallucinations are generated, with breakdown of a key structural subnetwork that exerts control across distributed brain regions. Expression of genes related to mRNA metabolism and membrane localization may be implicated, providing potential therapeutic targets.<\/jats:p>","DOI":"10.1093\/brain\/awaa270","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T15:13:12Z","timestamp":1595603592000},"page":"3435-3448","source":"Crossref","is-referenced-by-count":65,"title":["Differences in network controllability and regional gene expression underlie hallucinations in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-072X","authenticated-orcid":false,"given":"Angeliki","family":"Zarkali","sequence":"first","affiliation":[{"name":"Dementia Research Centre, University College London, 8-11 Queen Square, London, WC1N 3AR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McColgan","sequence":"additional","affiliation":[{"name":"Huntington\u2019s Disease Centre, University College London, Russell Square House, London, WC1B 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ryten","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, 10-12 Russell Square House, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-7919","authenticated-orcid":false,"given":"Regina","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, 10-12 Russell Square House, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise-Ann","family":"Leyland","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, University College London, 8-11 Queen Square, London, WC1N 3AR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-4385","authenticated-orcid":false,"given":"Andrew J","family":"Lees","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute of Neurological Studies, 1 Wakefield Street, London, WC1N 1PJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraint","family":"Rees","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience, University College London, 17-19 Queen Square, London, WC1N 3AR, UK"},{"name":"Wellcome Centre for Human Neuroimaging, University College London, 12 Queen Square, London, WC1N 3AR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-6325","authenticated-orcid":false,"given":"Rimona S","family":"Weil","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, University College London, 8-11 Queen Square, London, WC1N 3AR, UK"},{"name":"Wellcome Centre for Human Neuroimaging, University College London, 12 Queen Square, London, WC1N 3AR, UK"},{"name":"Movement Disorders Consortium, University College London, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"2021012813550926400_awaa270-B1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1532-5415.2000.tb06891.x","article-title":"Predictors of nursing home placement in Parkinson\u2019s disease: a population-based, prospective study","volume":"48","author":"Aarsland","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"2021012813550926400_awaa270-B2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","article-title":"Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission","volume":"42","author":"Alvarez-Erviti","year":"2011","journal-title":"Neurobiol Dis"},{"key":"2021012813550926400_awaa270-B3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/13538320600916767","article-title":"Assuring Quality\/Resisting Quality Assurance: academics\u2019 responses to \u2018quality\u2019 in some Australian universities","volume":"12","author":"Anderson","year":"2006","journal-title":"Qual High Educ"},{"key":"2021012813550926400_awaa270-B4","doi-asserted-by":"crossref","first-page":"e0139516","DOI":"10.1371\/journal.pone.0139516","article-title":"Re-annotator: annotation pipeline for microarray probe sequences","volume":"10","author":"Arloth","year":"2015","journal-title":"PLoS One"},{"key":"2021012813550926400_awaa270-B5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkevi\u010di\u016bt\u0117","year":"2019","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuroimage.2017.04.014","article-title":"Human brain mapping: a systematic comparison of parcellation methods for the human cerebral cortex","volume":"170","author":"Arslan","year":"2018","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/cns.12417","article-title":"Resting-state functional brain networks in Parkinson\u2019s disease","volume":"21","author":"Baggio","year":"2015","journal-title":"CNS Neurosci Ther"},{"key":"2021012813550926400_awaa270-B8","doi-asserted-by":"crossref","first-page":"e2209","DOI":"10.1212\/WNL.0000000000007447","article-title":"Temporal lobe epilepsy: hippocampal pathology modulates connectome topology and controllability","volume":"92","author":"Bernhardt","year":"2019","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/jamaneurol.2014.756","article-title":"Insights from cerebellar transcriptomic analysis into the pathogenesis of ataxia","volume":"71","author":"Bettencourt","year":"2014","journal-title":"JAMA Neurol"},{"key":"2021012813550926400_awaa270-B10","doi-asserted-by":"crossref","first-page":"30770","DOI":"10.1038\/srep30770","article-title":"Optimally controlling the human connectome: the role of network topology","volume":"6","author":"Betzel","year":"2016","journal-title":"Sci Rep"},{"key":"2021012813550926400_awaa270-B11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12918-017-0420-6","article-title":"An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks","volume":"11","author":"Bot\u00eda","year":"2017","journal-title":"BMC Syst Biol"},{"key":"2021012813550926400_awaa270-B12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0b013e318225ab77","article-title":"GBA-associated PD presents with nonmotor characteristics","volume":"77","author":"Brockmann","year":"2011","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B6323002","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41588-020-0610-9","article-title":"Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson\u2019s disease","volume":"52","author":"Bryois","year":"2020","journal-title":"Nat Genet"},{"key":"2021012813550926400_awaa270-B14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"2021012813550926400_awaa270-B15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/scisignal.aaw9277","article-title":"Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment","volume":"12","author":"Butler","year":"2019","journal-title":"Sci Signal"},{"key":"2021012813550926400_awaa270-B16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrg1248","article-title":"Systematic genome-wide screens of gene function","volume":"5","author":"Carpenter","year":"2004","journal-title":"Nat Rev Genet"},{"key":"2021012813550926400_awaa270-B17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrg2540","article-title":"Linking DNA methylation and histone modification: patterns and paradigms","volume":"10","author":"Cedar","year":"2009","journal-title":"Nat Rev Genet"},{"key":"2021012813550926400_awaa270-B18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nicl.2017.02.012","article-title":"Parkinson\u2019s disease diffusion MRI is not affected by acute antiparkinsonian medication","volume":"14","author":"Chung","year":"2017","journal-title":"Neuroimage Clin"},{"key":"2021012813550926400_awaa270-B19","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011145.pub2","article-title":"Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations","author":"Creavin","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2021012813550926400_awaa270-B20","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1002\/mds.22718","article-title":"Protein degradation, aggregation, and misfolding","volume":"25 (Suppl 1","author":"Cuervo","year":"2010","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B21","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/WNL.0b013e3181fc29c9","article-title":"The MoCA: well-suited screen for cognitive impairment in Parkinson disease","volume":"75","author":"Dalrymple-Alford","year":"2010","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B22","first-page":"165","article-title":"Parkinson\u2019s Disease Society Brain Bank, London: overview and research","volume":"39","author":"Daniel","year":"1993","journal-title":"J Neural Transm Suppl"},{"key":"2021012813550926400_awaa270-B23","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","article-title":"Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders","volume":"15","author":"Doyle","year":"2011","journal-title":"J Cell Mol Med"},{"key":"2021012813550926400_awaa270-B24","year":"1947"},{"key":"2021012813550926400_awaa270-B25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/brain\/123.4.733","article-title":"Hallucinations in Parkinson\u2019s disease: prevalence, phenomenology and risk factors","volume":"123","author":"F\u00e9nelon","year":"2000","journal-title":"Brain J Neurol"},{"key":"2021012813550926400_awaa270-B26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"2021012813550926400_awaa270-B27","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.neurobiolaging.2013.05.001","article-title":"Insights into TREM2 biology by network analysis of human brain gene expression data","volume":"34","author":"Forabosco","year":"2013","journal-title":"Neurobiol Aging"},{"key":"2021012813550926400_awaa270-B28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.nicl.2018.01.009","article-title":"Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease","volume":"18","author":"Freeze","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2021012813550926400_awaa270-B29","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1093\/brain\/awz223","article-title":"Regional transcriptional architecture of Parkinson\u2019s disease pathogenesis and network spread","volume":"142","author":"Freeze","year":"2019","journal-title":"Brain"},{"key":"2021012813550926400_awaa270-B30","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1212\/01.wnl.0000242630.52203.8f","article-title":"Clinical phenotype of Parkinson disease dementia","volume":"67","author":"Galvin","year":"2006","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"key":"2021012813550926400_awaa270-B32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1212\/WNL.45.4.669","article-title":"Mortality and hallucinations in nursing home patients with advanced Parkinson\u2019s disease","volume":"45","author":"Goetz","year":"1995","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B33","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat Rev Genet"},{"key":"2021012813550926400_awaa270-B35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms9414","article-title":"Controllability of structural brain networks","volume":"6","author":"Gu","year":"2015","journal-title":"Nat Commun"},{"key":"2021012813550926400_awaa270-B37","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nmeth.4407","article-title":"Massively parallel single-nucleus RNA-seq with DroNc-seq","volume":"14","author":"Habib","year":"2017","journal-title":"Nat Methods"},{"key":"2021012813550926400_awaa270-B38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1162\/netn_a_00078","article-title":"Changes in structural network topology correlate with severity of hallucinatory behavior in Parkinson\u2019s disease","volume":"3","author":"Hall","year":"2019","journal-title":"Netw Neurosci"},{"key":"2021012813550926400_awaa270-B39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol Cell"},{"key":"2021012813550926400_awaa270-B40","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/nn.4171","article-title":"Canonical genetic signatures of the adult human brain","volume":"18","author":"Hawrylycz","year":"2015","journal-title":"Nat Neurosci"},{"key":"2021012813550926400_awaa270-B41","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/mds.21956","article-title":"The Sydney multicenter study of Parkinson\u2019s disease: the inevitability of dementia at 20 years","volume":"23","author":"Hely","year":"2008","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B42","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1148\/radiol.2017170438","article-title":"Loss of functional connectivity in patients with Parkinson disease and visual hallucinations","volume":"285","author":"Hepp","year":"2017","journal-title":"Radiology"},{"key":"2021012813550926400_awaa270-B43","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/mds.20216","article-title":"Risk and incidence of dementia in a cohort of older subjects with Parkinson\u2019s disease in the United Kingdom","volume":"19","author":"Hobson","year":"2004","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B44","article-title":"Unsupervised 3-tissue response function estimation from single-shell or multi-shell diffusion MR data without a co-registered T1 image","author":"Hollander","journal-title":"Presented at the ISMRM Workshop Break Barriers Diffus MRI, Lisbon, Portugal, September 2016."},{"key":"2021012813550926400_awaa270-B45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/chemse\/22.1.39","article-title":"\u2018Sniffin\u2019 sticks\u2019: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold","volume":"22","author":"Hummel","year":"1997","journal-title":"Chem Senses"},{"key":"2021012813550926400_awaa270-B46","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/mrm.26054","article-title":"Gibbs-ringing artifact removal based on local subvoxel-shifts","volume":"76","author":"Kellner","year":"2016","journal-title":"Magn Reson Med"},{"key":"2021012813550926400_awaa270-B47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s42003-020-0804-9","article-title":"Transcriptomic signatures of brain regional vulnerability to Parkinson\u2019s disease","volume":"3","author":"Keo","year":"2020","journal-title":"Commun Biol"},{"key":"2021012813550926400_awaa270-B48","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-019-0565-3","article-title":"Lesions causing hallucinations localize to one common brain network","author":"Kim","year":"2019","journal-title":"Mol Psychiatry"},{"key":"2021012813550926400_awaa270-B49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2021012813550926400_awaa270-B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1001057","article-title":"Is my network module preserved and reproducible?","volume":"7","author":"Langfelder","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"2021012813550926400_awaa270-B51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41556-018-0244-7","article-title":"The lysosome as a cellular centre for signalling, metabolism and quality control","volume":"21","author":"Lawrence","year":"2019","journal-title":"Nat Cell Biol"},{"key":"2021012813550926400_awaa270-B52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13059-015-0584-6","article-title":"DNA methylation age of blood predicts all-cause mortality in later life","volume":"16","author":"Marioni","year":"2015","journal-title":"Genome Biol"},{"key":"2021012813550926400_awaa270-B53","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.biopsych.2017.10.019","article-title":"Brain regions showing white matter loss in Huntington\u2019s disease are enriched for synaptic and metabolic genes","volume":"83","author":"McColgan","year":"2018","journal-title":"Biol Psychiatry"},{"key":"2021012813550926400_awaa270-B54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.parkreldis.2007.05.009","article-title":"Profile of neuropsychiatric problems and their relationship to quality of life for Parkinson\u2019s disease patients without dementia","volume":"14","author":"McKinlay","year":"2007","journal-title":"Park Relat Disord"},{"key":"2021012813550926400_awaa270-B55","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41580-019-0143-1","article-title":"The roles of DNA, RNA and histone methylation in ageing and cancer","volume":"20","author":"Michalak","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2021012813550926400_awaa270-B56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/gm452","article-title":"Genes and pathways underlying regional and cell type changes in Alzheimer\u2019s disease","volume":"5","author":"Miller","year":"2013","journal-title":"Genome Med"},{"key":"2021012813550926400_awaa270-B57","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cell.2008.06.037","article-title":"Chemical and biological approaches synergize to ameliorate protein-folding diseases","volume":"134","author":"Mu","year":"2008","journal-title":"Cell"},{"key":"2021012813550926400_awaa270-B58","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26004","article-title":"Visual hallucinations in Parkinson\u2019s disease: theoretical models","volume":"29","author":"Muller","year":"2014","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B59","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/brain\/awt367","article-title":"Reduced glucocerebrosidase is associated with increased \u03b1-synuclein in sporadic Parkinson\u2019s disease","volume":"137","author":"Murphy","year":"2014","journal-title":"Brain"},{"key":"2021012813550926400_awaa270-B60","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson\u2019s disease","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"2021012813550926400_awaa270-B61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.concog.2016.05.003","article-title":"Predictions penetrate perception: converging insights from brain, behaviour and disorder","volume":"47","author":"O\u2019Callaghan","year":"2017","journal-title":"Conscious Cogn"},{"key":"2021012813550926400_awaa270-B62","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nn.2207","article-title":"Functional organization of the transcriptome in human brain","volume":"11","author":"Oldham","year":"2008","journal-title":"Nat Neurosci"},{"key":"2021012813550926400_awaa270-B63","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.2147\/NDT.S116116","article-title":"Psychosis in parkinsonism: an unorthodox approach","volume":"13","author":"Onofrj","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2021012813550926400_awaa270-B64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/mds.27781","article-title":"Hallucinations, somatic-functional disorders of PD-DLB as expressions of thalamic dysfunction","volume":"34","author":"Onofrj","year":"2019","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B65","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/brain\/awm318","article-title":"The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson\u2019s disease","volume":"131","author":"Pan","year":"2008","journal-title":"Brain"},{"key":"2021012813550926400_awaa270-B66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2377-8-21","article-title":"A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson\u2019s disease","volume":"8","author":"Papapetropoulos","year":"2008","journal-title":"BMC Neurol"},{"key":"2021012813550926400_awaa270-B67","first-page":"187","article-title":"The design of a new letter chart for measuring contrast sensitivity","volume":"2","author":"Pelli","year":"1988","journal-title":"Clin Vis Sci"},{"key":"2021012813550926400_awaa270-B68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fncel.2018.00399","article-title":"How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?","volume":"12","author":"Pepper","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2021012813550926400_awaa270-B69","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g: profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021012813550926400_awaa270-B70","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.biopsych.2016.07.012","article-title":"Connectome disconnectivity and cortical gene expression in patients with schizophrenia","volume":"81","author":"Romme","year":"2017","journal-title":"Biol Psychiatry"},{"key":"2021012813550926400_awaa270-B71","doi-asserted-by":"crossref","first-page":"31380","DOI":"10.1038\/srep31380","article-title":"Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models","volume":"6","author":"Sanchez-Martinez","year":"2016","journal-title":"Sci Rep"},{"key":"2021012813550926400_awaa270-B72","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.celrep.2016.04.071","article-title":"Inefficient DNA repair is an aging-related modifier of Parkinson\u2019s disease","volume":"15","author":"Sepe","year":"2016","journal-title":"Cell Rep"},{"key":"2021012813550926400_awaa270-B73","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/hbm.22321","article-title":"The role of dysfunctional attentional control networks in visual misperceptions in Parkinson\u2019s disease","volume":"35","author":"Shine","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2021012813550926400_awaa270-B74","doi-asserted-by":"crossref","first-page":"20142047","DOI":"10.1098\/rspb.2014.2047","article-title":"Imagine that: elevated sensory strength of mental imagery in individuals with Parkinson\u2019s disease and visual hallucinations","volume":"282","author":"Shine","year":"2015","journal-title":"Proc R Soc B"},{"key":"2021012813550926400_awaa270-B75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnins.2016.00016","article-title":"Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment","volume":"10","author":"Skene","year":"2016","journal-title":"Front Neurosci"},{"key":"2021012813550926400_awaa270-B76","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0002-9394(59)90626-9","article-title":"New test charts for the measurement of visual acuity at far and near distances*","volume":"48","author":"Sloan","year":"1959","journal-title":"Am J Ophthalmol"},{"key":"2021012813550926400_awaa270-B77","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.neuroimage.2012.06.005","article-title":"Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information","volume":"62","author":"Smith","year":"2012","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B78","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuroimage.2015.06.092","article-title":"SIFT2: enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography","volume":"119","author":"Smith","year":"2015","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B79","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire\u2013a new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B80","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.celrep.2018.10.094","article-title":"Widespread accumulation of ribosome-associated isolated 3\u2032 UTRs in neuronal cell populations of the aging brain","volume":"25","author":"Sudmant","year":"2018","journal-title":"Cell Rep"},{"key":"2021012813550926400_awaa270-B81","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"2021012813550926400_awaa270-B82","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov Disord"},{"key":"2021012813550926400_awaa270-B83","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B84","first-page":"1670","article-title":"Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions","author":"Tournier","year":"2010","journal-title":"Proc Int Soc Magn Reson Med"},{"key":"2021012813550926400_awaa270-B85","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"2021012813550926400_awaa270-B86","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11910-010-0102-x","article-title":"The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders","volume":"10","author":"Velayati","year":"2010","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2021012813550926400_awaa270-B87","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/mrm.26059","article-title":"Diffusion MRI noise mapping using random matrix theory","volume":"76","author":"Veraart","year":"2016","journal-title":"Magn Reson Med"},{"key":"2021012813550926400_awaa270-B88","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcz006","article-title":"Neuroimaging in Parkinson\u2019s disease dementia: connecting the dots","volume":"1","author":"Weil","year":"2019","journal-title":"Brain Commun"},{"key":"2021012813550926400_awaa270-B89","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1093\/brain\/aww175","article-title":"Visual dysfunction in Parkinson\u2019s disease","volume":"11","author":"Weil","year":"2016","journal-title":"Brain"},{"key":"2021012813550926400_awaa270-B90","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"2021012813550926400_awaa270-B91","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1002\/hbm.22577","article-title":"The default mode network is disrupted in Parkinson\u2019s disease with visual hallucinations","volume":"35","author":"Yao","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2021012813550926400_awaa270-B92","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2013.01.006","article-title":"Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling","volume":"77","author":"Young","year":"2013","journal-title":"Neuron"},{"key":"2021012813550926400_awaa270-B93","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"Neuroimage"},{"key":"2021012813550926400_awaa270-B94","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcz007","article-title":"Increased weighting on prior knowledge in Lewy body-associated visual hallucinations","author":"Zarkali","year":"2019","journal-title":"Brain Commun"},{"key":"2021012813550926400_awaa270-B95","doi-asserted-by":"crossref","first-page":"e1525","DOI":"10.1212\/WNL.0000000000009014","article-title":"Fibre-specific white matter reductions in Parkinson\u2019s hallucinations and visual dysfunction","author":"Zarkali","year":"2020","journal-title":"Neurology"},{"key":"2021012813550926400_awaa270-B96","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat Appl Genet Mol Biol"},{"key":"2021012813550926400_awaa270-B97","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/143\/11\/3435\/36134984\/awaa270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/143\/11\/3435\/36134984\/awaa270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T15:49:53Z","timestamp":1611848993000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/143\/11\/3435\/5942718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":97,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,10,29]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaa270","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11,1]]},"published":{"date-parts":[[2020,10,29]]}}}