{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:58:12Z","timestamp":1792803492412,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Monument Trust Discovery Award"},{"DOI":"10.13039\/501100013373","name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006149","name":"Oxford University Hospitals NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006149","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Oxford, the NIHR Clinical Research Network"},{"name":"Dementias and Neurodegenerative Diseases Research Network"},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion of idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data of 344 iRBD patients and 256 controls for centralized analysis. 123I-FP-CIT-SPECT images were semiquantified using DaTQUANTTM, obtaining putamen and caudate specific to non-displaceable binding ratios (SBRs). The following clinical variables were also analysed: (i) Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale, motor section score; (ii) Mini-Mental State Examination score; (iii) constipation; and (iv) hyposmia. Kaplan-Meier survival analysis was performed to estimate conversion risk. Hazard ratios for each variable were calculated with Cox regression. A generalized logistic regression model was applied to identify the best combination of risk factors. Bayesian classifier was used to identify the baseline features predicting phenoconversion to parkinsonism or dementia. After quality check of the data, 263 iRBD patients (67.6\u2009\u00b1\u20097.3 years, 229 males) and 243 control subjects (67.2\u2009\u00b1\u200910.1 years, 110 males) were analysed. Fifty-two (20%) patients developed a synucleinopathy after average follow-up of 2 years. The best combination of risk factors was putamen dopaminergic dysfunction of the most affected hemisphere on imaging, defined as the lower value between either putamina (P\u2009&amp;lt;\u20090.000001), constipation, (P\u2009&amp;lt;\u20090.000001) and age over 70 years (P\u2009=\u20090.0002). Combined features obtained from the generalized logistic regression achieved a hazard ratio of 5.71 (95% confidence interval 2.85\u201311.43). Bayesian classifier suggested that patients with higher Mini-Mental State Examination score and lower caudate SBR asymmetry were more likely to develop parkinsonism, while patients with the opposite pattern were more likely to develop dementia. This study shows that iRBD patients older than 70 with constipation and reduced nigro-putaminal dopaminergic function are at high risk of short-term phenoconversion to an overt synucleinopathy, providing an effective stratification approach for future neuroprotective trials. Moreover, we provide cut-off values for the significant predictors of phenoconversion to be used in single subjects.<\/jats:p>","DOI":"10.1093\/brain\/awaa365","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:22:29Z","timestamp":1601454149000},"page":"278-287","source":"Crossref","is-referenced-by-count":138,"title":["Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder"],"prefix":"10.1093","volume":"144","author":[{"given":"Dario","family":"Arnaldi","sequence":"first","affiliation":[{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Chincarini","sequence":"additional","affiliation":[{"name":"National Institute of Nuclear Physics (INFN), Genoa section, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T","family":"Hu","sequence":"additional","affiliation":[{"name":"Oxford Parkinson\u2019s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-9656","authenticated-orcid":false,"given":"Karel","family":"Sonka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dokkyo Medical University Saitama Medical Centre, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Puligheddu","sequence":"additional","affiliation":[{"name":"Sleep Disorder Centre, Department of Medical Sciences and Public Health, University of Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie Cochen","family":"De Cock","sequence":"additional","affiliation":[{"name":"Department of Sleep and Neurology, Beau Soleil Clinic, and EuroMov Digital Health in Motion, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Terzaghi","sequence":"additional","affiliation":[{"name":"Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy"},{"name":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Kansai Electric Power Medical Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Morbelli","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"},{"name":"Nuclear Medicine, Department of Health Sciences (DISSAL), University of Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Rolinski","sequence":"additional","affiliation":[{"name":"Oxford Parkinson\u2019s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK"},{"name":"Institute of Clinical Neurosciences, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Dusek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Centre of Sleep Medicine, Dokkyo Medical University Hospital, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Figorilli","sequence":"additional","affiliation":[{"name":"Sleep Disorder Centre, Department of Medical Sciences and Public Health, University of Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine de","family":"Verbizier","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, University hospital of Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bossert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, ICS Maugeri SpA SB IRCCS, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"Neurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Meli","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-9677","authenticated-orcid":false,"given":"Thomas R","family":"Barber","sequence":"additional","affiliation":[{"name":"Oxford Parkinson\u2019s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Trnka","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toji","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Serra","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-9116","authenticated-orcid":false,"given":"Matteo","family":"Bauckneht","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"},{"name":"Nuclear Medicine, Department of Health Sciences (DISSAL), University of Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Bradley","sequence":"additional","affiliation":[{"name":"PETIC, University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1667","authenticated-orcid":false,"given":"David","family":"Zogala","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R","family":"McGowan","sequence":"additional","affiliation":[{"name":"Radiation Physics and Protection Department, Churchill Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennon","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Manni","sequence":"additional","affiliation":[{"name":"Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Nobili","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"2021111805191403700_awaa365-B1","year":"2013"},{"key":"2021111805191403700_awaa365-B2","article-title":"The fate of patients with REM sleep behavior disorder and Mild Cognitive Impairment","author":"Arnaldi","year":"2020","journal-title":"Sleep Med"},{"key":"2021111805191403700_awaa365-B3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.smrv.2018.04.001","article-title":"Presynaptic dopaminergic neuroimaging in REM sleep behavior disorder: a systematic review and meta-analysis","volume":"41","author":"Bauckneht","year":"2018","journal-title":"Sleep Med Rev"},{"key":"2021111805191403700_awaa365-B4","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/mds.26431","article-title":"MDS research criteria for prodromal Parkinson's disease","volume":"30","author":"Berg","year":"2015","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B5","first-page":"145","article-title":"Smell diskettes as screening test of olfaction","volume":"37","author":"Briner","year":"1999","journal-title":"Rhinology"},{"key":"2021111805191403700_awaa365-B6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/cts.12492","article-title":"Dopamine transporter neuroimaging as an enrichment biomarker in Early Parkinson's disease clinical trials: a disease progression modeling analysis","volume":"11","author":"Conrado","year":"2018","journal-title":"Clin Transl Sci"},{"key":"2021111805191403700_awaa365-B7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00259-009-1267-x","article-title":"EANM procedure guidelines for brain neurotransmission SPECT using (123)I-labelled dopamine transporter ligands, version 2","volume":"37","author":"Darcourt","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2021111805191403700_awaa365-B8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0031-9384(84)90269-5","article-title":"Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function","volume":"32","author":"Doty","year":"1984","journal-title":"Physiol Behav"},{"key":"2021111805191403700_awaa365-B9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatric Res"},{"key":"2021111805191403700_awaa365-B10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/sim.4780010204","article-title":"Tables of the number of patients required in clinical trials using the logrank test","volume":"1","author":"Freedman","year":"1982","journal-title":"Stat Med"},{"key":"2021111805191403700_awaa365-B11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.smrv.2018.09.008","article-title":"The risk of neurodegeneration in REM sleep behavior disorder: a systematic review and meta-analysis of longitudinal studies","volume":"43","author":"Galbiati","year":"2019","journal-title":"Sleep Med Rev"},{"key":"2021111805191403700_awaa365-B12","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ana.25239","article-title":"How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder","volume":"83","author":"G\u00e9nier Marchand","year":"2018","journal-title":"Ann Neurol"},{"key":"2021111805191403700_awaa365-B13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan","volume":"22","author":"Goetz","year":"2007","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B14","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/mds.26435","article-title":"Simplified conversion method for unified Parkinson's disease rating scale motor examinations","volume":"30","author":"Hentz","year":"2015","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/chemse\/22.1.39","article-title":"\u2018Sniffin\u2019 sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold","volume":"22","author":"Hummel","year":"1997","journal-title":"Chem Senses"},{"key":"2021111805191403700_awaa365-B16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ana.25026","article-title":"Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic REM sleep behavior disorder","volume":"82","author":"Iranzo","year":"2017","journal-title":"Ann Neurol"},{"key":"2021111805191403700_awaa365-B17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.nicl.2018.04.009","article-title":"Lower (123)I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies","volume":"19","author":"Joling","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2021111805191403700_awaa365-B18","author":"Klein","year":"2014"},{"key":"2021111805191403700_awaa365-B19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/chemse\/bjj037","article-title":"Cross-cultural comparison of data using the odor stick identification test for Japanese (OSIT-J)","volume":"31","author":"Kobayashi","year":"2006","journal-title":"Chem Senses"},{"key":"2021111805191403700_awaa365-B20","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1212\/WNL.0000000000003838","article-title":"Predictive markers for early conversion of iRBD to neurodegenerative synucleinopathy diseases","volume":"88","author":"Li","year":"2017","journal-title":"Neurology"},{"key":"2021111805191403700_awaa365-B21","first-page":"1628","author":"Maltais","year":"2020"},{"key":"2021111805191403700_awaa365-B22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"2021111805191403700_awaa365-B23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1212\/WNL.0000000000009323","article-title":"Research criteria for the diagnosis of prodromal dementia with Lewy bodies","volume":"94","author":"McKeith","year":"2020","journal-title":"Neurology"},{"key":"2021111805191403700_awaa365-B24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"2021111805191403700_awaa365-B25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/mds.22899","article-title":"Cognitive-nigrostriatal relationships in de novo, drug-naive Parkinson's disease patients: a [I-123]FP-CIT SPECT study","volume":"25","author":"Nobili","year":"2010","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and predictors of dementia and Parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"key":"2021111805191403700_awaa365-B28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.parkreldis.2013.09.025","article-title":"The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort","volume":"20","author":"Szewczyk-Krolikowski","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"2021111805191403700_awaa365-B29","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/mds.26062","article-title":"Conversion between mini-mental state examination, montreal cognitive assessment, and dementia rating scale-2 scores in Parkinson's disease","volume":"29","author":"van Steenoven","year":"2014","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B30","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in Parkinson's disease: the SCOPA-AUT","volume":"19","author":"Visser","year":"2004","journal-title":"Mov Disord"},{"key":"2021111805191403700_awaa365-B31","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/01.WNL.0000123248.39847.1D","article-title":"Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison","volume":"62","author":"Walker","year":"2004","journal-title":"Neurology"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/144\/1\/278\/41162013\/awaa365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/144\/1\/278\/41162013\/awaa365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T03:08:24Z","timestamp":1637204904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/144\/1\/278\/6043137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12,29]]},"published-print":{"date-parts":[[2021,2,12]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awaa365","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739251389.793584279","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,12,29]]}}}