{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:09:21Z","timestamp":1792807761143,"version":"4.5.0"},"reference-count":105,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Dementia Research Centre"},{"name":"Alzheimer\u2019s Research UK, Brain Research Trust"},{"DOI":"10.13039\/501100001320","name":"The Wolfson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alzheimer\u2019s Society, Alzheimer\u2019s Research UK"},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"},{"name":"Association of British Neurologists Clinical Research Training Fellowship"},{"DOI":"10.13039\/501100000627","name":"Guarantors of Brain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bart\u2019s Charity"},{"name":"Wellcome Clinical Research Career Development Fellowship","award":["201567\/Z\/16\/Z"],"award-info":[{"award-number":["201567\/Z\/16\/Z"]}]},{"name":"BRC Hearing and Deafness"},{"name":"Action on Hearing Loss-Dunhill Medical Trust Pauline Ashley Fellowship"},{"name":"Action on Hearing Loss, Alzheimer\u2019s Research UK, Alzheimer\u2019s Society, Guarantors of Brain"},{"name":"Brain Research UK, MRC, Wellcome Trust, and the Wolfson Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The association between hearing impairment and dementia has emerged as a major public health challenge, with significant opportunities for earlier diagnosis, treatment and prevention. However, the nature of this association has not been defined. We hear with our brains, particularly within the complex soundscapes of everyday life: neurodegenerative pathologies target the auditory brain, and are therefore predicted to damage hearing function early and profoundly. Here we present evidence for this proposition, based on structural and functional features of auditory brain organization that confer vulnerability to neurodegeneration, the extensive, reciprocal interplay between \u2018peripheral\u2019 and \u2018central\u2019 hearing dysfunction, and recently characterized auditory signatures of canonical neurodegenerative dementias (Alzheimer\u2019s disease, Lewy body disease and frontotemporal dementia). Moving beyond any simple dichotomy of ear and brain, we argue for a reappraisal of the role of auditory cognitive dysfunction and the critical coupling of brain to peripheral organs of hearing in the dementias. We call for a clinical assessment of real-world hearing in these diseases that moves beyond pure tone perception to the development of novel auditory \u2018cognitive stress tests\u2019 and proximity markers for the early diagnosis of dementia and management strategies that harness retained auditory plasticity.<\/jats:p>","DOI":"10.1093\/brain\/awaa429","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T21:33:18Z","timestamp":1605735198000},"page":"391-401","source":"Crossref","is-referenced-by-count":182,"title":["Hearing and dementia: from ears to brain"],"prefix":"10.1093","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-7997","authenticated-orcid":false,"given":"Jeremy C S","family":"Johnson","sequence":"first","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R","family":"Marshall","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"},{"name":"Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-6325","authenticated-orcid":false,"given":"Rimona S","family":"Weil","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"},{"name":"Movement Disorders Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK"},{"name":"Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris-Eva","family":"Bamiou","sequence":"additional","affiliation":[{"name":"UCL Ear Institute and UCL\/UCLH Biomedical Research Centre, National Institute for Health Research, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J D","family":"Hardy","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2021030904133370500_awaa429-B1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/AUD.0b013e31822229d3","article-title":"A neural basis of speech-in-noise perception in older adults","volume":"32","author":"Anderson","year":"2011","journal-title":"Ear Heart"},{"key":"2021030904133370500_awaa429-B2","doi-asserted-by":"crossref","first-page":"E616","DOI":"10.1073\/pnas.1508523113","article-title":"Brain responses in humans reveal ideal observer-like sensitivity to complex acoustic patterns","volume":"113","author":"Barascud","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021030904133370500_awaa429-B3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnins.2014.00060","article-title":"Predictability effects in auditory scene analysis: a 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