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Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer\u2019s disease, Parkinson\u2019s disease and other cognitive disorders. We discuss the advances in human imaging and computational methods that quantify the locus coeruleus and its function in humans, and highlight the potential for new noradrenergic treatment strategies.<\/jats:p>","DOI":"10.1093\/brain\/awab111","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T15:10:47Z","timestamp":1615475447000},"page":"2243-2256","source":"Crossref","is-referenced-by-count":209,"title":["The role of noradrenaline in cognition and cognitive disorders"],"prefix":"10.1093","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-0882","authenticated-orcid":false,"given":"Negin","family":"Holland","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK"},{"name":"Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SZ, UK"},{"name":"Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK"},{"name":"MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"issue":"1","key":"2021090418513272800_awab111-B1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainresrev.2004.02.002","article-title":"Noradrenergic mechanisms in neurodegenerative diseases: A theory","volume":"45","author":"Marien","year":"2004","journal-title":"Brain Res Brain Res 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