{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:29:18Z","timestamp":1791919758776,"version":"4.3.4"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["# 164235"],"award-info":[{"award-number":["# 164235"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NE 2276\/1\u20131"],"award-info":[{"award-number":["NE 2276\/1\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["410169619"],"award-info":[{"award-number":["410169619"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["424778381"],"award-info":[{"award-number":["424778381"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,22]]},"abstract":"<jats:title>Abstarct<\/jats:title>\n               <jats:p>Because of its involvement in a wide variety of cardiovascular, metabolic and behavioural functions, the hypothalamus constitutes a potential target for neuromodulation in a number of treatment-refractory conditions. The precise neural substrates and circuitry subserving these responses, however, are poorly characterized to date. We sought to retrospectively explore the acute sequelae of hypothalamic region deep brain stimulation and characterize their neuroanatomical correlates. To this end we studied\u2014at multiple international centres\u201458 patients (mean age: 68.5\u2009\u00b1\u20097.9\u2009years, 26 females) suffering from mild Alzheimer\u2019s disease who underwent stimulation of the fornix region between 2007 and 2019. We catalogued the diverse spectrum of acutely induced clinical responses during electrical stimulation and interrogated their neural substrates using volume of tissue activated modelling, voxel-wise mapping, and supervised machine learning techniques. In total 627 acute clinical responses to stimulation\u2014including tachycardia, hypertension, flushing, sweating, warmth, coldness, nausea, phosphenes, and fear\u2014were recorded and catalogued across patients using standard descriptive methods. The most common manifestations during hypothalamic region stimulation were tachycardia (30.9%) and warmth (24.6%) followed by flushing (9.1%) and hypertension (6.9%). Voxel-wise mapping identified distinct, locally separable clusters for all sequelae that could be mapped to specific hypothalamic and extrahypothalamic grey and white matter structures. K-nearest neighbour classification further validated the clinico-anatomical correlates emphasizing the functional importance of identified neural substrates with area under the receiving operating characteristic curves between 0.67 and 0.91. Overall, we were able to localize acute effects of hypothalamic region stimulation to distinct tracts and nuclei within the hypothalamus and the wider diencephalon providing clinico-anatomical insights that may help to guide future neuromodulation work.<\/jats:p>","DOI":"10.1093\/brain\/awab170","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:56:58Z","timestamp":1619207818000},"page":"2837-2851","source":"Crossref","is-referenced-by-count":31,"title":["Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation"],"prefix":"10.1093","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-1045","authenticated-orcid":false,"given":"Clemens","family":"Neudorfer","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J B","family":"Elias","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jakobs","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-5195","authenticated-orcid":false,"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-8226","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Germann","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-2461","authenticated-orcid":false,"given":"Keshav","family":"Narang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Loh","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Paff","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-6025","authenticated-orcid":false,"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Movement Disorders and Neuromodulation Unit, Department for Neurology, Charit\u00e9 \u2013 University Medicine Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kucharczyk","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissam","family":"Deeb","sequence":"additional","affiliation":[{"name":"Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-2238","authenticated-orcid":false,"given":"Bryan","family":"Salvato","sequence":"additional","affiliation":[{"name":"Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D","family":"Foote","sequence":"additional","affiliation":[{"name":"Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Tang-Wai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Mari","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A","family":"Ponce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Wolk","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna D","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behaviour and Neurology, Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan N","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Mallar","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Cerebral Imaging Centre, Douglas Research Centre, Montreal QC, Canada"},{"name":"Department of Psychiatry, McGill University, Montreal, QC, Canada"},{"name":"Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenn S","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine G","family":"Lyketsos","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Psychiatry and Behavioural Sciences, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Okun","sequence":"additional","affiliation":[{"name":"Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida Health, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"issue":"1\u20132","key":"2021103110134232900_awab170-B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.autneu.2009.02.003","article-title":"Central sympathetic overactivity: Maladies and mechanisms","volume":"148","author":"Fisher","year":"2009","journal-title":"Auton Neurosci Basic Clin"},{"issue":"2","key":"2021103110134232900_awab170-B2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1152\/japplphysiol.00832.2009","article-title":"The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: The transition from mechanisms to medical management","volume":"108","author":"Esler","year":"2010","journal-title":"J Appl Physiol"},{"issue":"7","key":"2021103110134232900_awab170-B3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archpsyc.55.7.580","article-title":"The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment","volume":"55","author":"Musselman","year":"1998","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"2021103110134232900_awab170-B4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1152\/physrev.1929.9.3.399","article-title":"Organization for physiological homeostasis","volume":"9","author":"Cannon","year":"1929","journal-title":"Physiol Rev"},{"issue":"4","key":"2021103110134232900_awab170-B5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3171\/JNS\/2008\/109\/10\/0625","article-title":"Deep brain stimulation in the treatment of obesity: A review","volume":"109","author":"Halpern","year":"2008","journal-title":"J Neurosurg"},{"issue":"2","key":"2021103110134232900_awab170-B6","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/2010.5.FOCUS1094","article-title":"Deep brain stimulation of the posteromedial hypothalamus: Indications, long-term results, and neurophysiological considerations","volume":"29","author":"Franzini","year":"2010","journal-title":"Neurosurg Focus"},{"key":"2021103110134232900_awab170-B7","doi-asserted-by":"crossref","first-page":"E722","DOI":"10.1038\/tp.2015.222","article-title":"Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder","volume":"6","author":"de Koning","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"7","key":"2021103110134232900_awab170-B8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrneurol.2012.100","article-title":"The autonomic effects of deep brain stimulation-a therapeutic opportunity","volume":"8","author":"Hyam","year":"2012","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"2021103110134232900_awab170-B9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41582-018-0128-2","article-title":"Deep brain stimulation: Current challenges and future directions","volume":"15","author":"Lozano","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2021103110134232900_awab170-B10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jash.2008.09.001","article-title":"Baroreflex stimulation: A novel treatment option for resistant hypertension","volume":"3","author":"Navaneethan","year":"2009","journal-title":"J Am Soc Hypertens"},{"key":"2021103110134232900_awab170-B11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/B978-0-12-386525-0.00137-2","volume-title":"Primer on the autonomic nervous system.","author":"Esler","year":"2012","edition":"3rd ed"},{"issue":"1","key":"2021103110134232900_awab170-B12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ana.21295","article-title":"Memory enhancement induced by hypothalamic\/fornix deep brain stimulation","volume":"63","author":"Hamani","year":"2008","journal-title":"Ann Neurol"},{"issue":"4","key":"2021103110134232900_awab170-B13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.22089","article-title":"A Phase I trial of deep brain stimulation of memory circuits in Alzheimer\u2019s disease","volume":"68","author":"Laxton","year":"2010","journal-title":"Ann Neurol"},{"issue":"2","key":"2021103110134232900_awab170-B14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3233\/JAD-160017","article-title":"A phase II study of fornix deep brain stimulation in mild Alzheimer\u2019s disease","volume":"54","author":"Lozano","year":"2016","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"2021103110134232900_awab170-B15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-180121","article-title":"Deep brain stimulation targeting the fornix for mild Alzheimer Dementia (The ADvance Trial): A two year follow-up including results of delayed activation","volume":"64","author":"Leoutsakos","year":"2018","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"2021103110134232900_awab170-B16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1056\/NEJMc1905240","article-title":"Fornix-region deep brain stimulation\u2013induced memory flashbacks in Alzheimer\u2019s disease","volume":"381","author":"Deeb","year":"2019","journal-title":"N Engl J Med"},{"issue":"3","key":"2021103110134232900_awab170-B17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimer\u2019s Dement"},{"issue":"1","key":"2021103110134232900_awab170-B18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3171\/2015.6.JNS15716","article-title":"Bilateral deep brain stimulation of the fornix for Alzheimer\u2019s disease: Surgical safety in the ADvance trial","volume":"125","author":"Ponce","year":"2016","journal-title":"J Neurosurg"},{"key":"2021103110134232900_awab170-B19","article-title":"Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer\u2019s Disease","author":"Germann","journal-title":"Alzheimer\u2019s Dement"},{"issue":"6","key":"2021103110134232900_awab170-B20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.numecd.2017.04.004","article-title":"Resting heart rate and the risk of cardiovascular disease, total cancer, and all-cause mortality \u2013 A systematic review and dose\u2013response meta-analysis of prospective studies","volume":"27","author":"Aune","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"2021103110134232900_awab170-B21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI): MRI methods","volume":"27","author":"Jack","year":"2008","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"2021103110134232900_awab170-B22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jalz.2010.03.004","article-title":"Update on the magnetic resonance imaging core of the Alzheimer\u2019s disease neuroimaging initiative","volume":"6","author":"Jack","year":"2010","journal-title":"Alzheimer\u2019s Dement"},{"key":"2021103110134232900_awab170-B23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroimage.2018.08.068","article-title":"Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging","volume":"184","author":"Horn","year":"2019","journal-title":"Neuroimage"},{"issue":"3","key":"2021103110134232900_awab170-B24","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"2021103110134232900_awab170-B25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuroimage.2018.09.061","article-title":"Optimization and comparative evaluation of nonlinear deformation algorithms for atlas-based segmentation of DBS target nuclei","volume":"184","author":"Ewert","year":"2019","journal-title":"Neuroimage"},{"issue":"1","key":"2021103110134232900_awab170-B26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12938-018-0463-y","article-title":"The FieldTrip-SimBio pipeline for EEG forward solutions","volume":"17","author":"Vorwerk","year":"2018","journal-title":"Biomed Eng Online"},{"issue":"2","key":"2021103110134232900_awab170-B27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1109\/TBME.2014.2363494","article-title":"Relationship between neural activation and electric field distribution during deep brain stimulation","volume":"62","author":"\u00c5str\u00f6m","year":"2015","journal-title":"IEEE Trans Biomed Eng"},{"issue":"6","key":"2021103110134232900_awab170-B28","doi-asserted-by":"crossref","first-page":"066024","DOI":"10.1088\/1741-2552\/ab3c95","article-title":"Evaluation of methodologies for computing the deep brain stimulation volume of tissue activated","volume":"16","author":"Duffley","year":"2019","journal-title":"J Neural Eng"},{"issue":"3","key":"2021103110134232900_awab170-B29","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ana.25975","article-title":"Probabilistic mapping of deep brain stimulation: Insights from 15 years of therapy","volume":"89","author":"Elias","year":"2021","journal-title":"Ann Neurol"},{"issue":"10","key":"2021103110134232900_awab170-B30","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1093\/brain\/awz236","article-title":"Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor","volume":"142","author":"Al-Fatly","year":"2019","journal-title":"Brain"},{"issue":"11","key":"2021103110134232900_awab170-B31","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1093\/brain\/awz285","article-title":"Non-motor outcomes depend on location of neurostimulation in Parkinson\u2019s disease","volume":"142","author":"Petry-Schmelzer","year":"2019","journal-title":"Brain"},{"issue":"2","key":"2021103110134232900_awab170-B32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ana.24204","article-title":"Functional anatomy of subthalamic nucleus stimulation in Parkinson disease","volume":"76","author":"Eisenstein","year":"2014","journal-title":"Ann Neurol"},{"key":"2021103110134232900_awab170-B33","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.nicl.2016.11.019","article-title":"Probabilistic mapping of deep brain stimulation effects in essential tremor","volume":"13","author":"Dembek","year":"2017","journal-title":"NeuroImage Clin"},{"issue":"Pt 8","key":"2021103110134232900_awab170-B34","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/brain\/aws153","article-title":"Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping","volume":"135","author":"Sprenger","year":"2012","journal-title":"Brain"},{"issue":"12","key":"2021103110134232900_awab170-B35","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1093\/brain\/awy278","article-title":"Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor","volume":"141","author":"Boutet","year":"2018","journal-title":"Brain"},{"issue":"4","key":"2021103110134232900_awab170-B36","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"Genovese","year":"2002","journal-title":"Neuroimage"},{"issue":"28","key":"2021103110134232900_awab170-B37","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2021103110134232900_awab170-B38","doi-asserted-by":"crossref","first-page":"E3372","DOI":"10.1073\/pnas.1614502114","article-title":"Reevaluating \"cluster failure\" in fMRI using nonparametric control of the false discovery rate","volume":"114","author":"Kessler","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2021103110134232900_awab170-B39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41597-020-00644-6","article-title":"A high-resolution in-vivo MRI atlas of the human hypothalamus","volume":"7","author":"Neudorfer","year":"2020","journal-title":"Sci Data"},{"key":"2021103110134232900_awab170-B40","doi-asserted-by":"crossref","first-page":"180063","DOI":"10.1038\/sdata.2018.63","article-title":"A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei","volume":"5","author":"Pauli","year":"2018","journal-title":"Sci Data"},{"issue":"3","key":"2021103110134232900_awab170-B41","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.neuroimage.2007.09.027","article-title":"Region of interest template for the human basal ganglia: Comparing EPI and standardized space approaches","volume":"39","author":"Prodoehl","year":"2008","journal-title":"Neuroimage"},{"issue":"3","key":"2021103110134232900_awab170-B42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00701-014-2335-y","article-title":"DTI-based deterministic fibre tracking of the medial forebrain bundle","volume":"157","author":"Anthofer","year":"2015","journal-title":"Acta Neurochir (Wien)"},{"issue":"3","key":"2021103110134232900_awab170-B43","doi-asserted-by":"crossref","first-page":"ENEURO.0060-18.2018-18","DOI":"10.1523\/ENEURO.0060-18.2018","article-title":"Human motor thalamus reconstructed in 3D from continuous sagittal sections with identified subcortical afferent territories","volume":"5","author":"Ilinsky","year":"2018","journal-title":"eNeuro"},{"key":"2021103110134232900_awab170-B44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroimage.2018.05.027","article-title":"Population-averaged atlas of the macroscale human structural connectome and its network topology","volume":"178","author":"Yeh","year":"2018","journal-title":"Neuroimage"},{"key":"2021103110134232900_awab170-B45","doi-asserted-by":"crossref","first-page":"568","DOI":"10.7551\/mitpress\/11557.001.0001","volume-title":"Statistical Analysis of fMRI Data","author":"Ashby","year":"2019","edition":"2nd ed"},{"key":"2021103110134232900_awab170-B46","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511763281","volume-title":"Deep Brain Stimulation Management","author":"Marks","year":"2010","edition":"1st ed."},{"issue":"3","key":"2021103110134232900_awab170-B47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp.2006.095315","article-title":"Deep brain stimulation in the internal capsule and nucleus accumbens region: Responses observed during active and sham programming","volume":"78","author":"Okun","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2021103110134232900_awab170-B48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1212\/01.wnl.0000223319.56699.8a","article-title":"Hypothalamic stimulation for intractable cluster headache: Long-term experience","volume":"67","author":"Leone","year":"2006","journal-title":"Neurology"},{"issue":"5","key":"2021103110134232900_awab170-B49","doi-asserted-by":"crossref","first-page":"E1182; discussion E1182","DOI":"10.1227\/01.neu.0000325889.84785.69","article-title":"Disappearance of self-aggressive behaviour in a brain-injured patient after deep brain stimulation of the hypothalamus: Technical case report","volume":"62","author":"Kuhn","year":"2008","journal-title":"Neurosurgery"},{"issue":"7","key":"2021103110134232900_awab170-B50","doi-asserted-by":"crossref","first-page":"E185275","DOI":"10.1001\/jamanetworkopen.2018.5275","article-title":"Assessment of safety and outcome of lateral hypothalamic deep brain stimulation for obesity in a small series of patients with Prader-Willi syndrome","volume":"1","author":"Franco","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"7","key":"2021103110134232900_awab170-B51","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp.2006.103739","article-title":"Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson\u2019s disease","volume":"78","author":"Ludwig","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"2021103110134232900_awab170-B52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/advan.00027.2016","article-title":"Central neural control of the cardiovascular system: Current perspectives","volume":"40","author":"Dampney","year":"2016","journal-title":"Adv Physiol Educ"},{"issue":"5","key":"2021103110134232900_awab170-B53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"2021103110134232900_awab170-B54","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/HYPERTENSIONAHA.115.06425","article-title":"Cardiovascular regulation by the arcuate nucleus of the hypothalamus: neurocircuitry and signaling systems","volume":"67","author":"Rahmouni","year":"2016","journal-title":"Hypertension"},{"issue":"9","key":"2021103110134232900_awab170-B55","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1468-1331.2007.01850.x","article-title":"Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients","volume":"14","author":"Cortelli","year":"2007","journal-title":"Eur J Neurol"},{"issue":"6","key":"2021103110134232900_awab170-B56","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3171\/jns.1970.33.6.0689","article-title":"Results of stimulation and destruction of the posterior hypothalamus in man","volume":"33","author":"Sano","year":"1970","journal-title":"J Neurosurg"},{"issue":"5","key":"2021103110134232900_awab170-B57","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1212\/01.wnl.0000174436.36399.ca","article-title":"Sympathetic activation due to deep brain stimulation in the region of the STN","volume":"65","author":"Lipp","year":"2005","journal-title":"Neurology"},{"issue":"4","key":"2021103110134232900_awab170-B58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00415-005-0675-5","article-title":"Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson\u2019s disease","volume":"252","author":"Sauleau","year":"2005","journal-title":"J Neurol"},{"key":"2021103110134232900_awab170-B59","article-title":"Deep brain stimulation for aggressiveness: Long-term follow-up and tractography study of the stimulated brain areas","author":"Torres","year":"2020","journal-title":"J Neurosurg"},{"issue":"3","key":"2021103110134232900_awab170-B60","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3171\/2018.11.JNS181412","article-title":"Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: Case report","volume":"132","author":"Dantas","journal-title":"J Neurosurg"},{"issue":"8","key":"2021103110134232900_awab170-B61","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.psyneuen.2012.12.006","article-title":"Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes","volume":"38","author":"de Koning","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"2021103110134232900_awab170-B62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3171\/2013.2.JNS12903","article-title":"Lateral hypothalamic area deep brain stimulation for refractory obesity: A pilot study with preliminary data on safety, body weight, and energy metabolism: Clinical article","volume":"119","author":"Whiting","year":"2013","journal-title":"J Neurosurg"},{"issue":"3","key":"2021103110134232900_awab170-B63","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/1756285610370722","article-title":"Hypothalamic deep brain stimulation in the treatment of chronic cluster headache","volume":"3","author":"Leone","year":"2010","journal-title":"Ther Adv Neurol Disord"},{"issue":"8","key":"2021103110134232900_awab170-B64","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0166-2236(93)90110-8","article-title":"The contribution of the amygdala to normal and abnormal emotional states","volume":"16","author":"Aggleton","year":"1993","journal-title":"Trends Neurosci"},{"key":"2021103110134232900_awab170-B65","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.ne.15.030192.002033","article-title":"The role of the Amygdala in fear and anxiety","volume":"15","author":"Davis","year":"1992","journal-title":"Annu Rev Neurosci"},{"issue":"3127","key":"2021103110134232900_awab170-B66","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.120.3127.949","article-title":"Physiological evidence concerning importance of the amygdaloid nuclear region in the integration of circulatory function and emotion in man","volume":"120","author":"Chapman","year":"1954","journal-title":"Science"},{"issue":"6","key":"2021103110134232900_awab170-B67","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3171\/2009.9.JNS09577","article-title":"Induction of panic attack by stimulation of the ventromedial hypothalamus: Case report","volume":"112","author":"Wilent","year":"2010","journal-title":"J Neurosurg"},{"issue":"1","key":"2021103110134232900_awab170-B68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brs.2019.09.010","article-title":"Probing the circuitry of panic with deep brain stimulation: Connectomic analysis and review of the literature","volume":"13","author":"Elias","year":"2020","journal-title":"Brain Stimul"},{"issue":"3","key":"2021103110134232900_awab170-B69","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1227\/01.NEU.0000170434.44335.19","article-title":"A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle","volume":"57","author":"Jim\u00e9nez","year":"2005","journal-title":"Neurosurgery"},{"issue":"5","key":"2021103110134232900_awab170-B70","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1227\/01.NEU.0000140843.62311.24","article-title":"Anatomy of the anterior temporal lobe and the frontotemporal region demonstrated by fiber dissection","volume":"55","author":"Peuskens","year":"2004","journal-title":"Neurosurgery"},{"issue":"1","key":"2021103110134232900_awab170-B71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00429-017-1570-4","article-title":"Neuroanatomical background and functional considerations for stereotactic interventions in the H fields of Forel","volume":"223","author":"Neudorfer","year":"2018","journal-title":"Brain Struct Funct"},{"issue":"7","key":"2021103110134232900_awab170-B72","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1007\/s00429-015-1119-3","article-title":"Revealing the ventral amygdalofugal pathway of the human limbic system using high spatial resolution diffusion tensor tractography","volume":"221","author":"Kamali","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"2","key":"2021103110134232900_awab170-B73","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuron.2005.09.025","article-title":"Contributions of the amygdala to emotion processing: From animal models to human behavior","volume":"48","author":"Phelps","year":"2005","journal-title":"Neuron"},{"key":"2021103110134232900_awab170-B74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An Integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"2021103110134232900_awab170-B75","article-title":"Four deep brain stimulation targets for obsessive-compulsive disorder: Are they different?","author":"Haber","year":"2020","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2021103110134232900_awab170-B76","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/npp.2014.28","article-title":"Deep brain stimulation of the human reward system for major depression - Rationale, outcomes and outlook","volume":"39","author":"Schlaepfer","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"2021103110134232900_awab170-B77","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jad.2016.05.064","article-title":"Deep brain stimulation of the medial forebrain bundle: Distinctive responses in resistant depression","volume":"203","author":"Fenoy","year":"2016","journal-title":"J Affect Disord"},{"issue":"12","key":"2021103110134232900_awab170-B78","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biopsych.2013.01.034","article-title":"Rapid effects of deep brain stimulation for treatment-resistant major depression","volume":"73","author":"Schlaepfer","year":"2013","journal-title":"Biol Psychiatry"},{"key":"2021103110134232900_awab170-B79","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-physiol-020518-114546","article-title":"Central mechanisms for thermoregulation","volume":"81","author":"Morrison","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"2021103110134232900_awab170-B80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-3-540-34686-9_10","volume-title":"The human central nervous system. A synopsis and atlas","author":"Nieuwenhuys","year":"2008","edition":"4th ed"},{"issue":"1","key":"2021103110134232900_awab170-B81","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nn2027","article-title":"A thermosensory pathway that controls body temperature","volume":"11","author":"Nakamura","year":"2008","journal-title":"Nat Neurosci"},{"issue":"1","key":"2021103110134232900_awab170-B82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2016.08.028","article-title":"Warm-sensitive neurons that control body temperature","volume":"167","author":"Tan","year":"2016","journal-title":"Cell"},{"issue":"1","key":"2021103110134232900_awab170-B83","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1152\/ajpregu.00498.2006","article-title":"The dorsomedial hypothalamus: A new player in thermoregulation","volume":"292","author":"DiMicco","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"2021103110134232900_awab170-B84","doi-asserted-by":"crossref","first-page":"R831","DOI":"10.1152\/ajpregu.91007.2008","article-title":"Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue","volume":"296","author":"Madden","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1\u20133","key":"2021103110134232900_awab170-B85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1566-0702(00)00216-2","article-title":"Neuronal circuitries involved in thermoregulation","volume":"85","author":"Nagashima","year":"2000","journal-title":"Auton Neurosci Basic Clin"},{"issue":"3","key":"2021103110134232900_awab170-B86","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1469-7793.1998.883bd.x","article-title":"Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats","volume":"512","author":"Chen","year":"1998","journal-title":"J Physiol"},{"issue":"45","key":"2021103110134232900_awab170-B87","doi-asserted-by":"crossref","first-page":"14006","DOI":"10.1073\/pnas.1519358112","article-title":"Liver X receptor \u03b2 controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue","volume":"112","author":"Miao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021103110134232900_awab170-B88","author":"Swaab","year":"2004"},{"key":"2021103110134232900_awab170-B89","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/CBO9780511763281.009","volume-title":"Deep brain stimulation management","author":"Isaias","year":"2010"},{"issue":"8","key":"2021103110134232900_awab170-B90","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0002-9343(01)00849-X","article-title":"Central neurocircuitry associated with emesis","volume":"111","author":"Hornby","year":"2001","journal-title":"Am J Med"},{"issue":"6","key":"2021103110134232900_awab170-B91","first-page":"1001","article-title":"Neural networks in chemotherapy-induced delayed nausea: a pilot study using positron emission tomography","volume":"2","author":"Fredrikson","year":"1995","journal-title":"Oncol Rep"},{"key":"2021103110134232900_awab170-B92","doi-asserted-by":"crossref","first-page":"e44548","DOI":"10.7554\/eLife.44548","article-title":"Sensory perception drives food avoidance through excitatory basal forebrain circuits","volume":"8","author":"Patel","year":"2019","journal-title":"Elife"},{"issue":"1","key":"2021103110134232900_awab170-B93","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41597-019-0254-8","article-title":"7 Tesla MRI of the ex vivo human brain at 100 micron resolution","volume":"6","author":"Edlow","year":"2019","journal-title":"Sci Data"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awab170\/40394758\/awab170.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/144\/9\/2837\/40880314\/awab170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/brain\/article-pdf\/144\/9\/2837\/40880314\/awab170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T10:15:58Z","timestamp":1635675358000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/144\/9\/2837\/6255743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":93,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,4,27]]},"published-print":{"date-parts":[[2021,10,22]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awab170","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,4,27]]}}}