{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:55:16Z","timestamp":1770918916658,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH"},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01 GM051923-20"],"award-info":[{"award-number":["R01 GM051923-20"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["F32 GM128322"],"award-info":[{"award-number":["F32 GM128322"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Project ALS"},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorder and Stroke","doi-asserted-by":"crossref","award":["5R01-NS55256"],"award-info":[{"award-number":["5R01-NS55256"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorder and Stroke","doi-asserted-by":"crossref","award":["R56NS096104 (to L.W.)"],"award-info":[{"award-number":["R56NS096104 (to L.W.)"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Agents that raise cyclic guanosine monophosphate (cGMP) by activating protein kinase G increase 26S proteasome activities, protein ubiquitination and degradation of misfolded proteins. Therefore, they may be useful in treating neurodegenerative and other diseases caused by an accumulation of misfolded proteins.<\/jats:p>\n               <jats:p>Mutations in myelin protein zero (MPZ) cause the peripheral neuropathy Charcot-Marie-Tooth type 1B (CMT1B). In peripheral nerves of a mouse model of CMT1B, where the mutant MPZS63del is expressed, proteasome activities are reduced, mutant MPZS63del and polyubiquitinated proteins accumulate and the unfolded protein response (p-eif2\u03b1) is induced. In HEK293 cells, raising cGMP stimulated ubiquitination and degradation of MPZS63del, but not of wild-type MPZ. Treating S63del mice with the phosphodiesterase 5 inhibitor, sildenafil\u2014to raise cGMP\u2014increased proteasome activity in sciatic nerves and reduced the levels of polyubiquitinated proteins, the proteasome reporter ubG76V-GFP and p-elF2\u03b1. Furthermore, sildenafil treatment reduced the number of amyelinated axons, and increased myelin thickness and nerve conduction velocity in sciatic nerves.<\/jats:p>\n               <jats:p>Thus, agents that raise cGMP, including those widely used in medicine, may be useful therapies for CMT1B and other proteotoxic diseases.<\/jats:p>","DOI":"10.1093\/brain\/awab249","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T19:11:59Z","timestamp":1626117119000},"page":"168-178","source":"Crossref","is-referenced-by-count":20,"title":["Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy"],"prefix":"10.1093","volume":"145","author":[{"given":"Jordan J S","family":"VerPlank","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Department of Biochemistry, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Gawron","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Laura","family":"Feltri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Wrabetz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred L","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"52","key":"2022051921333149400_awab249-B1","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.1073\/pnas.1521919112","article-title":"mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy","volume":"112","author":"Zhao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022051921333149400_awab249-B2","doi-asserted-by":"crossref","first-page":"1179069518794675","DOI":"10.1177\/1179069518794675","article-title":"Could a common mechanism of protein degradation impairment underlie many neurodegenerative diseases?","volume":"12","author":"Smith","year":"2018","journal-title":"J Exp Neurosci"},{"key":"2022051921333149400_awab249-B3","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3389\/fphys.2019.00835","article-title":"Enzymatic logic of ubiquitin chain assembly","volume":"10","author":"Deol","year":"2019","journal-title":"Front Physiol"},{"issue":"19","key":"2022051921333149400_awab249-B4","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1042\/BCJ20160809","article-title":"Regulating protein breakdown through proteasome phosphorylation","volume":"474","author":"VerPlank","year":"2017","journal-title":"Biochem J"},{"issue":"4","key":"2022051921333149400_awab249-B5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s13238-017-0382-x","article-title":"Reversible phosphorylation of the 26S proteasome","volume":"8","author":"Guo","year":"2017","journal-title":"Protein Cell"},{"issue":"2","key":"2022051921333149400_awab249-B6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncb3289","article-title":"Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis","volume":"18","author":"Guo","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"25","key":"2022051921333149400_awab249-B7","doi-asserted-by":"crossref","first-page":"14220","DOI":"10.1073\/pnas.2003277117","article-title":"cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases","volume":"117","author":"VerPlank","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2022051921333149400_awab249-B8","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1073\/pnas.1809254116","article-title":"26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation","volume":"116","author":"VerPlank","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"52","key":"2022051921333149400_awab249-B9","doi-asserted-by":"crossref","first-page":"E7176","DOI":"10.1073\/pnas.1522332112","article-title":"cAMP-induced phosphorylation of 26S proteasomes on Rpn6\/PSMD11 enhances their activity and the degradation of misfolded proteins","volume":"112","author":"Lokireddy","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2022051921333149400_awab249-B10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nm.4011","article-title":"Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling","volume":"22","author":"Myeku","year":"2016","journal-title":"Nat Med"},{"issue":"10","key":"2022051921333149400_awab249-B11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41573-019-0033-4","article-title":"Therapeutic targeting of 3\u2032,5\u2032-cyclic nucleotide phosphodiesterases: Inhibition and beyond","volume":"18","author":"Baillie","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"2022051921333149400_awab249-B12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol Rev"},{"key":"2022051921333149400_awab249-B13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/164_2018_197","article-title":"Soluble guanylate cyclase stimulators and activators","volume":"264","author":"Sandner","year":"2021","journal-title":"Handb Exp Pharmacol"},{"issue":"2","key":"2022051921333149400_awab249-B14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/glia.23251","article-title":"Impairment of protein degradation and proteasome function in hereditary neuropathies","volume":"66","author":"VerPlank","year":"2018","journal-title":"Glia"},{"issue":"4","key":"2022051921333149400_awab249-B15","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2017.12.030","article-title":"In situ structure of neuronal C9orf72 Poly-GA aggregates reveals proteasome recruitment","volume":"172","author":"Guo","year":"2018","journal-title":"Cell"},{"issue":"2","key":"2022051921333149400_awab249-B16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molcel.2007.04.001","article-title":"Disease-associated prion protein oligomers inhibit the 26S proteasome","volume":"26","author":"Kristiansen","year":"2007","journal-title":"Mol Cell"},{"issue":"15","key":"2022051921333149400_awab249-B17","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1038\/emboj.2011.224","article-title":"Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry","volume":"30","author":"Deriziotis","year":"2011","journal-title":"EMBO J"},{"issue":"4","key":"2022051921333149400_awab249-B18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awx005","article-title":"A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction","volume":"140","author":"Lopez","year":"2017","journal-title":"Brain"},{"issue":"8","key":"2022051921333149400_awab249-B19","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1523\/JNEUROSCI.3819-05.2006","article-title":"Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice","volume":"26","author":"Wrabetz","year":"2006","journal-title":"J Neurosci"},{"issue":"4","key":"2022051921333149400_awab249-B20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbadis.2014.07.031","article-title":"Hereditary motor and sensory neuropathies: Understanding molecular pathogenesis could lead to future treatment strategies","volume":"1852","author":"Jerath","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"2022051921333149400_awab249-B21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.neuron.2007.12.021","article-title":"Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice","volume":"57","author":"Pennuto","year":"2008","journal-title":"Neuron"},{"issue":"4","key":"2022051921333149400_awab249-B22","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1084\/jem.20122005","article-title":"Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice","volume":"210","author":"D'Antonio","year":"2013","journal-title":"J Exp Med"},{"issue":"8","key":"2022051921333149400_awab249-B23","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nbt851","article-title":"A transgenic mouse model of the ubiquitin\/proteasome system","volume":"21","author":"Lindsten","year":"2003","journal-title":"Nat Biotechnol"},{"issue":"44","key":"2022051921333149400_awab249-B24","doi-asserted-by":"crossref","first-page":"11350","DOI":"10.1523\/JNEUROSCI.1637-16.2016","article-title":"Ablation of perk in Schwann cells improves myelination in the S63del Charcot-Marie-Tooth 1B Mouse","volume":"36","author":"Sidoli","year":"2016","journal-title":"J Neurosci"},{"key":"2022051921333149400_awab249-B25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4939-8706-1_18","article-title":"Methods to rapidly prepare mammalian 26S proteasomes for biochemical analysis","volume":"1844","author":"Kuo","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"4","key":"2022051921333149400_awab249-B26","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cell.2017.04.020","article-title":"Molecular mechanism of substrate processing by the Cdc48 ATPase complex","volume":"169","author":"Bodnar","year":"2017","journal-title":"Cell"},{"issue":"4","key":"2022051921333149400_awab249-B27","doi-asserted-by":"crossref","first-page":"e1008069","DOI":"10.1371\/journal.pgen.1008069","article-title":"Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice","volume":"15","author":"Volpi","year":"2019","journal-title":"PLoS Genet"},{"key":"2022051921333149400_awab249-B28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fmolb.2019.00030","article-title":"Dynamic regulation of proteasome expression","volume":"6","author":"Motosugi","year":"2019","journal-title":"Front Mol Biosci"},{"key":"2022051921333149400_awab249-B29","doi-asserted-by":"crossref","first-page":"113818","DOI":"10.1016\/j.bcp.2020.113818","article-title":"Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer\u2019s disease","volume":"176","author":"Zuccarello","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"2022051921333149400_awab249-B30","doi-asserted-by":"publisher","DOI":"10.1101\/493494","article-title":"Macrophages enforce the blood nerve barrier","author":"Malong","journal-title":"bioRxiv"},{"issue":"5","key":"2022051921333149400_awab249-B31","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/75406","article-title":"Short-lived green fluorescent proteins for quantifying ubiquitin\/proteasome-dependent proteolysis in living cells","volume":"18","author":"Dantuma","year":"2000","journal-title":"Nat Biotechnol"},{"issue":"14","key":"2022051921333149400_awab249-B32","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cub.2014.06.004","article-title":"Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97","volume":"24","author":"Sha","year":"2014","journal-title":"Curr Biol"},{"issue":"1","key":"2022051921333149400_awab249-B33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molcel.2010.02.029","article-title":"Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells","volume":"38","author":"Radhakrishnan","year":"2010","journal-title":"Mol Cell"},{"issue":"Pt 11","key":"2022051921333149400_awab249-B34","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1093\/brain\/awv241","article-title":"Genotype\u2013phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the MPZ gene","volume":"138","author":"Sanmaneechai","year":"2015","journal-title":"Brain"},{"issue":"2","key":"2022051921333149400_awab249-B35","doi-asserted-by":"crossref","DOI":"10.1177\/1759091416642351","article-title":"Perk ablation ameliorates myelination in S63del-Charcot-Marie-Tooth 1B neuropathy","volume":"8","author":"Musner","year":"2016","journal-title":"ASN Neuro"},{"issue":"6489","key":"2022051921333149400_awab249-B36","doi-asserted-by":"crossref","first-page":"eaat5314","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: From mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"issue":"6231","key":"2022051921333149400_awab249-B37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.aaa4484","article-title":"Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit","volume":"348","author":"Das","year":"2015","journal-title":"Science"},{"issue":"4","key":"2022051921333149400_awab249-B38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCULATIONAHA.113.001971","article-title":"Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins","volume":"128","author":"Ranek","year":"2013","journal-title":"Circulation"},{"issue":"8","key":"2022051921333149400_awab249-B39","doi-asserted-by":"crossref","first-page":"e102811","DOI":"10.15252\/embj.2019102811","article-title":"Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS\/FTD","volume":"39","author":"Khosravi","year":"2020","journal-title":"EMBO J"},{"issue":"1","key":"2022051921333149400_awab249-B40","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41467-018-03509-0","article-title":"A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers","volume":"9","author":"Thibaudeau","year":"2018","journal-title":"Nat Commun"},{"issue":"6220","key":"2022051921333149400_awab249-B41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1126\/science.1261197","article-title":"Proteasomes. A molecular census of 26S proteasomes in intact neurons","volume":"347","author":"Asano","year":"2015","journal-title":"Science"},{"issue":"52","key":"2022051921333149400_awab249-B42","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.1716305114","article-title":"Proteasomes tether to two distinct sites at the nuclear pore complex","volume":"114","author":"Albert","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2022051921333149400_awab249-B43","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1073\/pnas.1905641117","article-title":"Direct visualization of degradation microcompartments at the ER membrane","volume":"117","author":"Albert","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2022051921333149400_awab249-B44","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1073\/pnas.1915534117","article-title":"Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation","volume":"117","author":"Collins","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7615","key":"2022051921333149400_awab249-B45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature18943","article-title":"An evolutionarily conserved pathway controls proteasome homeostasis","volume":"536","author":"Rousseau","year":"2016","journal-title":"Nature"},{"issue":"11","key":"2022051921333149400_awab249-B46","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41580-018-0040-z","article-title":"Regulation of proteasome assembly and activity in health and disease","volume":"19","author":"Rousseau","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"2022051921333149400_awab249-B47","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2005.08.017","article-title":"Neuregulin-1 type III determines the ensheathment fate of axons","volume":"47","author":"Taveggia","year":"2005","journal-title":"Neuron"},{"issue":"1","key":"2022051921333149400_awab249-B48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: Molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2022051921333149400_awab249-B49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nbd.2005.10.010","article-title":"Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression","volume":"22","author":"Fortun","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"6","key":"2022051921333149400_awab249-B50","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1471-4159.2004.02987.x","article-title":"Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model","volume":"92","author":"Fortun","year":"2005","journal-title":"J Neurochem"},{"issue":"12","key":"2022051921333149400_awab249-B51","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1113\/JP273607","article-title":"Proteasome dysfunction in cardiomyopathies","volume":"595","author":"Gilda","year":"2017","journal-title":"J Physiol"},{"issue":"7","key":"2022051921333149400_awab249-B52","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.molmed.2020.02.007","article-title":"Priming the proteasome to protect against proteotoxicity","volume":"26","author":"Wang","year":"2020","journal-title":"Trends Mol Med"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awab249\/42225724\/awab249.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/1\/168\/43771997\/awab249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/1\/168\/43771997\/awab249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T21:35:12Z","timestamp":1652996112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/1\/168\/6348166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,8,11]]},"published-print":{"date-parts":[[2022,3,29]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awab249","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,8,11]]}}}