{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:19:28Z","timestamp":1793366368921,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"INSERM, University Grenoble Alpes, France Alzheimer and the French National Research Agency","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The sequence of cellular dysfunctions in preclinical Alzheimer\u2019s disease must be understood if we are to plot new therapeutic routes. Hippocampal neuronal hyperactivity is one of the earliest events occurring during the preclinical stages of Alzheimer\u2019s disease in both humans and mouse models. The most common hypothesis describes amyloid-\u03b2 accumulation as the triggering factor of the disease but the effects of this accumulation and the cascade of events leading to cognitive decline remain unclear. In mice, we previously showed that amyloid-\u03b2-dependent TRPA1 channel activation triggers hippocampal astrocyte hyperactivity, subsequently inducing hyperactivity in nearby neurons. In this work, we investigated the potential protection against Alzheimer's disease progression provided by early chronic pharmacological inhibition of the TRPA1 channel.<\/jats:p>\n                  <jats:p>A specific inhibitor of TRPA1 channel (HC030031) was administered intraperitoneally from the onset of amyloid-\u03b2 overproduction in the APP\/PS1-21 mouse model of Alzheimer\u2019s disease. Short-, medium- and long-term effects of this chronic pharmacological TRPA1 blockade were characterized on Alzheimer\u2019s disease progression at functional (astrocytic and neuronal activity), structural, biochemical and behavioural levels.<\/jats:p>\n                  <jats:p>Our results revealed that the first observable disruptions in the Alzheimer\u2019s disease transgenic mouse model used correspond to aberrant hippocampal astrocyte and neuron hyperactivity. We showed that chronic TRPA1 blockade normalizes astrocytic activity, avoids perisynaptic astrocytic process withdrawal, prevents neuronal dysfunction and preserves structural synaptic integrity. These protective effects preserved spatial working memory in this Alzheimer\u2019s disease mouse model.<\/jats:p>\n                  <jats:p>The toxic effect of amyloid-\u03b2 on astrocytes triggered by TRPA1 channel activation is pivotal to Alzheimer\u2019s disease progression. TRPA1 blockade prevents irreversible neuronal dysfunction, making this channel a potential therapeutic target to promote neuroprotection.<\/jats:p>","DOI":"10.1093\/brain\/awab281","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T15:10:59Z","timestamp":1626966659000},"page":"388-405","source":"Crossref","is-referenced-by-count":112,"title":["Astrocyte\u2013neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade"],"prefix":"10.1093","volume":"145","author":[{"given":"Adrien","family":"Paumier","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Boisseau","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Jacquier-Sarlin","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Pernet-Gallay","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Buisson","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-2563","authenticated-orcid":false,"given":"Mireille","family":"Albrieux","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"issue":"5580","key":"2022040311313156600_awab281-B1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"7","key":"2022040311313156600_awab281-B2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: From synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat Neurosci"},{"issue":"22","key":"2022040311313156600_awab281-B3","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6453","key":"2022040311313156600_awab281-B4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"A vicious cycle of \u03b2 amyloid-dependent neuronal hyperactivation","volume":"365","author":"Zott","year":"2019","journal-title":"Science"},{"issue":"3","key":"2022040311313156600_awab281-B5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s13311-017-0541-z","article-title":"Targeting neural hyperactivity as a treatment to stem progression of late-onset Alzheimer\u2019s disease","volume":"14","author":"Haberman","year":"2017","journal-title":"Neurotherapeutics"},{"issue":"6","key":"2022040311313156600_awab281-B6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/bies.201500004","article-title":"Neuronal hyperactivity - A key defect in Alzheimer\u2019s disease?","volume":"37","author":"Busche","year":"2015","journal-title":"BioEssays"},{"issue":"4","key":"2022040311313156600_awab281-B7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41593-018-0080-x","article-title":"Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer\u2019s disease","volume":"21","author":"Styr","year":"2018","journal-title":"Nat Neurosci"},{"issue":"3","key":"2022040311313156600_awab281-B8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/35058528","article-title":"GLIA: Listening and talking to the synapse","volume":"2","author":"Haydon","year":"2001","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2022040311313156600_awab281-B9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040996","article-title":"Aberrant calcium signals in reactive astrocytes: A key process in neurological disorders","volume":"20","author":"Shigetomi","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"5918","key":"2022040311313156600_awab281-B10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"2022040311313156600_awab281-B11","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/ncomms6422","article-title":"Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer\u2019s disease mouse model","volume":"5","author":"Delekate","year":"2014","journal-title":"Nat Commun"},{"issue":"1","key":"2022040311313156600_awab281-B12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13024-017-0194-8","article-title":"TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-\u03b2 peptide","volume":"12","author":"Bosson","year":"2017","journal-title":"Mol Neurodegener"},{"issue":"5","key":"2022040311313156600_awab281-B13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00424-012-1158-z","article-title":"The transient receptor potential channel TRPA1: From gene to pathophysiology","volume":"464","author":"Nilius","year":"2012","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"issue":"1","key":"2022040311313156600_awab281-B14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nn.3000","article-title":"TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3","volume":"15","author":"Shigetomi","year":"2011","journal-title":"Nat Neurosci"},{"issue":"24","key":"2022040311313156600_awab281-B15","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1523\/JNEUROSCI.5779-12.2013","article-title":"TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release","volume":"33","author":"Shigetomi","year":"2013","journal-title":"J Neurosci"},{"issue":"12","key":"2022040311313156600_awab281-B16","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1002\/glia.23042","article-title":"Ca(2+) transients in astrocyte fine processes occur via Ca(2+) influx in the adult mouse hippocampus","volume":"64","author":"Rungta","year":"2016","journal-title":"Glia"},{"issue":"7","key":"2022040311313156600_awab281-B17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/ejn.13188","article-title":"Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes","volume":"43","author":"Nakayama","year":"2016","journal-title":"Eur J Neurosci"},{"issue":"33","key":"2022040311313156600_awab281-B18","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022040311313156600_awab281-B19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8069-4-48","article-title":"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity","volume":"4","author":"Eid","year":"2008","journal-title":"Mol Pain"},{"issue":"5","key":"2022040311313156600_awab281-B20","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/aww038","article-title":"TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes\/macrophages and oxidative stress","volume":"139","author":"Trevisan","year":"2016","journal-title":"Brain"},{"issue":"4","key":"2022040311313156600_awab281-B21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: Few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res Ther"},{"issue":"9","key":"2022040311313156600_awab281-B22","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep"},{"key":"2022040311313156600_awab281-B23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2010.05.061","article-title":"Mapping of fluorescent protein-expressing neurons and axon pathways in adult and developing Thy1-eYFP-H transgenic mice","volume":"1345","author":"Porrero","year":"2010","journal-title":"Brain Res"},{"issue":"10","key":"2022040311313156600_awab281-B24","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/nn.2929","article-title":"Local Ca2+ detection and modulation of synaptic release by astrocytes","volume":"14","author":"Di Castro","year":"2011","journal-title":"Nat Neurosci"},{"issue":"1","key":"2022040311313156600_awab281-B25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1152\/jn.00268.2001","article-title":"Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity","volume":"87","author":"Nett","year":"2002","journal-title":"J Neurophysiol"},{"issue":"2","key":"2022040311313156600_awab281-B26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuron.2014.02.041","article-title":"Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway","volume":"82","author":"Haustein","year":"2014","journal-title":"Neuron"},{"issue":"4","key":"2022040311313156600_awab281-B27","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1460-9568.2007.05367.x","article-title":"Synchrony of spontaneous calcium activity in mouse neocortex before synaptogenesis","volume":"25","author":"Platel","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"21","key":"2022040311313156600_awab281-B28","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1523\/JNEUROSCI.5783-10.2011","article-title":"Sustained neuronal activity generated by glial plasticity","volume":"31","author":"Pirttimaki","year":"2011","journal-title":"J Neurosci"},{"issue":"4","key":"2022040311313156600_awab281-B29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2006.02.051","article-title":"Glia-derived D-serine controls NMDA receptor activity and synaptic memory","volume":"125","author":"Panatier","year":"2006","journal-title":"Cell"},{"issue":"20","key":"2022040311313156600_awab281-B30","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1523\/JNEUROSCI.5255-05.2006","article-title":"GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression","volume":"26","author":"Serrano","year":"2006","journal-title":"J Neurosci"},{"issue":"5","key":"2022040311313156600_awab281-B31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2011.07.022","article-title":"Astrocytes are endogenous regulators of basal transmission at central synapses","volume":"146","author":"Panatier","year":"2011","journal-title":"Cell"},{"issue":"4","key":"2022040311313156600_awab281-B32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/glia.22777","article-title":"Disruption of dopaminergic transmission remodels tripartite synapse morphology and astrocytic calcium activity within substantia nigra pars reticulata","volume":"63","author":"Bosson","year":"2015","journal-title":"Glia"},{"issue":"7278","key":"2022040311313156600_awab281-B33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature08673","article-title":"Long-term potentiation depends on release of D-serine from astrocytes","volume":"463","author":"Henneberger","year":"2010","journal-title":"Nature"},{"issue":"4","key":"2022040311313156600_awab281-B34","doi-asserted-by":"crossref","first-page":"e1997","DOI":"10.1371\/journal.pone.0001997","article-title":"Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images","volume":"3","author":"Rodriguez","year":"2008","journal-title":"PLoS ONE"},{"issue":"16","key":"2022040311313156600_awab281-B35","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1523\/JNEUROSCI.19-16-06897.1999","article-title":"Three-dimensional relationships between hippocampal synapses and astrocytes","volume":"19","author":"Ventura","year":"1999","journal-title":"J Neurosci"},{"issue":"1","key":"2022040311313156600_awab281-B36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1326-2-18","article-title":"Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers","volume":"2","author":"Kayed","year":"2007","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2022040311313156600_awab281-B37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(00)03176-0","article-title":"Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology","volume":"894","author":"Apelt","year":"2001","journal-title":"Brain Res"},{"issue":"1","key":"2022040311313156600_awab281-B38","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/ncomms7176","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar A\u03b242 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"2022040311313156600_awab281-B39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-0270(98)00169-1","article-title":"Adaptation of the circular platform spatial memory task for mice: Use in detecting cognitive impairment in the APP(sw) transgenic mouse model for Alzheimer\u2019s disease","volume":"87","author":"Pompl","year":"1999","journal-title":"J Neurosci Methods"},{"issue":"1","key":"2022040311313156600_awab281-B40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00210-018-1589-y","article-title":"Assessment of spatial learning and memory in the Barnes maze task in rodents\u2014methodological consideration","volume":"392","author":"Gawel","year":"2019","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"2022040311313156600_awab281-B41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12974-016-0557-z","article-title":"Role of transient receptor potential ankyrin 1 channels in Alzheimer\u2019s disease","volume":"13","author":"Lee","year":"2016","journal-title":"J Neuroinflamm"},{"issue":"11","key":"2022040311313156600_awab281-B42","doi-asserted-by":"crossref","first-page":"e81828","DOI":"10.1371\/journal.pone.0081828","article-title":"\u03b17 Nicotinic receptor-mediated astrocytic gliotransmitter release: A\u03b2 effects in a preclinical Alzheimer\u2019s mouse model","volume":"8","author":"Pirttimaki","year":"2013","journal-title":"PLoS ONE"},{"issue":"26","key":"2022040311313156600_awab281-B43","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1523\/JNEUROSCI.1717-08.2008","article-title":"Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons","volume":"28","author":"Shigetomi","year":"2008","journal-title":"J Neurosci"},{"issue":"1","key":"2022040311313156600_awab281-B44","doi-asserted-by":"crossref","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"2022040311313156600_awab281-B45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.20171487","article-title":"P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer\u2019s disease model","volume":"215","author":"Reichenbach","year":"2018","journal-title":"J Exp Med"},{"issue":"11","key":"2022040311313156600_awab281-B46","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.celrep.2015.05.021","article-title":"Quaternary structure defines a large class of amyloid-\u03b2 oligomers neutralized by sequestration","volume":"11","author":"Liu","year":"2015","journal-title":"Cell Rep"},{"key":"2022040311313156600_awab281-B47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fgene.2014.00088","article-title":"Using mice to model Alzheimer\u2019s dementia: An overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Front Genet"},{"issue":"3","key":"2022040311313156600_awab281-B48","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.neuroimage.2010.03.040","article-title":"High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment","volume":"51","author":"Yassa","year":"2010","journal-title":"Neuroimage"},{"issue":"6","key":"2022040311313156600_awab281-B49","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/jnnp.2007.124149","article-title":"Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline","volume":"79","author":"Miller","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2022040311313156600_awab281-B50","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer\u2019s disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"issue":"1","key":"2022040311313156600_awab281-B51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuron.2017.11.028","article-title":"Alzheimer\u2019s disease: From firing instability to homeostasis network collapse","volume":"97","author":"Frere","year":"2018","journal-title":"Neuron"},{"issue":"6453","key":"2022040311313156600_awab281-B52","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.aay5188","article-title":"Early network dysfunction in Alzheimer\u2019s disease","volume":"365","author":"Selkoe","year":"2019","journal-title":"Science"},{"issue":"8","key":"2022040311313156600_awab281-B53","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/90507","article-title":"Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation","volume":"4","author":"Parri","year":"2001","journal-title":"Nat Neurosci"},{"issue":"27","key":"2022040311313156600_awab281-B54","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2022040311313156600_awab281-B55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-2012-120394","article-title":"Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-beta peptide in the mouse hippocampus: Implication of extrasynaptic NMDA receptors","volume":"32","author":"Kervern","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"2022040311313156600_awab281-B56","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fnmol.2017.00451","article-title":"Astroglial glutamate signaling and uptake in the hippocampus","volume":"10","author":"Rose","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"2022040311313156600_awab281-B57","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"2022040311313156600_awab281-B58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuropharm.2018.11.003","article-title":"Neuroprotective action of diazepam at very low and moderate doses in Alzheimer\u2019s disease model rats","volume":"144","author":"Pilipenko","year":"2019","journal-title":"Neuropharmacology"},{"key":"2022040311313156600_awab281-B59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnmol.2018.00235","article-title":"Beneficial effect of a selective adenosine A2A receptor antagonist in the APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease","volume":"11","author":"Faivre","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"2022040311313156600_awab281-B60","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/ph11040117","article-title":"TRPA1 antagonists for pain relief","volume":"11","author":"Koivisto","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"10","key":"2022040311313156600_awab281-B61","first-page":"99","article-title":"Non-analgesic symptomatic or disease\u2014modifying potential of TRPA1","volume":"7","author":"Heber","year":"2019","journal-title":"Med Sci"},{"issue":"1","key":"2022040311313156600_awab281-B62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-neuro-070815-014015","article-title":"Alzheimer\u2019s disease mechanisms and emerging roads to novel therapeutics","volume":"39","author":"Sala Frigerio","year":"2016","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"2022040311313156600_awab281-B63","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mcna.2018.10.009","article-title":"The Alzheimer\u2019s disease clinical spectrum","volume":"103","author":"Atri","year":"2019","journal-title":"Med Clin North Am"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awab281\/42267864\/awab281.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/1\/388\/43246696\/awab281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/1\/388\/43246696\/awab281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:32:54Z","timestamp":1648971174000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/1\/388\/6327685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,24]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,7,24]]},"published-print":{"date-parts":[[2022,3,29]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awab281","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.03.29.437466","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,7,24]]}}}