{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:58:22Z","timestamp":1790312302033,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. 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Glial cytoplasmic inclusions are the pathological hallmark of multiple system atrophy and are associated with neuroinflammation, modest demyelination and, ultimately, neurodegeneration.<\/jats:p>\n               <jats:p>To evaluate the possible pathogenic role of glial cytoplasmic inclusions, we inoculated glial cytoplasmic inclusion-containing brain fractions obtained from multiple system atrophy patients into the striatum of non-human primates. After a 2-year in vivo phase, extensive histochemical and biochemical analyses were performed on the whole brain.<\/jats:p>\n               <jats:p>We found loss of both nigral dopamine neurons and striatal medium spiny neurons, as well as loss of oligodendrocytes in the same regions, which are characteristics of multiple system atrophy. Furthermore, demyelination, neuroinflammation and \u03b1-synuclein pathology were also observed. These results show that the \u03b1-synuclein species in multiple system atrophy-derived glial cytoplasmic inclusions can induce a pathological process in non-human primates, including nigrostriatal and striatofugal neurodegeneration, oligodendroglial cell loss, synucleinopathy and gliosis.<\/jats:p>\n               <jats:p>The present data pave the way for using this experimental model for MSA research and therapeutic development.<\/jats:p>","DOI":"10.1093\/brain\/awab374","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T11:50:16Z","timestamp":1633521016000},"page":"1001-1017","source":"Crossref","is-referenced-by-count":28,"title":["Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-5449","authenticated-orcid":false,"given":"Margaux","family":"Teil","sequence":"first","affiliation":[{"name":"Universit\u00e9 de 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