{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:56:05Z","timestamp":1792166165936,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union Horizon 2020 Framework Program","award":["935539"],"award-info":[{"award-number":["935539"]}]},{"name":"MIUR-SIR 2014","award":["RBSI146V1D"],"award-info":[{"award-number":["RBSI146V1D"]}]},{"name":"San Paolo Foundation 2016","award":["CSTO165140"],"award-info":[{"award-number":["CSTO165140"]}]},{"DOI":"10.13039\/501100005032","name":"BIAL Foundation","doi-asserted-by":"publisher","award":["311\/2020"],"award-info":[{"award-number":["311\/2020"]}],"id":[{"id":"10.13039\/501100005032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although clinical neuroscience and the neuroscience of consciousness have long sought mechanistic explanations of tactile-awareness disorders, mechanistic insights are rare, mainly because of the difficulty of depicting the fine-grained neural dynamics underlying somatosensory processes.<\/jats:p>\n               <jats:p>Here, we combined the stereo-EEG responses to somatosensory stimulation with the lesion mapping of patients with a tactile-awareness disorder, namely tactile extinction.<\/jats:p>\n               <jats:p>Whereas stereo-EEG responses present different temporal patterns, including early\/phasic and long-lasting\/tonic activities, tactile-extinction lesion mapping co-localizes only with the latter. Overlaps are limited to the posterior part of the perisylvian regions, suggesting that tonic activities may play a role in sustaining tactile awareness. To assess this hypothesis further, we correlated the prevalence of tonic responses with the tactile-extinction lesion mapping, showing that they follow the same topographical gradient. Finally, in parallel with the notion that visuotactile stimulation improves detection in tactile-extinction patients, we demonstrated an enhancement of tonic responses to visuotactile stimuli, with a strong voxel-wise correlation with the lesion mapping.<\/jats:p>\n               <jats:p>The combination of these results establishes tonic responses in the parietal operculum as the ideal neural correlate of tactile awareness.<\/jats:p>","DOI":"10.1093\/brain\/awab384","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T13:18:45Z","timestamp":1633699125000},"page":"3779-3787","source":"Crossref","is-referenced-by-count":24,"title":["Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum"],"prefix":"10.1093","volume":"144","author":[{"given":"Maria","family":"Del Vecchio","sequence":"first","affiliation":[{"name":"Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Fossataro","sequence":"additional","affiliation":[{"name":"MANIBUS Laboratory, Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-6068","authenticated-orcid":false,"given":"Flavia Maria","family":"Zauli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Cliniche \u2018L. 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