{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:53Z","timestamp":1790709533750,"version":"4.1.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AG2R-La-Mondiale"},{"name":"UCB"},{"name":"Genetically Encoded Neuronal Indicator and Effector"},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sepsis is a life-threatening condition induced by a deregulated host response to severe infection. Post-sepsis syndrome includes long-term psychiatric disorders, such as persistent anxiety and post-traumatic stress disorder, whose neurobiological mechanisms remain unknown.<\/jats:p>\n                  <jats:p>Using a reference mouse model of sepsis, we showed that mice that recovered from sepsis further developed anxiety-related behaviours associated with an exaggerated fear memory. In the brain, sepsis induced an acute pathological activation of a specific neuronal population of the central nucleus of the amygdala, which projects to the ventral bed nucleus of the stria terminalis. Using viral-genetic circuit tracing and in vivo calcium imaging, we observed that sepsis induced persistent changes in the connectivity matrix and in the responsiveness of these central amygdala neurons projecting to the ventral bed nucleus of the stria terminalis. The transient and targeted silencing of this subpopulation only during the acute phase of sepsis with a viral pharmacogenetic approach, or with the anti-epileptic and neuroprotective drug levetiracetam, prevented the subsequent development of anxiety-related behaviours.<\/jats:p>\n                  <jats:p>Specific inhibition of brain anxiety and fear circuits during the sepsis acute phase constitutes a preventive approach to preclude the post-infection psychiatric outcomes.<\/jats:p>","DOI":"10.1093\/brain\/awab475","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T15:14:05Z","timestamp":1640099645000},"page":"1391-1409","source":"Crossref","is-referenced-by-count":37,"title":["Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours"],"prefix":"10.1093","volume":"145","author":[{"given":"Lena","family":"Bourhy","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Laboratory for Experimental Neuropathology, F-75015 Paris, France"},{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Coll\u00e8ge doctoral, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mazeraud","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Laboratory for Experimental Neuropathology, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Coll\u00e8ge doctoral, F-75005 Paris, France"},{"name":"GHU Paris Psychiatrie Neurosciences, Service hospitalo-universitaire de Neuro-anesth\u00e9sie r\u00e9animation, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H. A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Laboratory for Experimental Neuropathology, F-75015 Paris, France"},{"name":"Department of Basic and Oral Biology, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod","family":"Levy","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Rei","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Est\u00e9ban","family":"Hecquet","sequence":"additional","affiliation":[{"name":"Institut 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Universit\u00e9 Paris Cit\u00e9, Laboratory for Experimental Neuropathology, F-75015 Paris, France"},{"name":"GHU Paris Psychiatrie Neurosciences, Service hospitalo-universitaire de Neuropathologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Lledo","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Sharshar","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie Neurosciences, Service hospitalo-universitaire de Neuro-anesth\u00e9sie r\u00e9animation, Paris, France"},{"name":"Institut de Psychiatrie et Neurosciences de Paris (IPNP), INSERM UMR 1266, F-75014 Paris, 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