{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:04:52Z","timestamp":1792854292953,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2019R1A2B5B03100844"],"award-info":[{"award-number":["2019R1A2B5B03100844"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Maladaptive habitual behaviours of obsessive-compulsive disorder are characterized by cognitive inflexibility, which hypothetically arises from dysfunctions of a certain cortico-basal ganglia-thalamo-cortical circuit including the ventrolateral prefrontal region. Inside this neurocircuit, an imbalance between distinct striatal projections to basal ganglia output nuclei, either directly or indirectly via the external globus pallidus, is suggested to be relevant for impaired arbitration between facilitation and inhibition of cortically initiated activity. However, current evidence of individually altered cortico-striatal or thalamo-cortical connectivities is insufficient to understand how cortical dysconnections are linked to the imbalanced basal ganglia system in patients.<\/jats:p>\n               <jats:p>In this study, we aimed to identify aberrant ventrolateral prefronto-basal ganglia-thalamic subnetworks representing direct-indirect imbalance and its association with cognitive inflexibility in patients.<\/jats:p>\n               <jats:p>To increase network detection sensitivity, we constructed a cortico-basal ganglia-thalamo-cortical network model incorporating striatal, pallidal and thalamic subregions defined by unsupervised clustering in 105 medication-free patients with obsessive-compulsive disorder (age\u2009=\u200925.05\u2009\u00b1\u20096.55 years, male\/female\u2009=\u200970\/35) and 99 healthy controls (age\u2009=\u200923.93\u2009\u00b1\u20095.80 years, male\/female\u2009=\u200964\/35). By using the network-based statistic method, we analysed group differences in subnetworks formed by suprathreshold dysconnectivities. Using linear regression models, we tested subnetwork dysconnectivity effects on symptom severity and set-shifting performance assessed by well-validated clinical and cognitive tests.<\/jats:p>\n               <jats:p>Compared with the healthy controls, patients were slower to track the Part B sequence of the Trail Making Test when the effects of psychomotor and visuospatial functions were adjusted (t\u2009=\u20093.89, P\u2009&amp;lt;\u20090.001) and made more extradimensional shift errors (t\u2009=\u20094.09, P\u2009&amp;lt;\u20090.001). In addition to reduced fronto-striatal and striato-external pallidal connectivities and hypoconnected striato-thalamic subnetwork [P\u2009=\u20090.001, family-wise error rate (FWER) corrected], patients had hyperconnected fronto-external pallidal (P\u2009=\u20090.012, FWER corrected) and intra-thalamic (P\u2009=\u20090.015, FWER corrected) subnetworks compared with the healthy controls. Among the patients, the fronto-pallidal subnetwork alteration, especially ventrolateral prefronto-external globus pallidal hyperconnectivity, was associated with relatively fewer extradimensional shifting errors (\u03b2\u2009=\u2009\u22120.30, P\u2009=\u20090.001).<\/jats:p>\n               <jats:p>Our findings suggest that the hyperconnected fronto-external pallidal subnetwork may have an opposite effect to the imbalance caused by the reduced indirect pathway (fronto-striato-external pallidal) connectivities in patients. This ventrolateral prefrontal hyperconnectivity may help the external globus pallidus disinhibit basal ganglia output nuclei, which results in behavioural inhibition, so as to compensate for the impaired set shifting. We suggest the ventrolateral prefrontal and external globus pallidus as neuromodulatory targets for inflexible habitual behaviours in obsessive-compulsive disorder.<\/jats:p>","DOI":"10.1093\/brain\/awab483","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T20:31:01Z","timestamp":1640637061000},"page":"979-990","source":"Crossref","is-referenced-by-count":19,"title":["Unbalanced fronto-pallidal neurocircuit underlying set shifting in obsessive-compulsive disorder"],"prefix":"10.1093","volume":"145","author":[{"given":"Taekwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea"},{"name":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea"},{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wi Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Psychology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Bin","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Kyungjin Lho","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhee","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-1462","authenticated-orcid":false,"given":"Jun Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea"},{"name":"Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"issue":"S35","key":"2022042902170347200_awab483-B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1192\/S0007125000297900","article-title":"Cognitive-behavioural approach to understanding obsessional thinking","volume":"173","author":"Salkovskis","year":"1998","journal-title":"Br J Psychiatry."},{"issue":"3","key":"2022042902170347200_awab483-B2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neubiorev.2004.11.006","article-title":"The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers","volume":"29","author":"Chamberlain","year":"2005","journal-title":"Neurosci Biobehav Rev."},{"key":"2022042902170347200_awab483-B3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroscience.2016.07.030","article-title":"Cognitive inflexibility in obsessive-compulsive disorder","volume":"345","author":"Gruner","year":"2017","journal-title":"Neuroscience."},{"issue":"2","key":"2022042902170347200_awab483-B4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1176\/ajp.2007.164.2.335","article-title":"Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder","volume":"164","author":"Chamberlain","year":"2007","journal-title":"Am J Psychiatry."},{"issue":"6","key":"2022042902170347200_awab483-B5","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1017\/S0033291713001803","article-title":"Cognitive functioning in obsessive-compulsive disorder: A meta-analysis","volume":"44","author":"Shin","year":"2014","journal-title":"Psychol Med."},{"key":"2022042902170347200_awab483-B6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/7854_2020_198","volume-title":"The neurobiology and treatment of OCD: Accelerating progress.","author":"Chamberlain","year":"2021"},{"issue":"1655","key":"2022042902170347200_awab483-B7","doi-asserted-by":"crossref","first-page":"20130475","DOI":"10.1098\/rstb.2013.0475","article-title":"Goal-directed learning and obsessive-compulsive disorder","volume":"369","author":"Gillan","year":"2014","journal-title":"Philos Trans R Soc B."},{"issue":"3","key":"2022042902170347200_awab483-B8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/mp.2014.44","article-title":"Disorders of compulsivity: a common bias towards learning habits","volume":"20","author":"Voon","year":"2015","journal-title":"Mol Psychiatry."},{"issue":"5","key":"2022042902170347200_awab483-B9","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.euroneuro.2015.12.005","article-title":"Brain circuitry of compulsivity","volume":"26","author":"van den Heuvel","year":"2016","journal-title":"Eur Neuropsychopharmacol."},{"issue":"3","key":"2022042902170347200_awab483-B10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1176\/appi.ajp.2014.14040525","article-title":"Functional neuroimaging of avoidance habits in obsessive-compulsive disorder","volume":"172","author":"Gillan","year":"2015","journal-title":"Am J Psychiatry."},{"issue":"8","key":"2022042902170347200_awab483-B11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopsych.2016.08.009","article-title":"Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive-compulsive disorder: evidence from resting-state functional connectivity","volume":"81","author":"Vaghi","year":"2017","journal-title":"Biol Psychiatry."},{"issue":"10","key":"2022042902170347200_awab483-B12","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/appi.ajp.2012.12010073","article-title":"Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder","volume":"169","author":"de Wit","year":"2012","journal-title":"Am J Psychiatry."},{"issue":"5887","key":"2022042902170347200_awab483-B13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1154433","article-title":"Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives","volume":"321","author":"Chamberlain","year":"2008","journal-title":"Science."},{"issue":"2","key":"2022042902170347200_awab483-B14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nn.2723","article-title":"From reinforcement learning models to psychiatric and neurological disorders","volume":"14","author":"Maia","year":"2011","journal-title":"Nat Neurosci."},{"issue":"12","key":"2022042902170347200_awab483-B15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrn4038","article-title":"A fronto-striato-subthalamic-pallidal network for goal-directed and habitual inhibition","volume":"16","author":"Jahanshahi","year":"2015","journal-title":"Nat Rev Neurosci."},{"issue":"10","key":"2022042902170347200_awab483-B16","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/S1471-1931(00)00019-7","article-title":"Molecular effects of dopamine on striatal-projection pathways","volume":"23","author":"Gerfen","year":"2000","journal-title":"Trends Neurosci."},{"issue":"6","key":"2022042902170347200_awab483-B17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrn3746","article-title":"Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective","volume":"15","author":"Pauls","year":"2014","journal-title":"Nat Rev Neurosci."},{"key":"2022042902170347200_awab483-B18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fpsyt.2019.00319","article-title":"Altered cortico-striatal functional connectivity during resting state in obsessive-compulsive disorder","volume":"10","author":"Calza","year":"2019","journal-title":"Front Psychiatry."},{"key":"2022042902170347200_awab483-B19","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1038\/s41380-020-01007-8","article-title":"Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder","volume":"26","author":"Shephard","year":"2021","journal-title":"Mol Psychiatry."},{"key":"2022042902170347200_awab483-B20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cortex.2015.11.004","article-title":"Fronto-striatal organization: defining functional and microstructural substrates of behavioural flexibility","volume":"74","author":"Morris","year":"2016","journal-title":"Cortex."},{"issue":"8","key":"2022042902170347200_awab483-B21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41562-017-0146","article-title":"Functional corticostriatal connection topographies predict goal directed behaviour in humans","volume":"1","author":"Marquand","year":"2017","journal-title":"Nat Hum Behav."},{"key":"2022042902170347200_awab483-B22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroimage.2017.02.019","article-title":"Connectivity-based parcellation reveals distinct cortico-striatal connectivity fingerprints in autism spectrum disorder","volume":"170","author":"Balsters","year":"2018","journal-title":"NeuroImage."},{"issue":"1","key":"2022042902170347200_awab483-B23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/hbm.23347","article-title":"Altered functional network architecture in orbitofronto-striato-thalamic circuit of unmedicated patients with obsessive-compulsive disorder","volume":"38","author":"Jung","year":"2017","journal-title":"Hum Brain Mapp."},{"issue":"4","key":"2022042902170347200_awab483-B24","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage."},{"issue":"11","key":"2022042902170347200_awab483-B25","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archgenpsychiatry.2009.152","article-title":"Altered corticostriatal functional connectivity in obsessive-compulsive disorder","volume":"66","author":"Harrison","year":"2009","journal-title":"Arch Gen Psychiatry."},{"issue":"4","key":"2022042902170347200_awab483-B26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biopsych.2012.10.006","article-title":"Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder","volume":"73","author":"Harrison","year":"2013","journal-title":"Biol Psychiatry."},{"issue":"1","key":"2022042902170347200_awab483-B27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1017\/S0033291719002988","article-title":"Limbic cortico-striato-thalamo-cortical functional connectivity in drug-naive patients of obsessive-compulsive disorder","volume":"51","author":"Zhao","year":"2021","journal-title":"Psychol Med."},{"issue":"6","key":"2022042902170347200_awab483-B28","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/hbm.22371","article-title":"Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder","volume":"35","author":"Posner","year":"2014","journal-title":"Hum Brain Mapp."},{"issue":"3","key":"2022042902170347200_awab483-B29","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"NeuroImage."},{"key":"2022042902170347200_awab483-B30","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-IV-TR","author":"American Psychiatric Association","year":"2000"},{"issue":"11","key":"2022042902170347200_awab483-B31","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch Gen Psychiatry."},{"issue":"1","key":"2022042902170347200_awab483-B32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol."},{"issue":"4","key":"2022042902170347200_awab483-B33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br J Soc Clin Psychol."},{"key":"2022042902170347200_awab483-B34","volume-title":"Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition.","author":"First","year":"2002"},{"issue":"1","key":"2022042902170347200_awab483-B35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41398-020-01045-4","article-title":"Defining data-driven subgroups of obsessive-compulsive disorder with different treatment responses based on resting-state functional connectivity","volume":"10","author":"Kwak","year":"2020","journal-title":"Transl Psychiatry."},{"issue":"2","key":"2022042902170347200_awab483-B36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1207\/S15324826AN0902_5","article-title":"The trail making test, part B: cognitive flexibility or ability to maintain set?","volume":"9","author":"Kortte","year":"2002","journal-title":"Appl Neuropsychol."},{"issue":"10","key":"2022042902170347200_awab483-B37","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0028-3932(91)90063-E","article-title":"Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man","volume":"29","author":"Owen","year":"1991","journal-title":"Neuropsychologia."},{"issue":"1","key":"2022042902170347200_awab483-B38","first-page":"39","article-title":"Demographic characteristics and normative observations for derived-trail making test indices","volume":"15","author":"Drane","year":"2002","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol."},{"key":"2022042902170347200_awab483-B39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroimage.2016.12.018","article-title":"Methods for cleaning the BOLD fMRI signal","volume":"154","author":"Caballero-Gaudes","year":"2017","journal-title":"NeuroImage."},{"issue":"4","key":"2022042902170347200_awab483-B40","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G","article-title":"Nonlinear spatial normalization using basis functions","volume":"7","author":"Ashburner","year":"1999","journal-title":"Hum Brain Mapp."},{"key":"2022042902170347200_awab483-B41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2013.05.116","article-title":"The nuisance of nuisance regression: spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity","volume":"82","author":"Hallquist","year":"2013","journal-title":"NeuroImage."},{"issue":"2","key":"2022042902170347200_awab483-B42","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.neuroimage.2011.08.048","article-title":"Anticorrelations in resting state networks without global signal regression","volume":"59","author":"Chai","year":"2012","journal-title":"NeuroImage."},{"key":"2022042902170347200_awab483-B43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0377-0427(87)90125-7","article-title":"Silhouettes: A graphical aid to the interpretation and validation of cluster analysis","volume":"20","author":"Rousseeuw","year":"1987","journal-title":"J Comput Appl Math."},{"key":"2022042902170347200_awab483-B44","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.nicl.2016.03.016","article-title":"Connectivity-based parcellation increases network detection sensitivity in resting state fMRI: an investigation into the cingulate cortex in autism","volume":"11","author":"Balsters","year":"2016","journal-title":"Neuroimage Clin."},{"key":"2022042902170347200_awab483-B45","doi-asserted-by":"crossref","first-page":"180063","DOI":"10.1038\/sdata.2018.63","article-title":"A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei","volume":"5","author":"Pauli","year":"2018","journal-title":"Sci Data."},{"issue":"3","key":"2022042902170347200_awab483-B46","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.neuroimage.2009.10.042","article-title":"A mean three-dimensional atlas of the human thalamus: generation from multiple histological data","volume":"49","author":"Krauth","year":"2010","journal-title":"NeuroImage."},{"key":"2022042902170347200_awab483-B47","doi-asserted-by":"crossref","first-page":"116189","DOI":"10.1016\/j.neuroimage.2019.116189","article-title":"Automated anatomical labelling atlas 3","volume":"206","author":"Rolls","year":"2020","journal-title":"NeuroImage."},{"issue":"8","key":"2022042902170347200_awab483-B48","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nmeth.1635","article-title":"Large-scale automated synthesis of human functional neuroimaging data","volume":"8","author":"Yarkoni","year":"2011","journal-title":"Nat Methods."},{"key":"2022042902170347200_awab483-B49","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J Mach Learn Res."},{"issue":"18","key":"2022042902170347200_awab483-B50","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1523\/JNEUROSCI.5253-10.2011","article-title":"Effective connectivity reveals important roles for both the hyperdirect (fronto-subthalamic) and the indirect (fronto-striatal-pallidal) fronto-basal ganglia pathways during response inhibition","volume":"31","author":"Jahfari","year":"2011","journal-title":"J Neurosci."},{"issue":"51","key":"2022042902170347200_awab483-B51","doi-asserted-by":"crossref","first-page":"13967","DOI":"10.1523\/JNEUROSCI.3834-08.2008","article-title":"Cortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystonia","volume":"28","author":"Chiken","year":"2008","journal-title":"J Neurosci."},{"issue":"7","key":"2022042902170347200_awab483-B52","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/brain\/awv109","article-title":"Cortico-pallidal oscillatory connectivity in patients with dystonia","volume":"138","author":"Neumann","year":"2015","journal-title":"Brain."},{"issue":"9","key":"2022042902170347200_awab483-B53","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1093\/brain\/aww102","article-title":"Role of cortico-pallidal connectivity in the pathophysiology of dystonia","volume":"139","author":"Cacciola","year":"2016","journal-title":"Brain."},{"issue":"3","key":"2022042902170347200_awab483-B54","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1017\/S1355617709090626","article-title":"Construct validity of the Trail Making Test: role of task-switching, working memory, inhibition\/interference control, and visuomotor abilities","volume":"15","author":"S\u00e1nchez-Cubillo","year":"2009","journal-title":"J Int Neuropsychol Soc."},{"key":"2022042902170347200_awab483-B55","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuropsychologia.2018.03.031","article-title":"Neural signatures of Trail Making Test performance: evidence from lesion-mapping and neuroimaging studies","volume":"115","author":"Varjacic","year":"2018","journal-title":"Neuropsychologia."},{"issue":"1","key":"2022042902170347200_awab483-B56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn Sci."},{"issue":"2","key":"2022042902170347200_awab483-B57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0896-6273(00)00113-6","article-title":"Toward a neurobiology of obsessive-compulsive disorder","volume":"28","author":"Graybiel","year":"2000","journal-title":"Neuron."},{"issue":"9","key":"2022042902170347200_awab483-B58","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/hbm.23236","article-title":"PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency","volume":"37","author":"Xu","year":"2016","journal-title":"Hum Brain Mapp."},{"issue":"10","key":"2022042902170347200_awab483-B59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.biopsych.2021.07.010","article-title":"Connectomic deep brain stimulation for obsessive-compulsive disorder","volume":"90","author":"Baldermann","year":"2021","journal-title":"Biol Psychiatry."},{"issue":"9","key":"2022042902170347200_awab483-B60","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopsych.2019.01.017","article-title":"A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: clinical and imaging evidence for dissociable effects","volume":"85","author":"Tyagi","year":"2019","journal-title":"Biol Psychiatry."},{"issue":"8","key":"2022042902170347200_awab483-B61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.biopsych.2013.10.021","article-title":"Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder","volume":"75","author":"Anticevic","year":"2014","journal-title":"Biol Psychiatry."},{"key":"2022042902170347200_awab483-B62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nicl.2013.06.013","article-title":"Abnormal corticostriatal-limbic functional connectivity in obsessive-compulsive disorder during reward processing and resting-state","volume":"3","author":"Jung","year":"2013","journal-title":"Neuroimage Clin."},{"issue":"12","key":"2022042902170347200_awab483-B63","doi-asserted-by":"crossref","first-page":"e83931","DOI":"10.1371\/journal.pone.0083931","article-title":"Morphologic and functional connectivity alterations of corticostriatal and default mode network in treatment-naive patients with obsessive-compulsive disorder","volume":"8","author":"Hou","year":"2013","journal-title":"PLoS ONE."},{"issue":"27","key":"2022042902170347200_awab483-B64","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1073\/pnas.1905961116","article-title":"The network organization of rat intrathalamic macroconnections and a comparison with other forebrain divisions","volume":"116","author":"Swanson","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2022042902170347200_awab483-B65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1523\/JNEUROSCI.0479-18.2018","article-title":"The cognitive thalamus as a gateway to mental representations","volume":"39","author":"Wolff","year":"2019","journal-title":"J Neurosci."},{"issue":"12","key":"2022042902170347200_awab483-B66","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/s41593-017-0020-1","article-title":"Thalamic functions in distributed cognitive control","volume":"20","author":"Halassa","year":"2017","journal-title":"Nat Neurosci."},{"issue":"2","key":"2022042902170347200_awab483-B67","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1089\/brain.2015.0349","article-title":"Data-driven and predefined ROI-based quantification of long-term resting-state fMRI reproducibility","volume":"6","author":"Song","year":"2016","journal-title":"Brain Connect."},{"issue":"40","key":"2022042902170347200_awab483-B68","doi-asserted-by":"crossref","first-page":"16187","DOI":"10.1073\/pnas.1301725110","article-title":"Integrated strategy for improving functional connectivity mapping using multiecho fMRI","volume":"110","author":"Kundu","year":"2013","journal-title":"Proc Natl Acad Sci USA."}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/3\/979\/43500020\/awab483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/3\/979\/43500020\/awab483.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:28:01Z","timestamp":1651199281000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/3\/979\/6575653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":68,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,4,29]]},"published-print":{"date-parts":[[2022,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awab483","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,3,1]]}}}