{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:46:38Z","timestamp":1790808398913,"version":"4.1.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS079166"],"award-info":[{"award-number":["R01NS079166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DA036165"],"award-info":[{"award-number":["R01DA036165"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS095747"],"award-info":[{"award-number":["R01NS095747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DA050530"],"award-info":[{"award-number":["R01DA050530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016391","name":"Cecil H. and Ida M. 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Ablation of astrogliosis blocked the development of gp120-induced mechanical hyperalgesia, and concomitantly the expression of neural circuit polarization in the spinal dorsal horn. We demonstrated that conditional knockout of either Wnt5a in neurons or its receptor ROR2 in astrocytes abolished not only gp120-induced astrogliosis but also hyperalgesia and neural circuit polarization. Furthermore, we found that the astrogliosis promoted expression of hyperalgesia and NCP via IL-1\u03b2 regulated by a Wnt5a-ROR2-MMP2 axis.<\/jats:p>\n               <jats:p>Our results shed light on the role and mechanism of astrogliosis in the pathogenesis of HIV-associated pain.<\/jats:p>","DOI":"10.1093\/brain\/awac015","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T20:12:31Z","timestamp":1642104751000},"page":"4108-4123","source":"Crossref","is-referenced-by-count":33,"title":["A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis"],"prefix":"10.1093","volume":"145","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Stony Brook University Pain and Analgesia Research Center (SPARC) and Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 , USA"},{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch , Galveston, TX 77555 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chilman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch , Galveston, TX 77555 , USA"},{"name":"School of Electrical, Computer, and Biomedical Engineering, Southern Illinois University , Carbondale, IL 62901 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin B","family":"Gelman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch , Galveston, TX 77555 , USA"},{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX 77555 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Mo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch , Galveston, TX 77555 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-5481","authenticated-orcid":false,"given":"Shao-Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Stony Brook University Pain and Analgesia Research Center (SPARC) and Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 , USA"},{"name":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch , Galveston, TX 77555 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"issue":"1","key":"2023053018554081400_awac015-B1","doi-asserted-by":"crossref","first-page":"18719","DOI":"10.7448\/IAS.17.1.18719","article-title":"Pain in people living with HIV\/AIDS: a systematic review","volume":"17","author":"Parker","year":"2014","journal-title":"J Int AIDS Soc"},{"issue":"4","key":"2023053018554081400_awac015-B2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2217\/pmt-2020-0004","article-title":"Chronic pain in people with HIV: a common comorbidity and threat to quality of life","volume":"10","author":"Madden","year":"2020","journal-title":"Pain Manag"},{"issue":"9","key":"2023053018554081400_awac015-B3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/AJP.0000000000000162","article-title":"Is HIV painful? 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