{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:10:49Z","timestamp":1790701849843,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Lundbeck Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in migraine treatment. However, up to 50% of patients do not benefit from monoclonal antibodies against CGRP or its receptor. Here, we test the hypothesis that a closely related peptide, pituitary adenylate cyclase-activating peptide (PACAP-38), works independently of CGRP and thus might represent a new, alternative drug target.<\/jats:p>\n               <jats:p>To understand differences in CGRP- and PACAP-mediated migraine pain, we used mouse models of provoked migraine-like pain based on multiple stimulations and subsequent measurement of tactile sensitivity response with von Frey filaments. Genetically modified mice lacking either functional CGRP receptors (Ramp1 knockout) or TRPA1 channels (Trpa1 knockout) were used together with CGRP-targeting antibodies and chemical inhibitors in wild-type mice (ntotal\u2009=\u2009299). Ex vivo myograph studies were used to measure dilatory responses to CGRP and PACAP-38 in mouse carotid arteries.<\/jats:p>\n               <jats:p>PACAP-38 provoked significant hypersensitivity and dilated the carotid arteries independently of CGRP. In contrast, glyceryl trinitrate-induced hypersensitivity is dependent on CGRP. Contrary to previous results with the migraine-inducing substances glyceryl trinitrate, cilostazol and levcromakalim, PACAP-38-induced hypersensitivity worked only partially through inhibition of ATP-sensitive potassium channels.<\/jats:p>\n               <jats:p>Using multiple migraine-relevant models, these findings establish the PACAP-38 pathway as distinct from other migraine provoking pathways such as CGRP and glyceryl trinitrate. PACAP antagonism may therefore be a novel therapeutic target of particular interest in patients unresponsive to CGRP-antagonizing drugs.<\/jats:p>","DOI":"10.1093\/brain\/awac040","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T20:18:01Z","timestamp":1643833081000},"page":"2450-2460","source":"Crossref","is-referenced-by-count":81,"title":["The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-1902","authenticated-orcid":false,"given":"Charlotte","family":"Ernstsen","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-4783","authenticated-orcid":false,"given":"Sarah L","family":"Christensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke H","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Jansen-Olesen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"},{"name":"University of Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail)\u2013UMR_S 1085 , F-35000 Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"issue":"1","key":"2022072919092787200_awac040-B1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/brain\/awn307","article-title":"PACAP38 induces migraine-like attacks in patients with migraine without aura","volume":"132","author":"Schytz","year":"2009","journal-title":"Brain"},{"issue":"6","key":"2022072919092787200_awac040-B2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.npep.2013.10.010","article-title":"CGRP and migraine: Could PACAP play a role too?","volume":"47","author":"Kaiser","year":"2013","journal-title":"Neuropeptides"},{"issue":"Suppl 2","key":"2022072919092787200_awac040-B3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/head.13084","article-title":"Overview of neuropeptides: Awakening the senses?","volume":"57","author":"Russo","year":"2017","journal-title":"Headache"},{"issue":"1","key":"2022072919092787200_awac040-B4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0333102419864507","article-title":"PACAP27 induces migraine-like attacks in migraine patients","volume":"40","author":"Ghanizada","year":"2020","journal-title":"Cephalalgia"},{"issue":"1","key":"2022072919092787200_awac040-B5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1124\/jpet.118.253443","article-title":"Pharmacologic characterization of ALD1910, a potent humanized monoclonal antibody against the pituitary adenylate cyclase-activating peptide","volume":"369","author":"Loomis","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"2022072919092787200_awac040-B6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0306-4522(93)90018-B","article-title":"Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: Immunocytochemical and immunochemical evidence","volume":"57","author":"Moller","year":"1993","journal-title":"Neuroscience"},{"issue":"5","key":"2022072919092787200_awac040-B7","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/endo-129-5-2787","article-title":"Tissue distribution of PACAP as determined by RIA: Highly abundant in the rat brain and testes","volume":"129","author":"Arimura","year":"1991","journal-title":"Endocrinology"},{"issue":"6","key":"2022072919092787200_awac040-B8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies\u2014Successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2022072919092787200_awac040-B9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"Lassen","year":"2002","journal-title":"Cephalalgia"},{"issue":"14","key":"2022072919092787200_awac040-B10","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1177\/0333102419861726","article-title":"Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain","volume":"39","author":"Christensen","year":"2019","journal-title":"Cephalalgia"},{"issue":"10","key":"2022072919092787200_awac040-B11","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1523\/JNEUROSCI.4542-06.2007","article-title":"Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion","volume":"27","author":"Zhang","year":"2007","journal-title":"J Neurosci"},{"issue":"11","key":"2022072919092787200_awac040-B12","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa030505","article-title":"Calcitonin gene\u2013related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine","volume":"350","author":"Olesen","year":"2004","journal-title":"N Engl J Med"},{"issue":"3","key":"2022072919092787200_awac040-B13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/0333102418821662","article-title":"CGRP ligand and receptor monoclonal antibodies for migraine prevention: Evidence review and clinical implications","volume":"39","author":"Dodick","year":"2019","journal-title":"Cephalalgia"},{"issue":"19","key":"2022072919092787200_awac040-B14","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine","volume":"383","author":"Ashina","year":"2020","journal-title":"N Engl J Med"},{"key":"2022072919092787200_awac040-B15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2018.10.004","article-title":"Expression of pituitary adenylate cyclase-activating peptide, calcitonin gene-related peptide and headache targets in the trigeminal ganglia of rats and humans","volume":"393","author":"Frederiksen","year":"2018","journal-title":"Neuroscience"},{"issue":"2","key":"2022072919092787200_awac040-B16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.npep.2014.01.004","article-title":"PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor","volume":"48","author":"Jansen-Olesen","year":"2014","journal-title":"Neuropeptides"},{"key":"2022072919092787200_awac040-B17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2014.11.031","article-title":"Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier","volume":"1600","author":"Eftekhari","year":"2015","journal-title":"Brain Res"},{"issue":"6","key":"2022072919092787200_awac040-B18","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/bph.12541","article-title":"PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells","volume":"171","author":"Walker","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"3","key":"2022072919092787200_awac040-B19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0167-0115(92)90518-Y","article-title":"Neuropeptides of the vasoactive intestinal peptide\/helodermin\/pituitary adenylate cyclase activating peptide family elevate plasma cAMP in mice: Comparison with a range of other regulatory peptides","volume":"40","author":"Absood","year":"1992","journal-title":"Regul Pept"},{"issue":"7","key":"2022072919092787200_awac040-B20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0333102420925513","article-title":"ATP sensitive potassium (KATP) channel inhibition: A promising new drug target for migraine","volume":"40","author":"Christensen","year":"2020","journal-title":"Cephalalgia"},{"issue":"1","key":"2022072919092787200_awac040-B21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s10194-018-0955-y","article-title":"European Headache Federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention","volume":"20","author":"Sacco","year":"2019","journal-title":"J Headache Pain"},{"issue":"3","key":"2022072919092787200_awac040-B22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/WCO.0000000000000806","article-title":"Gepants, calcitonin-gene-related peptide receptor antagonists","volume":"33","author":"Moreno-Ajona","year":"2020","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"2022072919092787200_awac040-B23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/0333102417741297","article-title":"CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data","volume":"39","author":"Khan","year":"2019","journal-title":"Cephalalgia"},{"issue":"9","key":"2022072919092787200_awac040-B24","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1177\/0333102420914913","article-title":"No central action of CGRP antagonising drugs in the GTN mouse model of migraine","volume":"40","author":"Christensen","year":"2020","journal-title":"Cephalalgia"},{"issue":"4","key":"2022072919092787200_awac040-B25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ejp.1528","article-title":"Von Frey testing revisited: provision of an online algorithm for improved accuracy of 50% thresholds","volume":"24","author":"Christensen","year":"2020","journal-title":"Eur J Pain"},{"issue":"42","key":"2022072919092787200_awac040-B26","doi-asserted-by":"crossref","first-page":"16702","DOI":"10.1073\/pnas.0705974104","article-title":"Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice","volume":"104","author":"Tsujikawa","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2022072919092787200_awac040-B27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/0333102420963857","article-title":"No additive effect of combining sumatriptan and olcegepant in the GTN mouse model of migraine","volume":"41","author":"Ernstsen","year":"2021","journal-title":"Cephalalgia"},{"issue":"11","key":"2022072919092787200_awac040-B28","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1177\/0333102415623070","article-title":"The effects of acute and preventive migraine therapies in a mouse model of chronic migraine","volume":"36","author":"Tipton","year":"2016","journal-title":"Cephalalgia"},{"issue":"2","key":"2022072919092787200_awac040-B29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","article-title":"Characterization of a novel model of chronic migraine","volume":"155","author":"Pradhan","year":"2014","journal-title":"Pain"},{"issue":"14","key":"2022072919092787200_awac040-B30","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1177\/03331024211038884","article-title":"CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine","volume":"41","author":"Christensen","year":"2021","journal-title":"Cephalalgia"},{"issue":"8","key":"2022072919092787200_awac040-B31","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1177\/0333102417737778","article-title":"Soluble guanylyl cyclase is a critical regulator of migraine-associated pain","volume":"38","author":"Aissa M","year":"2018","journal-title":"Cephalalgia"},{"issue":"2","key":"2022072919092787200_awac040-B32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"issue":"1","key":"2022072919092787200_awac040-B33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1468-1331.1994.tb00053.x","article-title":"A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks","volume":"1","author":"Thomsen","year":"1994","journal-title":"Eur J Neurol"},{"issue":"8","key":"2022072919092787200_awac040-B34","doi-asserted-by":"crossref","first-page":"e104458","DOI":"10.1371\/journal.pone.0104458","article-title":"Significant determinants of mouse pain behaviour","volume":"9","author":"Minett","year":"2014","journal-title":"PLoS ONE"},{"issue":"2","key":"2022072919092787200_awac040-B35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3758\/BF03207805","article-title":"Statistical power for the two-factor repeated measures ANOVA","volume":"32","author":"Potvin","year":"2000","journal-title":"Behav Res Methods Instrum Comput"},{"issue":"4","key":"2022072919092787200_awac040-B36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/head.13747","article-title":"Sumatriptan does not antagonize CGRP-induced symptoms in healthy volunteers","volume":"60","author":"Falkenberg","year":"2020","journal-title":"Headache"},{"issue":"8","key":"2022072919092787200_awac040-B37","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/brain\/awy177","article-title":"TRPA1\/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice","volume":"141","author":"Marone","year":"2018","journal-title":"Brain"},{"issue":"1","key":"2022072919092787200_awac040-B38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s10194-017-0804-4","article-title":"The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: Evaluation in an animal model","volume":"18","author":"Demartini","year":"2017","journal-title":"J Headache Pain"},{"key":"2022072919092787200_awac040-B39","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1038\/ncomms5381","article-title":"H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway","volume":"5","author":"Eberhardt","year":"2014","journal-title":"Nat Commun"},{"issue":"15","key":"2022072919092787200_awac040-B40","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1111\/bph.13519","article-title":"TRPA1 activation leads to neurogenic vasodilatation: Involvement of reactive oxygen nitrogen species in addition to CGRP and NO","volume":"173","author":"Aubdool","year":"2016","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2022072919092787200_awac040-B41","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0006-291X(89)91757-9","article-title":"Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells","volume":"164","author":"Miyata","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"2022072919092787200_awac040-B42","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0006-291X(90)92140-U","article-title":"Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)","volume":"170","author":"Miyata","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2022072919092787200_awac040-B43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2019.00114","article-title":"PACAP-38 and PACAP(638) degranulate rat meningeal mast cells via the orphan MrgB3-receptor","volume":"13","author":"Pedersen","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"2022072919092787200_awac040-B44","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/brain\/awt369","article-title":"Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38","volume":"137","author":"Amin","year":"2014","journal-title":"Brain"},{"issue":"3","key":"2022072919092787200_awac040-B45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pharmthera.2008.11.006","article-title":"VPAC and PAC receptors: From ligands to function","volume":"121","author":"Dickson","year":"2009","journal-title":"Pharmacol Ther"},{"issue":"8","key":"2022072919092787200_awac040-B46","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1468-2982.2008.01807.x","article-title":"The in vivo effect of VIP, PACAP-38 and PACAP-27 and mRNA expression of their receptors in rat middle meningeal artery","volume":"29","author":"Boni","year":"2009","journal-title":"Cephalalgia"},{"issue":"2","key":"2022072919092787200_awac040-B47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0333102410375624","article-title":"Pharmacological characterization of VIP and PACAP receptors in the human meningeal and coronary artery","volume":"31","author":"Chan","year":"2011","journal-title":"Cephalalgia"},{"issue":"1","key":"2022072919092787200_awac040-B48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/0333102420970889","article-title":"A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention","volume":"41","author":"Ashina","year":"2021","journal-title":"Cephalalgia"},{"issue":"308","key":"2022072919092787200_awac040-B49","doi-asserted-by":"crossref","first-page":"308ra157","DOI":"10.1126\/scitranslmed.aaa7557","article-title":"Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine","volume":"7","author":"Akerman","year":"2015","journal-title":"Sci Transl Med"},{"issue":"9","key":"2022072919092787200_awac040-B50","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/brain\/awz199","article-title":"Opening of ATP-sensitive potassium channels causes migraine attacks: A new target for the treatment of migraine","volume":"142","author":"Al-Karagholi","year":"2019","journal-title":"Brain"},{"issue":"10","key":"2022072919092787200_awac040-B51","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1177\/0333102410368444","article-title":"Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura","volume":"30","author":"Hansen","year":"2010","journal-title":"Cephalalgia"},{"issue":"12","key":"2022072919092787200_awac040-B52","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1074\/mcp.RA119.001767","article-title":"PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models","volume":"18","author":"Anapindi","year":"2019","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"2022072919092787200_awac040-B53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.nbd.2011.10.010","article-title":"Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice","volume":"45","author":"Markovics","year":"2012","journal-title":"Neurobiol Dis"},{"issue":"27","key":"2022072919092787200_awac040-B54","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1523\/JNEUROSCI.1727-09.2009","article-title":"Role of calcitonin gene-related peptide in light-aversive behavior: Implications for migraine","volume":"29","author":"Recober","year":"2009","journal-title":"J Neurosci"},{"issue":"1","key":"2022072919092787200_awac040-B55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2009.07.009","article-title":"Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP","volume":"58","author":"Recober","year":"2010","journal-title":"Neuropharmacology"},{"key":"2022072919092787200_awac040-B56","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPS regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"issue":"21","key":"2022072919092787200_awac040-B57","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1523\/JNEUROSCI.2200-20.2021","article-title":"PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP","volume":"41","author":"Kuburas","year":"2021","journal-title":"J Neurosci"},{"issue":"2","key":"2022072919092787200_awac040-B58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/0333102416639517","article-title":"Part II: Biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients","volume":"37","author":"Guo","year":"2017","journal-title":"Cephalalgia"},{"key":"2022072919092787200_awac040-B59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/365170a0","article-title":"Differential signal transduction by five splice variants of the PACAP receptor","volume":"365","author":"Spongier","year":"1993","journal-title":"Nature"},{"issue":"9","key":"2022072919092787200_awac040-B60","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.peptides.2007.05.002","article-title":"Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: A case study","volume":"28","author":"Li","year":"2007","journal-title":"Peptides"},{"issue":"11","key":"2022072919092787200_awac040-B61","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/0333102414523846","article-title":"PACAP-38 infusion causes sustained vasodilation of the middle meningeal artery in the rat: possible involvement of mast cells","volume":"34","author":"Bhatt","year":"2014","journal-title":"Cephalalgia"},{"key":"2022072919092787200_awac040-B62","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"issue":"1","key":"2022072919092787200_awac040-B63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1468-1331.1996.tb00184.x","article-title":"Sumatriptan has no clinically relevant effect in the treatment of episodic tension-type headache","volume":"3","author":"Brennum","year":"1996","journal-title":"Eur J Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awac040\/44814713\/awac040.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/7\/2450\/45190932\/awac040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/7\/2450\/45190932\/awac040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T19:10:21Z","timestamp":1659121821000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/7\/2450\/6523733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":63,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,2,8]]},"published-print":{"date-parts":[[2022,7,29]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awac040","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,2,8]]}}}