{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:07:21Z","timestamp":1788498441089,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100002076","name":"Emergency Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AHA Mentored Clinical & Population Research Award","award":["14CRP18860027"],"award-info":[{"award-number":["14CRP18860027"]}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01-NS085419"],"award-info":[{"award-number":["R01-NS085419"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R37-NS107230"],"award-info":[{"award-number":["R37-NS107230"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["U24-NS107230"],"award-info":[{"award-number":["U24-NS107230"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["K23-NS099487"],"award-info":[{"award-number":["K23-NS099487"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["K99-AG062723"],"award-info":[{"award-number":["K99-AG062723"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007338","name":"Barnes-Jewish Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"Bright Focus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsinki University Central Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Finland government subsidiary funds"},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI051737"],"award-info":[{"award-number":["PI051737"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondos de Investigaci\u00f3n Sanitaria ISC III","award":["PI10\/02064"],"award-info":[{"award-number":["PI10\/02064"]}]},{"name":"Fondos de Investigaci\u00f3n Sanitaria ISC III","award":["PI12\/01238"],"award-info":[{"award-number":["PI12\/01238"]}]},{"name":"Fondos de Investigaci\u00f3n Sanitaria ISC III","award":["PI15\/00451"],"award-info":[{"award-number":["PI15\/00451"]}]},{"name":"Fondos de Investigaci\u00f3n Sanitaria ISC III","award":["JR18\/00004"],"award-info":[{"award-number":["JR18\/00004"]}]},{"name":"Fondos FEDER\/EDRF Red de Investigaci\u00f3n Cardiovascular","award":["RD12\/0042\/0020"],"award-info":[{"award-number":["RD12\/0042\/0020"]}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 TV3","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genestroke Consortium","award":["76\/C\/2011"],"award-info":[{"award-number":["76\/C\/2011"]}]},{"name":"Recercaixa\u201913","award":["JJ086116"],"award-info":[{"award-number":["JJ086116"]}]},{"name":"Tom\u00e1s Sobrino","award":["CPII17\/00027"],"award-info":[{"award-number":["CPII17\/00027"]}]},{"name":"Francisco Campos","award":["CPII19\/00020"],"award-info":[{"award-number":["CPII19\/00020"]}]},{"name":"Fondos FEDER","award":["PI18\/01338"],"award-info":[{"award-number":["PI18\/01338"]}]},{"name":"Pre-test project","award":["PMP15\/00022"],"award-info":[{"award-number":["PMP15\/00022"]}]},{"name":"Marat\u00f3 TV3 Foundation"},{"name":"Invictus plus Network","award":["RD16\/0019"],"award-info":[{"award-number":["RD16\/0019"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP-2013\/07559-3"],"award-info":[{"award-number":["FAPESP-2013\/07559-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Juselius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS097000"],"award-info":[{"award-number":["NS097000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS101718"],"award-info":[{"award-number":["NS101718"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS075035"],"award-info":[{"award-number":["NS075035"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS079153"],"award-info":[{"award-number":["NS079153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS106950"],"award-info":[{"award-number":["NS106950"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During the first hours after stroke onset, neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between the National Institutes of Health Stroke Scale (NIHSS) within 6\u2005h of stroke onset and NIHSS at 24\u2005h.<\/jats:p>\n                  <jats:p>A total of 5876 individuals from seven countries (Spain, Finland, Poland, USA, Costa Rica, Mexico and Korea) were studied using a multi-ancestry meta-analyses. We found that 8.7% of NIHSS at 24\u2005h of variance was explained by common genetic variations, and also that early neurological instability has a different genetic architecture from that of stroke risk. Eight loci (1p21.1, 1q42.2, 2p25.1, 2q31.2, 2q33.3, 5q33.2, 7p21.2 and 13q31.1) were genome-wide significant and explained 1.8% of the variability suggesting that additional variants influence early change in neurological deficits. We used functional genomics and bioinformatic annotation to identify the genes driving the association from each locus. Expression quantitative trait loci mapping and summary data-based Mendelian randomization indicate that ADAM23 (log Bayes factor\u2009=\u20095.41) was driving the association for 2q33.3. Gene-based analyses suggested that GRIA1 (log Bayes factor\u2009=\u20095.19), which is predominantly expressed in the brain, is the gene driving the association for the 5q33.2 locus. These analyses also nominated GNPAT (log Bayes factor\u2009=\u20097.64) ABCB5 (log Bayes factor\u2009=\u20095.97) for the 1p21.1 and 7p21.1 loci. Human brain single-nuclei RNA-sequencing indicates that the gene expression of ADAM23 and GRIA1 is enriched in neurons. ADAM23, a presynaptic protein and GRIA1, a protein subunit of the AMPA receptor, are part of a synaptic protein complex that modulates neuronal excitability.<\/jats:p>\n                  <jats:p>These data provide the first genetic evidence in humans that excitotoxicity may contribute to early neurological instability after acute ischaemic stroke.<\/jats:p>","DOI":"10.1093\/brain\/awac080","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T15:13:46Z","timestamp":1645715626000},"page":"2394-2406","source":"Crossref","is-referenced-by-count":36,"title":["Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-7059","authenticated-orcid":false,"given":"Laura","family":"Ibanez","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Heitsch","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Emergency Medicine, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caty","family":"Carrera","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d\u2019Hebron University Hospital, Universitat de Barcelona , Barcelona 08035 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana H G","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L","family":"Del Aguila","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Harari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Hope Center for Neurological Disorders, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-7621","authenticated-orcid":false,"given":"Chia Ling","family":"Phuah","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-5956","authenticated-orcid":false,"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Katholieke Universiteit Leuven , Campus Gasthuisberg O&N2, Leuven BE-3000 , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro A","family":"Viana Oliveira Souza","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Cidade Universitaria , Campinas 13083-887 , Brazil"},{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), R. Tessalia Viera de Camargo , Campinas 13083-887 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-2909","authenticated-orcid":false,"given":"Francisco","family":"Moniche","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Virgen del Rocio, University of Seville , Seville 41013 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cabezas-Juan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Virgen del Rocio, University of Seville , Seville 41013 , Spain"},{"name":"Hospital Virgen de la Macarena, University of Seville , Seville 41009 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Arenillas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Clinico Universitario Valladolid, Valladolid University , Valladolid 47003 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Krupinksi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mutua Terrassa University Hospital, Universitat de Barcelona , Terrassa 08221 , Spain"},{"name":"Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona , Terrassa 08221 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cullell","sequence":"additional","affiliation":[{"name":"Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona , Terrassa 08221 , Spain"},{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9502-9310","authenticated-orcid":false,"given":"Nuria","family":"Torres-Aguila","sequence":"additional","affiliation":[{"name":"Fundacio Docencia i Recerca Mutua Terrassa, Universitat de Barcelona , Terrassa 08221 , Spain"},{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mui\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"C\u00e1rcel-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-8649","authenticated-orcid":false,"given":"Joan","family":"Marti-Fabregas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Delgado-Mederos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Marin-Bueno","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Neurology, Southern Illinois Healthcare Memorial Hospital of Carbondale , Carbondale 62901, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristofol","family":"Vives-Bauza","sequence":"additional","affiliation":[{"name":"Department of Biology, Universitat de les Illes Balears , Palma 07122 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Diaz","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears , Palma 07120 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tur","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears , Palma 07120 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari Son Espases, Universitat de les Illes Balears , Palma 07120 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Obach","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Clinic de Barcelona, Universitat de Barcelona , Barcelona 08036 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Segura","sequence":"additional","affiliation":[{"name":"Research Unit, Complejo Hospitalario Universitario de Albacete, \u00a0 Albacete 02008 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Serrano-Heras","sequence":"additional","affiliation":[{"name":"Research Unit, Complejo Hospitalario Universitario de Albacete, \u00a0 Albacete 02008 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Won","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Roquer","sequence":"additional","affiliation":[{"name":"Neurovascular Research Group, Institut Hospital del Mar de Investigacions Mediques , Barcelona 08003 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-273X","authenticated-orcid":false,"given":"Carol","family":"Soriano-Tarraga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Neurovascular Research Group, Institut Hospital del Mar de Investigacions Mediques , Barcelona 08003 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Giralt-Steinhauer","sequence":"additional","affiliation":[{"name":"Neurovascular Research Group, Institut Hospital del Mar de Investigacions Mediques , Barcelona 08003 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mola-Caminal","sequence":"additional","affiliation":[{"name":"Neurovascular Research Group, Institut Hospital del Mar de Investigacions Mediques , Barcelona 08003 , Spain"},{"name":"Department of Surgical Sciences, Orthopedics, Uppsala University , Uppsala 75185 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Pera","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jagiellonian University , Krakow 31-007 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Lapicka-Bodzioch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jagiellonian University , Krakow 31-007 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Derbisz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jagiellonian University , Krakow 31-007 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Davalos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona , Badalona 08916 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lopez-Cancio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Central de Asturias , Oviedo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona , Badalona 08916 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sahlgrenska University Hospital, University of Gothenburg , Gothenburg 413 45 , Sweden"},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d\u2019Hebron University Hospital, Universitat de Barcelona , Barcelona 08035 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d\u2019Hebron University Hospital, Universitat de Barcelona , Barcelona 08035 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona , Badalona 08916 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Sobrino","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castillo-Sanchez","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Rodriguez-Castro","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Arias-Rivas","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Herbosa","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-8943","authenticated-orcid":false,"given":"Andria L","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Hope Center for Neurological Disorders, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Radiology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Gutierrez-Romero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirurgia de Mexico , Ciudad de Mexico 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Uribe-Pacheco","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirurgia de Mexico , Ciudad de Mexico 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Arauz","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurologia y Neurocirurgia de Mexico , Ciudad de Mexico 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iscia","family":"Lopes-Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Cidade Universitaria , Campinas 13083-887 , Brazil"},{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), R. Tessalia Viera de Camargo , Campinas 13083-887 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Lowenkopf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Providence St. Vincent Medical Center , Portland 97225, OR , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Barboza","sequence":"additional","affiliation":[{"name":"Neurosciences Department, Hospital Rafael A. Calderon Guardia , Aranjuez, San Jos\u00e9 , Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Neurology and MIND Institute, University of California at Davis , Sacramento 95817, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boryana","family":"Stamova","sequence":"additional","affiliation":[{"name":"Department of Neurology and MIND Institute, University of California at Davis , Sacramento 95817, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley P","family":"Ander","sequence":"additional","affiliation":[{"name":"Department of Neurology and MIND Institute, University of California at Davis , Sacramento 95817, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank R","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Neurology and MIND Institute, University of California at Davis , Sacramento 95817, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Jimenez-Conde","sequence":"additional","affiliation":[{"name":"Neurovascular Research Group, Institut Hospital del Mar de Investigacions Mediques , Barcelona 08003 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Slowik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jagiellonian University , Krakow 31-007 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-2344","authenticated-orcid":false,"given":"Daniel","family":"Stribian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital , Helsinki 00290 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A","family":"Tsai","sequence":"additional","affiliation":[{"name":"Translational Biology, Biogen, Inc. , Cambridge 02142, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C","family":"Burkly","sequence":"additional","affiliation":[{"name":"Genetics and Neurodevelopmental Disease Research Unit, Biogen, Inc. , Cambridge 02142, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d\u2019Hebron University Hospital, Universitat de Barcelona , Barcelona 08035 , Spain"},{"name":"Department of Neurology, Hospital Virgen del Rocio, University of Seville , Seville 41013 , Spain"},{"name":"Hospital Virgen de la Macarena, University of Seville , Seville 41009 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Fernandez-Cadenas","sequence":"additional","affiliation":[{"name":"Stroke Unit, Vall d\u2019Hebron University Hospital, Universitat de Barcelona , Barcelona 08035 , Spain"},{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 08041 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Hope Center for Neurological Disorders, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Radiology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Biomedical Engineering, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Stroke and Cerebrovascular Center, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"NeuroGenomics and Informatics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Neurology, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Hope Center for Neurological Disorders, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center, School of Medicine, Washington University , Saint Louis 63110, MO , USA"},{"name":"Department of Genetics, School of Medicine, Washington University , Saint Louis 63110, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2023022501100025200_","volume-title":"The global burden of disease: 2004 update","author":"World Health Organization","year":"2008"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 update: A report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"10","key":"2023022501100025200_","first-page":"665","article-title":"The WHO STEPwise approach to stroke surveillance","volume":"18","author":"Farooq","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/STROKEAHA.111.636928","article-title":"Relationship between neurologic deficit severity and final functional outcome shifts and strengthens during first hours after onset","volume":"43","author":"Saver","year":"2012","journal-title":"Stroke"},{"issue":"24","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","author":"The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.","year":"1995","journal-title":"N Engl J Med"},{"key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/STROKEAHA.119.028687","article-title":"Early neurological change after ischemic stroke is associated with 90-day outcome","volume":"52","author":"Heitsch","year":"2021","journal-title":"Stroke"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1161\/01.STR.29.12.2522","article-title":"Spontaneous reperfusion after ischemic stroke is associated with improved outcome","volume":"29","author":"Barber","year":"1998","journal-title":"Stroke"},{"issue":"9","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/archneur.1994.00540210037011","article-title":"Spontaneous reperfusion of cerebral infarcts in patients with acute stroke. Incidence, time course, and clinical outcome in the Copenhagen Stroke Study","volume":"51","author":"Jorgensen","year":"1994","journal-title":"Arch Neurol"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/jnnp.2007.132100","article-title":"Impact of collateral flow on tissue fate in acute ischaemic stroke","volume":"79","author":"Bang","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3174\/ajnr.A1276","article-title":"Predictors of hemorrhage following intra-arterial thrombolysis for acute ischemic stroke: the role of pial collateral formation","volume":"30","author":"Christoforidis","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"2023022501100025200_","first-page":"85","article-title":"The ischemic stroke patient who worsens: New assessment and management approaches","volume":"4","author":"Ali","year":"2007","journal-title":"Rev Neurol Dis"},{"issue":"4","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.2333","article-title":"The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease","volume":"17","author":"Dreier","year":"2011","journal-title":"Nat Med"},{"issue":"8","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1161\/STROKEAHA.107.510321","article-title":"Early hemorrhagic transformation of brain infarction: Rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study","volume":"39","author":"Paciaroni","year":"2008","journal-title":"Stroke"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.119.026593","article-title":"Genome-wide association study of white blood cell counts in patients with ischemic stroke","volume":"50","author":"Torres-Aguila","year":"2019","journal-title":"Stroke"},{"issue":"4","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41588-018-0058-3","article-title":"Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes","volume":"50","author":"Malik","year":"2018","journal-title":"Nat Genet"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"e1271","DOI":"10.1212\/WNL.0000000000007138","article-title":"Genome-wide association meta-analysis of functional outcome after ischemic stroke","volume":"92","author":"Soderholm","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/CIRCRESAHA.118.313533","article-title":"PATJ low frequency variants are associated with worse ischemic stroke functional outcome","volume":"124","author":"Mola-Caminal","year":"2019","journal-title":"Circ Res"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/STROKEAHA.118.023097","article-title":"Overlap in the genetic architecture of stroke risk, early neurological changes, and cardiovascular risk factors","volume":"50","author":"Ibanez","year":"2019","journal-title":"Stroke"},{"issue":"8","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/gepi.20630","article-title":"Transethnic meta-analysis of genomewide association studies","volume":"35","author":"Morris","year":"2011","journal-title":"Genet Epidemiol"},{"issue":"11","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/hmg\/ddt064","article-title":"Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies","volume":"22","author":"Wang","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-019-0524-x","article-title":"A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain","volume":"11","author":"Del-Aguila","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/1471-2105-9-540","article-title":"Shape-IT: new rapid and accurate algorithm for haplotype inference","volume":"9","author":"Delaneau","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1534\/g3.111.001198","article-title":"Genotype imputation with thousands of genomes","volume":"1","author":"Howie","year":"2011","journal-title":"G3"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"issue":"3","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/aje\/kwi187","article-title":"When is baseline adjustment useful in analyses of change? An example with education and cognitive change","volume":"162","author":"Glymour","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"17","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: Fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"10","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/nprot.2015.105","article-title":"Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR","volume":"10","author":"Yang","year":"2015","journal-title":"Nat Protoc"},{"issue":"2","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly"},{"issue":"9","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res"},{"key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1038\/ncomms6890","article-title":"Biological interpretation of genome-wide association studies using predicted gene functions","volume":"6","author":"Pers","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1161\/STROKEAHA.108.517656","article-title":"The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial","volume":"39","author":"Pancioli","year":"2008","journal-title":"Stroke"},{"issue":"10","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1161\/STROKEAHA.110.588335","article-title":"Gene expression profiling of blood for the prediction of ischemic stroke","volume":"41","author":"Stamova","year":"2010","journal-title":"Stroke"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-018-0551-4","article-title":"Genetic variants associated with Alzheimer\u2019s disease confer different cerebral cortex cell-type population structure","volume":"10","author":"Li","year":"2018","journal-title":"Genome Med"},{"issue":"5","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"issue":"2","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/biostatistics\/kxn039","article-title":"Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13","volume":"10","author":"Plagnol","year":"2009","journal-title":"Biostatistics"},{"issue":"10","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"Westra","year":"2013","journal-title":"Nat Genet"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.ajhg.2016.10.003","article-title":"Colocalization of GWAS and eQTL signals detects target genes","volume":"99","author":"Hormozdiari","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"9","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/btu848","article-title":"PRSice: Polygenic risk score software","volume":"31","author":"Euesden","year":"2015","journal-title":"Bioinformatics"},{"issue":"3","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ajhg.2017.11.001","article-title":"A powerful approach to estimating annotation-stratified genetic covariance via GWAS summary statistics","volume":"101","author":"Lu","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.18632\/aging.101334","article-title":"Human longevity: 25 genetic loci associated in 389,166 UK biobank participants","volume":"9","author":"Pilling","year":"2017","journal-title":"Aging"},{"issue":"12","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/ng.3977","article-title":"Exome-wide association study of plasma lipids in &gt;300,000 individuals","volume":"49","author":"Liu","year":"2017","journal-title":"Nat Genet"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41588-017-0011-x","article-title":"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity","volume":"50","author":"Turcot","year":"2018","journal-title":"Nat Genet"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.53.1.126","article-title":"Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in acute stroke treatment (TOAST)","volume":"53","author":"Adams","year":"1999","journal-title":"Neurology"},{"issue":"8","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"e590","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.07.024","article-title":"Early and continuous neurologic improvements after intravenous thrombolysis are strong predictors of favorable long-term outcomes in acute ischemic stroke","volume":"22","author":"Yeo","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/STROKEAHA.116.014456","article-title":"Early trajectory of stroke severity predicts long-term functional outcomes in ischemic stroke subjects: Results from the ESCAPE Trial (endovascular treatment for small core and anterior circulation proximal occlusion with emphasis on minimizing CT to recanalization times)","volume":"48","author":"Sajobi","year":"2017","journal-title":"Stroke"},{"issue":"5","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20320","article-title":"ADAM23 is a cell-surface glycoprotein expressed by central nervous system neurons","volume":"78","author":"Goldsmith","year":"2004","journal-title":"J Neurosci Res"},{"issue":"3","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/90074","article-title":"Functional analysis of secreted and transmembrane proteins critical to mouse development","volume":"28","author":"Mitchell","year":"2001","journal-title":"Nat Genet"},{"issue":"6","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7150\/ijbs.4.387","article-title":"LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11","volume":"4","author":"Sagane","year":"2008","journal-title":"Int J Biol Sci"},{"issue":"30","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"E4129","DOI":"10.1073\/pnas.1511910112","article-title":"The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function","volume":"112","author":"Lovero","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7416","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1186\/s12864-015-1651-9","article-title":"Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene","volume":"16","author":"Koskinen","year":"2015","journal-title":"BMC Genomics"},{"issue":"1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12863-017-0478-6","article-title":"ADAM23 is a common risk gene for canine idiopathic epilepsy","volume":"18","author":"Koskinen","year":"2017","journal-title":"BMC Genet"},{"issue":"3","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"e33549","DOI":"10.1371\/journal.pone.0033549","article-title":"Identification of a novel idiopathic epilepsy locus in Belgian Shepherd dogs","volume":"7","author":"Sepp\u00e4l\u00e4","year":"2012","journal-title":"PLoS ONE"},{"issue":"7","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1212\/01.WNL.0000118213.94650.81","article-title":"LGI1 mutations in temporal lobe epilepsies","volume":"62","author":"Berkovic","year":"2004","journal-title":"Neurology"},{"issue":"10","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.autrev.2016.07.018","article-title":"From VGKC to LGI1 and Caspr2 encephalitis: The evolution of a disease entity over time","volume":"15","author":"van Sonderen","year":"2016","journal-title":"Autoimmun Rev"},{"issue":"6738 Suppl","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1038\/399a007","article-title":"The changing landscape of ischaemic brain injury mechanisms","volume":"399","author":"Lee","year":"1999","journal-title":"Nature"},{"issue":"2","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.57.2.7","article-title":"The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors","volume":"57","author":"Palmer","year":"2005","journal-title":"Pharmacol Rev"},{"issue":"8","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in acute stroke: Targeting excitotoxicity, oxidative and nitrosative stress, and inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol"},{"issue":"Suppl 1","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000074808","article-title":"Neuroprotection in cerebral ischaemia: Facts and fancies\u2013the need for new approaches","volume":"17","author":"Wahlgren","year":"2004","journal-title":"Cerebrovasc Dis"},{"issue":"8","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1093\/brain\/awx126","article-title":"Neuroprotection in stroke: The importance of collaboration and reproducibility","volume":"140","author":"Neuhaus","year":"2017","journal-title":"Brain"},{"issue":"9045","key":"2023022501100025200_","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0140-6736(96)04453-4","article-title":"Progression of ischaemic stroke and excitotoxic aminoacids","volume":"349","author":"Castillo","year":"1997","journal-title":"Lancet"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awac080\/44814226\/awac080.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/7\/2394\/49017675\/awac080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/7\/2394\/49017675\/awac080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:51:37Z","timestamp":1700254297000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/7\/2394\/6537118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,2,25]]},"published-print":{"date-parts":[[2022,7,29]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awac080","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.10.29.20222257","asserted-by":"object"}]},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,2,25]]}}}