{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:05:31Z","timestamp":1790402731274,"version":"4.1.0"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glial cell activation is a hallmark of several neurodegenerative and neuroinflammatory diseases. During HIV infection, neuroinflammation is associated with cognitive impairment, even during sustained long-term suppressive antiretroviral therapy. However, the cellular subsets contributing to neuronal damage in the CNS during HIV infection remain unclear.<\/jats:p>\n               <jats:p>Using post-mortem brain samples from eight HIV patients and eight non-neurological disease controls, we identify a subset of CNS phagocytes highly enriched in LGALS3, CTSB, GPNMB and HLA-DR, a signature identified in the context of ageing and neurodegeneration.<\/jats:p>\n               <jats:p>In HIV patients, the presence of this phagocyte phenotype was associated with synaptic stripping, suggesting an involvement in the pathogenesis of HIV-associated neurocognitive disorder.<\/jats:p>\n               <jats:p>Taken together, our findings elucidate some of the molecular signatures adopted by CNS phagocytes in HIV-positive patients and contribute to the understanding of how HIV might pave the way to other forms of cognitive decline in ageing HIV patient populations.<\/jats:p>","DOI":"10.1093\/brain\/awac102","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T20:15:44Z","timestamp":1647634544000},"page":"2730-2741","source":"Crossref","is-referenced-by-count":28,"title":["Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-0215","authenticated-orcid":false,"given":"Giovanni","family":"Di Liberto","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva , Geneva , Switzerland"},{"name":"Department of Clinical Neurosciences, Service of Neurology, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Egervari","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva , Geneva , Switzerland"},{"name":"Division of Clinical Pathology, Geneva University Hospital , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Kreutzfeldt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-1768","authenticated-orcid":false,"given":"Christian M","family":"Sch\u00fcrch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center T\u00fcbingen , T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Hewer","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Bern , Bern , 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