{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:11:20Z","timestamp":1790255480053,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"F\u00f6rderverein f\u00fcr HSP-Forschung"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Neurodevelopment and Vulnerability of the Central Nervous System","award":["270949263\/GRK2162"],"award-info":[{"award-number":["270949263\/GRK2162"]}]},{"name":"IZKF"},{"name":"Research Foundation Medicine at the University Clinic Erlangen"},{"name":"Federal Ministry of Education and Research TreatHSP consortium","award":["01GM1905B"],"award-info":[{"award-number":["01GM1905B"]}]},{"name":"Federal Ministry of Education and Research TreatHSP consortium","award":["01EK1609B"],"award-info":[{"award-number":["01EK1609B"]}]},{"name":"Tom Wahlig Foundation"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["CRC1027-C4; CRC894-A2"],"award-info":[{"award-number":["CRC1027-C4; CRC894-A2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["TRR219-C09"],"award-info":[{"award-number":["TRR219-C09"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["CRC877-A13"],"award-info":[{"award-number":["CRC877-A13"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["125440785"],"award-info":[{"award-number":["125440785"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pathogenic variants in SPAST, the gene coding for spastin, are the single most common cause of hereditary spastic paraplegia, a progressive motor neuron disease. Spastin regulates key cellular functions, including microtubule-severing and endoplasmic reticulum-morphogenesis. However, it remains unclear how alterations in these cellular functions due to SPAST pathogenic variants result in motor neuron dysfunction. Since spastin influences both microtubule network and endoplasmic reticulum structure, we hypothesized that spastin is necessary for the regulation of Ca2+ homeostasis via store-operated calcium entry.<\/jats:p>\n               <jats:p>Here, we show that the lack of spastin enlarges the endoplasmic reticulum and reduces store-operated calcium entry. In addition, elevated levels of different spastin variants induced clustering of STIM1 within the endoplasmic reticulum, altered the transport of STIM1 to the plasma membrane and reduced store-operated calcium entry, which could be rescued by exogenous expression of STIM1. Importantly, store-operated calcium entry was strongly reduced in induced pluripotent stem cell-derived neurons from hereditary spastic paraplegia patients with pathogenic variants in SPAST resulting in spastin haploinsufficiency. These neurons developed axonal swellings in response to lack of spastin. We were able to rescue both store-operated calcium entry and axonal swellings in SPAST patient neurons by restoring spastin levels, using CRISPR\/Cas9 to correct the pathogenic variants in SPAST.<\/jats:p>\n               <jats:p>These findings demonstrate that proper amounts of spastin are a key regulatory component for store-operated calcium entry mediated Ca2+ homeostasis and suggest store-operated calcium entry as a disease relevant mechanism of spastin-linked motor neuron disease.<\/jats:p>","DOI":"10.1093\/brain\/awac122","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T11:28:13Z","timestamp":1648553293000},"page":"3131-3146","source":"Crossref","is-referenced-by-count":14,"title":["Store-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-7719","authenticated-orcid":false,"given":"Tania","family":"Rizo","sequence":"first","affiliation":[{"name":"Department of Stem Cell Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-5747","authenticated-orcid":false,"given":"Lisa","family":"Gebhardt","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Riedlberger","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-7840","authenticated-orcid":false,"given":"Esther","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Fester","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Alansary","sequence":"additional","affiliation":[{"name":"Molecular Biophysics, University of Saarland, Center for Integrative Physiology and Molecular Medicine , 66421 Homburg\/Saar , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"},{"name":"Center of Rare Diseases Erlangen (ZSEER), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soeren","family":"Turan","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry (Emil-Fischer-Center), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Arnold","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-0575","authenticated-orcid":false,"given":"Barbara A","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Molecular Biophysics, University of Saarland, Center for Integrative Physiology and Molecular Medicine , 66421 Homburg\/Saar , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J M","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"},{"name":"Center of Physiology and Pharmacology, Medical University of Vienna , 1090 Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Winner","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"},{"name":"Center of Rare Diseases Erlangen (ZSEER), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"issue":"3","key":"2022122113343116600_awac122-B1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/15472","article-title":"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Article","volume":"23","author":"Hazan","year":"1999","journal-title":"Nat Genet"},{"issue":"3","key":"2022122113343116600_awac122-B2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/jmg.2005.035311","article-title":"Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases","volume":"43","author":"Depienne","year":"2006","journal-title":"J Med Genet"},{"issue":"4","key":"2022122113343116600_awac122-B3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.24611","article-title":"Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients","volume":"79","author":"Schule","year":"2016","journal-title":"Ann Neurol"},{"issue":"2","key":"2022122113343116600_awac122-B4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/archneurpsyc.1956.02330200038005","article-title":"Hereditary (familial) spastic paraplegia; further clinical and pathologic observations","volume":"75","author":"Schwarz","year":"1956","journal-title":"AMA Arch Neurol Psychiatry"},{"issue":"6","key":"2022122113343116600_awac122-B5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2990.2004.00587.x","article-title":"The extent of axonal loss in the long tracts in hereditary spastic paraplegia","volume":"30","author":"Deluca","year":"2004","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"2022122113343116600_awac122-B6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.yexcr.2005.06.009","article-title":"Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus","volume":"309","author":"Claudiani","year":"2005","journal-title":"Exp Cell Res"},{"issue":"7176","key":"2022122113343116600_awac122-B7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature06482","article-title":"Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin","volume":"451","author":"Roll-Mecak","year":"2008","journal-title":"Nature"},{"issue":"6404","key":"2022122113343116600_awac122-B8","doi-asserted-by":"crossref","first-page":"eaau1504","DOI":"10.1126\/science.aau1504","article-title":"Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation","volume":"361","author":"Vemu","year":"2018","journal-title":"Science"},{"issue":"21","key":"2022122113343116600_awac122-B9","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1091\/mbc.E16-05-0287","article-title":"Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration","volume":"27","author":"Rao","year":"2016","journal-title":"Mol Biol Cell"},{"key":"2022122113343116600_awac122-B10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1741-7007-6-31","article-title":"A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform","volume":"6","author":"Mancuso","year":"2008","journal-title":"BMC Biol"},{"issue":"10","key":"2022122113343116600_awac122-B11","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1093\/hmg\/ddt644","article-title":"Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients\u2019 neurons","volume":"23","author":"Havlicek","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"4","key":"2022122113343116600_awac122-B12","doi-asserted-by":"crossref","first-page":"e1005149","DOI":"10.1371\/journal.pgen.1005149","article-title":"Spastin binds to lipid droplets and affects lipid metabolism","volume":"11","author":"Papadopoulos","year":"2015","journal-title":"Plos Genet"},{"key":"2022122113343116600_awac122-B13","doi-asserted-by":"crossref","first-page":"dmm033704","DOI":"10.1242\/dmm.033704","article-title":"Functional differences of short and long isoforms of spastin harboring missense mutation","volume":"11","author":"Plaud","year":"2018","journal-title":"Dis Model Mech"},{"issue":"3","key":"2022122113343116600_awac122-B14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1124\/pr.110.003814","article-title":"Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease","volume":"63","author":"Stutzmann","year":"2011","journal-title":"Pharmacol Rev"},{"issue":"21","key":"2022122113343116600_awac122-B15","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1242\/jcs.015735","article-title":"Role of the microtubule cytoskeleton in the function of the store-operated Ca2\u2009+\u2009channel activator STIM1","volume":"120","author":"Smyth","year":"2007","journal-title":"J Cell Sci"},{"issue":"6","key":"2022122113343116600_awac122-B16","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1083\/jcb.201711151","article-title":"EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca(2+) entry","volume":"217","author":"Chang","year":"2018","journal-title":"J Cell Biol"},{"issue":"3","key":"2022122113343116600_awac122-B17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cub.2007.12.050","article-title":"STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER","volume":"18","author":"Grigoriev","year":"2008","journal-title":"Curr Biol"},{"issue":"1","key":"2022122113343116600_awac122-B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4160(86)90026-6","article-title":"A model for receptor-regulated calcium entry","volume":"7","author":"Putney JW","year":"1986","journal-title":"Cell Calcium"},{"issue":"1","key":"2022122113343116600_awac122-B19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.celrep.2017.12.030","article-title":"Coiled-coil formation conveys a STIM1 signal from ER lumen to cytoplasm","volume":"22","author":"Hirve","year":"2018","journal-title":"Cell Rep"},{"issue":"2","key":"2022122113343116600_awac122-B20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceca.2015.04.002","article-title":"Store-operated calcium entry compensates fast ER calcium loss in resting hippocampal neurons","volume":"58","author":"Samtleben","year":"2015","journal-title":"Cell Calcium"},{"key":"2022122113343116600_awac122-B21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/scisignal.2005242","article-title":"Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons","volume":"7","author":"Lalonde","year":"2014","journal-title":"Sci Signal"},{"issue":"5","key":"2022122113343116600_awac122-B22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/1073858415613277","article-title":"Roles of calcium stores and store-operated channels in plasticity of dendritic spines","volume":"22","author":"Segal","year":"2016","journal-title":"Neuroscientist"},{"key":"2022122113343116600_awac122-B23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fnmol.2018.00087","article-title":"On the role of store-operated calcium entry in acute and chronic neurodegenerative diseases","volume":"11","author":"Secondo","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"17","key":"2022122113343116600_awac122-B24","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.2401-20.2021","article-title":"Purkinje neurons with loss of STIM1 exhibit age-dependent changes in gene expression and synaptic components","volume":"41","author":"Dhanya","year":"2021","journal-title":"J Neurosci"},{"issue":"1","key":"2022122113343116600_awac122-B25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1523\/JNEUROSCI.1038-15.2016","article-title":"Enhanced store-operated calcium entry leads to striatal synaptic loss in a Huntington's Disease mouse model","volume":"36","author":"Wu","year":"2016","journal-title":"J Neurosci"},{"issue":"6","key":"2022122113343116600_awac122-B26","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.2689-13.2014","article-title":"Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis","volume":"34","author":"Kawamata","year":"2014","journal-title":"J Neurosci"},{"issue":"13","key":"2022122113343116600_awac122-B27","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1242\/jcs.008979","article-title":"Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes","volume":"120","author":"Nikonov","year":"2007","journal-title":"J Cell Sci"},{"key":"2022122113343116600_awac122-B28","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1083\/jcb.103.4.1557","article-title":"Microtubules and the endoplasmic reticulum are highly interdependent structures","volume":"103","author":"Terasaki","year":"1986","journal-title":"J Cell Biol."},{"key":"2022122113343116600_awac122-B29","doi-asserted-by":"crossref","first-page":"9380","DOI":"10.1074\/jbc.M114.548602","article-title":"Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry","volume":"289","author":"Levente","year":"2014","journal-title":"J Biol Chem."},{"issue":"2","key":"2022122113343116600_awac122-B30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10048-006-0034-4","article-title":"Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. journal article","volume":"7","author":"Mannan","year":"2006","journal-title":"Neurogenetics"},{"issue":"2","key":"2022122113343116600_awac122-B31","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/stem.1569","article-title":"Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia","volume":"32","author":"Denton","year":"2014","journal-title":"Stem Cells"},{"issue":"1","key":"2022122113343116600_awac122-B32","doi-asserted-by":"crossref","first-page":"9615","DOI":"10.1038\/s41598-019-45246-4","article-title":"Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons","volume":"9","author":"Rehbach","year":"2019","journal-title":"Sci Rep"},{"issue":"5","key":"2022122113343116600_awac122-B33","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1083\/jcb.201609033","article-title":"Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia","volume":"216","author":"Allison","year":"2017","journal-title":"J Cell Biol"},{"issue":"5","key":"2022122113343116600_awac122-B34","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"1","key":"2022122113343116600_awac122-B35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13059-016-1012-2","article-title":"Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR","volume":"17","author":"Haeussler","year":"2016","journal-title":"Genome Biol"},{"issue":"22","key":"2022122113343116600_awac122-B36","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1093\/nar\/gku936","article-title":"Easy quantitative assessment of genome editing by sequence trace decomposition","volume":"42","author":"Brinkman","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"2022122113343116600_awac122-B37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.201211045","article-title":"An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome","volume":"202","author":"Allison","year":"2013","journal-title":"J Cell Biol"},{"key":"2022122113343116600_awac122-B38","doi-asserted-by":"crossref","first-page":"33347","DOI":"10.1038\/srep33347","article-title":"Thiol dependent intramolecular locking of Orai1 channels","volume":"6","author":"Alansary","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"2022122113343116600_awac122-B39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0165-0270(98)00051-X","article-title":"A technique for fast application of heated solutions of different composition to cultured neurones","volume":"82","author":"Dittert","year":"1998","journal-title":"J Neurosci Methods"},{"issue":"3","key":"2022122113343116600_awac122-B40","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1167\/iovs.17-23266","article-title":"Differentiation patterns of immortalized human meibomian gland epithelial cells in three-dimensional culture","volume":"59","author":"Asano","year":"2018","journal-title":"Invest Ophthalmol Vis sci"},{"issue":"13","key":"2022122113343116600_awac122-B41","doi-asserted-by":"crossref","first-page":"9380","DOI":"10.1074\/jbc.M114.548602","article-title":"Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry","volume":"289","author":"Jozsef","year":"2014","journal-title":"J Biol Chem"},{"issue":"10","key":"2022122113343116600_awac122-B42","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00109-018-1677-y","article-title":"STIM1 deficiency is linked to Alzheimer\u2019s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca(2+) entry","volume":"96","author":"Pascual-Caro","year":"2018","journal-title":"J Mol Med (Berl)"},{"issue":"5","key":"2022122113343116600_awac122-B43","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1471-4159.2009.05875.x","article-title":"Pleiotropic effects of spastin on neurite growth depending on expression levels","volume":"108","author":"Riano","year":"2009","journal-title":"J Neurochem"},{"issue":"8","key":"2022122113343116600_awac122-B44","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/anie.201408614","article-title":"NeuO: a fluorescent chemical probe for live neuron labeling","volume":"54","author":"Er","year":"2015","journal-title":"Angew Chem Int Ed Engl"},{"issue":"4","key":"2022122113343116600_awac122-B45","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"J Clin Invest"},{"key":"2022122113343116600_awac122-B46","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3389\/fphys.2019.01544","article-title":"Microtubules stabilization by mutant spastin affects er morphology and Ca(2+) handling","volume":"10","author":"Vajente","year":"2019","journal-title":"Front Physiol"},{"key":"2022122113343116600_awac122-B47","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.expneurol.2014.06.011","article-title":"Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms","volume":"261","author":"Giudice T","year":"2014","journal-title":"Exp Neurol"},{"key":"2022122113343116600_awac122-B48","doi-asserted-by":"crossref","first-page":"43490","DOI":"10.1038\/srep43490","article-title":"Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"issue":"8","key":"2022122113343116600_awac122-B49","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.4049\/jimmunol.174.8.4584","article-title":"Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathway","volume":"174","author":"Oka","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"2022122113343116600_awac122-B50","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1083\/jcb.103.4.1557","article-title":"Microtubules and the endoplasmic reticulum are highly interdependent structures","volume":"103","author":"Terasaki","year":"1986","journal-title":"J Cell Biol"},{"issue":"7","key":"2022122113343116600_awac122-B51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.e13-12-0712","article-title":"ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays","volume":"25","author":"Joensuu","year":"2014","journal-title":"Mol Biol Cell"},{"issue":"2","key":"2022122113343116600_awac122-B52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.yexcr.2015.04.009","article-title":"ER sheet\u2013tubule balance is regulated by an array of actin filaments and microtubules","volume":"337","author":"Joensuu","year":"2015","journal-title":"Exp Cell Res"},{"issue":"11","key":"2022122113343116600_awac122-B53","doi-asserted-by":"crossref","first-page":"108844","DOI":"10.1016\/j.celrep.2021.108844","article-title":"A short isoform of STIM1 confers frequency-dependent synaptic enhancement","volume":"34","author":"Ramesh","year":"2021","journal-title":"Cell Rep"},{"issue":"4","key":"2022122113343116600_awac122-B54","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bcp.2011.05.017","article-title":"The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2\u2009+\u2009channel subunits Orai1 and TRPC1","volume":"82","author":"Galan","year":"2011","journal-title":"Biochem pharmacol"},{"issue":"7","key":"2022122113343116600_awac122-B55","doi-asserted-by":"crossref","first-page":"a035212","DOI":"10.1101\/cshperspect.a035212","article-title":"Calcium-handling defects and neurodegenerative disease","volume":"12","author":"Schrank","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"2022122113343116600_awac122-B56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stemcr.2018.11.021","article-title":"Neurite collapse and altered ER Ca(2+) control in human Parkinson disease patient iPSC-derived neurons with LRRK2 G2019S mutation","volume":"12","author":"Korecka","year":"2019","journal-title":"Stem Cell Rep"},{"issue":"25","key":"2022122113343116600_awac122-B57","doi-asserted-by":"crossref","first-page":"10326","DOI":"10.1073\/pnas.0902982106","article-title":"Intracellular Ca2\u2009+\u2009signaling and store-operated Ca2\u2009+\u2009entry are required in Drosophila neurons for flight","volume":"106","author":"Venkiteswaran","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2022122113343116600_awac122-B58","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/j.bbamcr.2016.08.001","article-title":"In vitro aging promotes endoplasmic reticulum (ER)-mitochondria Ca(2+) cross talk and loss of store-operated Ca(2+) entry (SOCE) in rat hippocampal neurons","volume":"1863","author":"Calvo-Rodriguez","year":"2016","journal-title":"Biochim Biophys Acta"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/9\/3131\/48304966\/awac122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/145\/9\/3131\/48304966\/awac122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T13:35:53Z","timestamp":1671629753000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/145\/9\/3131\/6651093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,7,28]]},"published-print":{"date-parts":[[2022,9,14]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awac122","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,7,28]]}}}