{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:30:58Z","timestamp":1790721058663,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Spinal Cord Consortium of the Christopher and Dana Reeve Foundation"},{"DOI":"10.13039\/100008191","name":"Wings for Life Spinal Cord Research Foundation","doi-asserted-by":"crossref","award":["WFL-CH-30\/17"],"award-info":[{"award-number":["WFL-CH-30\/17"]}],"id":[{"id":"10.13039\/100008191","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u2018Forschungskredit Candoc\u2019 of the University of Zurich","award":["FK-17-035"],"award-info":[{"award-number":["FK-17-035"]}]},{"DOI":"10.13039\/100012545","name":"Foundation for Research in Science and the Humanities at the University of Zurich","doi-asserted-by":"crossref","award":["STWF-19-011"],"award-info":[{"award-number":["STWF-19-011"]}],"id":[{"id":"10.13039\/100012545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe spinal cord injuries result in permanent paraparesis in spite of the frequent sparing of small portions of white matter. Spared fibre tracts are often incapable of maintaining and modulating the activity of lower spinal motor centres. Effects of rehabilitative training thus remain limited.<\/jats:p>\n               <jats:p>Here, we activated spared descending brainstem fibres by electrical deep brain stimulation of the cuneiform nucleus of the mesencephalic locomotor region, the main control centre for locomotion in the brainstem, in adult female Lewis rats.<\/jats:p>\n               <jats:p>We show that deep brain stimulation of the cuneiform nucleus enhances the weak remaining motor drive in highly paraparetic rats with severe, incomplete spinal cord injuries and enables high-intensity locomotor training. Stimulation of the cuneiform nucleus during rehabilitative aquatraining after subchronic (n = 8 stimulated versus n = 7 unstimulated versus n = 7 untrained rats) and chronic (n = 14 stimulated versus n = 9 unstimulated versus n = 9 untrained rats) spinal cord injury re-established substantial locomotion and improved long-term recovery of motor function. We additionally identified a safety window of stimulation parameters ensuring context-specific locomotor control in intact rats (n = 18) and illustrate the importance of timing of treatment initiation after spinal cord injury (n = 14).<\/jats:p>\n               <jats:p>This study highlights stimulation of the cuneiform nucleus as a highly promising therapeutic strategy to enhance motor recovery after subchronic and chronic incomplete spinal cord injury with direct clinical applicability.<\/jats:p>","DOI":"10.1093\/brain\/awac184","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:05:04Z","timestamp":1652871904000},"page":"3681-3697","source":"Crossref","is-referenced-by-count":33,"title":["Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury"],"prefix":"10.1093","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-2140","authenticated-orcid":false,"given":"Anna-Sophie","family":"Hofer","sequence":"first","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam I","family":"Scheuber","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M","family":"Sartori","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Good","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A","family":"Stalder","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hammer","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fricke","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina M","family":"Schalbetter","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K","family":"Engmann","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Z","family":"Weber","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Rust","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P","family":"Schneider","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Russi","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomin","family":"Favre","sequence":"additional","affiliation":[{"name":"Department of Economics, University of Zurich , 8032 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E","family":"Schwab","sequence":"additional","affiliation":[{"name":"Brain Research Institute, University of Zurich , 8057 Zurich , Switzerland"},{"name":"Institute for Regenerative Medicine, University of Zurich , 8952 Schlieren , Switzerland"},{"name":"Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"2022102119175694000_awac184-B1","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1089\/neu.2016.4513","article-title":"From the rodent spinal cord injury model to human application: Promises and 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