{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:05Z","timestamp":1792793825194,"version":"4.5.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Brain Tumour Research Charity","id":[{"id":"https:\/\/ror.org\/018kx8h28","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Vivace Therapeutics Inc."},{"DOI":"10.13039\/100001545","name":"Children\u2019s Tumor Foundation","doi-asserted-by":"crossref","award":["2020-01-008"],"award-info":[{"award-number":["2020-01-008"]}],"id":[{"id":"10.13039\/100001545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and the surgical removal of the tumour carries a high risk of damage to the eighth or other close cranial nerve tissue. New treatments for schwannoma and other NF2-null tumours such as meningioma are urgently required.<\/jats:p>\n                  <jats:p>Using a combination of human primary tumour cells and mouse models of schwannoma, we have examined the role of the Hippo signalling pathway in driving tumour cell growth. Using both genetic ablation of the Hippo effectors YAP and TAZ as well as novel TEAD palmitoylation inhibitors, we show that Hippo signalling may be successfully targeted in vitro and in vivo to both block and, remarkably, regress schwannoma tumour growth. In particular, successful use of TEAD palmitoylation inhibitors in a preclinical mouse model of schwannoma points to their potential future clinical use. We also identify the cancer stem cell marker aldehyde dehydrogenase 1A1 (ALDH1A1) as a Hippo signalling target, driven by the TAZ protein in human and mouse NF2-null schwannoma cells, as well as in NF2-null meningioma cells, and examine the potential future role of this new target in halting schwannoma and meningioma tumour growth.<\/jats:p>","DOI":"10.1093\/brain\/awac342","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T04:10:28Z","timestamp":1663906228000},"page":"1697-1713","source":"Crossref","is-referenced-by-count":64,"title":["Inhibition of YAP\/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma"],"prefix":"10.1093","volume":"146","author":[{"given":"Liyam","family":"Laraba","sequence":"first","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Hillson","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Grimm","family":"de Guibert","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisie R","family":"Jaques","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Bath , Bath, Somerset BA2 7AY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy T","family":"Tang","sequence":"additional","affiliation":[{"name":"Vivace Therapeutics Inc. , San Mateo, CA 94403 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Post","sequence":"additional","affiliation":[{"name":"Vivace Therapeutics Inc. , San Mateo, CA 94403 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Ercolano","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesha","family":"Rai","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD 20850 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD 20850 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Jagger","sequence":"additional","affiliation":[{"name":"UCL Ear Institute, University College London , London WC1X 8EE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Woznica","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Cellular and Anatomical Pathology, University Hospitals Plymouth NHS Trust , Derriford, Plymouth, Devon PL6 8DH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya G","family":"Shivane","sequence":"additional","affiliation":[{"name":"Department of Cellular and Anatomical Pathology, University Hospitals Plymouth NHS Trust , Derriford, Plymouth, Devon PL6 8DH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Oliver","family":"Hanemann","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-4923","authenticated-orcid":false,"given":"David B","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Faculty of Heath: Medicine, Dentistry and Human Sciences, Derriford Research Facility, University of Plymouth , Plymouth, Devon PL6 8BU , 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