{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:31:37Z","timestamp":1789543897964,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["NHMRC GN2001283"],"award-info":[{"award-number":["NHMRC GN2001283"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136649"],"award-info":[{"award-number":["APP1136649"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1118153"],"award-info":[{"award-number":["APP1118153"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Perrin and Dowling family foundations"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1U54MH091657"],"award-info":[{"award-number":["1U54MH091657"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The diagnosis of obsessive-compulsive disorder (OCD) has been linked with changes in frontostriatal resting-state connectivity. However, replication of prior findings is lacking, and the mechanistic understanding of these effects is incomplete. To confirm and advance knowledge on changes in frontostriatal functional connectivity in OCD, participants with OCD and matched healthy controls underwent resting-state functional, structural and diffusion neuroimaging.<\/jats:p>\n                  <jats:p>Functional connectivity changes in frontostriatal systems were here replicated in individuals with OCD (n = 52) compared with controls (n = 45). OCD participants showed greater functional connectivity (t = 4.3, PFWE = 0.01) between the nucleus accumbens (NAcc) and the orbitofrontal cortex (OFC) but lower functional connectivity between the dorsal putamen and lateral prefrontal cortex (t = 3.8, PFWE = 0.04) relative to controls. Computational modelling suggests that NAcc-OFC connectivity changes reflect an increased influence of NAcc over OFC activity and reduced OFC influence over NAcc activity (posterior probability, Pp &amp;gt; 0.66). Conversely, dorsal putamen showed reduced modulation over lateral prefrontal cortex activity (Pp &amp;gt; 0.90). These functional deregulations emerged on top of a generally intact anatomical substrate.<\/jats:p>\n                  <jats:p>We provide out-of-sample replication of opposite changes in ventro-anterior and dorso-posterior frontostriatal connectivity in OCD and advance the understanding of the neural underpinnings of these functional perturbations. These findings inform the development of targeted therapies normalizing frontostriatal dynamics in OCD.<\/jats:p>","DOI":"10.1093\/brain\/awac425","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T01:01:19Z","timestamp":1668560479000},"page":"1322-1327","source":"Crossref","is-referenced-by-count":31,"title":["Mechanisms of imbalanced frontostriatal functional connectivity in obsessive-compulsive disorder"],"prefix":"10.1093","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-402X","authenticated-orcid":false,"given":"Sebastien","family":"Naze","sequence":"first","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J","family":"Hearne","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Sanz-Leon","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Burgher","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-0579","authenticated-orcid":false,"given":"Saurabh","family":"Sonkusare","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoie","family":"Nott","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , 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University of Melbourne and Melbourne Health , Melbourne 3053 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Breakspear","sequence":"additional","affiliation":[{"name":"College of Engineering Science and Environment, College of Health and Medicine, University of Newcastle , Callaghan 2308 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-2676","authenticated-orcid":false,"given":"Luca","family":"Cocchi","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute , Brisbane 4006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"2023080918550448700_awac425-B1","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1038\/s41380-020-01007-8","article-title":"Toward a neurocircuit-based taxonomy to 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