{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:41:20Z","timestamp":1771382480785,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ForeFront"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1132524"],"award-info":[{"award-number":["1132524"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1095127"],"award-info":[{"award-number":["1095127"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1060992"],"award-info":[{"award-number":["1060992"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NHMRC Practitioner Fellowship","award":["1156093"],"award-info":[{"award-number":["1156093"]}]},{"name":"NHMRC Senior Leadership Fellowship","award":["1176607"],"award-info":[{"award-number":["1176607"]}]},{"name":"FightMND Mid-Career Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"DOI":"10.1093\/brain\/awac467","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T17:21:40Z","timestamp":1671643300000},"page":"e17-e19","source":"Crossref","is-referenced-by-count":4,"title":["Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis"],"prefix":"10.1093","volume":"146","author":[{"given":"Srestha","family":"Mazumder","sequence":"first","affiliation":[{"name":"Brain and Mind Centre, University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-8969","authenticated-orcid":false,"given":"Heather","family":"McCann","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick, NSW 2031 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"D\u2019Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University Centre for Motor Neuron Disease Research, Macquarie University , Sydney, NSW 2109 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Furlong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University Centre for Motor Neuron Disease Research, Macquarie University , Sydney, NSW 2109 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-3218","authenticated-orcid":false,"given":"Claire E","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick, NSW 2031 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-8674","authenticated-orcid":false,"given":"Jillian J","family":"Kril","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences, University of Sydney , Camperdown, NSW 2006 , Australia"},{"name":"Dementia Research Centre, Macquarie Medical School, Macquarie University , Sydney, NSW 2109 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-8398","authenticated-orcid":false,"given":"Glenda M","family":"Halliday","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Faculty of Medicine and Health, School of Medical Sciences, University of Sydney , Camperdown, NSW 2006 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University Centre for Motor Neuron Disease Research, Macquarie University , Sydney, NSW 2109 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-026X","authenticated-orcid":false,"given":"Matthew C","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Institute of Clinical Neurosciences, Royal Prince Alfred Hospital , Sydney, NSW 2050 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel H","family":"Tan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, University of Sydney , Sydney, NSW 2050 , Australia"},{"name":"Faculty of Medicine and Health, School of Medical Sciences, University of Sydney , Camperdown, NSW 2006 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1093\/brain\/awab222","article-title":"Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer's disease","volume":"144","author":"Matthews","year":"2021","journal-title":"Brain"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/awt085","article-title":"Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis","volume":"136","author":"Vucic","year":"2013","journal-title":"Brain"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1093\/brain\/awv220","article-title":"TDP-43 proteinopathies: Pathological identification of brain regions differentiating clinical phenotypes","volume":"138","author":"Tan","year":"2015","journal-title":"Brain"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3233\/JAD-160365","article-title":"Neuritic and diffuse plaque associations with memory in non-cognitively impaired elderly","volume":"53","author":"Malek-Ahmadi","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.25246","article-title":"Combined neuropathological pathways account for age-related risk of dementia","volume":"84","author":"Power","year":"2018","journal-title":"Ann Neurol"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-020-02211-0","article-title":"Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy","volume":"140","author":"Katsumata","year":"2020","journal-title":"Acta Neuropathol"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2023030117464257000_","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40478-020-00934-5","article-title":"Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: Relationship with clinical phenotypes","volume":"8","author":"Tome","year":"2020","journal-title":"Acta Neuropathol Commun"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awac467\/48804150\/awac467.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/3\/e17\/49356284\/awac467.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/3\/e17\/49356284\/awac467.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T16:44:31Z","timestamp":1679071471000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/146\/3\/e17\/6948436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,12,21]]},"published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awac467","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,12,21]]}}}