{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:50:17Z","timestamp":1789678217429,"version":"4.0.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020410","name":"John and Lucille van Geest Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020410","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"the Medical Research Council UK","doi-asserted-by":"crossref","award":["MR\/K500811\/1"],"award-info":[{"award-number":["MR\/K500811\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cohen Charitable Trust"},{"name":"the Medical Research Councils UK","award":["MR\/N030087\/1"],"award-info":[{"award-number":["MR\/N030087\/1"]}]},{"name":"the Medical Research Councils UK","award":["MR\/S00484X\/1"],"award-info":[{"award-number":["MR\/S00484X\/1"]}]},{"name":"the Medical Research Councils UK","award":["MC_PC_18052"],"award-info":[{"award-number":["MC_PC_18052"]}]},{"name":"the Galen and Hilary Weston Foundation"},{"name":"Rhodes Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer\u2019s disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer\u2019s disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer\u2019s disease or remained cognitively stable. Mild cognitive impairment to Alzheimer\u2019s disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of \u2018baseline\u2019 cellular readouts together with education level were able to predict Alzheimer\u2019s disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.<\/jats:p>","DOI":"10.1093\/brain\/awac472","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T17:53:35Z","timestamp":1670954015000},"page":"2045-2058","source":"Crossref","is-referenced-by-count":30,"title":["Predicting progression to Alzheimer\u2019s disease with human hippocampal progenitors exposed to serum"],"prefix":"10.1093","volume":"146","author":[{"given":"Aleksandra","family":"Maruszak","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Silajd\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytus","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamine","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"de Lucia","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Douiri","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, King's College London , London, SE1 1UL , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Salta","sequence":"additional","affiliation":[{"name":"Netherlands Institute for Neuroscience , 1105 BA Amsterdam , The Netherlands"},{"name":"Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center , 1007 MB Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejo J","family":"Nevado","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center , 1007 MB Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University , 6200 MD Maastricht , The Netherlands"},{"name":"Department of Neurology, Alzheimer Center, VU University Medical Center , 1081 HZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , S-431 80 M\u00f6lndal , Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology , London, WC1N 3BG , UK"},{"name":"Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg , S-431 80 M\u00f6lndal , Sweden"},{"name":"UK Dementia Research Institute at UCL , London, WC1E 6BT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford , Oxford, OX3 7JX , UK"},{"name":"Janssen Medical UK , B-2340 Beerse , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-8083","authenticated-orcid":false,"given":"Sandrine","family":"Thuret","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King\u2019s College London , London, SE5 9RX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"2023050200144654000_awac472-B1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1474-4422(03)00262-X","article-title":"Mild cognitive impairment: Prevalence, prognosis, aetiology, and 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