{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:22:28Z","timestamp":1782919348639,"version":"3.54.5"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:p>This scientific commentary refers to \u2018Extremes of baseline cognitive function determine the severity of delirium: a population study\u2019 by Tsui et al. (https:\/\/doi.org\/10.1093\/brain\/awad062).<\/jats:p>","DOI":"10.1093\/brain\/awad115","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T03:02:35Z","timestamp":1680750155000},"page":"1743-1744","source":"Crossref","is-referenced-by-count":1,"title":["The U-shaped curve predicting cognitive vulnerability to delirium severity"],"prefix":"10.1093","volume":"146","author":[{"given":"Richard C","family":"Lennertz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin , Madison , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-0328","authenticated-orcid":false,"given":"Robert D","family":"Sanders","sequence":"additional","affiliation":[{"name":"Central Clinical School, Faculty of Medicine and Health, The University of Sydney , New South Wales , Australia"},{"name":"Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District , New South Wales , Australia"},{"name":"Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney Local Health District , New South Wales , Australia"},{"name":"NHMRC Clinical Trials Centre, The University of Sydney , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"2024041009322124700_awad115-B1","doi-asserted-by":"crossref","first-page":"l4466","DOI":"10.1136\/bmj.l4466","article-title":"Association between major surgical admissions and the cognitive trajectory: 19 year follow-up of Whitehall II cohort study","volume":"366","author":"Krause","year":"2019","journal-title":"BMJ"},{"key":"2024041009322124700_awad115-B2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/gps.5104","article-title":"Predicting postoperative delirium severity in older adults: The role of surgical risk and executive function","volume":"34","author":"Lindroth","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"2024041009322124700_awad115-B3","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1093\/brain\/awad062","article-title":"Extremes of baseline cognitive function determine the severity of delirium: A population study","volume":"146","author":"Tsui","year":"2023","journal-title":"Brain"},{"key":"2024041009322124700_awad115-B4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bja.2021.02.028","article-title":"Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium","volume":"127","author":"White","year":"2021","journal-title":"Br J Anaesth"},{"key":"2024041009322124700_awad115-B5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bja.2020.02.027","article-title":"Cohort study into the neural correlates of postoperative delirium: The role of connectivity and slow-wave activity","volume":"125","author":"Tanabe","year":"2020","journal-title":"Br J Anaesth"},{"key":"2024041009322124700_awad115-B6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.mehy.2011.03.048","article-title":"Hypothesis for the pathophysiology of delirium: Role of baseline brain network connectivity and changes in inhibitory tone","volume":"77","author":"Sanders","year":"2011","journal-title":"Med Hypotheses"},{"key":"2024041009322124700_awad115-B7","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1523\/JNEUROSCI.4673-11.2012","article-title":"Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: Reconciling inflammatory and cholinergic hypotheses of delirium","volume":"32","author":"Field","year":"2012","journal-title":"J Neurosci"},{"key":"2024041009322124700_awad115-B8","doi-asserted-by":"crossref","first-page":"15248","DOI":"10.1523\/JNEUROSCI.6361-11.2013","article-title":"Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction","volume":"33","author":"Griffin","year":"2013","journal-title":"J Neurosci"},{"key":"2024041009322124700_awad115-B9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bja.2020.12.040","article-title":"Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: Potential implications for delirium science","volume":"126","author":"Sultan","year":"2021","journal-title":"Br J Anaesth"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awad115\/50010570\/awad115.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/5\/1743\/57196182\/awad115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/5\/1743\/57196182\/awad115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T09:39:33Z","timestamp":1712741973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/146\/5\/1743\/7109292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,4,6]]},"published-print":{"date-parts":[[2023,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awad115","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,2]]},"published":{"date-parts":[[2023,4,6]]}}}