{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:12:51Z","timestamp":1792548771692,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32EB021937"],"award-info":[{"award-number":["T32EB021937"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS075270"],"award-info":[{"award-number":["R01 NS075270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS108445"],"award-info":[{"award-number":["R01 NS108445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS110130"],"award-info":[{"award-number":["R01 NS110130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00 NS097618"],"award-info":[{"award-number":["R00 NS097618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epilepsy surgery consists of surgical resection of the epileptic focus and is recommended for patients with drug-resistant focal epilepsy. However, focal brain lesions can lead to effects in distant brain regions. Similarly, the focal resection in temporal lobe epilepsy surgery has been shown to lead to functional changes distant from the resection. Here we hypothesize that there are changes in brain function caused by temporal lobe epilepsy surgery in regions distant from the resection that are due to their structural disconnection from the resected epileptic focus. Therefore, the goal of this study was to localize changes in brain function caused by temporal lobe epilepsy surgery and relate them to the disconnection from the resected epileptic focus. This study takes advantage of the unique opportunity that epilepsy surgery provides to investigate the effects of focal disconnections on brain function in humans, which has implications in epilepsy and broader neuroscience.<\/jats:p>\n               <jats:p>Changes in brain function from pre- to post-epilepsy surgery were quantified in a group of temporal lobe epilepsy patients (n = 36) using a measure of resting state functional MRI activity fluctuations. We identified regions with significant functional MRI changes that had high structural connectivity to the resected region in healthy controls (n = 96) and patients based on diffusion MRI. The structural disconnection from the resected epileptic focus was then estimated using presurgical diffusion MRI and related to the functional MRI changes from pre- to post-surgery in these regions.<\/jats:p>\n               <jats:p>Functional MRI activity fluctuations increased from pre- to post-surgery in temporal lobe epilepsy in the two regions most highly structurally connected to the resected epileptic focus in healthy controls and patients\u2014the thalamus and the fusiform gyrus ipsilateral to the side of surgery (PFWE &amp;lt; 0.05). Broader surgeries led to larger functional MRI changes in the thalamus than more selective surgeries (P &amp;lt; 0.05), but no other clinical variables were related to functional MRI changes in either the thalamus or fusiform. The magnitude of the functional MRI changes in both the thalamus and fusiform increased with a higher estimated structural disconnection from the resected epileptic focus when controlling for the type of surgery (P &amp;lt; 0.05). These results suggest that the structural disconnection from the resected epileptic focus may contribute to the functional changes seen after epilepsy surgery. Broadly, this study provides a novel link between focal disconnections in the structural brain network and downstream effects on function in distant brain regions.<\/jats:p>","DOI":"10.1093\/brain\/awad117","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T16:22:37Z","timestamp":1680711757000},"page":"3913-3922","source":"Crossref","is-referenced-by-count":24,"title":["Structural disconnection relates to functional changes after temporal lobe epilepsy surgery"],"prefix":"10.1093","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-5871","authenticated-orcid":false,"given":"Lucas E","family":"Sainburg","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA"},{"name":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , 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Medical Center , Nashville, TN 37232 , USA"},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baxter P","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA"},{"name":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-9579","authenticated-orcid":false,"given":"Catie","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA"},{"name":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"},{"name":"Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario J","family":"Englot","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA"},{"name":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"},{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"},{"name":"Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-2324","authenticated-orcid":false,"given":"Victoria L","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt 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