{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:34:04Z","timestamp":1780086844626,"version":"3.54.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prominent positive effects on the pathophysiology of many neurological disorders, the mechanism of action is obscure. Attention paid to elucidating the role of Nkcc1 has mainly been focused on neurons, but recent single cell mRNA sequencing analysis has demonstrated that the major cellular populations expressing NKCC1 in the cortex are non-neuronal.<\/jats:p>\n               <jats:p>We used a combination of conditional transgenic animals, in vivo electrophysiology, two-photon imaging, cognitive behavioural tests and flow cytometry to investigate the role of Nkcc1 inhibition by bumetanide in a mouse model of controlled cortical impact (CCI).<\/jats:p>\n               <jats:p>Here, we found that bumetanide rescues parvalbumin-positive interneurons by increasing interneuron-microglia contacts shortly after injury. The longitudinal phenotypic changes in microglia were significantly modified by bumetanide, including an increase in the expression of microglial-derived BDNF. These effects were accompanied by the prevention of CCI-induced decrease in hippocampal neurogenesis. Treatment with bumetanide during the first week post-CCI resulted in significant recovery of working and episodic memory as well as changes in theta band oscillations 1 month later.<\/jats:p>\n               <jats:p>These results disclose a novel mechanism for the neuroprotective action of bumetanide mediated by an acceleration of microglial activation dynamics that leads to an increase in parvalbumin interneuron survival following CCI, possibly resulting from increased microglial BDNF expression and contact with interneurons. Salvage of interneurons may normalize ambient GABA, resulting in the preservation of adult neurogenesis processes as well as contributing to bumetanide-mediated improvement of cognitive performance.<\/jats:p>","DOI":"10.1093\/brain\/awad132","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T08:58:36Z","timestamp":1682067516000},"page":"4247-4261","source":"Crossref","is-referenced-by-count":16,"title":["Bumetanide induces post-traumatic microglia\u2013interneuron contact to promote neurogenesis and recovery"],"prefix":"10.1093","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-829X","authenticated-orcid":false,"given":"Marine","family":"Tessier","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Saez","family":"Garcia","sequence":"additional","affiliation":[{"name":"Neuroscience Center, 00014 University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Goubert","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Blasco","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Consumi","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Dehapiot","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, IBDM-UMR7288, Turing Center for Living Systems , 13288 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-7920","authenticated-orcid":false,"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Translational Medicine, University of Tartu , 50411 Tartu , Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Molinari","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, MMG , 50411 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Laurin","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guillemot","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute , London NW1 1AT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik, Universit\u00e4tsklinikum Jena , 07747 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Rivera","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, INMED , 13273 Marseille , France"},{"name":"Neuroscience Center, 00014 University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"2023100302130837300_awad132-B1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: A systematic analysis for the global burden of disease study 2016","volume":"18","author":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators","year":"2019","journal-title":"Lancet Neurol"},{"key":"2023100302130837300_awad132-B2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0029-1223878","article-title":"Neuropsychiatric sequelae of traumatic brain injury","volume":"29","author":"Nicholl","year":"2009","journal-title":"Semin Neurol"},{"key":"2023100302130837300_awad132-B3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/neu.2015.4097","article-title":"Traumatic brain injury severity affects neurogenesis in adult mouse hippocampus","volume":"33","author":"Wang","year":"2016","journal-title":"J Neurotrauma."},{"key":"2023100302130837300_awad132-B4","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1089\/neu.2010.1579","article-title":"Neurogenesis in adult human brain after traumatic brain injury","volume":"30","author":"Zheng","year":"2013","journal-title":"J Neurotrauma."},{"key":"2023100302130837300_awad132-B5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1750-3639.1995.tb00618.x","article-title":"The nature, distribution and causes of traumatic brain injury","volume":"5","author":"Graham","year":"1995","journal-title":"Brain Pathol"},{"key":"2023100302130837300_awad132-B6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnmol.2019.00012","article-title":"Bumetanide prevents brain trauma-induced depressive-like behavior","volume":"12","author":"Goubert","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"2023100302130837300_awad132-B7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nature11306","article-title":"Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision","volume":"489","author":"Song","year":"2012","journal-title":"Nature"},{"key":"2023100302130837300_awad132-B8","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/ana.1230","article-title":"Long-term hyperexcitability in the hippocampus after experimental head trauma","volume":"50","author":"Santhakumar","year":"2001","journal-title":"Ann Neurol."},{"key":"2023100302130837300_awad132-B9","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1038\/s41598-017-09202-4","article-title":"The NADPH oxidase NOX2 mediates loss of parvalbumin interneurons in traumatic brain injury: Human autoptic immunohistochemical evidence","volume":"7","author":"Schiavone","year":"2017","journal-title":"Sci Rep"},{"key":"2023100302130837300_awad132-B10","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1523\/JNEUROSCI.17-21-08106.1997","article-title":"Instantaneous perturbation of dentate interneuronal networks by a pressure wave-transient delivered to the neocortex","volume":"17","author":"Toth","year":"1997","journal-title":"J Neurosci."},{"key":"2023100302130837300_awad132-B11","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1089\/neu.2013.3080","article-title":"Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage","volume":"31","author":"Glushakova","year":"2014","journal-title":"J Neurotrauma"},{"key":"2023100302130837300_awad132-B12","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: Etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2023100302130837300_awad132-B13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1126\/science.1227901","article-title":"Microglia: Scapegoat, saboteur, or something else?","volume":"339","author":"Aguzzi","year":"2013","journal-title":"Science"},{"key":"2023100302130837300_awad132-B14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00024382-200116030-00001","article-title":"Role of cerebral inflammation after traumatic brain injury: A revisited concept","volume":"16","author":"Morganti-Kossmann","year":"2001","journal-title":"Shock"},{"key":"2023100302130837300_awad132-B15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.aax6752","article-title":"Microglia monitor and protect neuronal function through specialized somatic purinergic junctions","volume":"367","author":"Cser\u00e9p","year":"2020","journal-title":"Science"},{"key":"2023100302130837300_awad132-B16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural stem and progenitor cells in nestin-GFP transgenic mice","volume":"469","author":"Mignone","year":"2004","journal-title":"J Comp Neurol."},{"key":"2023100302130837300_awad132-B17","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1523\/JNEUROSCI.3095-08.2009","article-title":"Pten deletion in adult neural stem\/progenitor cells enhances constitutive neurogenesis","volume":"29","author":"Gregorian","year":"2009","journal-title":"J Neurosci"},{"key":"2023100302130837300_awad132-B18","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1126\/science.1240405","article-title":"A causative link between inner ear defects and long-term striatal dysfunction","volume":"341","author":"Antoine","year":"2013","journal-title":"Science"},{"key":"2023100302130837300_awad132-B19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"2023100302130837300_awad132-B20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bbi.2014.02.008","article-title":"Microglia are polarized to M1 type in high-anxiety inbred mice in response to lipopolysaccharide challenge","volume":"38","author":"Li","year":"2014","journal-title":"Brain Behav Immun"},{"key":"2023100302130837300_awad132-B21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1109\/83.650848","article-title":"A pyramid approach to subpixel registration based on intensity","volume":"7","author":"Th\u00e9venaz","year":"1998","journal-title":"IEEE Trans Image Process"},{"key":"2023100302130837300_awad132-B22","doi-asserted-by":"crossref","first-page":"17749","DOI":"10.1523\/JNEUROSCI.0957-13.2013","article-title":"Specific impairment of \u201cwhat-where-when\u201d episodic-like memory in experimental models of temporal lobe epilepsy","volume":"33","author":"Inostroza","year":"2013","journal-title":"J Neurosci."},{"key":"2023100302130837300_awad132-B23","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/9609.001.0001","volume-title":"Analyzing neural time series data: theory and practice","author":"Cohen","year":"2014"},{"key":"2023100302130837300_awad132-B24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34518","article-title":"A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo","volume":"7","author":"Yger","year":"2018","journal-title":"eLife"},{"key":"2023100302130837300_awad132-B25","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2016.03.036","article-title":"Network homeostasis and state dynamics of neocortical sleep","volume":"90","author":"Watson","year":"2016","journal-title":"Neuron"},{"key":"2023100302130837300_awad132-B26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-6273(00)80525-5","article-title":"Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: An ensemble approach in the behaving rat","volume":"21","author":"Csicsvari","year":"1998","journal-title":"Neuron"},{"key":"2023100302130837300_awad132-B27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2008.09.014","article-title":"Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm","volume":"60","author":"Sirota","year":"2008","journal-title":"Neuron"},{"key":"2023100302130837300_awad132-B28","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1089\/neu.2010.1370","article-title":"Hippocampal \u03b8 dysfunction after lateral fluid percussion injury","volume":"27","author":"Fedor","year":"2010","journal-title":"J Neurotrauma."},{"key":"2023100302130837300_awad132-B29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1126\/science.663646","article-title":"Loss of hippocampal theta rhythm results in spatial memory deficit in the rat","volume":"201","author":"Winson","year":"1978","journal-title":"Science"},{"key":"2023100302130837300_awad132-B30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/epi.13359","article-title":"Pathologic electrographic changes after experimental traumatic brain injury","volume":"57","author":"Bragin","year":"2016","journal-title":"Epilepsia"},{"key":"2023100302130837300_awad132-B31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2019.02.009","article-title":"From adagio to allegretto: The changing tempo of theta frequencies in epilepsy and its relation to interneuron function","volume":"129","author":"Moxon","year":"2019","journal-title":"Neurobiol Dis"},{"key":"2023100302130837300_awad132-B32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.conb.2008.04.001","article-title":"Development of neural stem cell in the adult brain","volume":"18","author":"Duan","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"2023100302130837300_awad132-B33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals Complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"2023100302130837300_awad132-B34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrneurol.2017.13","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"2023100302130837300_awad132-B35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.aax6752","article-title":"Microglia monitor and protect neuronal function via specialized somatic purinergic junctions","volume":"367","author":"Cser\u00e9p","year":"2020","journal-title":"Science"},{"key":"2023100302130837300_awad132-B36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001526","article-title":"The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner","volume":"20","author":"T\u00f3th","year":"2022","journal-title":"PLoS Biol"},{"key":"2023100302130837300_awad132-B37","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/429815","article-title":"Microglia control neuronal network excitability via BDNF signalling","volume":"2013","author":"Ferrini","year":"2013","journal-title":"Neural Plast"},{"key":"2023100302130837300_awad132-B38","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","article-title":"Brain-Derived neurotrophic factor in brain disorders: Focus on neuroinflammation","volume":"56","author":"Lima Giacobbo","year":"2019","journal-title":"Mol Neurobiol"},{"key":"2023100302130837300_awad132-B39","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF From microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"2023100302130837300_awad132-B40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/21622965.2016.1167491","article-title":"Working memory: A selective review","volume":"5","author":"Kent","year":"2016","journal-title":"Appl Neuropsychol Child"},{"key":"2023100302130837300_awad132-B41","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/hipo.20113","article-title":"Theta rhythm of navigation: Link between path integration and landmark navigation, episodic and semantic memory","volume":"15","author":"Buzs\u00e1ki","year":"2005","journal-title":"Hippocampus"},{"key":"2023100302130837300_awad132-B42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/hipo.20118","article-title":"Hippocampal theta rhythm: A tag for short-term memory","volume":"15","author":"Vertes","year":"2005","journal-title":"Hippocampus"},{"key":"2023100302130837300_awad132-B43","doi-asserted-by":"crossref","first-page":"14211","DOI":"10.1523\/JNEUROSCI.2378-13.2013","article-title":"Theta oscillations in the medial prefrontal Cortex are modulated by spatial working memory and synchronize with the hippocampus through its ventral subregion","volume":"33","author":"O\u2019Neill","year":"2013","journal-title":"J Neurosci"},{"key":"2023100302130837300_awad132-B44","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.tics.2003.10.012","article-title":"Synchronous neural oscillations and cognitive processes","volume":"7","author":"Ward","year":"2003","journal-title":"Trends Cogn Sci"},{"key":"2023100302130837300_awad132-B45","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1089\/neu.2015.4107","article-title":"Mild traumatic brain injury decreases broadband power in area CA1","volume":"33","author":"Paterno","year":"2016","journal-title":"J Neurotrauma"},{"key":"2023100302130837300_awad132-B46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnsys.2016.00030","article-title":"Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury","volume":"10","author":"Pevzner","year":"2016","journal-title":"Front Syst Neurosci"},{"key":"2023100302130837300_awad132-B47","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1038\/s41467-019-11641-8","article-title":"Activating newborn neurons suppresses depression and anxiety-like behaviors","volume":"10","author":"Tunc-Ozcan","year":"2019","journal-title":"Nat Commun"},{"key":"2023100302130837300_awad132-B48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.expneurol.2009.07.007","article-title":"Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus","volume":"219","author":"Gao","year":"2009","journal-title":"Exp Neurol"},{"key":"2023100302130837300_awad132-B49","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"2023100302130837300_awad132-B50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.10945","article-title":"Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli","volume":"467","author":"Kronenberg","year":"2003","journal-title":"J Comp Neurol."},{"key":"2023100302130837300_awad132-B51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1044-7431(03)00207-0","article-title":"Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice","volume":"24","author":"Brandt","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"2023100302130837300_awad132-B52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1242\/dev.102608","article-title":"GABA Suppresses neurogenesis in the adult hippocampus through GABAB receptors","volume":"141","author":"Giachino","year":"2014","journal-title":"Development"},{"key":"2023100302130837300_awad132-B53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2015.07.028","article-title":"GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury","volume":"273","author":"Almeida-Suhett","year":"2015","journal-title":"Exp Neurol."},{"key":"2023100302130837300_awad132-B54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility\u2014linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat Rev Neurosci."},{"key":"2023100302130837300_awad132-B55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2006.11.001","article-title":"GABA Sets the tempo for activity-dependent adult neurogenesis","volume":"30","author":"Ge","year":"2007","journal-title":"Trends Neurosci"},{"key":"2023100302130837300_awad132-B56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fneur.2013.00018","article-title":"The role of markers of inflammation in traumatic brain injury","volume":"4","author":"Woodcock","year":"2013","journal-title":"Front Neurol"},{"key":"2023100302130837300_awad132-B57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ncl.2017.03.011","article-title":"Pathophysiology of sports-related concussion","volume":"35","author":"Steenerson","year":"2017","journal-title":"Neurol Clin"},{"key":"2023100302130837300_awad132-B58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br J Pharmacol"},{"key":"2023100302130837300_awad132-B59","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1152\/jn.00234.2018","article-title":"Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB\/BDNF pathway in rats","volume":"120","author":"Miao","year":"2018","journal-title":"J Neurophysiol"},{"key":"2023100302130837300_awad132-B60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","article-title":"Repopulating microglia promote brain repair in an IL-6-dependent manner","volume":"180","author":"Willis","year":"2020","journal-title":"Cell"},{"key":"2023100302130837300_awad132-B61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2013.11.036","article-title":"Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice","volume":"266","author":"Chen","year":"2014","journal-title":"Neuroscience"},{"key":"2023100302130837300_awad132-B62","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s12035-013-8620-6","article-title":"Phagocytosis of microglia in the central nervous system diseases","volume":"49","author":"Fu","year":"2014","journal-title":"Mol Neurobiol"},{"key":"2023100302130837300_awad132-B63","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1523\/JNEUROSCI.0060-08.2008","article-title":"Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege","volume":"28","author":"Neumann","year":"2008","journal-title":"J Neurosci"},{"key":"2023100302130837300_awad132-B64","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1523\/JNEUROSCI.3282-11.2012","article-title":"The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons","volume":"32","author":"Shulga","year":"2012","journal-title":"J Neurosci."},{"key":"2023100302130837300_awad132-B65","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"2023100302130837300_awad132-B66","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1523\/JNEUROSCI.5265-03.2004","article-title":"Mechanism of activity-dependent downregulation of the neuron-specific K-cl cotransporter KCC2","volume":"24","author":"Rivera","year":"2004","journal-title":"J Neurosci"},{"key":"2023100302130837300_awad132-B67","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1523\/JNEUROSCI.5268-07.2008","article-title":"Posttraumatic GABA(A)-mediated [ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons","volume":"28","author":"Shulga","year":"2008","journal-title":"J Neurosci."},{"key":"2023100302130837300_awad132-B68","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420911770","article-title":"Spatiotemporal distribution of microglia after traumatic brain injury in male mice","volume":"12","author":"Caplan","year":"2020","journal-title":"ASN Neuro"},{"key":"2023100302130837300_awad132-B69","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fnmol.2020.00109","article-title":"Cosyntropin attenuates neuroinflammation in a mouse model of traumatic brain injury","volume":"13","author":"Siebold","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"2023100302130837300_awad132-B70","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"J Neurosci"},{"key":"2023100302130837300_awad132-B71","first-page":"950","article-title":"The effect of gender on patients with moderate to severe head injuries","volume":"67","author":"Berry","year":"2009","journal-title":"J Trauma"},{"key":"2023100302130837300_awad132-B72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/01.TA.0000058314.31655.5F","article-title":"Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no!","volume":"54","author":"Coimbra","year":"2003","journal-title":"J Trauma"},{"key":"2023100302130837300_awad132-B73","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1089\/neu.2017.5547","article-title":"Male and female mice exhibit divergent responses of the cortical vasculature to traumatic brain injury","volume":"35","author":"Jullienne","year":"2018","journal-title":"J Neurotrauma"},{"key":"2023100302130837300_awad132-B74","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.678971","article-title":"Systematic review of sex and gender effects in traumatic brain injury: equity in clinical and functional outcomes","volume":"12","author":"Mollayeva","year":"2021","journal-title":"Front Neurol"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awad132\/50546727\/awad132.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/10\/4247\/51824127\/awad132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/10\/4247\/51824127\/awad132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:21:12Z","timestamp":1696299672000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/146\/10\/4247\/7134130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":74,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,4,21]]},"published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awad132","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,4,21]]}}}