{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:34Z","timestamp":1790775814999,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"US National Institute of Deafness and Communication Disorders","award":["R01 DC014296"],"award-info":[{"award-number":["R01 DC014296"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG032306"],"award-info":[{"award-number":["R01 AG032306"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG062241"],"award-info":[{"award-number":["P30 AG062241"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Athinoula A. Martinos Center for Biomedical Imaging at the MGH"},{"name":"Center for Functional Neuroimaging Technologies","award":["P41EB015896"],"award-info":[{"award-number":["P41EB015896"]}]},{"name":"P41 Biotechnology Resource Grant"},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The identification of a neurodegenerative disorder\u2019s distributed pattern of atrophy\u2014or atrophy \u2018signature\u2019\u2014can lend insights into the cortical networks that degenerate in individuals with specific constellations of symptoms. In addition, this signature can be used as a biomarker to support early diagnoses and to potentially reveal pathological changes associated with said disorder. Here, we characterized the cortical atrophy signature of behavioural variant frontotemporal dementia (bvFTD).<\/jats:p>\n               <jats:p>We used a data-driven approach to estimate cortical thickness using surface-based analyses in two independent, sporadic bvFTD samples (n = 30 and n = 71, total n = 101), using age- and gender-matched cognitively and behaviourally normal individuals. We found highly similar patterns of cortical atrophy across the two independent samples, supporting the reliability of our bvFTD signature. Next, we investigated whether our bvFTD signature targets specific large-scale cortical networks, as is the case for other neurodegenerative disorders. We specifically asked whether the bvFTD signature topographically overlaps with the salience network, as previous reports have suggested. We hypothesized that because phenotypic presentations of bvFTD are diverse, this would not be the case, and that the signature would cross canonical network boundaries. Consistent with our hypothesis, the bvFTD signature spanned rostral portions of multiple networks, including the default mode, limbic, frontoparietal control and salience networks. We then tested whether the signature comprised multiple anatomical subtypes, which themselves overlapped with specific networks. To explore this, we performed a hierarchical clustering analysis. This yielded three clusters, only one of which extensively overlapped with a canonical network (the limbic network).<\/jats:p>\n               <jats:p>Taken together, these findings argue against the hypothesis that the salience network is preferentially affected in bvFTD, but rather suggest that\u2014at least in patients who meet diagnostic criteria for the full-blown syndrome\u2014neurodegeneration in bvFTD encompasses a distributed set of prefrontal, insular and anterior temporal nodes of multiple large-scale brain networks, in keeping with the phenotypic diversity of this disorder.<\/jats:p>","DOI":"10.1093\/brain\/awad167","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T21:52:36Z","timestamp":1684446756000},"page":"4476-4485","source":"Crossref","is-referenced-by-count":26,"title":["Atrophy in behavioural variant frontotemporal dementia spans multiple large-scale prefrontal and temporal networks"],"prefix":"10.1093","volume":"146","author":[{"given":"Mark C","family":"Eldaief","sequence":"first","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , USA"},{"name":"Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Center for Brain Sciences, Harvard University , Cambridge, MA 02138 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brickhouse","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-747X","authenticated-orcid":false,"given":"Yuta","family":"Katsumi","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, University of California, San Francisco , San Francisco, CA 94158 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Touroutoglou","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford C","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , USA"},{"name":"Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"2023110723370434500_awad167-B1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer's disease: Regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"Dickerson","year":"2009","journal-title":"Cereb Cortex"},{"key":"2023110723370434500_awad167-B2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102491","article-title":"Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer 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