{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:46Z","timestamp":1787008546202,"version":"build-2736575974"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01 AG006786"],"award-info":[{"award-number":["U01 AG006786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 NS097495"],"award-info":[{"award-number":["R01 NS097495"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG56366"],"award-info":[{"award-number":["R01 AG56366"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50 AG016574"],"award-info":[{"award-number":["P50 AG016574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG062677"],"award-info":[{"award-number":["P30 AG062677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R37 AG011378"],"award-info":[{"award-number":["R37 AG011378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG041851"],"award-info":[{"award-number":["R01 AG041851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 AG55151"],"award-info":[{"award-number":["RF1 AG55151"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54 NS100693"],"award-info":[{"award-number":["U54 NS100693"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG034676"],"award-info":[{"award-number":["R01 AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"GHR Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liston Award"},{"DOI":"10.13039\/100016293","name":"Elsie and Marvin Dekelboum Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016293","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Schuler Foundation","award":["C06 RR018898"],"award-info":[{"award-number":["C06 RR018898"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood-based biomarkers offer strong potential to revolutionize diagnosis, trial enrolment and treatment monitoring in Alzheimer\u2019s disease (AD). However, further advances are needed before these biomarkers can achieve wider deployment beyond selective research studies and specialty memory clinics, including the development of frameworks for optimal interpretation of biomarker profiles. We hypothesized that integrating Alzheimer\u2019s disease genetic risk score (AD-GRS) data would enhance the diagnostic value of plasma AD biomarkers by better capturing extant disease heterogeneity. Analysing 962 individuals from a population-based sample, we observed that an AD-GRS was independently associated with amyloid PET levels (an early marker of AD pathophysiology) over and above APOE \u03b54 or plasma p-tau181, amyloid-\u03b242\/40, glial fibrillary acidic protein or neurofilament light chain. Among individuals with a high or moderately high plasma p-tau181, integrating AD-GRS data significantly improved classification accuracy of amyloid PET positivity, including the finding that the combination of a high AD-GRS and high plasma p-tau181 outperformed p-tau181 alone in classifying amyloid PET positivity (88% versus 68%; P = 0.001). A machine learning approach incorporating plasma biomarkers, demographics and the AD-GRS was highly accurate in predicting amyloid PET levels (90% training set; 89% test set) and Shapley value analyses (an explainer method based in cooperative game theory) indicated that the AD-GRS and plasma biomarkers had differential importance in explaining amyloid deposition across individuals. Polygenic risk for AD dementia appears to account for a unique portion of disease heterogeneity, which could non-invasively enhance the interpretation of blood-based AD biomarker profiles in the population.<\/jats:p>","DOI":"10.1093\/brain\/awad196","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T04:19:33Z","timestamp":1685765973000},"page":"4508-4519","source":"Crossref","is-referenced-by-count":26,"title":["Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis"],"prefix":"10.1093","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-8734","authenticated-orcid":false,"given":"Vijay K","family":"Ramanan","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robel K","family":"Gebre","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-0691","authenticated-orcid":false,"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Hofrenning","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Algeciras-Schimnich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Figdore","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, Wake Forest University School of Medicine , Winston-Salem, NC 27101 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-066X","authenticated-orcid":false,"given":"David S","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen A","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic , Jacksonville, FL 32224 , USA"},{"name":"Department of Clinical Genomics, Mayo Clinic , Jacksonville, FL 32224 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-622X","authenticated-orcid":false,"suffix":"Jr","given":"Clifford R","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"},{"name":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-0589","authenticated-orcid":false,"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"2023110723371014700_awad196-B1","first-page":"822","article-title":"Fluid biomarkers in dementia diagnosis","volume":"28","author":"Schindler","year":"2022","journal-title":"Continuum (Minneap Minn)"},{"key":"2023110723371014700_awad196-B2","first-page":"800","article-title":"The value of neuroimaging in dementia diagnosis","volume":"28","author":"Raji","year":"2022","journal-title":"Continuum (Minneap Minn)"},{"key":"2023110723371014700_awad196-B3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B4","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/alz.12756","article-title":"The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease","volume":"18","author":"Hansson","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","article-title":"Plasma P-tau181 in Alzheimer's disease: Relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia","volume":"26","author":"Janelidze","year":"2020","journal-title":"Nat Med"},{"key":"2023110723371014700_awad196-B6","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1212\/WNL.0000000000008081","article-title":"High-precision plasma beta-amyloid 42\/40 predicts current and future brain amyloidosis","volume":"93","author":"Schindler","year":"2019","journal-title":"Neurology"},{"key":"2023110723371014700_awad196-B7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2021.3180","article-title":"Head-to-head comparison of 8 plasma amyloid-beta 42\/40 assays in Alzheimer disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol"},{"key":"2023110723371014700_awad196-B8","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41591-022-01822-2","article-title":"Performance of plasma phosphorylated tau 181 and 217 in the community","volume":"28","author":"Mielke","year":"2022","journal-title":"Nat Med"},{"key":"2023110723371014700_awad196-B9","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12697","article-title":"Comparative analytical performance of multiple plasma A\u03b242 and A\u03b240 assays and their ability to predict positron emission tomography amyloid positivity","author":"Zicha","journal-title":"Alzheimers Demen"},{"key":"2023110723371014700_awad196-B10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-021-00451-6","article-title":"A blood-based diagnostic test incorporating plasma A\u03b242\/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: Findings from a multi cohort validity analysis","volume":"167","author":"West","year":"2021","journal-title":"Mol Neurodegener"},{"key":"2023110723371014700_awad196-B11","doi-asserted-by":"crossref","first-page":"e228392","DOI":"10.1001\/jamanetworkopen.2022.8392","article-title":"Assessment of a plasma amyloid probability score to estimate amyloid positron emission tomography findings among adults with cognitive impairment","volume":"5","author":"Hu","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2023110723371014700_awad196-B12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13195-018-0455-y","article-title":"Heterogeneity of Alzheimer's disease: Consequence for drug trials?","volume":"10","author":"Devi","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"2023110723371014700_awad196-B13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/brain\/awac128","article-title":"Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease","volume":"146","author":"Stevenson-Hoare","year":"2023","journal-title":"Brain"},{"key":"2023110723371014700_awad196-B14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tig.2019.02.005","article-title":"Progress in polygenic composite scores in Alzheimer's and other complex diseases","volume":"35","author":"Chasioti","year":"2019","journal-title":"Trends Genet"},{"key":"2023110723371014700_awad196-B15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jalz.2019.09.004","article-title":"Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease","volume":"16","author":"Elahi","year":"2020","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3233\/JAD-170773","article-title":"The past and the future of Alzheimer's disease fluid biomarkers","volume":"62","author":"Blennow","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2023110723371014700_awad196-B17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000115751","article-title":"The Mayo Clinic study of aging: Design and sampling, participation, baseline measures and sample characteristics","volume":"30","author":"Roberts","year":"2008","journal-title":"Neuroepidemiology"},{"key":"2023110723371014700_awad196-B18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1212\/WNL.0b013e3181f11d85","article-title":"Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic study of aging","volume":"75","author":"Petersen","year":"2010","journal-title":"Neurology"},{"key":"2023110723371014700_awad196-B19","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.mayocp.2012.08.012","article-title":"History of the Rochester epidemiology project: Half a century of medical records linkage in a US population","volume":"87","author":"Rocca","year":"2012","journal-title":"Mayo Clinic Proc"},{"key":"2023110723371014700_awad196-B20","doi-asserted-by":"crossref","first-page":"fcaa159","DOI":"10.1093\/braincomms\/fcaa159","article-title":"Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition","volume":"2","author":"Ramanan","year":"2020","journal-title":"Brain Commun"},{"key":"2023110723371014700_awad196-B21","first-page":"7","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume-title":"Gigascience","author":"Chang","year":"2015"},{"key":"2023110723371014700_awad196-B22","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat Genet"},{"key":"2023110723371014700_awad196-B23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","article-title":"Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program","volume":"590","author":"Taliun","year":"2021","journal-title":"Nature"},{"key":"2023110723371014700_awad196-B24","doi-asserted-by":"crossref","first-page":"e1008500","DOI":"10.1371\/journal.pgen.1008500","article-title":"Use of &gt;100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic\/Latino populations","volume":"15","author":"Kowalski","year":"2019","journal-title":"PLoS Genet."},{"key":"2023110723371014700_awad196-B25","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1038\/s41467-021-22491-8","article-title":"Common variants in Alzheimer\u2019s disease and risk stratification by polygenic risk scores","volume":"12","author":"de Rojas","year":"2021","journal-title":"Nat Commun"},{"key":"2023110723371014700_awad196-B26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: A diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"Lancet Neurol"},{"key":"2023110723371014700_awad196-B27","doi-asserted-by":"crossref","first-page":"e1580","DOI":"10.1212\/WNL.0000000000009240","article-title":"Total Abeta42\/Abeta40 ratio in plasma predicts amyloid-PET status, independent of clinical AD diagnosis","volume":"94","author":"Doecke","year":"2020","journal-title":"Neurology"},{"key":"2023110723371014700_awad196-B28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B29","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1212\/WNL.0000000000007728","article-title":"Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults","volume":"93","author":"Lowe","year":"2019","journal-title":"Neurology"},{"key":"2023110723371014700_awad196-B30","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1038\/s41380-022-01675-8","article-title":"Sex differences in plasma p-tau181 associations with Alzheimer\u2019s disease biomarkers, cognitive decline, and clinical progression","volume":"27","author":"Tsiknia","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2023110723371014700_awad196-B31","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/alz.12466","article-title":"Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities","volume":"18","author":"Syrjanen","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B32","first-page":"2825","article-title":"Scikit-learn: Machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J Mach Learn Res"},{"key":"2023110723371014700_awad196-B33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s42256-019-0138-9","article-title":"From local explanations to global understanding with explainable AI for trees","volume":"2","author":"Lundberg","year":"2020","journal-title":"Nat Mach Intell"},{"key":"2023110723371014700_awad196-B34","author":"Lundberg"},{"key":"2023110723371014700_awad196-B35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ana.25071","article-title":"Age, vascular health, and Alzheimer disease biomarkers in an elderly sample","volume":"82","author":"Vemuri","year":"2017","journal-title":"Ann Neurol"},{"key":"2023110723371014700_awad196-B36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2023110723371014700_awad196-B37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13195-021-00942-0","article-title":"The accuracy and robustness of plasma biomarker models for amyloid PET positivity","volume":"14","author":"Benedet","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"2023110723371014700_awad196-B38","doi-asserted-by":"crossref","first-page":"e14398","DOI":"10.15252\/emmm.202114398","article-title":"Tau PET correlates with different Alzheimer\u2019s disease-related features compared to CSF and plasma p-tau biomarkers","volume":"13","author":"Ossenkoppele","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2023110723371014700_awad196-B39","doi-asserted-by":"crossref","first-page":"103837","DOI":"10.1016\/j.ebiom.2022.103837","article-title":"Comparing tau status determined via plasma pTau181, pTau231 and [(18)F]MK6240 tau-PET","volume":"76","author":"Tissot","year":"2022","journal-title":"EBioMedicine"},{"key":"2023110723371014700_awad196-B40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00401-022-02408-5","article-title":"Plasma biomarkers for Alzheimer\u2019s disease in relation to neuropathology and cognitive change","volume":"143","author":"Smirnov","year":"2022","journal-title":"Acta Neuropathol"},{"key":"2023110723371014700_awad196-B41","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41467-021-23746-0","article-title":"Plasma biomarkers of Alzheimer\u2019s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations","volume":"12","author":"Cullen","year":"2021","journal-title":"Nat Commun"},{"key":"2023110723371014700_awad196-B42","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/alz.12301","article-title":"Plasma p-tau181, p-tau217, and other blood-based Alzheimer\u2019s disease biomarkers in a multi-ethnic, community study","volume":"17","author":"Brickman","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B43","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/alz.12662","article-title":"Consideration of sex and gender in Alzheimer\u2019s disease and related disorders from a global perspective","volume":"18","author":"Mielke","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B44","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/ana.25600","article-title":"Amyloid, vascular, and resilience pathways associated with cognitive aging","volume":"86","author":"Vemuri","year":"2019","journal-title":"Ann Neurol"},{"key":"2023110723371014700_awad196-B45","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41591-021-01348-z","article-title":"Prediction of future Alzheimer\u2019s disease dementia using plasma phospho-tau combined with other accessible measures","volume":"27","author":"Palmqvist","year":"2021","journal-title":"Nat Med"},{"key":"2023110723371014700_awad196-B46","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/alz.12751","article-title":"An accurate fully automated panel of plasma biomarkers for Alzheimer\u2019s disease","volume":"19","author":"Palmqvist","year":"2022","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamaneurol.2019.1632","article-title":"Performance of fully automated plasma assays as screening tests for Alzheimer disease-related \u03b2-amyloid status","volume":"76","author":"Palmqvist","year":"2019","journal-title":"JAMA Neurol"},{"key":"2023110723371014700_awad196-B48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jamaneurol.2020.3921","article-title":"Association of initial beta-amyloid levels with subsequent flortaucipir positron emission tomography changes in persons without cognitive impairment","volume":"78","author":"Knopman","year":"2021","journal-title":"JAMA Neurol."},{"key":"2023110723371014700_awad196-B49","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer\u2019s disease","volume":"28","author":"Mila-Aloma","year":"2022","journal-title":"Nat Med"},{"key":"2023110723371014700_awad196-B50","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol"},{"key":"2023110723371014700_awad196-B51","doi-asserted-by":"crossref","first-page":"e12291","DOI":"10.1002\/dad2.12291","article-title":"Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer\u2019s disease and vascular pathology","volume":"14","author":"Shir","year":"2022","journal-title":"Alzheimers Dement (Amst)"},{"key":"2023110723371014700_awad196-B52","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/brain\/awac399","article-title":"Plasma biomarker profiles in autosomal dominant Alzheimer\u2019s disease","volume":"146","author":"Johansson","year":"2023","journal-title":"Brain"},{"key":"2023110723371014700_awad196-B53","doi-asserted-by":"crossref","first-page":"fcaa068","DOI":"10.1093\/braincomms\/fcaa068","article-title":"Progressive dysexecutive syndrome due to Alzheimer\u2019s disease: A description of 55 cases and comparison to other phenotypes","volume":"2","author":"Townley","year":"2020","journal-title":"Brain Commun"},{"key":"2023110723371014700_awad196-B54","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jalz.2018.02.013","article-title":"Plasma phospho-tau181 increases with Alzheimer\u2019s disease clinical severity and is associated with tau- and amyloid-positron emission tomography","volume":"14","author":"Mielke","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2023110723371014700_awad196-B55","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41591-020-0762-2","article-title":"Diagnostic value of plasma phosphorylated tau181 in Alzheimer\u2019s disease and frontotemporal lobar degeneration","volume":"26","author":"Thijssen","year":"2020","journal-title":"Nat Med"},{"key":"2023110723371014700_awad196-B56","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1474-4422(21)00214-3","article-title":"Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer\u2019s disease and frontotemporal lobar degeneration: A retrospective diagnostic performance study","volume":"20","author":"Thijssen","year":"2021","journal-title":"Lancet Neurol"},{"key":"2023110723371014700_awad196-B57","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/brain\/awac333","article-title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer\u2019s disease","volume":"146","author":"Janelidze","year":"2022","journal-title":"Brain"},{"key":"2023110723371014700_awad196-B58","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/brain\/awy327","article-title":"Polygenic hazard score, amyloid deposition and Alzheimer\u2019s neurodegeneration","volume":"142","author":"Tan","year":"2019","journal-title":"Brain"},{"key":"2023110723371014700_awad196-B59","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1038\/s41467-021-24082-z","article-title":"Identifying individuals with high risk of Alzheimer\u2019s disease using polygenic risk scores","volume":"12","author":"Leonenko","year":"2021","journal-title":"Nat Commun"},{"key":"2023110723371014700_awad196-B60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"2023110723371014700_awad196-B61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13195-021-00884-7","article-title":"Probability of Alzheimer\u2019s disease based on common and rare genetic variants","volume":"13","author":"Escott-Price","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"2023110723371014700_awad196-B62","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-022-02419-2","article-title":"Tau polygenic risk scoring: A cost-effective aid for prognostic counseling in Alzheimer\u2019s disease","volume":"143","author":"Ramanan","year":"2022","journal-title":"Acta Neuropathol"},{"key":"2023110723371014700_awad196-B63","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","article-title":"Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer\u2019s disease risk","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat Genet"},{"key":"2023110723371014700_awad196-B64","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41596-020-0353-1","article-title":"Tutorial: A guide to performing polygenic risk score analyses","volume":"15","author":"Choi","year":"2020","journal-title":"Nat Protoc"},{"key":"2023110723371014700_awad196-B65","doi-asserted-by":"crossref","first-page":"e2247162","DOI":"10.1001\/jamanetworkopen.2022.47162","article-title":"Transferability of Alzheimer disease polygenic risk score across populations and its association with Alzheimer disease-related phenotypes","volume":"5","author":"Jung","year":"2022","journal-title":"JAMA Netw Open"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awad196\/51007831\/awad196.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/11\/4508\/52809095\/awad196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/11\/4508\/52809095\/awad196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T18:38:06Z","timestamp":1699382286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/146\/11\/4508\/7190554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":65,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6,5]]},"published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awad196","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,6,5]]}}}