{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:02:10Z","timestamp":1792202530461,"version":"4.4.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071286"],"award-info":[{"award-number":["82071286"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671132"],"award-info":[{"award-number":["81671132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471180"],"award-info":[{"award-number":["81471180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Moyamoya disease is an uncommon cerebrovascular disorder characterized by steno-occlusive changes in the circle of Willis and abnormal vascular network development. Ring finger protein 213 (RNF213) has been identified as an important susceptibility gene for Asian patients, but researchers have not completely elucidated whether RNF213 mutations affect the pathogenesis of moyamoya disease.<\/jats:p>\n               <jats:p>Using donor superficial temporal artery samples, whole-genome sequencing was performed to identify RNF213 mutation types in patients with moyamoya disease, and histopathology was performed to compare morphological differences between patients with moyamoya disease and intracranial aneurysm. The vascular phenotype of RNF213-deficient mice and zebrafish was explored in vivo, and RNF213 knockdown in human brain microvascular endothelial cells was employed to analyse cell proliferation, migration and tube formation abilities in vitro. After bioinformatics analysis of both cell and bulk RNA-seq data, potential signalling pathways were measured in RNF213-knockdown or RNF213-knockout endothelial cells.<\/jats:p>\n               <jats:p>We found that patients with moyamoya disease carried pathogenic mutations of RNF213 that were positively associated with moyamoya disease histopathology. RNF213 deletion exacerbated pathological angiogenesis in the cortex and retina. Reduced RNF213 expression led to increased endothelial cell proliferation, migration and tube formation. Endothelial knockdown of RNF213 activated the Hippo pathway effector Yes-associated protein (YAP)\/tafazzin (TAZ) and promoted the overexpression of the downstream effector VEGFR2. Additionally, inhibition of YAP\/TAZ resulted in altered cellular VEGFR2 distribution due to defects in trafficking from the Golgi apparatus to the plasma membrane and reversed RNF213 knockdown-induced angiogenesis. All these key molecules were validated in ECs isolated from RNF213-deficient animals.<\/jats:p>\n               <jats:p>Our findings may suggest that loss-of-function of RNF213 mediates the pathogenesis of moyamoya disease via the Hippo pathway.<\/jats:p>","DOI":"10.1093\/brain\/awad225","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T20:41:34Z","timestamp":1688244094000},"page":"4674-4689","source":"Crossref","is-referenced-by-count":76,"title":["<i>RNF213<\/i> loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway"],"prefix":"10.1093","volume":"146","author":[{"given":"Fei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"},{"name":"Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University) , Chongqing 400038 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"},{"name":"Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-sen University , Shenzhen 517108 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiewei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-371X","authenticated-orcid":false,"given":"Wenli","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"2023110723363982200_awad225-B1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMra0804622","article-title":"Moyamoya disease and moyamoya syndrome","volume":"360","author":"Scott","year":"2009","journal-title":"N Engl J Med"},{"key":"2023110723363982200_awad225-B2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5853\/jos.2015.01627","article-title":"Moyamoya disease: Epidemiology, clinical features, and diagnosis","volume":"18","author":"Kim","year":"2016","journal-title":"J Stroke"},{"key":"2023110723363982200_awad225-B3","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/jnnp.2007.130666","article-title":"Novel epidemiological features of moyamoya disease","volume":"79","author":"Baba","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2023110723363982200_awad225-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2176\/nmc.47.1","article-title":"Histological features of middle cerebral arteries from patients treated for moyamoya disease","volume":"47","author":"Takagi","year":"2007","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"2023110723363982200_awad225-B5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2176\/nmc.52.245","article-title":"Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of willis).","volume":"52","author":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis","year":"2012","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"2023110723363982200_awad225-B6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2176\/nmc.ra.2014-0307","article-title":"Diagnosis of moyamoya disease: International standard and regional differences","volume":"55","author":"Fujimura","year":"2015","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"2023110723363982200_awad225-B7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5853\/jos.2014.16.2.65","article-title":"Genetics and biomarkers of moyamoya disease: Significance of RNF213 as a susceptibility gene","volume":"16","author":"Fujimura","year":"2014","journal-title":"J Stroke"},{"key":"2023110723363982200_awad225-B8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5853\/jos.2015.01739","article-title":"Moyamoya disease: Treatment and outcomes","volume":"18","author":"Kim","year":"2016","journal-title":"J Stroke"},{"key":"2023110723363982200_awad225-B9","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"2023110723363982200_awad225-B10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/STROKEAHA.117.017430","article-title":"Novel susceptibility loci for moyamoya disease revealed by a genome-wide association study","volume":"49","author":"Duan","year":"2018","journal-title":"Stroke"},{"key":"2023110723363982200_awad225-B11","first-page":"35","article-title":"Novel missense variants in the RNF213 gene from a European family with moyamoya disease","volume-title":"Hum Genome Var","author":"Gagunashvili","year":"2019"},{"key":"2023110723363982200_awad225-B12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/jhg.2012.105","article-title":"Sibling cases of moyamoya disease having homozygous and heterozygous c.14576G &gt; A variant in RNF213 showed varying clinical course and severity","volume":"57","author":"Miyatake","year":"2012","journal-title":"J Hum Genet"},{"key":"2023110723363982200_awad225-B13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1212\/WNL.0b013e318249f71f","article-title":"Homozygous c.14576G &gt; A variant of RNF213 predicts early-onset and severe form of moyamoya disease","volume":"78","author":"Miyatake","year":"2012","journal-title":"Neurology"},{"key":"2023110723363982200_awad225-B14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first moyamoya disease gene","volume":"56","author":"Kamada","year":"2011","journal-title":"J Hum Genet"},{"key":"2023110723363982200_awad225-B15","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1161\/STROKEAHA.114.006244","article-title":"RNF213 Rare variants in an ethnically diverse population with moyamoya disease","volume":"45","author":"Cecchi","year":"2014","journal-title":"Stroke"},{"key":"2023110723363982200_awad225-B16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56185","article-title":"Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism","volume":"9","author":"Ahel","year":"2020","journal-title":"Elife"},{"key":"2023110723363982200_awad225-B17","doi-asserted-by":"crossref","first-page":"e1783","DOI":"10.1212\/WNL.0000000000011653","article-title":"Association of De Novo RNF213 variants with childhood onset moyamoya disease and diffuse occlusive vasculopathy","volume":"96","author":"Pinard","year":"2021","journal-title":"Neurology"},{"key":"2023110723363982200_awad225-B18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ejhg.2011.174","article-title":"Practical guidelines for interpreting copy number gains detected by high-resolution array in routine diagnostics","volume":"20","author":"Hanemaaijer","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"2023110723363982200_awad225-B19","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000807","article-title":"MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation","volume":"5","author":"Bhardwaj","year":"2022","journal-title":"Life Sci Alliance"},{"key":"2023110723363982200_awad225-B20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1474-4422(22)00165-X","article-title":"Moyamoya disease: Diagnosis and interventions","volume":"21","author":"Ihara","year":"2022","journal-title":"Lancet Neurol"},{"key":"2023110723363982200_awad225-B21","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2023110723363982200_awad225-B22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2014.01.011","article-title":"Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: A susceptibility gene for moyamoya disease","volume":"1552","author":"Sonobe","year":"2014","journal-title":"Brain Res"},{"key":"2023110723363982200_awad225-B23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.brainres.2015.07.039","article-title":"Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease","volume":"1624","author":"Kanoke","year":"2015","journal-title":"Brain Res"},{"key":"2023110723363982200_awad225-B24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027385","article-title":"A computational tool for quantitative analysis of vascular networks","volume":"6","author":"Zudaire","year":"2011","journal-title":"PLoS One"},{"key":"2023110723363982200_awad225-B25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2016.04.051","article-title":"Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish","volume":"1644","author":"Wen","year":"2016","journal-title":"Brain Res"},{"key":"2023110723363982200_awad225-B26","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1177\/0271678X20914996","article-title":"Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish","volume":"41","author":"Lin","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"2023110723363982200_awad225-B27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.brainres.2014.11.014","article-title":"Enhanced postischaemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease","volume":"1594","author":"Ito","year":"2015","journal-title":"Brain Res"},{"key":"2023110723363982200_awad225-B28","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"Networkanalyst 3.0: A visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023110723363982200_awad225-B29","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2023110723363982200_awad225-B30","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene ontology consortium: Going forward","volume":"43","author":"Gene Ontology Consortium","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023110723363982200_awad225-B31","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: New perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023110723363982200_awad225-B32","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J Clin Invest"},{"key":"2023110723363982200_awad225-B33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo-YAP\/TAZ signalling in organ regeneration and regenerative medicine","volume":"20","author":"Moya","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023110723363982200_awad225-B34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.devcel.2017.08.002","article-title":"YAP\/TAZ orchestrate VEGF signalling during developmental angiogenesis","volume":"42","author":"Wang","year":"2017","journal-title":"Dev Cell"},{"key":"2023110723363982200_awad225-B35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105305","article-title":"Vascular smooth muscle cell derived from IPS cell of moyamoya disease - comparative characterization with endothelial cell transcriptome","volume":"29","author":"Tokairin","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2023110723363982200_awad225-B36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169714","article-title":"Chemokine ligand 5 (CCL5) derived from endothelial colony-forming cells (ECFCs) mediates recruitment of smooth muscle progenitor cells (SPCs) toward critical vascular locations in moyamoya disease","volume":"12","author":"Phi","year":"2017","journal-title":"PLoS One"},{"key":"2023110723363982200_awad225-B37","doi-asserted-by":"crossref","first-page":"16161","DOI":"10.1038\/srep16161","article-title":"Neuromuscular regulation in zebrafish by a large AAA+ ATPase\/ubiquitin ligase, mysterin\/RNF213","volume":"5","author":"Kotani","year":"2015","journal-title":"Sci Rep"},{"key":"2023110723363982200_awad225-B38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajhg.2009.04.007","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and moyamoya disease, along with thoracic aortic disease","volume":"84","author":"Guo","year":"2009","journal-title":"Am J Hum Genet"},{"key":"2023110723363982200_awad225-B39","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.3390\/cells11233792","article-title":"CircZXDC promotes vascular smooth muscle cell transdifferentiation via regulating miRNA-125a-3p\/ABCC6 in moyamoya disease","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"2023110723363982200_awad225-B40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-021-03566-4","article-title":"Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection","volume":"594","author":"Otten","year":"2021","journal-title":"Nature"},{"key":"2023110723363982200_awad225-B41","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jaci.2022.06.016","article-title":"RNF213-associated Urticarial lesions with hypercytokinemia","volume":"150","author":"Louvrier","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"2023110723363982200_awad225-B42","doi-asserted-by":"crossref","first-page":"19260","DOI":"10.1038\/s41598-021-98691-5","article-title":"Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis","volume":"11","author":"Imani","year":"2021","journal-title":"Sci Rep"},{"key":"2023110723363982200_awad225-B43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5853\/jos.2015.01760","article-title":"The pathophysiology of moyamoya disease: An update","volume":"18","author":"Bang","year":"2016","journal-title":"J Stroke"},{"key":"2023110723363982200_awad225-B44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000365286","article-title":"Neovascularization precedes occlusion in moyamoya disease: Angiographic findings in 172 paediatric patients","volume":"72","author":"Kim","year":"2014","journal-title":"Eur Neurol"},{"key":"2023110723363982200_awad225-B45","first-page":"734","article-title":"How does angiogenesis develop in paediatric moyamoya disease after surgery? A prospective study with MR angiography","volume":"20","author":"Houkin","year":"2004","journal-title":"Childs Nerv Syst"},{"key":"2023110723363982200_awad225-B46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/STROKEAHA.120.032691","article-title":"Moyamoya disease susceptibility gene RNF213Regulates endothelial barrier function","volume":"53","author":"Roy","year":"2022","journal-title":"Stroke"},{"key":"2023110723363982200_awad225-B47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbrc.2013.07.004","article-title":"Downregulation of securin by the variant RNF213 R4810K (rs112735431, G &gt; A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients","volume":"438","author":"Hitomi","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"2023110723363982200_awad225-B48","doi-asserted-by":"crossref","first-page":"13191","DOI":"10.1038\/srep13191","article-title":"Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells","volume":"5","author":"Ohkubo","year":"2015","journal-title":"Sci Rep"},{"key":"2023110723363982200_awad225-B49","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41467-018-03278-w","article-title":"A LATS biosensor screen identifies VEGFR as a regulator of the hippo pathway in angiogenesis","volume":"9","author":"Azad","year":"2018","journal-title":"Nat Commun"},{"key":"2023110723363982200_awad225-B50","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1038\/s41467-018-07022-2","article-title":"Reciprocal inhibition of YAP\/TAZ and NF-\u03baB regulates osteoarthritic cartilage degradation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat Commun"},{"key":"2023110723363982200_awad225-B51","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI88486","article-title":"Hippo signalling interactions with wnt\/\u03b2-catenin and notch signalling repress liver tumorigenesis","volume":"127","author":"Kim","year":"2017","journal-title":"J Clin Invest"},{"key":"2023110723363982200_awad225-B52","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo pathway inhibits wnt signalling to restrain cardiomyocyte proliferation and heart size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"2023110723363982200_awad225-B53","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2020.02.024","article-title":"Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NF\u03baB activation and apoptosis in an AAA+ domain-dependent manner","volume":"525","author":"Takeda","year":"2020","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awad225\/51541248\/awad225.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/11\/4674\/52809028\/awad225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/146\/11\/4674\/52809028\/awad225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T23:39:21Z","timestamp":1699400361000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/146\/11\/4674\/7218493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,7,3]]},"published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awad225","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,7,3]]}}}