{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:04:28Z","timestamp":1791637468144,"version":"4.3.4"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100\u2013400 million infections annually. Among those hospitalized, the mortality is about 1%. Neurological involvement has been reported to be about 5%. The spectrum of neurological manifestations spans both the peripheral and central nervous systems. These manifestations could possibly be categorized into those directly related to dengue infection, i.e. acute and chronic encephalitis, indirect complications leading to dengue encephalopathy, and post-infectious syndrome due to immune-mediated reactions, and manifestations with uncertain mechanisms, such as acute transverse myelitis, acute cerebellitis and myositis.<\/jats:p>\n               <jats:p>The rising trend in global dengue incidence calls for attention to a more explicit definition of each neurological manifestation for more accurate epidemiological data. The actual global burden of dengue infection with neurological manifestation is essential for future planning and execution of strategies, especially in the development of effective antivirals and vaccines against the dengue virus.<\/jats:p>\n               <jats:p>In this article, we discuss the recent findings of different spectrums of neurological manifestations in dengue infection and provide an update on antiviral and vaccine development and their challenges.<\/jats:p>","DOI":"10.1093\/brain\/awad415","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T06:47:49Z","timestamp":1702104469000},"page":"830-838","source":"Crossref","is-referenced-by-count":47,"title":["Dengue virus infection and neurological manifestations: an update"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-6380","authenticated-orcid":false,"given":"Si-Lei","family":"Fong","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine , University of Malaya, 50603 Federal Territory of Kuala Lumpur , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum-Thong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Malaya , 50603 Federal Territory of Kuala Lumpur , Malaysia"},{"name":"Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia , 47500 Subang Jaya, Selangor , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Tin","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine , University of Malaya, 50603 Federal Territory of Kuala Lumpur , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"2024030122265134900_awad415-B1"},{"key":"2024030122265134900_awad415-B2","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1016\/S2542-5196(21)00132-7","article-title":"Projecting the risk of mosquito-borne diseases in a warmer and more populated world: A multi-model, multi-scenario intercomparison modelling study","volume":"5","author":"Col\u00f3n-Gonz\u00e1lez","year":"2021","journal-title":"Lancet Planet Health"},{"key":"2024030122265134900_awad415-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.AID-0022-2014","article-title":"Dengue antibody-dependent enhancement: Knowns and unknowns","volume":"2","author":"Halstead","year":"2014","journal-title":"Microbiol Spectr"},{"key":"2024030122265134900_awad415-B4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"2024030122265134900_awad415-B5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.4269\/ajtmh.2001.65.848","article-title":"Prospective case-control study of encephalopathy in children with dengue hemorrhagic fever","volume":"65","author":"Cam","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"2024030122265134900_awad415-B6","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(13)70150-9","article-title":"Neurological complications of dengue virus infection","volume":"12","author":"Carod-Artal","year":"2013","journal-title":"Lancet Neurol"},{"key":"2024030122265134900_awad415-B7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jns.2011.04.010","article-title":"Dengue encephalitis: Suggestion for case definition response","volume":"306","author":"Soares","year":"2011","journal-title":"J Neurol Sci."},{"key":"2024030122265134900_awad415-B8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.54029\/2022zzy","article-title":"Dengue virus encephalitis: A systematic review and critique","volume":"27","author":"Fong","year":"2022","journal-title":"Neurol Asia"},{"key":"2024030122265134900_awad415-B9"},{"key":"2024030122265134900_awad415-B10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jcv.2007.10.030","article-title":"Cross-reactive IgM responses in patients with dengue or Japanese encephalitis","volume":"42","author":"Atchareeya","year":"2008","journal-title":"J Clin Virol"},{"key":"2024030122265134900_awad415-B11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s15010-012-0284-z","article-title":"Concurrent dengue virus and Japanese encephalitis virus infection of the brain: Is it co-infection or co-detection?","volume":"40","author":"Garg","year":"2012","journal-title":"Infection"},{"key":"2024030122265134900_awad415-B12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S1995-7645(14)60007-9","article-title":"Co-positivity of anti-dengue virus and anti-Japanese encephalitis virus IgM in endemic area: Co-infection or cross reactivity?","volume":"7","author":"Singh","year":"2014","journal-title":"Asian Pac J Trop Med"},{"key":"2024030122265134900_awad415-B13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0028-3886.198194","article-title":"Diagnostic dilemma-dengue or Japanese encephalitis?","volume":"65","author":"Sivamani","year":"2017","journal-title":"Neurol India"},{"key":"2024030122265134900_awad415-B14","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1038\/emi.2017.15","article-title":"Aetiology of acute meningoencephalitis in Cambodian children, 2010\u20132013","volume":"6","author":"Horwood","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"2024030122265134900_awad415-B15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1743-422X-11-164","article-title":"Evaluation of four commercial real-time RT-PCR kits for the detection of dengue viruses in clinical samples","volume":"11","author":"Najioullah","year":"2014","journal-title":"Virol J"},{"key":"2024030122265134900_awad415-B16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4269\/ajtmh.2011.09-0798","article-title":"Factors influencing dengue virus isolation by C6\/36 cell culture and mosquito inoculation of nested PCR-positive clinical samples","volume":"84","author":"Jarman","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"2024030122265134900_awad415-B17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijid.2022.03.010","article-title":"A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with dengue virus","volume":"119","author":"Pichl","year":"2022","journal-title":"Int J Infect Dis"},{"key":"2024030122265134900_awad415-B18","first-page":"e29048","article-title":"The Spectrum of MRI findings in dengue encephalitis","volume":"14","author":"Lnu","year":"2022","journal-title":"Cureus"},{"key":"2024030122265134900_awad415-B19","doi-asserted-by":"crossref","first-page":"e01440","DOI":"10.1002\/brb3.1440","article-title":"Reversible lesion in the splenium of the corpus callosum","volume":"9","author":"Tetsuka","year":"2019","journal-title":"Brain Behav"},{"key":"2024030122265134900_awad415-B20","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2024030122265134900_awad415-B21","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3201\/eid1108.050289b","article-title":"Virology, pathology, and clinical manifestations of west Nile virus disease","volume":"11","author":"Hayes","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"2024030122265134900_awad415-B22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/jnen\/64.6.506","article-title":"Visualization of central European tick-borne encephalitis infection in fatal human cases","volume":"64","author":"Gelpi","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024030122265134900_awad415-B23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/archneur.1981.00510060031002","article-title":"St louis encephalitis. Quantitative histologic and immunofluorescent studies","volume":"38","author":"Reyes","year":"1981","journal-title":"Arch Neurol"},{"key":"2024030122265134900_awad415-B24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/nan.12285","article-title":"Viral neuronotropism is important in the pathogenesis of Murray valley encephalitis","volume":"42","author":"Fu","year":"2016","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024030122265134900_awad415-B25","first-page":"107","article-title":"Immunohistochemical characterization of a new monoclonal antibody reactive with dengue virus-infected cells in frozen tissue using immunoperoxidase technique","volume":"14","author":"Bhoopat","year":"1996","journal-title":"Asian Pac J Allergy Immunol"},{"key":"2024030122265134900_awad415-B26","first-page":"157","article-title":"Dengue: Neuropathological findings in 5 fatal cases from Brazil","volume":"9","author":"Chimelli","year":"1990","journal-title":"Clin Neuropathol"},{"key":"2024030122265134900_awad415-B27","first-page":"204","article-title":"Retrospective study on dengue fatal cases","volume":"16","author":"Miagostovich","year":"1997","journal-title":"Clin Neuropathol"},{"key":"2024030122265134900_awad415-B28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/13550289809114548","article-title":"Dengue virus in the brain of a fatal case of hemorrhagic dengue fever","volume":"4","author":"Ramos","year":"1998","journal-title":"J Neurovirol"},{"key":"2024030122265134900_awad415-B29","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.4103\/0028-3886.246276","article-title":"Autopsy in dengue encephalitis: An analysis of three cases","volume":"66","author":"Jois","year":"2018","journal-title":"Neurol India"},{"key":"2024030122265134900_awad415-B30","first-page":"147","volume-title":"Flaviviruses 2: West Nile, St. Louis encephalitis, Murray valley encephalitis, yellow fever, and dengue","author":"Johnson","year":"2020"},{"issue":"Pt 4","key":"2024030122265134900_awad415-B31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1099\/0022-1317-72-4-859","article-title":"Breakdown of the blood-brain barrier during dengue virus infection of mice","volume":"72","author":"Chaturvedi","year":"1991","journal-title":"J Gen Virol"},{"key":"2024030122265134900_awad415-B32","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1038\/s41598-018-28137-y","article-title":"BALB\/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system","volume":"8","author":"Salom\u00e3o","year":"2018","journal-title":"Sci Rep."},{"key":"2024030122265134900_awad415-B33","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.imbio.2015.06.002","article-title":"Novel evidence of microglial immune response in impairment of dengue infection of CNS","volume":"220","author":"Bhatt","year":"2015","journal-title":"Immunobiology"},{"key":"2024030122265134900_awad415-B34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/femsre\/fuu004","article-title":"Receptors and routes of dengue virus entry into the host cells","volume":"39","author":"Cruz-Oliveira","year":"2015","journal-title":"FEMS Microbiol Rev"},{"key":"2024030122265134900_awad415-B35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fmicb.2019.00525","article-title":"Pathways exploited by flaviviruses to counteract the blood-brain barrier and invade the central nervous system","volume":"10","author":"Mustaf\u00e1","year":"2019","journal-title":"Front Microbiol"},{"key":"2024030122265134900_awad415-B36","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.25588","article-title":"Chronic dengue virus panencephalitis in a patient with progressive dementia with extrapyramidal features","volume":"86","author":"Johnson","year":"2019","journal-title":"Ann Neurol"},{"key":"2024030122265134900_awad415-B37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/0255-0857.71806","article-title":"Displacement of dengue virus type 3 and type 2 by dengue virus type 1 in Delhi during 2008","volume":"28","author":"Chakravarti","year":"2010","journal-title":"Indian J Med Microbiol"},{"key":"2024030122265134900_awad415-B38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00705-012-1522-5","article-title":"Genotypic characterization of dengue virus strains circulating during 2007\u20132009 in New Delhi","volume":"158","author":"Chakravarti","year":"2013","journal-title":"Arch Virol"},{"key":"2024030122265134900_awad415-B39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/648731","article-title":"Persistent infection with west Nile virus years after initial infection","volume":"201","author":"Murray","year":"2010","journal-title":"J Infect Dis"},{"key":"2024030122265134900_awad415-B40","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4269\/ajtmh.17-0405","article-title":"Visualization of west Nile virus in urine sediment using electron microscopy and immunogold up to nine years postinfection","volume":"97","author":"Murray","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"2024030122265134900_awad415-B41","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2017.04.008","article-title":"Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys","volume":"169","author":"Aid","year":"2017","journal-title":"Cell"},{"key":"2024030122265134900_awad415-B42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2990.1991.tb00737.x","article-title":"Autopsy neuropathological findings in \u2018burnt out\u2019 herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA","volume":"17","author":"Nicoll","year":"1991","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024030122265134900_awad415-B43","first-page":"65","volume-title":"Cytomegalovirus infections of the CNS","author":"Adle-Biassette","year":"2020"},{"key":"2024030122265134900_awad415-B44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.10212","article-title":"Relapsed and late-onset nipah encephalitis","volume":"51","author":"Tan","year":"2002","journal-title":"Ann Neurol"},{"key":"2024030122265134900_awad415-B45","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/jmv.25717","article-title":"A lesson learnt from the emergence of Zika virus: What flaviviruses can trigger guillain-barr\u00e9 syndrome?","volume":"92","author":"Leung","year":"2020","journal-title":"J Med Virol."},{"key":"2024030122265134900_awad415-B46","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1590\/0004-282x20160161","article-title":"Guillain-Barr\u00e9 syndrome and dengue fever: Report on ten new cases in Brazil","volume":"74","author":"Fragoso","year":"2016","journal-title":"Arq Neuropsiquiatr"},{"key":"2024030122265134900_awad415-B47","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/jnnp-2019-320756","article-title":"Association of dengue infection and guillain-barr\u00e9 syndrome in Malaysia","volume":"90","author":"Tan","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024030122265134900_awad415-B48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1473-3099(01)00019-6","article-title":"Infectious origins of, and molecular mimicry in, guillain-barr\u00e9 and fisher syndromes","volume":"1","author":"Yuki","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"2024030122265134900_awad415-B49","first-page":"OL01","article-title":"Opsoclonus-Myoclonus syndrome (OMS) due to dengue meningoencephalitis","volume":"13","author":"Aniket Patil","year":"2019","journal-title":"J Clin Diagn Res."},{"key":"2024030122265134900_awad415-B50","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.parkreldis.2014.09.002","article-title":"Opsoclonus-myoclonus-ataxia syndrome associated with dengue virus infection","volume":"20","author":"Tan","year":"2014","journal-title":"Parkinsonism Relat Disord."},{"key":"2024030122265134900_awad415-B51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4103\/JPN.JPN_55_18","article-title":"Opsoclonus myoclonus syndrome: A rare manifestation of dengue infection in a child","volume":"13","author":"Desai","year":"2018","journal-title":"J Pediatr Neurosci"},{"key":"2024030122265134900_awad415-B52","doi-asserted-by":"crossref","first-page":"e0005715","DOI":"10.1371\/journal.pntd.0005715","article-title":"Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis","volume":"11","author":"Kamel","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2024030122265134900_awad415-B53","first-page":"e10042","article-title":"A rare case of dengue fever presenting with acute disseminated encephalomyelitis","volume":"12","author":"Farooque","year":"2020","journal-title":"Cureus"},{"key":"2024030122265134900_awad415-B54","doi-asserted-by":"crossref","first-page":"e00862","DOI":"10.1016\/j.idcr.2020.e00862","article-title":"Acute disseminated encephalomyelitis after dengue","volume":"21","author":"Diallo","year":"2020","journal-title":"IDCases"},{"key":"2024030122265134900_awad415-B55","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.msard.2016.10.001","article-title":"Acute disseminated encephalomyelitis complicating dengue infection with neuroimaging mimicking multiple sclerosis: A report of two cases","volume":"10","author":"Viswanathan","year":"2016","journal-title":"Mult Scler Relat Disord"},{"issue":"15 Suppl","key":"2024030122265134900_awad415-B56","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1212\/WNL.96.15_supplement.1574","article-title":"Acute disseminated encephalomyelitis as manifestation of dengue infection in an adult female nonresponsive to high dose steroids (1574)","volume":"96","author":"Ladak","year":"2021","journal-title":"Neurology"},{"key":"2024030122265134900_awad415-B57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jcv.2016.03.015","article-title":"Rhombencephalitis associated with dengue fever","volume":"78","author":"Verma","year":"2016","journal-title":"J Clin Virol"},{"key":"2024030122265134900_awad415-B58","first-page":"9008","article-title":"Dengue encephalitis with unilateral 3rd nerve palsy","volume":"9","author":"Chakrabarti","year":"2019","journal-title":"Int J Sci Res Publ (IJSRP)"},{"key":"2024030122265134900_awad415-B59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/aian.AIAN_462_18","article-title":"Dengue fever with facial palsy: A rare neurological manifestation","volume":"22","author":"Sardana","year":"2019","journal-title":"Ann Indian Acad Neurol"},{"key":"2024030122265134900_awad415-B60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1995-7645(12)60207-7","article-title":"Isolated bell's palsy\u2014An unusual presentation of dengue infection","volume":"6","author":"Peter","year":"2013","journal-title":"Asian Pac J Trop Med"},{"key":"2024030122265134900_awad415-B61","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1097\/WNO.0000000000001223","article-title":"Isolated oculomotor neuritis after dengue fever","volume":"41","author":"Bhate","year":"2021","journal-title":"J Neuroophthalmol"},{"key":"2024030122265134900_awad415-B62","first-page":"32","article-title":"Bilateral optic neuritis with maculopathy: A rare manifestation of dengue fever","volume":"12","author":"Boo","year":"2017","journal-title":"Malays Fam Physician"},{"key":"2024030122265134900_awad415-B63","first-page":"25","article-title":"Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever","volume":"11","author":"Mazliha","year":"2016","journal-title":"Malays Fam Physician"},{"key":"2024030122265134900_awad415-B64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13256-018-1627-x","article-title":"Cerebral vasculitis and lateral rectus palsy \u2013 two rare central nervous system complications of dengue fever: Two case reports and review of the literature","volume":"12","author":"Herath","year":"2018","journal-title":"J Med Case Rep."},{"key":"2024030122265134900_awad415-B65","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1186\/s12879-020-05430-8","article-title":"Case report: Mononeuritis multiplex in the course of dengue fever","volume":"20","author":"Ho","year":"2020","journal-title":"BMC Infect Dis."},{"key":"2024030122265134900_awad415-B66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/pharmacy7010003","article-title":"Risk of transverse myelitis following dengue infection: A systematic review of the literature","volume":"7","author":"Badat","year":"2019","journal-title":"Pharmacy"},{"key":"2024030122265134900_awad415-B67","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1212\/01.WNL.0000144194.29643.D0","article-title":"Preferential gray matter involvement in dengue myelitis","volume":"63","author":"Kunishige","year":"2004","journal-title":"Neurology"},{"key":"2024030122265134900_awad415-B68","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00428-003-0785-3","article-title":"The pathogenesis of spinal cord involvement in dengue virus infection","volume":"442","author":"An","year":"2003","journal-title":"Virchows Arch."},{"key":"2024030122265134900_awad415-B69","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s13365-022-01082-3","article-title":"Dengue fever presenting as acute cerebellar ataxia: Case report and literature review","volume":"28","author":"de Holanda","year":"2022","journal-title":"J Neurovirol"},{"key":"2024030122265134900_awad415-B70","doi-asserted-by":"crossref","first-page":"864","DOI":"10.12659\/AJCR.909884","article-title":"Dengue cerebellitis: A case report and literature review","volume":"19","author":"Khoo","year":"2018","journal-title":"Am J Case Rep"},{"key":"2024030122265134900_awad415-B71","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1756-0500-7-125","article-title":"Dengue fever presenting with acute cerebellitis: A case report","volume":"7","author":"Withana","year":"2014","journal-title":"BMC Res Notes"},{"key":"2024030122265134900_awad415-B72","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00330-014-3473-6","article-title":"Dengue encephalitis with predominant cerebellar involvement: Report of eight cases with MR and CT imaging features","volume":"25","author":"Hegde","year":"2015","journal-title":"Eur Radiol."},{"key":"2024030122265134900_awad415-B73","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/practneurol-2013-000571","article-title":"Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: A case series from Sri Lanka","volume":"14","author":"Weeratunga","year":"2014","journal-title":"Pract Neurol"},{"key":"2024030122265134900_awad415-B74","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s15010-011-0203-8","article-title":"Dengue-associated transient muscle dysfunction: Clinical, electromyography and histopathological changes","volume":"40","author":"Misra","year":"2012","journal-title":"Infection"},{"key":"2024030122265134900_awad415-B75","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jns.2010.10.022","article-title":"Acute dengue virus myositis: A report of seven patients of varying clinical severity including two cases with severe fulminant myositis","volume":"300","author":"Paliwal","year":"2011","journal-title":"J Neurol Sci."},{"key":"2024030122265134900_awad415-B76","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/0028-3886.161990","article-title":"Dengue-associated neuromuscular complications. Review article","volume":"63","author":"Garg","year":"2015","journal-title":"Neurol India."},{"issue":"Pt 7","key":"2024030122265134900_awad415-B77","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1099\/vir.0.2008\/000968-0","article-title":"Efficient dengue virus (DENV) infection of human muscle satellite cells upregulates type I interferon response genes and differentially modulates MHC I expression on bystander and DENV-infected cells","volume":"89","author":"Warke","year":"2008","journal-title":"J Gen Virol"},{"key":"2024030122265134900_awad415-B78","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcv.2015.08.021","article-title":"Central nervous system and muscle involvement in dengue patients: A study from a tertiary care center","volume":"72","author":"Misra","year":"2015","journal-title":"J Clin Virol"},{"key":"2024030122265134900_awad415-B79","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0140-6736(00)02036-5","article-title":"Neurological manifestations of dengue infection","volume":"355","author":"Solomon","year":"2000","journal-title":"Lancet"},{"key":"2024030122265134900_awad415-B80","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.3390\/molecules26226768","article-title":"Updates on dengue vaccine and antiviral: Where are we heading?","volume":"26","author":"Norshidah","year":"2021","journal-title":"Molecules"},{"key":"2024030122265134900_awad415-B81","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/v15030705","article-title":"Molecular mechanisms of antiviral agents against dengue virus","volume":"15","author":"Lee","year":"2023","journal-title":"Viruses"},{"key":"2024030122265134900_awad415-B82","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coviro.2020.07.009","article-title":"Recent advances in antiviral drug development towards dengue virus","volume":"43","author":"Troost","year":"2020","journal-title":"Curr Opin Virol."},{"key":"2024030122265134900_awad415-B83","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s00705-022-05555-y","article-title":"Inhibition of dengue virus infection by trifluoperazine","volume":"167","author":"Piccini","year":"2022","journal-title":"Arch Virol."},{"key":"2024030122265134900_awad415-B84","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S1473-3099(14)70730-3","article-title":"Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): A phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial","volume":"14","author":"Low","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"2024030122265134900_awad415-B85","doi-asserted-by":"crossref","first-page":"e0010636","DOI":"10.1371\/journal.pntd.0010636","article-title":"Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of iminosugar UV-4 hydrochloride (UV-4B) in healthy subjects","volume":"16","author":"Callahan","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"2024030122265134900_awad415-B86","author":"Emergent BioSolutions"},{"key":"2024030122265134900_awad415-B87","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-021-03990-6","article-title":"A pan-serotype dengue virus inhibitor targeting the NS3\u2013NS4B interaction","volume":"598","author":"Kaptein","year":"2021","journal-title":"Nature"},{"key":"2024030122265134900_awad415-B88","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41586-023-05790-6","article-title":"Blocking NS3\u2013NS4B interaction inhibits dengue virus in non-human primates","volume":"615","author":"Goethals","year":"2023","journal-title":"Nature"},{"key":"2024030122265134900_awad415-B89","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/tropicalmed6040180","article-title":"Current trends and limitations in dengue antiviral research","volume":"6","author":"Obi","year":"2021","journal-title":"Trop Med Infect Dis"},{"key":"2024030122265134900_awad415-B90","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/cid\/ciad284","article-title":"Safety, tolerability, and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a phase 1, double-blind, randomized, dose-escalation study in healthy volunteers","volume":"77","author":"Ackaert","year":"2023","journal-title":"Clin Infect Dis."},{"key":"2024030122265134900_awad415-B91"},{"key":"2024030122265134900_awad415-B92","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1021\/acsinfecdis.8b00054","article-title":"Preclinical antiviral testing for dengue virus infection in mouse models and its association with clinical studies","volume":"4","author":"Watanabe","year":"2018","journal-title":"ACS Infect Dis"},{"key":"2024030122265134900_awad415-B93","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00705-021-05298-2","article-title":"Mammalian animal models for dengue virus infection: A recent overview","volume":"167","author":"Kayesh","year":"2022","journal-title":"Arch Virol"},{"key":"2024030122265134900_awad415-B94","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12250-020-00229-y","article-title":"Establishment of murine infection models with biological clones of dengue viruses derived from a single clinical viral isolate","volume":"35","author":"Zheng","year":"2020","journal-title":"Virol Sin"},{"key":"2024030122265134900_awad415-B95","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.antiviral.2015.12.008","article-title":"Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy","volume":"127","author":"Watanabe","year":"2016","journal-title":"Antiviral Res."},{"key":"2024030122265134900_awad415-B96","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/v13050771","article-title":"Antiviral evaluation of UV-4B and interferon-alpha combination regimens against dengue virus","volume":"13","author":"Franco","year":"2021","journal-title":"Viruses"},{"key":"2024030122265134900_awad415-B97","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1186\/1743-422X-8-560","article-title":"Antiviral activity of four types of bioflavonoid against dengue virus type-2","volume":"8","author":"Zandi","year":"2011","journal-title":"Virol J."},{"key":"2024030122265134900_awad415-B98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40259-022-00531-z","article-title":"Dengue vaccines: An update","volume":"36","author":"Torres-Flores","year":"2022","journal-title":"BioDrugs"},{"key":"2024030122265134900_awad415-B99","first-page":"178","article-title":"Dengue vaccine: Global development update","volume":"38","author":"Prompetchara","year":"2020","journal-title":"Asian Pac J Allergy Immunol"},{"key":"2024030122265134900_awad415-B100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40506-023-00263-w","article-title":"Dengue: Update on clinically relevant therapeutic strategies and vaccines","volume":"15","author":"Palanichamy Kala","year":"2023","journal-title":"Curr Treat Options Infect Dis"},{"key":"2024030122265134900_awad415-B101","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(14)61060-6","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: A phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"Capeding","year":"2014","journal-title":"Lancet"},{"key":"2024030122265134900_awad415-B102","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of dengue serostatus on dengue vaccine safety and efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N Engl J Med"},{"key":"2024030122265134900_awad415-B103","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1056\/NEJMoa1903869","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children and adolescents","volume":"381","author":"Biswal","year":"2019","journal-title":"N Engl J Med"},{"key":"2024030122265134900_awad415-B104","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/cid\/ciab864","article-title":"Three-year efficacy and safety of takeda\u2019s dengue vaccine candidate (TAK-003)","volume":"75","author":"Rivera","year":"2021","journal-title":"Clin Infect Dis."},{"key":"2024030122265134900_awad415-B105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1473-3099(20)30023-2","article-title":"Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine butantan-DV in adults in Brazil: A two-step, double-blind, randomised placebo-controlled phase 2 trial","volume":"20","author":"Kallas","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"2024030122265134900_awad415-B106","author":"The Butantan Portal"},{"key":"2024030122265134900_awad415-B107","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(20)30414-1","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children aged 4\u201316 years: A randomised, placebo-controlled, phase 3 trial","volume":"395","author":"Biswal","year":"2020","journal-title":"Lancet"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awad415\/56664490\/awad415.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/3\/830\/56816876\/awad415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/3\/830\/56816876\/awad415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T22:31:46Z","timestamp":1709332306000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/3\/830\/7469371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":107,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,12,11]]},"published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awad415","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,12,11]]}}}