{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:45:23Z","timestamp":1792622723817,"version":"4.5.0"},"reference-count":129,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Repetitive behaviours are common manifestations of frontotemporal dementia (FTD). Patients with FTD exhibit various types of repetitive behaviours with unique behavioural and cognitive substrates, including compulsivity, lack of impulse control, stereotypy and hoarding. Other sources of repetitive behaviours, such as restrictive interests and insistence on sameness, may also be seen in FTD. Although repetitive behaviours are highly prevalent and potentially discriminatory in this population, their expression varies widely between patients, and the field lacks consensus about the classification of these behaviours. Terms used to describe repetitive behaviours in FTD are highly heterogeneous and may lack precise definitions. This lack of harmonization of the definitions for distinct forms of repetitive behaviour limits the ability to differentiate between pathological behaviours and impedes understanding of their underlying mechanisms.<\/jats:p>\n               <jats:p>This review examines established definitions of well-characterized repetitive behaviours in other neuropsychiatric disorders and proposes operational definitions applicable to patients with FTD. Building on extant models of repetitive behaviours in non-human and lesion work and models of social behavioural changes in FTD, we describe the potential neurocognitive bases for the emergence of different types of repetitive behaviours in FTD and their potential perpetuation by a predisposition towards habit formation. Finally, examples of distinct therapeutic approaches for different forms of repetitive behaviours are highlighted, along with future directions to accurately classify, measure and treat these symptoms when they impair quality of life.<\/jats:p>","DOI":"10.1093\/brain\/awad431","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T19:23:49Z","timestamp":1703273029000},"page":"1149-1165","source":"Crossref","is-referenced-by-count":16,"title":["Defining repetitive behaviours in frontotemporal dementia"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-2699","authenticated-orcid":false,"given":"Miguel","family":"Restrepo-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University , London, ON N6A 5C1 , Canada"},{"name":"Deparment of Cognitive Neurology, Parkwood Institute , London, ON N6C 5J1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-5258","authenticated-orcid":false,"given":"Jesus","family":"Ramirez-Bermudez","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez , Mexico City, 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Chacon-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez , Mexico City, 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro","family":"Ruiz-Garcia","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez , Mexico City, 14269 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University , London, ON N6A 5C1 , Canada"},{"name":"Deparment of Cognitive Neurology, Parkwood Institute , London, ON N6C 5J1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University , London, ON N6A 5C1 , Canada"},{"name":"Deparment of Cognitive Neurology, Parkwood Institute , London, ON N6C 5J1 , 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