{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:18:46Z","timestamp":1791674326387,"version":"4.3.4"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","award":["A-5497"],"award-info":[{"award-number":["A-5497"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["NE 2372\/1-1"],"award-info":[{"award-number":["NE 2372\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington\u2019s disease (HD) predominantly affects the brain, causing a mixed movement disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral phenotype involving skeletal muscle. Mitochondrial dysfunction has been reported in tissues of HD models, including skeletal muscle, and lymphoblast and fibroblast cultures from patients with HD. Mutant huntingtin protein (mutHTT) expression can impair mitochondrial quality control and accelerate mitochondrial ageing.<\/jats:p>\n                  <jats:p>Here, we obtained fresh human skeletal muscle, a post-mitotic tissue expressing the mutated HTT allele at physiological levels since birth, and primary cell lines from HTT CAG repeat expansion mutation carriers and matched healthy volunteers to examine whether such a mitochondrial phenotype exists in human HD. Using ultra-deep mitochondrial DNA (mtDNA) sequencing, we showed an accumulation of mtDNA mutations affecting oxidative phosphorylation. Tissue proteomics indicated impairments in mtDNA maintenance with increased mitochondrial biogenesis of less efficient oxidative phosphorylation (lower complex I and IV activity). In full-length mutHTT expressing primary human cell lines, fission-inducing mitochondrial stress resulted in normal mitophagy. In contrast, expression of high levels of N-terminal mutHTT fragments promoted mitochondrial fission and resulted in slower, less dynamic mitophagy. Expression of high levels of mutHTT fragments due to somatic nuclear HTT CAG instability can thus affect mitochondrial network dynamics and mitophagy, leading to pathogenic mtDNA mutations.<\/jats:p>\n                  <jats:p>We show that life-long expression of mutant HTT causes a mitochondrial phenotype indicative of mtDNA instability in fresh post-mitotic human skeletal muscle. Thus, genomic instability may not be limited to nuclear DNA, where it results in somatic expansion of the HTT CAG repeat length in particularly vulnerable cells such as striatal neurons. In addition to efforts targeting the causative mutation, promoting mitochondrial health may be a complementary strategy in treating diseases with DNA instability such as HD.<\/jats:p>","DOI":"10.1093\/brain\/awae007","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:15:56Z","timestamp":1704730556000},"page":"2009-2022","source":"Crossref","is-referenced-by-count":46,"title":["Huntington\u2019s disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-5236","authenticated-orcid":false,"given":"Andreas","family":"Neueder","sequence":"first","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Kojer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-432X","authenticated-orcid":false,"given":"Zhenglong","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University , Ithaca, NY 14853 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences, Cornell University , Ithaca, NY 14853 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Hering","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"UCL Huntington\u2019s Disease Centre, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery , London WC1N 3BG ,","place":["UK"]},{"name":"Dementia Research Institute at UCL , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Willem","family":"Taanman","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology , London NW3 2PF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Orth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm ,","place":["Germany"]},{"name":"Swiss Huntington Centre, Siloah AG , 3073 G\u00fcmligen ,","place":["Switzerland"]},{"name":"University Hospital of Old Age Psychiatry and Psychotherapy, Bern University , CH-3000 Bern 60 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