{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:07:12Z","timestamp":1785816432169,"version":"3.56.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071192"],"award-info":[{"award-number":["82071192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101484"],"award-info":[{"award-number":["82101484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271456"],"award-info":[{"award-number":["82271456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101444"],"award-info":[{"award-number":["82101444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Key Clinical Discipline","award":["shslczdzk06103"],"award-info":[{"award-number":["shslczdzk06103"]}]},{"name":"Program for Young Excellent Talents in Pudong New Area Health System, Shanghai, China","award":["PWRq2020-10"],"award-info":[{"award-number":["PWRq2020-10"]}]},{"name":"Shanghai Science and Technology Innovation Action Plan Project Shanghai Sailing Program","award":["21YF1437600"],"award-info":[{"award-number":["21YF1437600"]}]},{"name":"Talents Training Program of Shanghai East Hospital","award":["2019xrrcjh06"],"award-info":[{"award-number":["2019xrrcjh06"]}]},{"name":"Clinical Plateau Discipline Construction Project of Shanghai Pudong New Area Health Committee","award":["PWYgy2021-05"],"award-info":[{"award-number":["PWYgy2021-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alzheimer\u2019s disease is neurodegenerative and characterized by progressive cognitive impairment. Synaptic dysfunction appears in the early stage of Alzheimer\u2019s disease and is significantly correlated with cognitive impairment. However, the specific regulatory mechanism remains unclear.<\/jats:p>\n               <jats:p>Here, we found the transcription factor Maf1 to be upregulated in Alzheimer\u2019s disease and determined that conditional knockout of Maf1 in a transgenic mouse model of Alzheimer\u2019s disease restored learning and memory function; the downregulation of Maf1 reduced the intraneuronal calcium concentration and restored neuronal synaptic morphology. We also demonstrated that Maf1 regulated the expression of NMDAR1 by binding to the promoter region of Grin1, further regulating calcium homeostasis and synaptic remodelling in neurons.<\/jats:p>\n               <jats:p>Our results clarify the important role and mechanism of the Maf1-NMDAR1 signalling pathway in stabilizing synaptic structure, neuronal function and behaviour during Alzheimer\u2019s disease pathogenesis. This therefore serves as a potential diagnostic and therapeutic target for the early stage of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/brain\/awae015","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T05:42:45Z","timestamp":1705124565000},"page":"2128-2143","source":"Crossref","is-referenced-by-count":16,"title":["Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"147","author":[{"given":"Yingying","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), the Second Military Medical University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"2024060314255883800_awae015-B1","doi-asserted-by":"crossref","first-page":"778822","DOI":"10.3389\/fnins.2021.778822","article-title":"Synapses, microglia, and lipids in Alzheimer\u2019s disease","volume":"15","author":"Paasila","year":"2021","journal-title":"Front 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