{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:45:26Z","timestamp":1794084326762,"version":"4.8.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"European Union\u2019s Horizon 2020","doi-asserted-by":"publisher","award":["799638"],"award-info":[{"award-number":["799638"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimerfonden and Margaretha af Ugglas Stiftelse"},{"name":"Fisher Center for Alzheimer\u2019s Disease Research"},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 AG054564"],"award-info":[{"award-number":["RF1 AG054564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RF1 AG047779"],"award-info":[{"award-number":["RF1 AG047779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer\u2019s disease. Gaining insight into the molecular mechanisms underlying this vulnerability will help reveal genes and pathways at play during incipient stages of the disease. Here, we use a data-driven functional genomics approach to model ECII neurons in silico and identify the proto-oncogene DEK as a regulator of tau pathology.<\/jats:p>\n               <jats:p>We show that epigenetic changes caused by Dek silencing alter activity-induced transcription, with major effects on neuronal excitability. This is accompanied by the gradual accumulation of tau in the somatodendritic compartment of mouse ECII neurons in vivo, reactivity of surrounding microglia, and microglia-mediated neuron loss. These features are all characteristic of early Alzheimer\u2019s disease.<\/jats:p>\n               <jats:p>The existence of a cell-autonomous mechanism linking Alzheimer\u2019s disease pathogenic mechanisms in the precise neuron type where the disease starts provides unique evidence that synaptic homeostasis dysregulation is of central importance in the onset of tau pathology in Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/brain\/awae051","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:01:13Z","timestamp":1710129673000},"page":"2384-2399","source":"Crossref","is-referenced-by-count":22,"title":["A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer\u2019s disease vulnerable neurons"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-3515","authenticated-orcid":false,"given":"Patricia","family":"Rodriguez-Rodriguez","sequence":"first","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Enrique","family":"Arroyo-Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tsagkogianni","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9652-7074","authenticated-orcid":false,"given":"Lechuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Rice University , Houston, TX 77004 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Bioinformatics Resource Center, The Rockefeller University , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e9gv\u00e1ri","sequence":"additional","affiliation":[{"name":"Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Salas-Allende","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakary","family":"Plautz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Cedazo-Minguez","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash C","family":"Sinha","sequence":"additional","affiliation":[{"name":"Helen and Robert Appel Alzheimer\u2019s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Troyanskaya","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Princeton University , Princeton, NJ 08540 , USA"},{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, NJ 08544 , USA"},{"name":"Center for Computational Biology, Flatiron Institute, Simons Foundation , New York, NY 10010 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Flajolet","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , 17 164, Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-6046","authenticated-orcid":false,"given":"Jean-Pierre","family":"Roussarie","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Neurobiology, Boston University Chobanian and Avedisian School of Medicine , Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"2024070507210910100_awae051-B1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"2024070507210910100_awae051-B2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in Alzheimer\u2019s disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nat Med"},{"key":"2024070507210910100_awae051-B3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B4","doi-asserted-by":"crossref","first-page":"eaau5732","DOI":"10.1126\/scitranslmed.aau5732","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La Joie","year":"2020","journal-title":"Sci Transl Med"},{"key":"2024070507210910100_awae051-B5","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"key":"2024070507210910100_awae051-B6","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1093\/brain\/awx243","article-title":"Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer\u2019s disease","volume":"140","author":"Bejanin","year":"2017","journal-title":"Brain"},{"key":"2024070507210910100_awae051-B7","doi-asserted-by":"crossref","first-page":"e49132","DOI":"10.7554\/eLife.49132","article-title":"Cortical tau deposition follows patterns of entorhinal functional connectivity in aging","volume":"8","author":"Adams","year":"2019","journal-title":"Elife"},{"key":"2024070507210910100_awae051-B8","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/s41467-020-15701-2","article-title":"Spread of pathological tau proteins through communicating neurons in human Alzheimer\u2019s disease","volume":"11","author":"Vogel","year":"2020","journal-title":"Nat Commun"},{"key":"2024070507210910100_awae051-B9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/alz.12656","article-title":"Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer\u2019s disease","volume":"19","author":"Jacobs","year":"2023","journal-title":"Alzheimers Dement"},{"key":"2024070507210910100_awae051-B10","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: Age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024070507210910100_awae051-B11","doi-asserted-by":"crossref","first-page":"eabj2511","DOI":"10.1126\/scitranslmed.abj2511","article-title":"In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer\u2019s disease pathology and cognitive decline","volume":"13","author":"Jacobs","year":"2021","journal-title":"Sci Transl Med"},{"key":"2024070507210910100_awae051-B12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","article-title":"Tau seeding activity begins in the transentorhinal\/entorhinal regions and anticipates phospho-tau pathology in Alzheimer\u2019s disease and PART","volume":"136","author":"Kaufman","year":"2018","journal-title":"Acta Neuropathol"},{"key":"2024070507210910100_awae051-B13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s40478-021-01255-x","article-title":"Anatomic survey of seeding in Alzheimer\u2019s disease brains reveals unexpected patterns","volume":"9","author":"Stopschinski","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"2024070507210910100_awae051-B14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuron.2020.06.010","article-title":"Selective neuronal vulnerability in Alzheimer\u2019s disease: A network-based analysis","volume":"107","author":"Roussarie","year":"2020","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B15","doi-asserted-by":"crossref","first-page":"e1004606","DOI":"10.1371\/journal.pgen.1004606","article-title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer\u2019s disease and related dementias","volume":"10","author":"Beecham","year":"2014","journal-title":"PLoS Genet"},{"key":"2024070507210910100_awae051-B16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","article-title":"Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms","volume":"86","author":"Andorfer","year":"2003","journal-title":"J Neurochem"},{"key":"2024070507210910100_awae051-B17","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nprot.2014.085","article-title":"Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP)","volume":"9","author":"Heiman","year":"2014","journal-title":"Nat Protoc"},{"key":"2024070507210910100_awae051-B18","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"2024070507210910100_awae051-B19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-Seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2024070507210910100_awae051-B20","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2024070507210910100_awae051-B21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"D1","key":"2024070507210910100_awae051-B22","doi-asserted-by":"crossref","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2024070507210910100_awae051-B23","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0950-3536(11)80049-1","article-title":"Translocation t(6; 9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene","volume":"5","author":"Von Lindern","year":"1992","journal-title":"Baillieres Clin Haematol"},{"key":"2024070507210910100_awae051-B24","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.4161\/cc.5.11.2801","article-title":"DEK expression is controlled by E2F and deregulated in diverse tumor types","volume":"5","author":"Carro","year":"2006","journal-title":"Cell Cycle"},{"key":"2024070507210910100_awae051-B25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/1529-0131(200001)43:1<85::AID-ANR11>3.0.CO;2-D","article-title":"Autoantibodies to DEK oncoprotein in human inflammatory disease","volume":"43","author":"Dong","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2024070507210910100_awae051-B26","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1128\/MCB.24.13.6000-6010.2004","article-title":"Functional domains of the ubiquitous chromatin protein DEK","volume":"24","author":"Kappes","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2024070507210910100_awae051-B27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1476-4598-13-215","article-title":"The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation","volume":"13","author":"Sand\u00e9n","year":"2014","journal-title":"Mol Cancer"},{"key":"2024070507210910100_awae051-B28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neuron.2018.10.013","article-title":"Activity-Regulated transcription: Bridging the gap between neural activity and behavior","volume":"100","author":"Yap","year":"2018","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/85138","article-title":"A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories","volume":"4","author":"Jones","year":"2001","journal-title":"Nat Neurosci"},{"key":"2024070507210910100_awae051-B30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0896-6273(03)00674-3","article-title":"A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval","volume":"40","author":"Bozon","year":"2003","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuron.2018.04.001","article-title":"Different neuronal activity patterns induce different gene expression programs","volume":"98","author":"Tyssowski","year":"2018","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B32","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.celrep.2019.01.032","article-title":"Enhancer histone acetylation modulates transcriptional bursting dynamics of neuronal activity-inducible genes","volume":"26","author":"Chen","year":"2019","journal-title":"Cell Rep"},{"key":"2024070507210910100_awae051-B33","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/nn.3808","article-title":"Genome-wide identification and characterization of functional neuronal activity-dependent enhancers","volume":"17","author":"Malik","year":"2014","journal-title":"Nat Neurosci"},{"key":"2024070507210910100_awae051-B34","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.febslet.2006.04.081","article-title":"Regulation of histone acetyltransferase activity of p300 and PCAF by proto-oncogene protein DEK","volume":"580","author":"Ko","year":"2006","journal-title":"FEBS Lett"},{"key":"2024070507210910100_awae051-B35","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/jcs.115.16.3319","article-title":"Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek","volume":"115","author":"Hollenbach","year":"2002","journal-title":"J Cell Sci"},{"key":"2024070507210910100_awae051-B36","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1038\/ncomms5091","article-title":"A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice","volume":"5","author":"Pai","year":"2014","journal-title":"Nat Commun"},{"key":"2024070507210910100_awae051-B37","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1074\/jbc.M607909200","article-title":"Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification","volume":"282","author":"Morris","year":"2007","journal-title":"J Biol Chem"},{"key":"2024070507210910100_awae051-B38","doi-asserted-by":"crossref","first-page":"e1006286","DOI":"10.1371\/journal.ppat.1006286","article-title":"The NF-\u03baB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells","volume":"13","author":"Poppe","year":"2017","journal-title":"PLoS Pathog"},{"key":"2024070507210910100_awae051-B39","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.stem.2018.02.005","article-title":"SETD7 drives cardiac lineage commitment through stage-specific transcriptional activation","volume":"22","author":"Lee","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2024070507210910100_awae051-B40","doi-asserted-by":"crossref","first-page":"e1000850","DOI":"10.1371\/journal.pcbi.1000850","article-title":"A threshold equation for action potential initiation","volume":"6","author":"Platkiewicz","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"2024070507210910100_awae051-B41","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1007\/s12035-019-1506-5","article-title":"Spike-related electrophysiological identification of cultured hippocampal excitatory and inhibitory neurons","volume":"56","author":"Prestigio","year":"2019","journal-title":"Mol Neurobiol"},{"key":"2024070507210910100_awae051-B42","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.neuron.2017.07.012","article-title":"Proximodistal heterogeneity of hippocampal CA3 pyramidal neuron intrinsic properties, connectivity, and reactivation during memory recall","volume":"95","author":"Sun","year":"2017","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B43","doi-asserted-by":"crossref","first-page":"102213","DOI":"10.1016\/j.pneurobio.2021.102213","article-title":"Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3","volume":"210","author":"Balleza-Tapia","year":"2022","journal-title":"Prog Neurobiol"},{"key":"2024070507210910100_awae051-B44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-012-1038-9","article-title":"Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy","volume":"124","author":"Crimins","year":"2012","journal-title":"Acta Neuropathol"},{"key":"2024070507210910100_awae051-B45","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.07.029","article-title":"Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs","volume":"223","author":"Rocher","year":"2010","journal-title":"Exp Neurol"},{"key":"2024070507210910100_awae051-B46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41419-021-04007-w","article-title":"Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia","volume":"12","author":"Kopach","year":"2021","journal-title":"Cell Death Dis"},{"key":"2024070507210910100_awae051-B47","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1038\/emboj.2011.376","article-title":"Novel diffusion barrier for axonal retention of tau in neurons and its failure in neurodegeneration","volume":"30","author":"Li","year":"2011","journal-title":"EMBO J"},{"key":"2024070507210910100_awae051-B48","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.15252\/embj.201797724","article-title":"Somatodendritic accumulation of tau in Alzheimer\u2019s disease is promoted by fyn-mediated local protein translation","volume":"36","author":"Li","year":"2017","journal-title":"EMBO J"},{"key":"2024070507210910100_awae051-B49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3233\/JAD-2007-12410","article-title":"Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer\u2019s disease1","volume":"12","author":"Luna-Mu\u00f1oz","year":"2007","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2024070507210910100_awae051-B50","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1097\/00001756-199411000-00037","article-title":"Early phosphorylation of tau in Alzheimer\u2019s disease occurs at Ser-202 and is preferentially located within neurites","volume":"5","author":"Su","year":"1994","journal-title":"Neuroreport"},{"key":"2024070507210910100_awae051-B51","doi-asserted-by":"crossref","first-page":"eabb1540","DOI":"10.1126\/sciadv.abb1540","article-title":"Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson\u2019s disease-linked DNAJC6 mutations","volume":"7","author":"Wulansari","year":"2021","journal-title":"Sci Adv"},{"key":"2024070507210910100_awae051-B52","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2016.04.001","article-title":"Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation","volume":"165","author":"Lui","year":"2016","journal-title":"Cell"},{"key":"2024070507210910100_awae051-B53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature18283","article-title":"A complement-microglial axis drives synapse loss during virus-induced memory impairment","volume":"534","author":"Vasek","year":"2016","journal-title":"Nature"},{"key":"2024070507210910100_awae051-B54","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"2024070507210910100_awae051-B55","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1038\/s41467-020-19737-2","article-title":"Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer\u2019s disease","volume":"11","author":"Olah","year":"2020","journal-title":"Nat Commun"},{"key":"2024070507210910100_awae051-B56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-020-2777-8","article-title":"Negative feedback control of neuronal activity by microglia","volume":"586","author":"Badimon","year":"2020","journal-title":"Nature"},{"key":"2024070507210910100_awae051-B57","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","article-title":"Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer\u2019s disease model","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nat Commun"},{"key":"2024070507210910100_awae051-B58","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/alz.12106","article-title":"Genome-wide association study of rate of cognitive decline in Alzheimer\u2019s disease patients identifies novel genes and pathways","volume":"16","author":"Sherva","year":"2020","journal-title":"Alzheimer\u2019s Dement"},{"key":"2024070507210910100_awae051-B59","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nmeth.3547","article-title":"Predicting effects of noncoding variants with deep learning\u2013based sequence model","volume":"12","author":"Zhou","year":"2015","journal-title":"Nat Methods"},{"key":"2024070507210910100_awae051-B60","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome","volume":"40","author":"Wang","year":"2008","journal-title":"Nat Genet"},{"key":"2024070507210910100_awae051-B61","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stemcr.2017.08.019","article-title":"Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening","volume":"9","author":"Wang","year":"2017","journal-title":"Stem Cell Reports"},{"key":"2024070507210910100_awae051-B62","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuron.2016.09.022","article-title":"Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model","volume":"92","author":"Lasagna-Reeves","year":"2016","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B63","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stem.2018.12.013","article-title":"Cholesterol metabolism is a druggable axis that independently regulates tau and amyloid-\u03b2 in iPSC-derived Alzheimer\u2019s disease neurons","volume":"24","author":"van der Kant","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2024070507210910100_awae051-B64","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1128\/MCB.24.13.6011-6020.2004","article-title":"Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK","volume":"24","author":"Kappes","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2024070507210910100_awae051-B65","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.20100830","article-title":"FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation","volume":"208","author":"Babaei-Jadidi","year":"2011","journal-title":"J Exp Med"},{"key":"2024070507210910100_awae051-B66","doi-asserted-by":"crossref","first-page":"e113246","DOI":"10.15252\/embj.2022113246","article-title":"Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer\u2019s disease models","volume":"42","author":"Rueda-Carrasco J, Sokolova D, Lee S,","year":"2023","journal-title":"EMBO J"},{"key":"2024070507210910100_awae051-B67","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuron.2019.01.014","article-title":"Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer\u2019s disease model","volume":"101","author":"Merlini","year":"2019","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B68","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"2024070507210910100_awae051-B69","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer\u2019s disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"2024070507210910100_awae051-B70","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/cercor\/bhn242","article-title":"The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging","volume":"19","author":"Kabaso","year":"2009","journal-title":"Cereb Cortex"},{"key":"2024070507210910100_awae051-B71","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/cercor\/bhh144","article-title":"Increased action potential firing rates of layer 2\/3 pyramidal cells in the prefrontal Cortex are significantly related to cognitive performance in aged monkeys","volume":"15","author":"Chang","year":"2005","journal-title":"Cereb Cortex"},{"key":"2024070507210910100_awae051-B72","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1523\/JNEUROSCI.2692-08.2008","article-title":"Picomolar amyloid-\u03b2 positively modulates synaptic plasticity and memory in hippocampus","volume":"28","author":"Puzzo","year":"2008","journal-title":"J Neurosci"},{"key":"2024070507210910100_awae051-B73","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-\u03b2 as a positive endogenous regulator of release probability at hippocampal synapses","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat Neurosci"},{"key":"2024070507210910100_awae051-B74","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41467-017-01444-0","article-title":"Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer\u2019s disease-like pathology","volume":"8","author":"Nuriel","year":"2017","journal-title":"Nat Commun"},{"key":"2024070507210910100_awae051-B75","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuron.2019.08.008","article-title":"Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis","volume":"104","author":"Sohn","year":"2019","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B76","doi-asserted-by":"crossref","first-page":"734001","DOI":"10.3389\/fnins.2021.734001","article-title":"Astrocytic and neuronal apolipoprotein E isoforms differentially affect neuronal excitability","volume":"15","author":"Konings","year":"2021","journal-title":"Front Neurosci"},{"key":"2024070507210910100_awae051-B77","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer\u2019s disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat Med"},{"key":"2024070507210910100_awae051-B78","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B79","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol"},{"key":"2024070507210910100_awae051-B80","doi-asserted-by":"crossref","first-page":"e6344","DOI":"10.1371\/journal.pone.0006344","article-title":"The excitotoxin quinolinic acid induces tau phosphorylation in human neurons","volume":"4","author":"Rahman","year":"2009","journal-title":"PLoS One"},{"key":"2024070507210910100_awae051-B81","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B82","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-\u03b2 deposition","volume":"14","author":"Bero","year":"2011","journal-title":"Nat Neurosci"},{"key":"2024070507210910100_awae051-B83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.20131685","article-title":"Neuronal activity regulates extracellular tau in vivo","volume":"211","author":"Yamada","year":"2014","journal-title":"J Exp Med"},{"key":"2024070507210910100_awae051-B84","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in vivo","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci"},{"key":"2024070507210910100_awae051-B85","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/embor.2013.15","article-title":"Physiological release of endogenous tau is stimulated by neuronal activity","volume":"14","author":"Pooler","year":"2013","journal-title":"EMBO Rep"},{"key":"2024070507210910100_awae051-B86","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.neuron.2022.06.021","article-title":"Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer\u2019s disease","volume":"110","author":"Otero-Garcia","year":"2022","journal-title":"Neuron"},{"key":"2024070507210910100_awae051-B87","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2017.05.012","article-title":"Local somatodendritic translation and hyperphosphorylation of tau protein triggered by AMPA and NMDA receptor stimulation","volume":"20","author":"Kobayashi","year":"2017","journal-title":"EBioMedicine"},{"key":"2024070507210910100_awae051-B88","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12031-015-0692-5","article-title":"NPAS4 facilitates the autophagic clearance of endogenous tau in rat cortical neurons","volume":"58","author":"Fan","year":"2016","journal-title":"J Mol Neurosci"},{"key":"2024070507210910100_awae051-B89","doi-asserted-by":"crossref","first-page":"2109.e1","DOI":"10.1016\/j.neurobiolaging.2011.05.025","article-title":"Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer\u2019s disease","volume":"32","author":"Brown","year":"2011","journal-title":"Neurobiol Aging"},{"key":"2024070507210910100_awae051-B90","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024070507210910100_awae051-B91","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1523\/JNEUROSCI.2552-14.2015","article-title":"Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Hall","year":"2015","journal-title":"J Neurosci"},{"key":"2024070507210910100_awae051-B92","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2014.10.024","article-title":"Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer\u2019s disease","volume":"84","author":"\u0160i\u0161kov\u00e1","year":"2014","journal-title":"Neuron"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae051\/58196067\/awae051.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/7\/2384\/58447042\/awae051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/7\/2384\/58447042\/awae051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:22:37Z","timestamp":1720164157000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/7\/2384\/7625227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":92,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,3,11]]},"published-print":{"date-parts":[[2024,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae051","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,3,11]]}}}