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The immune escape mechanism of VZV remains elusive. As to mice have no VZV infection receptor, herpes simplex virus type 1 (HSV-1) infection is a well established PHN mice model.<\/jats:p>\n               <jats:p>Transcriptional expression analysis identified that the protein arginine methyltransferases 6 (Prmt6) was upregulated upon HSV-1 infection, which was further confirmed by immunofluorescence staining in spinal dorsal horn. Prmt6 deficiency decreased HSV-1-induced neuroinflammation and PHN by enhancing antiviral innate immunity and decreasing HSV-1 load in vivo and in vitro. Overexpression of Prmt6 in microglia dampened antiviral innate immunity and increased HSV-1 load. Mechanistically, Prmt6 methylated and inactivated STING, resulting in reduced phosphorylation of TANK binding kinase-1 (TBK1) and interferon regulatory factor 3 (IRF3), diminished production of type I interferon (IFN-I) and antiviral innate immunity. Furthermore, intrathecal or intraperitoneal administration of the Prmt6 inhibitor EPZ020411 decreased HSV-1-induced neuroinflammation and PHN by enhancing antiviral innate immunity and decreasing HSV-1 load.<\/jats:p>\n               <jats:p>Our findings revealed that HSV-1 escapes antiviral innate immunity and results in PHN by upregulating Prmt6 expression and inhibiting the cGAS-STING pathway, providing novel insights and a potential therapeutic target for PHN.<\/jats:p>","DOI":"10.1093\/brain\/awae053","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T07:01:07Z","timestamp":1708153267000},"page":"2552-2565","source":"Crossref","is-referenced-by-count":35,"title":["HSV-1 reactivation results in post-herpetic neuralgia by upregulating Prmt6 and inhibiting cGAS-STING"],"prefix":"10.1093","volume":"147","author":[{"given":"Erliang","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"},{"name":"Department of Anesthesiology, The 988th Hospital of Joint Logistic Support Force of Chinese People\u2019s Liberation Army , Zhengzhou, Henan 450042 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University , Shanghai 200003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The 988th Hospital of Joint Logistic Support Force of Chinese People\u2019s Liberation Army , Zhengzhou, Henan 450042 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical University , Shanghai 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Changzheng 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