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Blast mTBI, caused by exposure to a pressure wave from an explosion, is predominantly experienced by military personnel and has increased in prevalence and severity in recent decades. Yet the underlying pathology of blast mTBI is largely unknown.<\/jats:p>\n                  <jats:p>We examined the expression and localization of AQP4 in human post-mortem frontal cortex and observed distinct laminar differences in AQP4 expression following blast exposure. We also observed similar laminar changes in AQP4 expression and localization and delayed impairment of glymphatic function that emerged 28\u2005days following blast injury in a mouse model of repetitive blast mTBI. In a cohort of veterans with blast mTBI, we observed that blast exposure was associated with an increased burden of frontal cortical MRI-visible perivascular spaces, a putative neuroimaging marker of glymphatic perivascular dysfunction.<\/jats:p>\n                  <jats:p>These findings suggest that changes in AQP4 and delayed glymphatic impairment following blast injury may render the post-traumatic brain vulnerable to post-concussive symptoms and chronic neurodegeneration.<\/jats:p>","DOI":"10.1093\/brain\/awae065","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T17:47:20Z","timestamp":1709142440000},"page":"2214-2229","source":"Crossref","is-referenced-by-count":52,"title":["Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function"],"prefix":"10.1093","volume":"147","author":[{"given":"Molly","family":"Braun","sequence":"first","affiliation":[{"name":"VISN 20 Northwest Mental Illness 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Harker","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. , Bethesda, MD 20817 , USA"},{"name":"Department of Pathology, F Edward H\u00e9bert School of Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814 , USA"},{"name":"DoD\/USU Brain Tissue Repository, Uniformed Services University of the Health Sciences , Bethesda, MD 20814 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deidre","family":"Jansson","sequence":"additional","affiliation":[{"name":"VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System , Seattle, WA 98108 , USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine , Seattle, WA 98195 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cook","sequence":"additional","affiliation":[{"name":"VISN 20 Geriatric Research, Education and Clinical Center (GRECC), VA Puget 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