{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:28Z","timestamp":1792511908418,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271464"],"award-info":[{"award-number":["82271464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Frontotemporal dementia (FTD) is a disease of high heterogeneity, apathy and disinhibition present in all subtypes of FTD and imposes a significant burden on families\/society. Traditional neuroimaging analysis has limitations in elucidating the network localization due to individual clinical and neuroanatomical variability.<\/jats:p>\n                  <jats:p>The study aims to identify the atrophy network map associated with different FTD clinical subtypes and determine the specific localization of the network for apathy and disinhibition.<\/jats:p>\n                  <jats:p>Eighty FTD patients [45 behavioural variant FTD (bvFTD) and 35 semantic variant progressive primary aphasia (svPPA)] and 58 healthy controls at Xuanwu Hospital were enrolled as Dataset 1; 112 FTD patients including 50 bvFTD, 32 svPPA and 30 non-fluent variant PPA (nfvPPA) cases, and 110 healthy controls from the Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI) dataset were included as Dataset 2. Initially, single-subject atrophy maps were defined by comparing cortical thickness in each FTD patient versus healthy controls. Next, the network of brain regions functionally connected to each FTD patient\u2019s location of atrophy was determined using seed-based functional connectivity in a large (n = 1000) normative connectome.<\/jats:p>\n                  <jats:p>Finally, we used atrophy network mapping to define clinical subtype-specific network (45 bvFTD, 35 svPPA and 58 healthy controls in Dataset 1; 50 bvFTD, 32 svPPA, 30 nfvPPA and 110 healthy controls in Dataset 2) and symptom-specific networks [combined Datasets 1 and 2, apathy without depression versus non-apathy without depression (80:26), disinhibition versus non-disinhibition (88:68)]. We compare the result with matched symptom networks derived from patients with focal brain lesions or conjunction analysis.<\/jats:p>\n                  <jats:p>Through the analysis of two datasets, we identified heterogeneity in atrophy patterns among FTD patients. However, these atrophy patterns are connected to a common brain network. The primary regions affected by atrophy in FTD included the frontal and temporal lobes, particularly the anterior temporal lobe. bvFTD connects to frontal and temporal cortical areas, svPPA mainly impacts the anterior temporal region and nfvPPA targets the inferior frontal gyrus and precentral cortex regions. The apathy-specific network was localized in the orbital frontal cortex and ventral striatum, while the disinhibition-specific network was localized in the bilateral orbital frontal gyrus and right temporal lobe. Apathy and disinhibition atrophy networks resemble known motivational and criminal lesion networks, respectively. A significant correlation was found between the apathy\/disinhibition scores and functional connectivity between atrophy maps and the peak of the networks.<\/jats:p>\n                  <jats:p>This study localizes the common network of clinical subtypes and main symptoms in FTD, guiding future FTD neuromodulation interventions.<\/jats:p>","DOI":"10.1093\/brain\/awae067","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T01:36:32Z","timestamp":1709170592000},"page":"3048-3058","source":"Crossref","is-referenced-by-count":37,"title":["Atrophy network mapping of clinical subtypes and main symptoms in frontotemporal dementia"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-6162","authenticated-orcid":false,"given":"Min","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitian","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-3068","authenticated-orcid":false,"given":"Liankun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Banner Alzheimer\u2019s Institute, University of Arizona, Arizona Alzheimer\u2019s Consortium, Arizona State University , Tempe, AZ 85014-3666 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-1376","authenticated-orcid":false,"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[{"name":"McGill Centre for Studies in Aging, Alzheimer\u2019s Disease Research Unit , Montreal H4H 1R3 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, 100053 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"2024090322104631500_awae067-B1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"2024090322104631500_awae067-B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ajp.2016.02.007","article-title":"Use of transcranial direct current stimulation (tDCS) in a woman with behavioral variant fronto-temporal dementia","volume":"21","author":"Agarwal","year":"2016","journal-title":"Asian J Psychiatr"},{"key":"2024090322104631500_awae067-B4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1212\/01.wnl.0000324920.96835.95","article-title":"Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates","volume":"71","author":"Zamboni","year":"2008","journal-title":"Neurology"},{"key":"2024090322104631500_awae067-B5","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/brain\/awx101","article-title":"Apathy and impulsivity in frontotemporal lobar degeneration syndromes","volume":"140","author":"Lansdall","year":"2017","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1155\/2012\/286427","article-title":"Apathy in frontotemporal dementia: Behavioral and neuroimaging correlates","volume":"25","author":"Eslinger","year":"2012","journal-title":"Behav Neurol"},{"key":"2024090322104631500_awae067-B7","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1007\/s11682-019-00150-3","article-title":"Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia","volume":"14","author":"Sheelakumari","year":"2020","journal-title":"Brain Imaging Behavior"},{"key":"2024090322104631500_awae067-B8","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3233\/JAD-215127","article-title":"Investigating the roles of anterior cingulate in behavioral variant frontotemporal dementia: A PET\/MRI study","volume":"84","author":"Chu","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"2024090322104631500_awae067-B9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neurobiolaging.2023.01.004","article-title":"Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia","volume":"124","author":"Chu","year":"2023","journal-title":"Neurobiol Aging"},{"key":"2024090322104631500_awae067-B10","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMra1706158","article-title":"Mapping symptoms to brain networks with the human connectome","volume":"379","author":"Fox","year":"2018","journal-title":"N Engl J Med"},{"issue":"Pt 10","key":"2024090322104631500_awae067-B11","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/brain\/awv228","article-title":"Network localization of neurological symptoms from focal brain lesions","volume":"138","author":"Boes","year":"2015","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/brain\/awaa058","article-title":"Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease","volume":"143","author":"Tetreault","year":"2020","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B13","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/ana.25901","article-title":"Network localization of alien limb in patients with corticobasal syndrome","volume":"88","author":"Tetreault","year":"2020","journal-title":"Ann Neurol"},{"key":"2024090322104631500_awae067-B14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-022-02476-0","article-title":"Network alterations underlying anxiety symptoms in early multiple sclerosis","volume":"19","author":"Ellwardt","year":"2022","journal-title":"J Neuroinflammation"},{"key":"2024090322104631500_awae067-B15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/awab032","article-title":"Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia","volume":"144","author":"Shaw","year":"2021","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41583-018-0029-9","article-title":"Neuroscience of apathy and anhedonia: A transdiagnostic approach","volume":"19","author":"Husain","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2024090322104631500_awae067-B17","doi-asserted-by":"crossref","first-page":"102189","DOI":"10.1016\/j.cpr.2022.102189","article-title":"Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping","volume":"96","author":"Feng","year":"2022","journal-title":"Clin Psychol Rev"},{"key":"2024090322104631500_awae067-B18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1001\/jamaneurol.2014.3781","article-title":"Criminal behavior in frontotemporal dementia and Alzheimer disease","volume":"72","author":"Liljegren","year":"2015","journal-title":"JAMA Neurol"},{"key":"2024090322104631500_awae067-B19","first-page":"219","article-title":"Behavioral variant of frontotemporal dementia and homicide in a historical case","volume":"49","author":"Zago","year":"2021","journal-title":"J Am Acad Psychiatry Law"},{"key":"2024090322104631500_awae067-B20","doi-asserted-by":"crossref","first-page":"e190261","DOI":"10.1001\/jamanetworkopen.2019.0261","article-title":"Association of neuropathologically confirmed frontotemporal dementia and Alzheimer disease with criminal and socially inappropriate behavior in a Swedish cohort","volume":"2","author":"Liljegren","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2024090322104631500_awae067-B21","first-page":"82","article-title":"Late-onset sex offending and the assessment of behavioral variant frontotemporal dementia (bvFTD)","volume":"51","author":"MacIntyre","year":"2023","journal-title":"J Am Acad Psychiatry Law"},{"key":"2024090322104631500_awae067-B22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jagp.2020.11.011","article-title":"Criminal behavior in the four years preceding diagnosis of neurocognitive disorder: A nationwide register study in Finland","volume":"29","author":"Talaslahti","year":"2021","journal-title":"Am J Geriatr Psychiatry"},{"key":"2024090322104631500_awae067-B23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1073\/pnas.1706587115","article-title":"Lesion network localization of criminal behavior","volume":"115","author":"Darby","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024090322104631500_awae067-B24","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/brain\/awaa225","article-title":"A clinical-radiological framework of the right temporal variant of frontotemporal dementia","volume":"143","author":"Ulugut Erkoyun","year":"2020","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B25","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1093\/brain\/awac217","article-title":"Right temporal degeneration and socioemotional semantics: Semantic behavioural variant frontotemporal dementia","volume":"145","author":"Younes","year":"2022","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"2024090322104631500_awae067-B27","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"key":"2024090322104631500_awae067-B28","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"key":"2024090322104631500_awae067-B29","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"2024090322104631500_awae067-B30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/brain\/awy292","article-title":"Network localization of heterogeneous neuroimaging findings","volume":"142","author":"Darby","year":"2019","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cortex.2022.01.001","article-title":"Are there distinct dimensions of apathy? The argument for reappraisal","volume":"149","author":"Dickson","year":"2022","journal-title":"Cortex"},{"key":"2024090322104631500_awae067-B32","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/brain\/awac427","article-title":"Effort avoidance as a core mechanism of apathy in frontotemporal dementia","volume":"146","author":"Le Bouc","year":"2023","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B33","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/brain\/awac133","article-title":"A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia","volume":"145","author":"Jenkins","year":"2022","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000194658","article-title":"Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration","volume":"27","author":"Massimo","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2024090322104631500_awae067-B35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/jnnp-2017-316277","article-title":"Apathy: A neurocircuitry model based on frontotemporal dementia","volume":"89","author":"Ducharme","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024090322104631500_awae067-B36","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/hbm.22225","article-title":"Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries","volume":"35","author":"Knutson","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2024090322104631500_awae067-B37","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1212\/WNL.0000000000004215","article-title":"Behavioral-variant frontotemporal dementia: Distinct phenotypes with unique functional profiles","volume":"89","author":"O'Connor","year":"2017","journal-title":"Neurology"},{"issue":"5\u20136","key":"2024090322104631500_awae067-B38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000091898","article-title":"Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia","volume":"21","author":"Peters","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2024090322104631500_awae067-B39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ana.20365","article-title":"Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration","volume":"57","author":"Franceschi","year":"2005","journal-title":"Ann Neurol"},{"key":"2024090322104631500_awae067-B40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pscychresns.2011.06.009","article-title":"Dissociating behavioral disorders in early dementia-an FDG-PET study","volume":"194","author":"Schroeter","year":"2011","journal-title":"Psychiatry Res"},{"key":"2024090322104631500_awae067-B41","first-page":"1249","article-title":"Salience network resting-state activity: Prediction of frontotemporal dementia progression","volume":"70","author":"Day","year":"2013","journal-title":"JAMA Neurol"},{"issue":"Pt 11","key":"2024090322104631500_awae067-B42","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awh628","article-title":"Neuroanatomical correlates of behavioural disorders in dementia","volume":"128","author":"Rosen","year":"2005","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/WNN.0000000000000044","article-title":"White matter disease contributes to apathy and disinhibition in behavioral variant frontotemporal dementia","volume":"27","author":"Powers","year":"2014","journal-title":"Cogn Behav Neurol"},{"issue":"Pt 11","key":"2024090322104631500_awae067-B44","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1093\/brain\/awl288","article-title":"Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia","volume":"129","author":"Le Ber","year":"2006","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B45","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.cortex.2012.09.008","article-title":"Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation","volume":"49","author":"Farb","year":"2013","journal-title":"Cortex"},{"key":"2024090322104631500_awae067-B46","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3389\/fneur.2019.01059","article-title":"The association between distinct frontal brain volumes and behavioral symptoms in mild cognitive impairment, Alzheimer's disease, and frontotemporal dementia","volume":"10","author":"Cajanus","year":"2019","journal-title":"Front Neurol"},{"key":"2024090322104631500_awae067-B47","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/brain\/awr173","article-title":"Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia","volume":"134","author":"Hornberger","year":"2011","journal-title":"Brain"},{"key":"2024090322104631500_awae067-B48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000513979","article-title":"Neurobehavioral characteristics of FDG-PET defined right-dominant semantic dementia: A longitudinal study","volume":"50","author":"Curet Burleson","year":"2021","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2024090322104631500_awae067-B49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1176\/appi.neuropsych.14060126","article-title":"Areas of brain damage underlying increased reports of behavioral disinhibition","volume":"27","author":"Knutson","year":"2015","journal-title":"J Neuropsychiatry Clin Neurosci"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae067\/58721271\/awae067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3048\/59004024\/awae067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/9\/3048\/59004024\/awae067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T06:46:42Z","timestamp":1725432402000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/9\/3048\/7616954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,3,1]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae067","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,3,1]]}}}