{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:07:37Z","timestamp":1791857257510,"version":"4.3.4"},"reference-count":114,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT012312"],"award-info":[{"award-number":["R01AT012312"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT011439"],"award-info":[{"award-number":["R01AT011439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 NS128613"],"award-info":[{"award-number":["U19 NS128613"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL122578"],"award-info":[{"award-number":["R01HL122578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"U.S. Army Research Office","doi-asserted-by":"publisher","award":["MURI W911NF1910280"],"award-info":[{"award-number":["MURI W911NF1910280"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Simon Foundation"},{"DOI":"10.13039\/100005984","name":"Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNS2, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal ageing. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis is a potential mediator of neuronal injury as K+ elevations increase excitatory activity. The dysregulation of extracellular K+ and potassium channel expressions during neurodegeneration could contribute to this distinction. Here we measured the cortical extracellular K+ concentration ([K+]e) in awake wild-type mice as well as murine models of neurodegeneration using K+-sensitive microelectrodes.<\/jats:p>\n                  <jats:p>Unexpectedly, aged wild-type mice exhibited significantly lower cortical [K+]e than young mice. In contrast, cortical [K+]e was consistently elevated in Alzheimer\u2019s disease (APP\/PS1), amyotrophic lateral sclerosis (ALS) (SOD1G93A) and Huntington\u2019s disease (R6\/2) models. Cortical resting [K+]e correlated inversely with neuronal density and the [K+]e buffering rate but correlated positively with the predicted neuronal firing rate. Screening of astrocyte-selective genomic datasets revealed a number of potassium channel genes that were downregulated in these disease models but not in normal ageing. In particular, the inwardly rectifying potassium channel Kcnj10 was downregulated in ALS and Huntington\u2019s disease models but not in normal ageing, while Fxyd1 and Slc1a3, each of which acts as a negative regulator of potassium uptake, were each upregulated by astrocytes in both Alzheimer\u2019s disease and ALS models. Chronic elevation of [K+]e in response to changes in gene expression and the attendant neuronal hyperexcitability may drive the neuronal loss characteristic of these neurodegenerative diseases. These observations suggest that the dysregulation of extracellular K+ homeostasis in a number of neurodegenerative diseases could be due to aberrant astrocytic K+ buffering and as such, highlight a fundamental role for glial dysfunction in neurodegeneration.<\/jats:p>","DOI":"10.1093\/brain\/awae075","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T01:19:14Z","timestamp":1709860754000},"page":"1726-1739","source":"Crossref","is-referenced-by-count":50,"title":["Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration"],"prefix":"10.1093","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-3668","authenticated-orcid":false,"given":"Fengfei","family":"Ding","sequence":"first","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]},{"name":"Department of Pharmacology, Shanghai Medical College, Fudan University , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]},{"name":"Department of Pharmacology, Shanghai Medical College, Fudan University , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Long","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune Nguyen","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, Neurology Department, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwu","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Weikop","sequence":"additional","affiliation":[{"name":"Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, Neurology Department, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-4303","authenticated-orcid":false,"given":"Steven A","family":"Goldman","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]},{"name":"Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, Neurology Department, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-6031","authenticated-orcid":false,"given":"Maiken","family":"Nedergaard","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]},{"name":"Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, Neurology Department, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"2025031100020896200_awae075-B1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"key":"2025031100020896200_awae075-B2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000445751","article-title":"The incidence of Parkinson's disease: A systematic review and meta-analysis","volume":"46","author":"Hirsch","year":"2016","journal-title":"Neuroepidemiology"},{"key":"2025031100020896200_awae075-B3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"2025031100020896200_awae075-B4","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.3390\/ijms19103082","article-title":"Neuronal cell death mechanisms in Major neurodegenerative diseases","volume":"19","author":"Chi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2025031100020896200_awae075-B5","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1523\/JNEUROSCI.4825-12.2013","article-title":"Altered synaptic dynamics during normal brain aging","volume":"33","author":"Mostany","year":"2013","journal-title":"J Neurosci"},{"issue":"Suppl 1","key":"2025031100020896200_awae075-B6","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/S0197-4580(03)00051-4","article-title":"Neurons, glia, and plasticity in normal brain aging","volume":"24","author":"Finch","year":"2003","journal-title":"Neurobiol Aging"},{"key":"2025031100020896200_awae075-B7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1126\/science.278.5337.412","article-title":"Life and death of neurons in the aging brain","volume":"278","author":"Morrison","year":"1997","journal-title":"Science"},{"key":"2025031100020896200_awae075-B8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2025031100020896200_awae075-B9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41467-018-03509-0","article-title":"A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers","volume":"9","author":"Thibaudeau","year":"2018","journal-title":"Nat Commun"},{"key":"2025031100020896200_awae075-B10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: A focus on human studies","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"2025031100020896200_awae075-B11","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02264","article-title":"Folding proteins in fatal ways","volume":"426","author":"Selkoe","year":"2003","journal-title":"Nature"},{"key":"2025031100020896200_awae075-B12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/jn.1988.59.1.259","article-title":"Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice","volume":"59","author":"Traynelis","year":"1988","journal-title":"J Neurophysiol"},{"key":"2025031100020896200_awae075-B13","doi-asserted-by":"crossref","first-page":"101802","DOI":"10.1016\/j.pneurobio.2020.101802","article-title":"Interstitial ions: A key regulator of state-dependent neural activity?","volume":"193","author":"Rasmussen","year":"2020","journal-title":"Prog Neurobiol"},{"key":"2025031100020896200_awae075-B14","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.bpj.2017.06.052","article-title":"Brain extracellular space: The final frontier of neuroscience","volume":"113","author":"Nicholson","year":"2017","journal-title":"Biophys J"},{"key":"2025031100020896200_awae075-B15","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.celrep.2019.06.082","article-title":"Cortex-wide changes in extracellular potassium ions parallel brain state transitions in awake behaving mice","volume":"28","author":"Rasmussen","year":"2019","journal-title":"Cell Rep"},{"key":"2025031100020896200_awae075-B16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.aad4821","article-title":"Changes in the composition of brain interstitial ions control the sleep-wake cycle","volume":"352","author":"Ding","year":"2016","journal-title":"Science"},{"key":"2025031100020896200_awae075-B17","doi-asserted-by":"crossref","first-page":"e22127","DOI":"10.1371\/journal.pone.0022127","article-title":"Neural dynamics during anoxia and the \u201cwave of death\u201d","volume":"6","author":"Zandt","year":"2011","journal-title":"PLoS One"},{"issue":"2\u20133","key":"2025031100020896200_awae075-B18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0079-6107(83)90006-8","article-title":"Extracellular K+ accumulation in the central nervous system","volume":"42","author":"Sykova","year":"1983","journal-title":"Prog Biophys Mol Biol"},{"key":"2025031100020896200_awae075-B19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.ph.41.030179.001111","article-title":"Extracellular potassium in the mammalian central nervous system","volume":"41","author":"Somjen","year":"1979","journal-title":"Annu Rev Physiol"},{"key":"2025031100020896200_awae075-B20","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0021-9258(18)49357-X","article-title":"Potassium migration and amino acid transport","volume":"233","author":"Riggs","year":"1958","journal-title":"J Biol Chem"},{"key":"2025031100020896200_awae075-B21","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1038\/ncomms11758","article-title":"Human glia can both induce and rescue aspects of disease phenotype in Huntington disease","volume":"7","author":"Benraiss","year":"2016","journal-title":"Nat Commun"},{"key":"2025031100020896200_awae075-B22","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington\u2019s disease model mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat Neurosci"},{"key":"2025031100020896200_awae075-B23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum Mol Genet"},{"key":"2025031100020896200_awae075-B24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/mus.20228","article-title":"Gait analysis detects early changes in transgenic SOD1(G93A) mice","volume":"32","author":"Wooley","year":"2005","journal-title":"Muscle Nerve"},{"key":"2025031100020896200_awae075-B25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"2025031100020896200_awae075-B26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.92.3.689","article-title":"Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis","volume":"92","author":"Ripps","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"2025031100020896200_awae075-B27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2005.02.006","article-title":"Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS","volume":"236","author":"Heiman-Patterson","year":"2005","journal-title":"J Neurol Sci"},{"key":"2025031100020896200_awae075-B28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0960-8966(03)00104-4","article-title":"Sexual differences in onset of disease and response to exercise in a transgenic model of ALS","volume":"13","author":"Veldink","year":"2003","journal-title":"Neuromuscul Disord"},{"key":"2025031100020896200_awae075-B29","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1038\/s41598-021-87609-w","article-title":"Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization","volume":"11","author":"Monai","year":"2021","journal-title":"Sci Rep"},{"key":"2025031100020896200_awae075-B30","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1073\/pnas.1120380109","article-title":"Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake","volume":"109","author":"Wang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025031100020896200_awae075-B31","doi-asserted-by":"crossref","first-page":"ra26","DOI":"10.1126\/scisignal.2002334","article-title":"Astrocytes modulate neural network activity by Ca(2)+-dependent uptake of extracellular K+","volume":"5","author":"Wang","year":"2012","journal-title":"Sci Signal"},{"key":"2025031100020896200_awae075-B32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-1-4899-2468-1_19","article-title":"Diffusion properties of brain tissue measured with electrode methods and prospects for optical analysis","volume":"333","author":"Nicholson","year":"1993","journal-title":"Adv Exp Med Biol"},{"key":"2025031100020896200_awae075-B33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(78)90886-7","article-title":"The clearing of excess potassium from extracellular space in spinal cord and cerebral cortex","volume":"151","author":"Cordingley","year":"1978","journal-title":"Brain Res"},{"key":"2025031100020896200_awae075-B34","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1523\/JNEUROSCI.2223-19.2020","article-title":"Meningeal lymphangiogenesis and enhanced glymphatic activity in mice with chronically implanted EEG electrodes","volume":"40","author":"Hauglund","year":"2020","journal-title":"J Neurosci"},{"key":"2025031100020896200_awae075-B35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cels.2017.11.011","article-title":"Chaotic dynamics mediate brain state transitions, driven by changes in extracellular ion concentrations","volume":"5","author":"Rasmussen","year":"2017","journal-title":"Cell Syst"},{"key":"2025031100020896200_awae075-B36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2016.02.032","article-title":"Involvement of Ca(2+)-dependent hyperpolarization in sleep duration in mammals","volume":"90","author":"Tatsuki","year":"2016","journal-title":"Neuron"},{"key":"2025031100020896200_awae075-B37","article-title":"Biophysical modeling of dopaminergic denervation landscapes in the striatum reveals new therapeutic strategy","volume":"9","author":"Heltberg","year":"2022","journal-title":"eNeuro"},{"key":"2025031100020896200_awae075-B38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The aging astrocyte transcriptome from multiple regions of the mouse brain","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep"},{"key":"2025031100020896200_awae075-B39","first-page":"430","article-title":"Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Zeng","year":"2023","journal-title":"Nat Neurosci"},{"key":"2025031100020896200_awae075-B40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer's disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat Neurosci"},{"key":"2025031100020896200_awae075-B41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41467-023-36519-8","article-title":"Single-cell RNA-Sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice","volume":"14","author":"Park","year":"2023","journal-title":"Nat Commun"},{"key":"2025031100020896200_awae075-B42","doi-asserted-by":"crossref","first-page":"104877","DOI":"10.1016\/j.nbd.2020.104877","article-title":"Single-cell RNA-Seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis","volume":"141","author":"Liu","year":"2020","journal-title":"Neurobiol Dis"},{"key":"2025031100020896200_awae075-B43","doi-asserted-by":"crossref","first-page":"109308","DOI":"10.1016\/j.celrep.2021.109308","article-title":"Cell-intrinsic glial pathology is conserved across human and murine models of Huntington\u2019s disease","volume":"36","author":"Benraiss","year":"2021","journal-title":"Cell Rep"},{"key":"2025031100020896200_awae075-B44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinform"},{"key":"2025031100020896200_awae075-B45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-Seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinform"},{"key":"2025031100020896200_awae075-B46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinform"},{"issue":"W1","key":"2025031100020896200_awae075-B47","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2025031100020896200_awae075-B48","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr Protoc"},{"key":"2025031100020896200_awae075-B49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: A comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol Eng"},{"key":"2025031100020896200_awae075-B50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jphs.2019.02.009","article-title":"Involvement of sex hormonal regulation of K(+) channels in electrophysiological and contractile functions of muscle tissues","volume":"139","author":"Sakamoto","year":"2019","journal-title":"J Pharmacol Sci"},{"key":"2025031100020896200_awae075-B51","doi-asserted-by":"crossref","first-page":"e106345","DOI":"10.1371\/journal.pone.0106345","article-title":"Na+K+-ATPase activity and K+ channels differently contribute to vascular relaxation in male and female rats","volume":"9","author":"Dias","year":"2014","journal-title":"PLoS One"},{"key":"2025031100020896200_awae075-B52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","article-title":"Astrocytes: A central element in neurological diseases","volume":"131","author":"Pekny","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2025031100020896200_awae075-B53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","article-title":"Immune modulation of learning, memory, neural plasticity and neurogenesis","volume":"25","author":"Yirmiya","year":"2011","journal-title":"Brain Behav Immun"},{"key":"2025031100020896200_awae075-B54","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1194\/jlr.M015412","article-title":"Deletion of the murine scavenger receptor CD68","volume":"52","author":"Song","year":"2011","journal-title":"J Lipid Res"},{"key":"2025031100020896200_awae075-B55","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bbrc.2005.12.021","article-title":"Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments","volume":"340","author":"Chen","year":"2006","journal-title":"Biochem Bioph Res Commun"},{"key":"2025031100020896200_awae075-B56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0197-4580(90)90546-C","article-title":"Neuronal population of area 4 during the life span of the rhesus monkey","volume":"11","author":"Tigges","year":"1990","journal-title":"Neurobiol Aging"},{"key":"2025031100020896200_awae075-B57","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/NEN.0b013e31818fc72f","article-title":"Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease","volume":"67","author":"Freeman","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025031100020896200_awae075-B58","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(86)90863-2","article-title":"The effects of moderate changes of extracellular K+ and Ca2+ on synaptic and neural function in the CA1 region of the hippocampal slice","volume":"377","author":"Balestrino","year":"1986","journal-title":"Brain Res"},{"key":"2025031100020896200_awae075-B59","doi-asserted-by":"crossref","first-page":"111197","DOI":"10.1016\/j.mad.2019.111197","article-title":"Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer\u2019s disease: An update","volume":"185","author":"Villa","year":"2020","journal-title":"Mech Ageing Dev"},{"key":"2025031100020896200_awae075-B60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.03.019","article-title":"Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons","volume":"7","author":"Wainger","year":"2014","journal-title":"Cell Rep"},{"key":"2025031100020896200_awae075-B61","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1096\/fj.201801751R","article-title":"Ca(2+) homeostasis dysregulation in Alzheimer\u2019s disease: A focus on plasma membrane and cell organelles","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J"},{"key":"2025031100020896200_awae075-B62","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1093\/hmg\/ddz107","article-title":"Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations","volume":"28","author":"Bursch","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"1\u20133","key":"2025031100020896200_awae075-B63","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.10.032","article-title":"Excitotoxicity: Bridge to various triggers in neurodegenerative disorders","volume":"698","author":"Mehta","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"2025031100020896200_awae075-B64","doi-asserted-by":"crossref","first-page":"F241","DOI":"10.1152\/ajprenal.00126.2005","article-title":"FXYD proteins: New regulators of Na-K-ATPase","volume":"290","author":"Geering","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025031100020896200_awae075-B65","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bpj.2014.05.046","article-title":"The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation","volume":"107","author":"Cater","year":"2014","journal-title":"Biophys J"},{"key":"2025031100020896200_awae075-B66","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1471-4159.2006.04131.x","article-title":"Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis","volume":"99","author":"Kaiser","year":"2006","journal-title":"J Neurochem"},{"key":"2025031100020896200_awae075-B67","doi-asserted-by":"crossref","first-page":"eaaw8546","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte molecular signatures in Huntington\u2019s disease","volume":"11","author":"Diaz-Castro","year":"2019","journal-title":"Sci Transl Med"},{"key":"2025031100020896200_awae075-B68","first-page":"641","article-title":"Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue","volume":"44","author":"Heinemann","year":"1986","journal-title":"Adv Neurol"},{"issue":"Pt 2","key":"2025031100020896200_awae075-B69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroimage.2014.07.067","article-title":"Changes in structural and functional connectivity among resting-state networks across the human lifespan","volume":"102","author":"Betzel","year":"2014","journal-title":"Neuroimage"},{"key":"2025031100020896200_awae075-B70","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.nicl.2018.03.013","article-title":"Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?","volume":"18","author":"Hohenfeld","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2025031100020896200_awae075-B71","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1038\/cddis.2011.117","article-title":"A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics","volume":"2","author":"Nguyen","year":"2011","journal-title":"Cell Death Dis"},{"key":"2025031100020896200_awae075-B72","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: What are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2025031100020896200_awae075-B73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnagi.2018.00039","article-title":"Resting state BOLD variability in Alzheimer\u2019s disease: A marker of cognitive decline or cerebrovascular Status?","volume":"10","author":"Scarapicchia","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"2025031100020896200_awae075-B74","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0418-20.2020","article-title":"Neuronal network excitability in Alzheimer\u2019s disease: The puzzle of similar versus divergent roles of amyloid \u03b2 and tau","volume":"8","author":"Kazim","year":"2021","journal-title":"eNeuro"},{"key":"2025031100020896200_awae075-B75","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fnagi.2017.00418","article-title":"Amyloid associated intermittent network disruptions in cognitively intact older subjects: Structural connectivity matters","volume":"9","author":"Mueller","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"2025031100020896200_awae075-B76","doi-asserted-by":"crossref","first-page":"e1418","DOI":"10.1212\/WNL.0000000000005333","article-title":"Increased cerebral functional connectivity in ALS: A resting-estate magnetoencephalography study","volume":"90","author":"Proudfoot","year":"2018","journal-title":"Neurology"},{"key":"2025031100020896200_awae075-B77","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/hbm.24790","article-title":"Aberrant brain network connectivity in presymptomatic and manifest Huntington\u2019s disease: A systematic review","volume":"41","author":"Pini","year":"2020","journal-title":"Hum Brain Mapp"},{"key":"2025031100020896200_awae075-B78","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-76937-5","volume-title":"Ionic and volume changes in the microenvironment of nerve and receptor cells","author":"Sykov\u00e9","year":"1992"},{"key":"2025031100020896200_awae075-B79","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.167.3922.1248","article-title":"Neuroglia: Biophysical properties and physiologic function","volume":"167","author":"Trachtenberg","year":"1970","journal-title":"Science"},{"key":"2025031100020896200_awae075-B80","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.3726539","article-title":"High potassium conductance in astrocyte endfeet","volume":"233","author":"Newman","year":"1986","journal-title":"Science"},{"key":"2025031100020896200_awae075-B81","doi-asserted-by":"crossref","first-page":"20130595","DOI":"10.1098\/rstb.2013.0595","article-title":"Astroglial cradle in the life of the synapse","volume":"369","author":"Verkhratsky","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2025031100020896200_awae075-B82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1986.tb27134.x","article-title":"The neuronal microenvironment: A comparative view","volume":"481","author":"Cserr","year":"1986","journal-title":"Ann N Y Acad Sci"},{"key":"2025031100020896200_awae075-B83","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuroscience.2009.01.023","article-title":"Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer\u2019s disease","volume":"159","author":"Wilcock","year":"2009","journal-title":"Neuroscience"},{"key":"2025031100020896200_awae075-B84","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11357-011-9330-5","article-title":"Glial molecular alterations with mouse brain development and aging: Up-regulation of the kir4.1 and aquaporin-4","volume":"35","author":"Gupta","year":"2013","journal-title":"Age (Dordr)"},{"key":"2025031100020896200_awae075-B85","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: Transcriptomic, proteomic, morphological, and functional evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"2025031100020896200_awae075-B86","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/glia.22629","article-title":"Contributions of the Na\u207a\/K\u207a-ATPase, NKCC1, and kir4.1 to hippocampal K\u207a clearance and volume responses","volume":"62","author":"Larsen","year":"2014","journal-title":"Glia"},{"key":"2025031100020896200_awae075-B87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40478-016-0390-8","article-title":"Rubidium and potassium levels are altered in Alzheimer\u2019s disease brain and blood but not in cerebrospinal fluid","volume":"4","author":"Roberts","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"2025031100020896200_awae075-B88","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1152\/physrev.00027.2007","article-title":"Diffusion in brain extracellular space","volume":"88","author":"Sykov\u00e1","year":"2008","journal-title":"Physiol Rev"},{"key":"2025031100020896200_awae075-B89","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/BF00236151","article-title":"Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration","volume":"40","author":"Dietzel","year":"1980","journal-title":"Exp Brain Res"},{"key":"2025031100020896200_awae075-B90","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1523\/JNEUROSCI.05-02-00532.1985","article-title":"Activity-dependent shrinkage of extracellular space in rat optic nerve: A developmental study","volume":"5","author":"Ransom","year":"1985","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"2025031100020896200_awae075-B91","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0006-8993(91)91235-S","article-title":"Extracellular space volume changes in the rat spinal cord produced by nerve stimulation and peripheral injury","volume":"560","author":"Svoboda","year":"1991","journal-title":"Brain Res"},{"key":"2025031100020896200_awae075-B92","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1073\/pnas.0408235102","article-title":"Changes in extracellular space size and geometry in APP23 transgenic mice: A model of Alzheimer\u2019s disease","volume":"102","author":"Sykov\u00e1","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025031100020896200_awae075-B93","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-pathol-052016-100218","article-title":"Disorders of astrocytes: Alexander disease as a model","volume":"12","author":"Olabarria","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"2025031100020896200_awae075-B94","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1152\/jn.2001.85.4.1719","article-title":"Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia","volume":"85","author":"Bordey","year":"2001","journal-title":"J Neurophysiol"},{"key":"2025031100020896200_awae075-B95","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1098-1136(199909)27:3<213::AID-GLIA3>3.0.CO;2-1","article-title":"K(+) inward rectifier currents in reactive astrocytes from adult rat brain","volume":"27","author":"Perill\u00e1n","year":"1999","journal-title":"Glia"},{"key":"2025031100020896200_awae075-B96","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/glia.20145","article-title":"Potassium homeostasis in the ischemic brain","volume":"50","author":"Leis","year":"2005","journal-title":"Glia"},{"key":"2025031100020896200_awae075-B97","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1097\/00001756-200009280-00022","article-title":"Reactive astrocytes show enhanced inwardly rectifying K+ currents in situ","volume":"11","author":"Bordey","year":"2000","journal-title":"Neuroreport"},{"key":"2025031100020896200_awae075-B98","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-022-04739-5","article-title":"Divergent transcriptional regulation of astrocyte reactivity across disorders","volume":"606","author":"Burda","year":"2022","journal-title":"Nature"},{"key":"2025031100020896200_awae075-B99","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archpsyc.1984.01790150033006","article-title":"Norepinephrine and MHPG levels in CSF and plasma in Alzheimer\u2019s disease","volume":"41","author":"Raskind","year":"1984","journal-title":"Arch Gen Psychiatry"},{"issue":"Suppl 2","key":"2025031100020896200_awae075-B100","first-page":"S61","article-title":"Serum and cerebrospinal fluid biochemical markers of ALS","volume":"1","author":"Shaw","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"2025031100020896200_awae075-B101","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1471-4159.1992.tb09283.x","article-title":"Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington\u2019s disease: Evidence for an overactive dopaminergic brain transmission","volume":"58","author":"Garrett","year":"1992","journal-title":"J Neurochem"},{"key":"2025031100020896200_awae075-B102","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(86)90314-9","article-title":"Norepinephrine enhances stimulus-evoked calcium and potassium concentration changes in dentate granule cell layer","volume":"67","author":"Stanton","year":"1986","journal-title":"Neurosci Lett"},{"key":"2025031100020896200_awae075-B103","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front Neurosci"},{"key":"2025031100020896200_awae075-B104","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/jpet.107.123182","article-title":"Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury","volume":"322","author":"Deshpande","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"2025031100020896200_awae075-B105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s42003-020-01532-w","article-title":"Excess extracellular K(+) causes inner hair cell ribbon synapse degeneration","volume":"4","author":"Zhao","year":"2021","journal-title":"Commun Biol"},{"key":"2025031100020896200_awae075-B106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0306-4522(96)00171-6","article-title":"In vivo elevation of extracellular potassium in the rat amygdala increases extracellular glutamate and aspartate and damages neurons","volume":"74","author":"Fujikawa","year":"1996","journal-title":"Neuroscience"},{"key":"2025031100020896200_awae075-B107","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/jn.1987.58.2.404","article-title":"Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus","volume":"58","author":"Poolos","year":"1987","journal-title":"J Neurophysiol"},{"key":"2025031100020896200_awae075-B108","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/157015908784533879","article-title":"Water and ion channels: Crucial in the initiation and progression of apoptosis in central nervous system?","volume":"6","author":"Jessica Chen","year":"2008","journal-title":"Curr Neuropharmacol"},{"key":"2025031100020896200_awae075-B109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/09687680110047373","article-title":"Molecular physiology of neuronal K-ATP channels (review)","volume":"18","author":"Liss","year":"2001","journal-title":"Mol Membr Biol"},{"key":"2025031100020896200_awae075-B110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00424-004-1255-8","article-title":"The 2P-domain K+ channels: Role in apoptosis and tumorigenesis","volume":"448","author":"Patel","year":"2004","journal-title":"Pflugers Arch"},{"key":"2025031100020896200_awae075-B111","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1113\/JP275477","article-title":"Ether-\u00e0-go-go K(+) channels: Effective modulators of neuronal excitability","volume":"596","author":"Bauer","year":"2018","journal-title":"J Physiol"},{"key":"2025031100020896200_awae075-B112","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/cns.12804","article-title":"Potassium channel dysfunction in neurons and astrocytes in Huntington\u2019s disease","volume":"24","author":"Zhang","year":"2018","journal-title":"CNS Neurosci Ther"},{"key":"2025031100020896200_awae075-B113","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(85)90930-8","article-title":"Differences in cation transport properties of primary astrocyte cultures from mouse and rat brain","volume":"340","author":"Walz","year":"1985","journal-title":"Brain Res"},{"key":"2025031100020896200_awae075-B114","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1528-1157.1986.tb03511.x","article-title":"Extracellular (36Cl) space, electrolyte, protein, and DNA content in brain of DBA and C57 mice: Effects of age","volume":"27","author":"Engstrom","year":"1986","journal-title":"Epilepsia"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae075\/57311642\/awae075.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/5\/1726\/57400051\/awae075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/5\/1726\/57400051\/awae075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T20:03:46Z","timestamp":1741637026000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/5\/1726\/7625226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":114,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3,11]]},"published-print":{"date-parts":[[2024,5,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae075","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,3,11]]}}}