{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:32Z","timestamp":1791644432313,"version":"4.3.4"},"reference-count":121,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS105437"],"award-info":[{"award-number":["R21NS105437"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS101156"],"award-info":[{"award-number":["R01NS101156"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077692"],"award-info":[{"award-number":["R01AG077692"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutional National Research Service Award","award":["T32AG000255"],"award-info":[{"award-number":["T32AG000255"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF-22-972333"],"award-info":[{"award-number":["AARF-22-972333"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["AG010124"],"award-info":[{"award-number":["AG010124"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["U19 AG062418"],"award-info":[{"award-number":["U19 AG062418"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["P50 NS053488"],"award-info":[{"award-number":["P50 NS053488"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["P01-AG-066597"],"award-info":[{"award-number":["P01-AG-066597"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","award":["R01-AG-054519"],"award-info":[{"award-number":["R01-AG-054519"]}],"id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Approximately 22% of Alzheimer\u2019s disease (AD) patients suffer from seizures, and the co-occurrence of seizures and epileptiform activity exacerbates AD pathology and related cognitive deficits, suggesting that seizures may be a targetable component of AD progression. Given that alterations in neuronal excitatory:inhibitory (E:I) balance occur in epilepsy, we hypothesized that decreased markers of inhibition relative to those of excitation would be present in AD patients. We similarly hypothesized that in 5XFAD mice, the E:I imbalance would progress from an early stage (prodromal) to later symptomatic stages and be further exacerbated by pentylenetetrazol (PTZ) kindling.<\/jats:p>\n                  <jats:p>Post-mortem AD temporal cortical tissues from patients with or without seizure history were examined for changes in several markers of E:I balance, including levels of the inhibitory GABAA receptor, the sodium potassium chloride cotransporter 1 (NKCC1) and potassium chloride cotransporter 2 (KCC2) and the excitatory NMDA and AMPA type glutamate receptors. We performed patch-clamp electrophysiological recordings from CA1 neurons in hippocampal slices and examined the same markers of E:I balance in prodromal 5XFAD mice. We next examined 5XFAD mice at chronic stages, after PTZ or control protocols, and in response to chronic mTORC1 inhibitor rapamycin, administered following kindled seizures, for markers of E:I balance.<\/jats:p>\n                  <jats:p>We found that AD patients with comorbid seizures had worsened cognitive and functional scores and decreased GABAA receptor subunit expression, as well as increased NKCC1\/KCC2 ratios, indicative of depolarizing GABA responses. Patch clamp recordings of prodromal 5XFAD CA1 neurons showed increased intrinsic excitability, along with decreased GABAergic inhibitory transmission and altered glutamatergic neurotransmission, indicating that E:I imbalance may occur in early disease stages. Furthermore, seizure induction in prodromal 5XFAD mice led to later dysregulation of NKCC1\/KCC2 and a reduction in GluA2 AMPA glutamate receptor subunit expression, indicative of depolarizing GABA receptors and calcium permeable AMPA receptors. Finally, we found that chronic treatment with the mTORC1 inhibitor, rapamycin, at doses we have previously shown to attenuate seizure-induced amyloid-\u03b2 pathology and cognitive deficits, could also reverse elevations of the NKCC1\/KCC2 ratio in these mice.<\/jats:p>\n                  <jats:p>Our data demonstrate novel mechanisms of interaction between AD and epilepsy and indicate that targeting E:I balance, potentially with US Food and Drug Administration-approved mTOR inhibitors, hold therapeutic promise for AD patients with a seizure history.<\/jats:p>","DOI":"10.1093\/brain\/awae126","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:31:37Z","timestamp":1713915097000},"page":"2169-2184","source":"Crossref","is-referenced-by-count":59,"title":["Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer\u2019s disease and 5XFAD mice"],"prefix":"10.1093","volume":"147","author":[{"given":"Aaron J","family":"Barbour","sequence":"first","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gourmaud","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjoo","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Duke University School of Medicine , Durham, NC 27708 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keegan F","family":"Hoag","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-5098","authenticated-orcid":false,"given":"David J","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Frontotemporal Degeneration Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia M","family":"Talos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances E","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"2024060314264493800_awae126-B1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer\u2019s disease: Causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol"},{"key":"2024060314264493800_awae126-B2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.24794","article-title":"Incidence and impact of subclinical epileptiform activity in Alzheimer\u2019s disease","volume":"80","author":"Vossel","year":"2016","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B3","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.clinph.2021.03.050","article-title":"Subclinical epileptiform activity accelerates the progression of Alzheimer\u2019s disease: A long-term EEG study","volume":"132","author":"Horvath","year":"2021","journal-title":"Clin Neurophysiol"},{"key":"2024060314264493800_awae126-B4","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3389\/fneur.2019.01266","article-title":"A longitudinal study of epileptic seizures in Alzheimer\u2019s disease","volume":"10","author":"Baker","year":"2019","journal-title":"Front Neurol"},{"key":"2024060314264493800_awae126-B5","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1007\/s00415-020-09937-7","article-title":"Seizures in Alzheimer's disease are highly recurrent and associated with a poor disease course","volume":"267","author":"Voglein","year":"2020","journal-title":"J Neurol"},{"key":"2024060314264493800_awae126-B6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/brain\/awz381","article-title":"Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy","volume":"143","author":"Gourmaud","year":"2020","journal-title":"Brain"},{"key":"2024060314264493800_awae126-B7","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/brain\/awr209","article-title":"Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: A post-mortem study","volume":"134","author":"Thom","year":"2011","journal-title":"Brain"},{"issue":"Pt 9","key":"2024060314264493800_awae126-B8","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/brain\/aww187","article-title":"Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: A study of temporal lobe resections","volume":"139","author":"Tai","year":"2016","journal-title":"Brain"},{"key":"2024060314264493800_awae126-B9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneurol.2009.15","article-title":"Epilepsy and cognitive impairments in Alzheimer disease","volume":"66","author":"Palop","year":"2009","journal-title":"Arch Neurol"},{"key":"2024060314264493800_awae126-B10","first-page":"157","article-title":"Seizure susceptibility and mortality in mice that over-express amyloid precursor protein","volume":"1","author":"Westmark","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"2024060314264493800_awae126-B11","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1523\/JNEUROSCI.2107-13.2013","article-title":"Antisense reduction of tau in adult mice protects against seizures","volume":"33","author":"DeVos","year":"2013","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13024-020-00393-5","article-title":"Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer\u2019s disease mutations but not by inhibition of BACE1","volume":"15","author":"Johnson","year":"2020","journal-title":"Mol Neurodegener"},{"key":"2024060314264493800_awae126-B13","doi-asserted-by":"crossref","first-page":"109855","DOI":"10.1016\/j.celrep.2021.109855","article-title":"Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation\/inhibition ratios, and counteracts network hypersynchrony","volume":"37","author":"Chang","year":"2021","journal-title":"Cell Rep"},{"key":"2024060314264493800_awae126-B14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/brain\/awab268","article-title":"The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer\u2019s disease","volume":"145","author":"Gourmaud","year":"2022","journal-title":"Brain"},{"key":"2024060314264493800_awae126-B15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: Emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"2024060314264493800_awae126-B16","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1523\/JNEUROSCI.0496-13.2013","article-title":"Phosphorylation of AMPA-type glutamate receptors: The trigger of epileptogenesis?","volume":"33","author":"Bakker","year":"2013","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B17","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3389\/fneur.2019.01407","article-title":"Role of NKCC1 and KCC2 in epilepsy: From expression to function","volume":"10","author":"Liu","year":"2019","journal-title":"Front Neurol"},{"key":"2024060314264493800_awae126-B18","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1124\/jpet.104.068478","article-title":"Epileptogenesis causes acute and chronic increases in GABAA receptor endocytosis that contributes to the induction and maintenance of seizures in the hippocampal culture model of acquired epilepsy","volume":"310","author":"Blair","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"2024060314264493800_awae126-B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2010.02792.x","article-title":"\u201cJasper's Basic Mechanisms of the Epilepsies\u201d workshop","volume":"51","author":"Noebels","year":"2010","journal-title":"Epilepsia"},{"key":"2024060314264493800_awae126-B20","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/2661","article-title":"Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy","volume":"4","author":"Brooks-Kayal","year":"1998","journal-title":"Nat Med"},{"key":"2024060314264493800_awae126-B21","doi-asserted-by":"crossref","first-page":"21458","DOI":"10.1074\/jbc.M112.444372","article-title":"Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome","volume":"288","author":"Zhou","year":"2013","journal-title":"J Biol Chem"},{"key":"2024060314264493800_awae126-B22","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1523\/JNEUROSCI.6495-11.2012","article-title":"Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor alpha subunit isoforms","volume":"32","author":"Eyre","year":"2012","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ana.22696","article-title":"Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia","volume":"71","author":"Talos","year":"2012","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B24","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1073\/pnas.0602979103","article-title":"Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory","volume":"103","author":"Palma","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024060314264493800_awae126-B25","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/j.1528-1167.2011.03247.x","article-title":"Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus","volume":"52","author":"Barmashenko","year":"2011","journal-title":"Epilepsia"},{"key":"2024060314264493800_awae126-B26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ana.24870","article-title":"Depolarizing gamma-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy","volume":"81","author":"Kourdougli","year":"2017","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mcn.2016.08.002","article-title":"Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity","volume":"76","author":"Lippman-Bell","year":"2016","journal-title":"Mol Cell Neurosci"},{"key":"2024060314264493800_awae126-B28","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1523\/JNEUROSCI.1734-08.2008","article-title":"Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures","volume":"28","author":"Rakhade","year":"2008","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mcn.2018.07.004","article-title":"Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy","volume":"92","author":"Egbenya","year":"2018","journal-title":"Mol Cell Neurosci"},{"key":"2024060314264493800_awae126-B30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.eplepsyres.2014.01.015","article-title":"Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus","volume":"108","author":"Loddenkemper","year":"2014","journal-title":"Epilepsy Res"},{"key":"2024060314264493800_awae126-B31","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nbd.2011.02.012","article-title":"Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1\/2 mechanisms","volume":"42","author":"Di Maio","year":"2011","journal-title":"Neurobiol Dis"},{"key":"2024060314264493800_awae126-B32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nbd.2012.07.013","article-title":"Thiol oxidation and altered NR2B\/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis","volume":"49","author":"Di Maio","year":"2013","journal-title":"Neurobiol Dis"},{"key":"2024060314264493800_awae126-B33","doi-asserted-by":"crossref","first-page":"753274","DOI":"10.3389\/fnins.2021.753274","article-title":"Excitation\/inhibition modulators in autism spectrum disorder: Current clinical research","volume":"15","author":"Canitano","year":"2021","journal-title":"Front Neurosci"},{"key":"2024060314264493800_awae126-B34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.12703\/r\/10-58","article-title":"Recent advances in the role of excitation-inhibition balance in motor recovery post-stroke","volume":"10","author":"Grigoras","year":"2021","journal-title":"Fac Rev"},{"key":"2024060314264493800_awae126-B35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1515\/revneuro-2019-0014","article-title":"Excitation\/inhibition imbalance and impaired neurogenesis in neurodevelopmental and neurodegenerative disorders","volume":"30","author":"Lopatina","year":"2019","journal-title":"Rev Neurosci"},{"key":"2024060314264493800_awae126-B36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"2024060314264493800_awae126-B37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jnc.14325","article-title":"GABAA receptor subunit expression changes in the human Alzheimer\u2019s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus","volume":"145","author":"Kwakowsky","year":"2018","journal-title":"J Neurochem"},{"key":"2024060314264493800_awae126-B38","doi-asserted-by":"crossref","first-page":"10071","DOI":"10.1073\/pnas.1204606109","article-title":"Loss of functional GABA(A) receptors in the Alzheimer diseased brain","volume":"109","author":"Limon","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024060314264493800_awae126-B39","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/molecules27082440","article-title":"Beta-amyloid (Abeta1-42) increases the expression of NKCC1 in the mouse hippocampus","volume":"27","author":"Lam","year":"2022","journal-title":"Molecules"},{"key":"2024060314264493800_awae126-B40","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1523\/JNEUROSCI.3326-09.2010","article-title":"In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction","volume":"30","author":"Lagostena","year":"2010","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B41","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1093\/brain\/awad250","article-title":"Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer\u2019s disease mutations","volume":"146","author":"Keramidis","year":"2023","journal-title":"Brain"},{"key":"2024060314264493800_awae126-B42","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1523\/JNEUROSCI.0605-12.2012","article-title":"Synaptic distributions of GluA2 and PKMzeta in the monkey dentate gyrus and their relationships with aging and memory","volume":"32","author":"Hara","year":"2012","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B43","doi-asserted-by":"crossref","first-page":"3204519","DOI":"10.1155\/2016\/3204519","article-title":"Amyloid-beta-induced dysregulation of AMPA receptor trafficking","volume":"2016","author":"Guntupalli","year":"2016","journal-title":"Neural Plast"},{"key":"2024060314264493800_awae126-B44","doi-asserted-by":"crossref","first-page":"109786","DOI":"10.1016\/j.celrep.2021.109786","article-title":"\u03b2-Amyloid disruption of LTP\/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors","volume":"37","author":"Sanderson","year":"2021","journal-title":"Cell Rep"},{"key":"2024060314264493800_awae126-B45","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.celrep.2018.04.108","article-title":"Early seizures prematurely unsilence auditory synapses to disrupt thalamocortical critical period plasticity","volume":"23","author":"Sun","year":"2018","journal-title":"Cell Rep"},{"key":"2024060314264493800_awae126-B46","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/acel.12057","article-title":"mTOR regulates tau phosphorylation and degradation: Implications for Alzheimer\u2019s disease and other tauopathies","volume":"12","author":"Caccamo","year":"2013","journal-title":"Aging Cell"},{"key":"2024060314264493800_awae126-B47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.febslet.2005.11.059","article-title":"P70 S6 kinase mediates tau phosphorylation and synthesis","volume":"580","author":"Pei","year":"2006","journal-title":"FEBS Lett"},{"key":"2024060314264493800_awae126-B48","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2741\/s310","article-title":"The role of mTOR signaling in Alzheimer disease","volume":"4","author":"Oddo","year":"2012","journal-title":"Front Biosci (Schol Ed)"},{"key":"2024060314264493800_awae126-B49","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2147\/NDT.S75717","article-title":"Activation of mTOR: A culprit of Alzheimer\u2019s disease?","volume":"11","author":"Cai","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2024060314264493800_awae126-B50","first-page":"S123","article-title":"Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration","volume":"33 Suppl 1","author":"Wang","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"2024060314264493800_awae126-B51","doi-asserted-by":"crossref","first-page":"e51440","DOI":"10.7554\/eLife.51440","article-title":"Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission","volume":"9","author":"McCabe","year":"2020","journal-title":"Elife"},{"key":"2024060314264493800_awae126-B52","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/s41467-021-22908-4","article-title":"Tanc2-mediated mTOR inhibition balances mTORC1\/2 signaling in the developing mouse brain and human neurons","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"2024060314264493800_awae126-B53","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ana.21342","article-title":"Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers","volume":"63","author":"Talos","year":"2008","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B54","doi-asserted-by":"crossref","first-page":"111085","DOI":"10.1016\/j.celrep.2022.111085","article-title":"Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex","volume":"40","author":"Wu","year":"2022","journal-title":"Cell Rep"},{"key":"2024060314264493800_awae126-B55","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1038\/s41467-021-23939-7","article-title":"Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss","volume":"12","author":"Amegandjin","year":"2021","journal-title":"Nat Commun"},{"key":"2024060314264493800_awae126-B56","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuron.2013.03.017","article-title":"Excitatory\/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis","volume":"78","author":"Bateup","year":"2013","journal-title":"Neuron"},{"key":"2024060314264493800_awae126-B57","doi-asserted-by":"crossref","first-page":"e150120","DOI":"10.1172\/jci.insight.150120","article-title":"Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis","volume":"6","author":"Koene","year":"2021","journal-title":"JCI Insight"},{"key":"2024060314264493800_awae126-B58","doi-asserted-by":"crossref","first-page":"E1070","DOI":"10.1073\/pnas.1106454108","article-title":"Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex","volume":"108","author":"Goto","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024060314264493800_awae126-B59","doi-asserted-by":"crossref","first-page":"106401","DOI":"10.1016\/j.phrs.2022.106401","article-title":"Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder","volume":"183","author":"Iezzi","year":"2022","journal-title":"Pharmacol Res"},{"key":"2024060314264493800_awae126-B60","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41419-020-02966-0","article-title":"Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain","volume":"11","author":"Ma","year":"2020","journal-title":"Cell Death Dis"},{"key":"2024060314264493800_awae126-B61","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1016\/j.jalz.2010.08.233","article-title":"Building an integrated neurodegenerative disease database at an academic health center","volume":"7","author":"Xie","year":"2011","journal-title":"Alzheimers Dement"},{"key":"2024060314264493800_awae126-B62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"2024060314264493800_awae126-B63","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/WAD.0000000000000279","article-title":"Version 3 of the National Alzheimer's Coordinating Center\u2019s Uniform Data Set","volume":"32","author":"Besser","year":"2018","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2024060314264493800_awae126-B64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157015908783769653","article-title":"GABA(a) receptors in normal development and seizures: Friends or foes?","volume":"6","author":"Galanopoulou","year":"2008","journal-title":"Curr Neuropharmacol"},{"key":"2024060314264493800_awae126-B65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/dneu.20853","article-title":"Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons","volume":"71","author":"Rudy","year":"2011","journal-title":"Dev Neurobiol"},{"key":"2024060314264493800_awae126-B66","doi-asserted-by":"crossref","first-page":"16778","DOI":"10.1038\/srep16778","article-title":"Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility","volume":"5","author":"Murray","year":"2015","journal-title":"Sci Rep"},{"key":"2024060314264493800_awae126-B67","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuroscience.2011.05.021","article-title":"Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures","volume":"189","author":"Drexel","year":"2011","journal-title":"Neuroscience"},{"key":"2024060314264493800_awae126-B68","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.brainresbull.2005.10.008","article-title":"Densities of parvalbumin-immunoreactive neurons in non-malformed hippocampal sclerosis-temporal neocortex and in cortical dysplasias","volume":"68","author":"Zamecnik","year":"2006","journal-title":"Brain Res Bull"},{"key":"2024060314264493800_awae126-B69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13041-021-00774-x","article-title":"Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation","volume":"14","author":"Kim","year":"2021","journal-title":"Mol Brain"},{"key":"2024060314264493800_awae126-B70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fnagi.2017.00071","article-title":"Early-onset network hyperexcitability in presymptomatic Alzheimer\u2019s disease transgenic mice is suppressed by passive immunization with anti-human APP\/abeta antibody and by mGluR5 blockade","volume":"9","author":"Kazim","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"2024060314264493800_awae126-B71","doi-asserted-by":"crossref","first-page":"e91203","DOI":"10.1371\/journal.pone.0091203","article-title":"Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer's disease in vivo","volume":"9","author":"Davis","year":"2014","journal-title":"PLoS One"},{"key":"2024060314264493800_awae126-B72","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","article-title":"Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model","volume":"33","author":"Kimura","year":"2009","journal-title":"Neurobiol Dis"},{"key":"2024060314264493800_awae126-B73","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40478-020-00936-3","article-title":"Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model","volume":"8","author":"Abe","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"2024060314264493800_awae126-B75","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neubiorev.2018.05.001","article-title":"Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions","volume":"90","author":"Schulte","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"2024060314264493800_awae126-B76","doi-asserted-by":"crossref","first-page":"8704","DOI":"10.3390\/ijms21228704","article-title":"Impaired expression of GABA signaling components in the Alzheimer\u2019s disease middle temporal gyrus","volume":"21","author":"Govindpani","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024060314264493800_awae126-B77","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0306-4522(03)00030-7","article-title":"Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology","volume":"120","author":"Rissman","year":"2003","journal-title":"Neuroscience"},{"key":"2024060314264493800_awae126-B78","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/neuro.05.028.2009","article-title":"Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques","volume":"3","author":"Garcia-Marin","year":"2009","journal-title":"Front Neuroanat"},{"key":"2024060314264493800_awae126-B79","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/JAD-2008-14305","article-title":"Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer's disease","volume":"14","author":"Agarwal","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"2024060314264493800_awae126-B80","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/bpa.12785","article-title":"Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer\u2019s mice and patients","volume":"30","author":"Sanchez-Mejias","year":"2020","journal-title":"Brain Pathol"},{"key":"2024060314264493800_awae126-B81","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00004691-200212000-00010","article-title":"Generalized synchronization of MEG recordings in Alzheimer\u2019s disease: Evidence for involvement of the gamma band","volume":"19","author":"Stam","year":"2002","journal-title":"J Clin Neurophysiol"},{"key":"2024060314264493800_awae126-B82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnsys.2016.00083","article-title":"Early cortical changes in gamma oscillations in Alzheimer\u2019s disease","volume":"10","author":"Klein","year":"2016","journal-title":"Front Syst Neurosci"},{"key":"2024060314264493800_awae126-B83","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jchemneu.2004.05.003","article-title":"Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment","volume":"28","author":"Rissman","year":"2004","journal-title":"J Chem Neuroanat"},{"key":"2024060314264493800_awae126-B84","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3233\/JAD-181190","article-title":"Parvalbumin-positive neuron loss and amyloid-beta deposits in the frontal cortex of Alzheimer's disease-related mice","volume":"72","author":"Ali","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"2024060314264493800_awae126-B85","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/gbb.12133","article-title":"Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics","volume":"13","author":"Flanigan","year":"2014","journal-title":"Genes Brain Behav"},{"key":"2024060314264493800_awae126-B86","doi-asserted-by":"crossref","first-page":"1759091420925356","DOI":"10.1177\/1759091420925356","article-title":"Loss of hippocampal calretinin and parvalbumin interneurons in the 5XFAD mouse model of Alzheimer's disease","volume":"12","author":"Giesers","year":"2020","journal-title":"ASN Neuro"},{"key":"2024060314264493800_awae126-B87","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1523\/JNEUROSCI.0425-20.2020","article-title":"Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer\u2019s disease","volume":"40","author":"Caccavano","year":"2020","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B88","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"2024060314264493800_awae126-B89","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13195-021-00859-8","article-title":"Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model","volume":"13","author":"Li","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"2024060314264493800_awae126-B90","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1523\/JNEUROSCI.0950-15.2015","article-title":"Amyloid-beta impairs synaptic inhibition via GABA(A) receptor endocytosis","volume":"35","author":"Ulrich","year":"2015","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B91","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.expneurol.2003.12.010","article-title":"Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer\u2019s disease patients according to Braak stage","volume":"187","author":"Carter","year":"2004","journal-title":"Exp Neurol"},{"key":"2024060314264493800_awae126-B92","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/00005072-199709000-00007","article-title":"The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains","volume":"56","author":"Ikonomovic","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024060314264493800_awae126-B93","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuint.2011.03.010","article-title":"Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer\u2019s disease","volume":"58","author":"Mohamed","year":"2011","journal-title":"Neurochem Int"},{"key":"2024060314264493800_awae126-B94","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0896-6273(92)90120-3","article-title":"Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit","volume":"8","author":"Burnashev","year":"1992","journal-title":"Neuron"},{"key":"2024060314264493800_awae126-B95","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ana.23570","article-title":"Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus","volume":"72","author":"Rajasekaran","year":"2012","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B96","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnsyn.2018.00042","article-title":"The role of calcium-permeable AMPARs in long-term potentiation at principal neurons in the rodent hippocampus","volume":"10","author":"Park","year":"2018","journal-title":"Front Synaptic Neurosci"},{"key":"2024060314264493800_awae126-B97","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.arr.2004.07.002","article-title":"Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: Role of secreted proteins tPA and BDNF","volume":"3","author":"Pang","year":"2004","journal-title":"Ageing Res Rev"},{"key":"2024060314264493800_awae126-B98","doi-asserted-by":"crossref","first-page":"588295","DOI":"10.3389\/fnsyn.2020.588295","article-title":"Transient enhanced GluA2 expression in young hippocampal neurons of a fragile X mouse model","volume":"12","author":"Banke","year":"2020","journal-title":"Front Synaptic Neurosci"},{"key":"2024060314264493800_awae126-B99","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1038\/s41467-021-22742-8","article-title":"Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer\u2019s disease","volume":"12","author":"Lauterborn","year":"2021","journal-title":"Nat Commun"},{"key":"2024060314264493800_awae126-B100","doi-asserted-by":"crossref","first-page":"12537","DOI":"10.1523\/JNEUROSCI.2332-16.2016","article-title":"NR2A-containing NMDARs in the prefrontal cortex are required for working memory and associated with age-related cognitive decline","volume":"36","author":"McQuail","year":"2016","journal-title":"J Neurosci"},{"key":"2024060314264493800_awae126-B101","doi-asserted-by":"crossref","first-page":"174310","DOI":"10.1016\/j.ejphar.2021.174310","article-title":"NMDA and AMPA receptors dysregulation in Alzheimer\u2019s disease","volume":"908","author":"Babaei","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"2024060314264493800_awae126-B102","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12017-013-8221-6","article-title":"AMPA receptor properties are modulated in the early stages following pilocarpine-induced status epilepticus","volume":"15","author":"Russo","year":"2013","journal-title":"Neuromolecular Med"},{"key":"2024060314264493800_awae126-B103","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/epi.14082","article-title":"The role of AMPA receptors and their antagonists in status epilepticus","volume":"59","author":"Leo","year":"2018","journal-title":"Epilepsia"},{"key":"2024060314264493800_awae126-B104","doi-asserted-by":"crossref","first-page":"922535","DOI":"10.3389\/fneur.2022.922535","article-title":"The clinical correlation between Alzheimer\u2019s disease and epilepsy","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Neurol"},{"key":"2024060314264493800_awae126-B105","doi-asserted-by":"crossref","first-page":"e2259","DOI":"10.1212\/WNL.0000000000010612","article-title":"Association of epileptiform abnormalities and seizures in Alzheimer disease","volume":"95","author":"Lam","year":"2020","journal-title":"Neurology"},{"key":"2024060314264493800_awae126-B106","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer\u2019s disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat Med"},{"key":"2024060314264493800_awae126-B107","doi-asserted-by":"crossref","first-page":"e3248","DOI":"10.1212\/WNL.0000000000011080","article-title":"Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities study","volume":"95","author":"Johnson","year":"2020","journal-title":"Neurology"},{"key":"2024060314264493800_awae126-B108","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jns.2018.09.010","article-title":"Incidence of dementia in patients with adult-onset epilepsy of unknown causes","volume":"395","author":"Kawakami","year":"2018","journal-title":"J Neurol Sci"},{"key":"2024060314264493800_awae126-B109","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamaneurol.2021.3310","article-title":"Effect of levetiracetam on cognition in patients with Alzheimer disease with and without epileptiform activity: A randomized clinical trial","volume":"78","author":"Vossel","year":"2021","journal-title":"JAMA Neurol"},{"key":"2024060314264493800_awae126-B110","doi-asserted-by":"crossref","first-page":"17590914211022089","DOI":"10.1177\/17590914211022089","article-title":"Restoration of KCC2 membrane localization in striatal dopamine D2 receptor-expressing medium spiny neurons rescues locomotor deficits in HIV tat-transgenic mice","volume":"13","author":"Barbour","year":"2021","journal-title":"ASN Neuro"},{"key":"2024060314264493800_awae126-B111","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s43587-021-00122-7","article-title":"Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer\u2019s disease","volume":"1","author":"Taubes","year":"2021","journal-title":"Nature Aging"},{"key":"2024060314264493800_awae126-B112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: What are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2024060314264493800_awae126-B113","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3340\/jkns.2019.0027","article-title":"Mechanistic target of rapamycin pathway in epileptic disorders","volume":"62","author":"Kim","year":"2019","journal-title":"J Korean Neurosurg Soc"},{"key":"2024060314264493800_awae126-B114","doi-asserted-by":"crossref","first-page":"eaar4289","DOI":"10.1126\/scitranslmed.aar4289","article-title":"Rapamycin and Alzheimer\u2019s disease: Time for a clinical trial?","volume":"11","author":"Kaeberlein","year":"2019","journal-title":"Sci Transl Med"},{"key":"2024060314264493800_awae126-B115","doi-asserted-by":"crossref","first-page":"e13277","DOI":"10.1111\/acel.13277","article-title":"Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus","volume":"20","author":"Kodali","year":"2021","journal-title":"Aging Cell"},{"key":"2024060314264493800_awae126-B116","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.21331","article-title":"Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex","volume":"63","author":"Zeng","year":"2008","journal-title":"Ann Neurol"},{"key":"2024060314264493800_awae126-B117","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/npp.2014.16","article-title":"mTORC1 inhibition in the nucleus accumbens \u2018protects\u2019 against the expression of drug seeking and \u2018relapse\u2019 and is associated with reductions in GluA1 AMPAR and CAMKIIalpha levels","volume":"39","author":"James","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"2024060314264493800_awae126-B118","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2016.05.013","article-title":"Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum","volume":"784","author":"James","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"2024060314264493800_awae126-B119","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fnagi.2020.00230","article-title":"Rapamycin, by inhibiting mTORC1 signaling, prevents the loss of striatal bidirectional synaptic plasticity in a rat model of L-DOPA-induced dyskinesia","volume":"12","author":"Calabrese","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"2024060314264493800_awae126-B120","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11064-018-2470-6","article-title":"BDNF activates mTOR to upregulate NR2B expression in the rostral anterior cingulate cortex required for inflammatory pain-related aversion in rats","volume":"43","author":"Zhang","year":"2018","journal-title":"Neurochem Res"},{"key":"2024060314264493800_awae126-B121","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1474-9726.2011.00791.x","article-title":"Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling","volume":"11","author":"Majumder","year":"2012","journal-title":"Aging Cell"}],"container-title":["Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/brain\/advance-article-pdf\/doi\/10.1093\/brain\/awae126\/57942822\/awae126.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/6\/2169\/58062095\/awae126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/brain\/article-pdf\/147\/6\/2169\/58062095\/awae126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T16:35:37Z","timestamp":1717432537000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/brain\/article\/147\/6\/2169\/7658323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":121,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,4,25]]},"published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/brain\/awae126","relation":{},"ISSN":["0006-8950","1460-2156"],"issn-type":[{"value":"0006-8950","type":"print"},{"value":"1460-2156","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,4,25]]}}}