{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:19:49Z","timestamp":1789773589814,"version":"4.0.1"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de la Recherche du Qu\u00e9bec\u2013Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Richard and Ann Sievers Neuroscience"},{"DOI":"10.13039\/501100003725","name":"National Research 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PJT-174995"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SickKids Foundation","award":["NI17-039"],"award-info":[{"award-number":["NI17-039"]}]},{"name":"Azrieli Center for Autism Research of the Montreal Neurological Institute"},{"name":"BrainCanada"},{"name":"Helmholtz International BigBrain Analytics and Learning Laboratory"},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Network neuroscience offers a unique framework to understand the organizational principles of the human brain. Despite recent progress, our understanding of how the brain is modulated by focal lesions remains incomplete. Resection of the temporal lobe is the most effective treatment to control seizures in pharmaco-resistant temporal lobe epilepsy (TLE), making this syndrome a powerful model to study lesional effects on network organization in young and middle-aged adults. Here, we assessed the downstream consequences of a focal lesion and its surgical resection on the brain\u2019s structural connectome, and explored how this reorganization relates to clinical variables at the individual patient level.<\/jats:p>\n                  <jats:p>We included adults with pharmaco-resistant TLE (n = 37) who underwent anterior temporal lobectomy between two imaging time points, as well as age- and sex-matched healthy controls who underwent comparable imaging (n = 31). Core to our analysis was the projection of high-dimensional structural connectome data\u2014derived from diffusion MRI tractography from each subject\u2014into lower-dimensional gradients. We then compared connectome gradients in patients relative to controls before surgery, tracked surgically-induced connectome reconfiguration from pre- to postoperative time points, and examined associations to patient-specific clinical and imaging phenotypes.<\/jats:p>\n                  <jats:p>Before surgery, individuals with TLE presented with marked connectome changes in bilateral temporo-parietal regions, reflecting an increased segregation of the ipsilateral anterior temporal lobe from the rest of the brain. Surgery-induced connectome reorganization was localized to this temporo-parietal subnetwork, but primarily involved postoperative integration of contralateral regions with the rest of the brain. Using a partial least-squares analysis, we uncovered a latent clinical imaging signature underlying this pre- to postoperative connectome reorganization, showing that patients who displayed postoperative integration in bilateral fronto-occipital cortices also had greater preoperative ipsilateral hippocampal atrophy, lower seizure frequency and secondarily generalized seizures.<\/jats:p>\n                  <jats:p>Our results bridge the effects of focal brain lesions and their surgical resections with large-scale network reorganization and interindividual clinical variability, thus offering new avenues to examine the fundamental malleability of the human brain.<\/jats:p>","DOI":"10.1093\/brain\/awae141","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T16:12:54Z","timestamp":1714666374000},"page":"2483-2495","source":"Crossref","is-referenced-by-count":33,"title":["Connectome reorganization associated with temporal lobe pathology and its surgical resection"],"prefix":"10.1093","volume":"147","author":[{"given":"Sara","family":"Larivi\u00e8re","sequence":"first","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"},{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Harvard University , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-337X","authenticated-orcid":false,"given":"Bo-yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Data Science, Inha University , Incheon 22212 , Republic of Korea"},{"name":"Center for Neuroscience Imaging Research, Institute for Basic Science , Suwon 34126 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-8998","authenticated-orcid":false,"given":"Jessica","family":"Royer","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"DeKraker","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ngo","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Sahlas","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Chen","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Rodr\u00edguez-Cruces","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine , Nanjing 210002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Frauscher","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Laboratory, Montreal Neurological Institute, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine , Nanjing 210002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengge","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golia","family":"Shafiei","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-2862","authenticated-orcid":false,"given":"Bratislav","family":"Mi\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-5703","authenticated-orcid":false,"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Harvard University , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine , Nanjing 210002 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris C","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"2024070507220366300_awae141-B1","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.pcbi.0010042","article-title":"The human connectome: A structural description of the human brain","volume":"1","author":"Sporns","year":"2005","journal-title":"PLoS Comput Biol."},{"key":"2024070507220366300_awae141-B2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/1073858416667720","article-title":"Small-World brain networks 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disorders, 1990\u20132016: A systematic analysis for the global burden of disease study 2016","volume":"18","author":"GBD 2016 Neurology Collaborators","year":"2019","journal-title":"Lancet Neurol"},{"key":"2024070507220366300_awae141-B12","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1212\/01.wnl.0000264000.11511.30","article-title":"Worsening of quality of life after epilepsy surgery: Effect of seizures and memory decline","volume":"68","author":"Langfitt","year":"2007","journal-title":"Neurology"},{"key":"2024070507220366300_awae141-B13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.yebeh.2004.06.008","article-title":"Depressed mood and memory impairment in temporal lobe epilepsy as a function of focus lateralization and localization","volume":"5","author":"Helmstaedter","year":"2004","journal-title":"Epilepsy 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